Search for Bc(ns)B_c(ns) via the Bc(ns)→Bc(ms)π+π−B_c(ns)\to B_c(ms)\pi^+\pi^- transition at LHCb and Z0Z_0 factory

It is interesting to study the characteristics of the whole family of $B_c$ which contains two different heavy flavors. LHC and the proposed $Z^0$ factory provide an opportunity because a large database on the $B_c$ family will be achieved. $B_c$ and its excited states can be identified via their decay modes. As suggested by experimentalists, $B_c^*(ns)\to B_c+\gamma$ is not easy to be clearly measured, instead, the trajectories of $\pi^+$ and $\pi^-$ occurring in the decay of $B_c(ns)\to B_c(ms)+\pi^+\pi^-$ ($n>m$) can be unambiguously identified, thus the measurement seems easier and more reliable, therefore this mode is more favorable at early running stage of LHCb and the proposed $Z^0$ factory. In this work, we calculate the rate of $B_c(ns)\to B_c(ms)+\pi^+\pi^-$ in terms of the QCD multipole-expansion and the numerical results indicate that the experimental measurements with the luminosity of LHC and $Z^0$ factory are feasible.Comment: 12 pages, 1 figures and 4 tables, acceptted by SCIENCE CHINA Physics, Mechanics & Astronomy (Science in China Series G

High-throughput avian molecular sexing by SYBR green-based real-time PCR combined with melting curve analysis

<p>Abstract</p> <p>Background</p> <p>Combination of <it>CHD </it>(chromo-helicase-DNA binding protein)-specific polymerase chain reaction (PCR) with electrophoresis (PCR/electrophoresis) is the most common avian molecular sexing technique but it is lab-intensive and gel-required. Gender determination often fails when the difference in length between the PCR products of <it>CHD-Z </it>and <it>CHD-W </it>genes is too short to be resolved.</p> <p>Results</p> <p>Here, we are the first to introduce a PCR-melting curve analysis (PCR/MCA) to identify the gender of birds by genomic DNA, which is gel-free, quick, and inexpensive. <it>Spilornis cheela hoya </it>(<it>S. c. hoya</it>) and <it>Pycnonotus sinensis </it>(<it>P. sinensis</it>) were used to illustrate this novel molecular sexing technique. The difference in the length of <it>CHD </it>genes in <it>S. c. hoya </it>and <it>P. sinensis </it>is 13-, and 52-bp, respectively. Using Griffiths' P2/P8 primers, molecular sexing failed both in PCR/electrophoresis of <it>S. c. hoya </it>and in PCR/MCA of <it>S. c. hoya </it>and <it>P. sinensis</it>. In contrast, we redesigned sex-specific primers to yield 185- and 112-bp PCR products for the <it>CHD-Z </it>and <it>CHD-W </it>genes of <it>S. c. hoya</it>, respectively, using PCR/MCA. Using this specific primer set, at least 13 samples of <it>S. c. hoya </it>were examined simultaneously and the Tm peaks of <it>CHD-Z </it>and <it>CHD-W </it>PCR products were distinguished.</p> <p>Conclusion</p> <p>In this study, we introduced a high-throughput avian molecular sexing technique and successfully applied it to two species. This new method holds a great potential for use in high throughput sexing of other avian species, as well.</p

A batch-service queueing model with a discrete batch Markovian arrival process

Queueing systems with batch service have been investigated extensively during the past decades. However, nearly all the studied models share the common feature that an uncorrelated arrival process is considered, which is unrealistic in several real-life situations. In this paper, we study a discrete-time queueing model, with a server that only initiates service when the amount of customers in system (system content) reaches or exceeds a threshold. Correlation is taken into account by assuming a discrete batch Markovian arrival process (D-BMAP), i.e. the distribution of the number of customer arrivals per slot depends on a background state which is determined by a first-order Markov chain. We deduce the probability generating function of the system content at random slot marks and we examine the influence of correlation in the arrival process on the behavior of the system. We show that correlation merely has a small impact on the threshold that minimizes the mean system content. In addition, we demonstrate that correlation might have a significant influence on the system content and therefore has to be included in the model

