Inferring equilibrium magnetization from hysteretic M-H curves of type-II superconductors

Isothermal M-H curves, coupled with the critical state model, are routinely used to extract critical current density Jc(B); and the limitations and validity are well understood. These hysteretic M-H curves can also be used to estimate the equilibrium magnetization Meq(H), and this paper discusses the validity of such a procedure using analytically tractable models for Jc(H). We put special emphasis on the case where the M-H curve shows a fish tail or peak effect, and an experimental procedure to estimate errors in the inferred Meq(H) is presented. The need to infer Meq(H) is underscored by recent experimental works speculating on thermodynamic phase transitions between vortex phases having intrinsic pinning

Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report.

BACKGROUND: Zoonotic malaria caused by Plasmodium knowlesi is an important, but newly recognized, human pathogen. For the first time, post-mortem findings from a fatal case of knowlesi malaria are reported here. CASE PRESENTATION: A formerly healthy 40 year-old male became symptomatic 10 days after spending time in the jungle of North Borneo. Four days later, he presented to hospital in a state of collapse and died within two hours. He was hyponatraemic and had elevated blood urea, potassium, lactate dehydrogenase and amino transferase values; he was also thrombocytopenic and eosinophilic. Dengue haemorrhagic shock was suspected and a post-mortem examination performed. Investigations for dengue virus were negative. Blood for malaria parasites indicated hyperparasitaemia and single species P. knowlesi infection was confirmed by nested-PCR. Macroscopic pathology of the brain and endocardium showed multiple petechial haemorrhages, the liver and spleen were enlarged and lungs had features consistent with ARDS. Microscopic pathology showed sequestration of pigmented parasitized red blood cells in the vessels of the cerebrum, cerebellum, heart and kidney without evidence of chronic inflammatory reaction in the brain or any other organ examined. Brain sections were negative for intracellular adhesion molecule-1. The spleen and liver had abundant pigment containing macrophages and parasitized red blood cells. The kidney had evidence of acute tubular necrosis and endothelial cells in heart sections were prominent. CONCLUSIONS: The overall picture in this case was one of systemic malaria infection that fit the WHO classification for severe malaria. Post-mortem findings in this case were unexpectedly similar to those that define fatal falciparum malaria, including cerebral pathology. There were important differences including the absence of coma despite petechial haemorrhages and parasite sequestration in the brain. These results suggest that further study of knowlesi malaria will aid the interpretation of, often conflicting, information on malaria pathophysiology in humans

Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites

Background information The pathology causing stages of the human malaria parasite Plasmodium falciparum reside within red blood cells that are devoid of any regulated transport system. The parasite, therefore, is entirely responsible for mediating vesicular transport within itself and in the infected erythrocyte cytoplasm, and it does so in part via its family of 11 Rab GTPases. Putative functions have been ascribed to Plasmodium Rabs due to their homology with Rabs of yeast, particularly with Saccharomyces that has an equivalent number of rab/ypt genes and where analyses of Ypt function is well characterized. Results Rabs are important regulators of vesicular traffic due to their capacity to recruit specific effectors. In order to identify P. falciparum Rab (PfRab) effectors, we first built a Ypt-interactome by exploiting genetic and physical binding data available at the Saccharomyces genome database (SGD). We then constructed a PfRab-interactome using putative parasite Rab-effectors identified by homology to Ypt-effectors. We demonstrate its potential by wet-bench testing three predictions; that casein kinase-1 (PfCK1) is a specific Rab5B interacting protein and that the catalytic subunit of cAMP-dependent protein kinase A (PfPKA-C) is a PfRab5A and PfRab7 effector. Conclusions The establishment of a shared set of physical Ypt/PfRab-effector proteins sheds light on a core set Plasmodium Rab-interactants shared with yeast. The PfRab-interactome should benefit vesicular trafficking studies in malaria parasites. The recruitment of PfCK1 to PfRab5B+ and PfPKA-C to PfRab5A+ and PfRab7+ vesicles, respectively, suggests that PfRab-recruited kinases potentially play a role in early and late endosome function in malaria parasites

Thermal conduction and particle transport in strong MHD turbulence, with application to galaxy-cluster plasmas

We investigate field-line separation in strong MHD turbulence analytically and with direct numerical simulations. We find that in the static-magnetic-field approximation the thermal conductivity in galaxy clusters is reduced by a factor of about 5-10 relative to the Spitzer thermal conductivity of a non-magnetized plasma. We also estimate how the thermal conductivity would be affected by efficient turbulent resistivity.Comment: Major revision: higher resolution simulations lead to significantly different conclusions. 26 pages, 10 figure

Scale dependent alignment between velocity and magnetic field fluctuations in the solar wind and comparisons to Boldyrev's phenomenological theory