Contributions of dry and wet depositions of polychlorinated dibenzo-p-dioxins and dibenzofurans to a contaminated site resulting from a penetachlorophenol manufacturing process

The soils at a factory for manufacturing pentachlorophenol were heavily contaminated by polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). In order to verify the contributions of dry and wet deposition of PCDD/Fs from the ambient air, the concentration of PCDD/Fs in ambient air and soil were measured, the partition of particle- and gas-phases of atmospheric PCDD/Fs was calculated, and the annual fluxes of total dry and wet PCDD/F depositions were modeled. Average atmospheric PCDD/F concentration was 1.24 ng Nm (-aEuro parts per thousand 3) (or 0.0397 ng I-TEQ Nm (-aEuro parts per thousand 3)). Moreover, over 92.8% of total PCDD/Fs were in the particle phase, and the dominant species were high chlorinated congeners. The total PCDD/F fluxes of dry and wet deposition were 119.5 ng m (-aEuro parts per thousand 2) year (-aEuro parts per thousand 1) (1.34 ng I-TEQ m (-aEuro parts per thousand 2) year (-aEuro parts per thousand 1)) and 82.0 ng m (-aEuro parts per thousand 2) year (-aEuro parts per thousand 1) (1.07 ng I-TEQ m (-aEuro parts per thousand 2) year (-aEuro parts per thousand 1)), respectively. By scenario simulation, the total fluxes of dry and wet PCDD/F depositions were 87.1 and 68.6 ng I-TEQ, respectively. However, the estimated PCDD/F contents in the contaminated soil were 839.9 mu g I-TEQ. Hence, the contributions of total depositions of atmospheric PCDD/F were only 0.02%. The results indicated that the major sources of PCDD/F for the contaminated soil could be attributed to the pentachlorophenol manufacturing process

Exploring how cyanobacterial traits affect nutrient loading thresholds in shallow lakes: A modelling approach

Globally, many shallow lakes have shifted from a clear macrophyte-dominated state to a turbid phytoplankton-dominated state due to eutrophication. Such shifts are often accompanied by toxic cyanobacterial blooms, with specialized traits including buoyancy regulation and nitrogen fixation. Previous work has focused on how these traits contribute to cyanobacterial competitiveness. Yet, little is known on how these traits affect the value of nutrient loading thresholds of shallow lakes. These thresholds are defined as the nutrient loading at which lakes shift water quality state. Here, we used a modelling approach to estimate the effects of traits on nutrient loading thresholds. We incorporated cyanobacterial traits in the process-based ecosystem model PCLake+, known for its ability to determine nutrient loading thresholds. Four scenarios were simulated, including cyanobacteria without traits, with buoyancy regulation, with nitrogen fixation, and with both traits. Nutrient loading thresholds were obtained under N-limited, P-limited, and colimited conditions. Results show that cyanobacterial traits can impede lake restoration actions aimed at removing cyanobacterial blooms via nutrient loading reduction. However, these traits hardly affect the nutrient loading thresholds for clear lakes experiencing eutrophication. Our results provide references for nutrient loading thresholds and draw attention to cyanobacterial traits during the remediation of eutrophic water bodies

Dynamical Behavior of dilaton in de Sitter space

We study the dynamical behavior of the dilaton in the background of three-dimensional Kerr-de Sitter space which is inspired from the low-energy string effective action. The perturbation analysis around the cosmological horizon of Kerr-de Sitter space reveals a mixing between the dilaton and other fields. Introducing a gauge (dilaton gauge), we can disentangle this mixing completely and obtain one decoupled dilaton equation. However it turns out that this belongs to the tachyon. The stability of de Sitter solution with J=0 is discussed. Finally we compute the dilaton absorption cross section to extract information on the cosmological horizon of de Sitter space.Comment: 11 pages, reference added and a version to appear in PL

Liquid 4He: contributions to first principles theory of quantized vortices, thermohydrodynamic properties, and the lambda transition

Liquid 4He has been studied extensively for almost a century, but there are still a number of outstanding weak or missing links in our comprehension of it. This paper reviews some of the principal paths taken in previous research and then proceeds to fill gaps and create an integrated picture with more complete understanding through first principles treatment of a realistic model that starts with a microscopic, atomistic description of the liquid. Newly derived results for vortex cores and thermohydrodynamic properties for a two-fluid model are used to show that interacting quantized vortices may produce a lambda anomaly in specific heat near the superfluid transition where flow properties change. The nature of the order in the superfluid state is explained. Experimental support for new calculations is exhibited, and a unique specific heat experiment is proposed to test predictions of the theory. Relevance of the theory to modern research in cosmology, astrophysics, and Bose-Einstein condensates is discussed.Comment: 155 pages, 28 figure

A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8⁺ T cells.

Strategies to increase intratumoral concentrations of an anticancer agent are desirable to optimize its therapeutic potential when said agent is efficacious primarily within a tumor but also have significant systemic side effects. Here, we generate a bifunctional protein by fusing interleukin-10 (IL-10) to a colony-stimulating factor-1 receptor (CSF-1R)-blocking antibody. The fusion protein demonstrates significant antitumor activity in multiple cancer models, especially head and neck cancer. Moreover, this bifunctional protein not only leads to the anticipated reduction in tumor-associated macrophages but also triggers proliferation, activation, and metabolic reprogramming of CD8 &lt;sup&gt;+&lt;/sup&gt; T cells. Furthermore, it extends the clonotype diversity of tumor-infiltrated T cells and shifts the tumor microenvironment (TME) to an immune-active state. This study suggests an efficient strategy for designing immunotherapeutic agents by fusing a potent immunostimulatory molecule to an antibody targeting TME-enriched factors

Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy

Background: Non-small cell lung cancer (NSCLC) patients with L858R or exon 19 deletion mutations in epidermal growth factor receptor (EGFR) have good responses to the tyrosine kinase inhibitor (TKI), gefitinib. However, patients with wild-type EGFR and acquired mutation in EGFR T790M are resistant to gefitinib treatment. Here, we showed that curcumin can improve the efficiency of gefitinib in the resistant NSCLC cells both in vitro and in vivo models. Methods/Principal Findings: After screening 598 herbal and natural compounds, we found curcumin could inhibit cell proliferation in different gefitinib-resistant NSCLC cell lines; concentration-dependently down-regulate EGFR phosphorylation through promoting EGFR degradation in NSCLC cell lines with wild-type EGFR or T790M EGFR. In addition, the antitumor activity of gefitinib was potentiated via curcumin through blocking EGFR activation and inducing apoptosis in gefitinib-resistant NSCLC cell lines; also the combined treatment with curcumin and gefitinib exhibited significant inhibition in the CL1-5, A549 and H1975 xenografts tumor growth in SCID mice through reducing EGFR, c-MET, cyclin D1 expression, and inducing apoptosis activation through caspases-8, 9 and PARP. Interestingly, we observed that the combined treatment group represented better survival rate and less intestinal mucosal damage compare to gefitinib-alone therapy. We showed that curcumin attenuated the gefitinib-induced cell proliferation inhibition and apoptosis through altering p38 mitogen-activated protein kinase (MAPK) activation in intestinal epithelia cell. Conclusions/Significance: Curcumin potentiates antitumor activity of gefitinib in cell lines and xenograft mice model of NSCLC through inhibition of proliferation, EGFR phosphorylation, and induction EGFR ubiquitination and apoptosis. In addition, curcumin attenuates gefitinib-induced gastrointestinal adverse effects via altering p38 activation. These findings provide a novel treatment strategy that curcumin as an adjuvant to increase the spectrum of the usage of gefitinib and overcome the gefitinib inefficiency in NSCLC patients

Abundances of the elements in the solar system

A review of the abundances and condensation temperatures of the elements and their nuclides in the solar nebula and in chondritic meteorites. Abundances of the elements in some neighboring stars are also discussed.Comment: 42 pages, 11 tables, 8 figures, chapter, In Landolt- B\"ornstein, New Series, Vol. VI/4B, Chap. 4.4, J.E. Tr\"umper (ed.), Berlin, Heidelberg, New York: Springer-Verlag, p. 560-63