(Abridged abstract) A theory of incompressible MHD turbulence recently developed by Boldyrev predicts the existence of a scale dependent angle of alignment between velocity and magnetic field fluctuations that is proportional to the lengthscale of the fluctuations to the power 1/4. In this study, plasma and magnetic field data from the Wind spacecraft are used to investigate the angle between velocity and magnetic field fluctuations in the solar wind as a function of the timescale of the fluctuations and to look for the power law scaling predicted by Boldyrev.Comment: Particle Acceleration and Transport in the Heliosphere and Beyond, 7th Annual International Astrophysics Conference, Kauai, Hawaii, G. Li, Q. Hu, O. Verkhoglyadova, G. P. Zank, R. P. Lin, J. Luhmann (eds), AIP Conference Proceedings 1039, 81-8

Multinuclear Solid-State NMR Study of Local Structure and Dynamics in Li0.7Nb3S4

The present work focuses on channel-structured Li0.7Nb3S4, where, among others, the question of the dimensionality of the diffusion pathway arises

Pharmacogenomics: The Right Drug to the Right Person

Pharmacogenomics is the branch of pharmacology which deals with the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity. It aims to develop rational means to optimize drug therapy, with respect to the patients genotype, to ensure maximum efficacy with minimal adverse effects. Such approaches promise the advent of personalized medicine, in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Pharmacogenomics is the whole genome application of pharmacogenetics, which examines the single gene interactions with drugs

Spherical Accretion with Anisotropic Thermal Conduction

We study the effects of anisotropic thermal conduction on magnetized spherical accretion flows using global axisymmetric MHD simulations. In low collisionality plasmas, the Bondi spherical accretion solution is unstable to the magnetothermal instability (MTI). The MTI grows rapidly at large radii where the inflow is subsonic. For a weak initial field, the MTI saturates by creating a primarily radial magnetic field, i.e., by aligning the field lines with the background temperature gradient. The saturation is quasilinear in the sense that the magnetic field is amplified by a factor of $\sim 10-30$ independent of the initial field strength (for weak fields). In the saturated state, the conductive heat flux is much larger than the convective heat flux, and is comparable to the field-free (Spitzer) value (since the field lines are largely radial). The MTI by itself does not appreciably change the accretion rate $\dot M$ relative to the Bondi rate $\dot M_B$. However, the radial field lines created by the MTI are amplified by flux freezing as the plasma flows in to small radii. Oppositely directed field lines are brought together by the converging inflow, leading to significant resistive heating. When the magnetic energy density is comparable to the gravitational potential energy density, the plasma is heated to roughly the virial temperature; the mean inflow is highly subsonic; most of the energy released by accretion is transported to large radii by thermal conduction; and the accretion rate $\dot M \ll \dot M_B$. The predominantly radial magnetic field created by the MTI at large radii in spherical accretion flows may account for the stable Faraday rotation measure towards Sgr A* in the Galactic Center.Comment: accepted in MNRAS with some modifications suggested by the referee; 15 pages, 16 figure

Meteorite impact craters as hotspots for mineral resources and energy fuels: A global review

The ever-increasing recovery rate of natural resources from terrestrial impact craters over the last few decades across the globe offers new avenues for further exploration of mineral and hydrocarbon resources in such settings. As of today, 60 of the 208 terrestrial craters have been identified to host diverse resources such as hydrocarbons, metals and construction materials. The potential of craters as plausible resource contributors to the energy sector is therefore, worthy of consideration, as 42 (70%) of the 60 craters host energy resources such as oil, gas, coal, uranium, mercury, critical and major minerals as well as hydropower resources. Among others, 19 craters are of well-developed hydrocarbon reserves. Mineral deposits associated with craters are also classified similar to other mineral resources such as progenetic, syngenetic and epigenetic sources. Of these, the progenetic and syngenetic mineralization are confined to the early and late excavation stage of impact crater evolution, respectively, whereas epigenetic deposits are formed during and after the modification stage of crater formation. Thus, progenetic and syngenetic mineral deposits (like Fe, Ni, Pb, Zn and Cu) associated with craters are formed as a direct result of the impact event, whereas epigenetic deposits (e.g. hydrocarbon) are hosted by the impact structure and result from post-impact processes. In the progenetic and syngenetic deposits, the shock-wave induced fracturing and melting aid the formation of deposits, whereas in the epigenetic deposits, the highly fractured lithostratigraphic units of higher porosity and permeability, like the central elevated area (CEA) or the rim, act as traps. In this review, we provide a holistic view of the mineral and energy resources associated with impact craters, and use some of the remote sensing techniques to identify the mineral deposits as supplemented by a schematic model of the types of deposits formed during cratering process

Effect of electron beam irradiation on thermal and mechanical properties of epoxy polymer

This study investigates the thermal and mechanical properties of epoxy polymer after exposure to different doses of electron beam irradiation. The epoxy polymer was prepared using epoxy-diane resin ED-20 cured by polyethylenepolyamine. The irradiation of the samples was carried out with doses of 30, 100 and 300 kGy. The effects of doses on thermal and mechanical properties of the epoxy polymer were investigated by the methods of thermal gravimetric analysis, tensile test, and dynamic mechanical analysis. The thermal properties of the epoxy polymer slightly increased after irradiation at the heating in air. The tensile strength and Young's modulus of the epoxy polymer increased by the action of electron beam up to dose of 100 kGy and then decreased. The elongation at break decreased with increasing the irradiation dose