6,602 research outputs found
Ru-Catalyzed, cis-Selective Living Ring-Opening Metathesis Polymerization of Various Monomers, Including a Dendronized Macromonomer, and Implications to Enhanced Shear Stability
An unsaturated polymer’s cis/trans-olefin content has a significant influence on its properties. For polymers obtained by ring-opening metathesis polymerization (ROMP), the cis/trans-olefin content can be tuned by using specific catalysts. However, cis-selective ROMP has suffered from narrow monomer scope and lack of control over the polymerization (giving polymers with broad molecular weight distributions and prohibiting the synthesis of block copolymers). Herein, we report the versatile cis-selective controlled living ROMP of various endo-tricyclo[4.2.2.0^(2,5)]deca-3,9-diene and various norbornene derivatives using a fast-initiating dithiolate-chelated Ru catalyst. Polymers with cis-olefin content as high as 99% could be obtained with high molecular weight (up to M_n of 105.1 kDa) and narrow dispersity (<1.4). The living nature of the polymerization was also exploited to prepare block copolymers with high cis-olefin content for the first time. Furthermore, owing to the successful control over the stereochemistry and narrow dispersity, we could compare cis- and trans-rich polynorbornene and found the former to have enhanced resistance to shear degradation
Synthesis of boron nitride nanotubes by arc-jet plasma
author's versionBoron nitride nanotubes (BNNTs) are synthesized by the arc-jet plasma of high temperature (5000 – 20000 K), which is generated by a dc non-transferred plasma torch with a mixture of argon and nitrogen gas. The BNNTs produced by the thermal plasma process are resulted from the chemical reaction of a precursor material of hexagonal boron nitride with catalytic metal powders of Ni and Y introduced into the hot arc-jet plasma flame, which is ejected inside the cylindrical carbon reactor. The synthesized materials are evaluated by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and electron energy loss spectroscopy (EELS). These material analyses reveal that multi-walled nanobubes including single- and double-walled ons with high crystallinity are synthesized in quantity, and that the diameter of nanotubes is estimated in the range of 3 – 10 nm.Korea Institute of Science and Technology Evaluation and Planning (KISTEP
String theoretic axion coupling and the evolution of cosmic structures
We examine the effects of the axion coupling to on the evolution
of cosmic structures. It is shown that the evolutions of the scalar- and
vector-type perturbations are not affected by this axion coupling. However the
axion coupling causes an asymmetric evolution of the two polarization states of
the tensor-type perturbation, which may lead to a sizable polarization
asymmetry in the cosmological gravitational wave if inflation involves a period
in which the axion coupling is important. The polarization asymmetry produced
during inflation are conserved over the subsequent evolution as long as the
scales remain in the large-scale limit, and thus this may lead to an observable
trace in the cosmic microwave background radiation.Comment: 10 pages, REVte
APE1 Promotes Pancreatic Cancer Proliferation through GFRα1/Src/ERK Axis-Cascade Signaling in Response to GDNF
Pancreatic cancer is the worst exocrine gastrointestinal cancer leading to the highest mortality. Recent studies reported that aberrant expression of apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) is involved in uncontrolled cell growth. However, the molecular mechanism of APE1 biological role remains unrevealed in pancreatic cancer progression. Here, we demonstrate that APE1 accelerates pancreatic cancer cell proliferation through glial cell line-derived neurotrophic factor (GDNF)/glial factor receptor α1 (GFRα1)/Src/ERK axis-cascade signaling. The proliferation of endogenous APE1 expressed-MIA PaCa-2, a human pancreatic carcinoma cell line, was increased by treatment with GDNF, a ligand of GFRα1. Either of downregulated APE1 or GFRα1 expression using small interference RNA (siRNA) inhibited GDNF-induced cancer cell proliferation. The MEK-1 inhibitor PD98059 decreased GDNF-induced MIA PaCa-2 cell proliferation. Src inactivation by either its siRNA or Src inhibitor decreased ERK-phosphorylation in response to GDNF in MIA PaCa-2 cells. Overexpression of GFRα1 in APE1-deficient MIA PaCa-2 cells activated the phosphorylation of Src and ERK. The expression of both APE1 and GFRα1 was gradually increased as progressing pancreatic cancer grades. Our results highlight a critical role for APE1 in GDNF-induced pancreatic cancer cell proliferation through APE1/GFRα1/Src/ERK axis-cascade signaling and provide evidence for future potential therapeutic drug targets for the treatment of pancreatic cancer
Dihydrolipoic Acid Induces Cytotoxicity in Mouse Blastocysts through Apoptosis Processes
α-Lipoic acid (LA) is a thiol with antioxidant properties that protects against oxidative stress-induced apoptosis. LA is absorbed from the diet, taken up by cells and tissues, and subsequently reduced to dihydrolipoic acid (DHLA). In view of the recent application of DHLA as a hydrophilic nanomaterial preparation, determination of its biosafety profile is essential. In the current study, we examined the cytotoxic effects of DHLA on mouse embryos at the blastocyst stage, subsequent embryonic attachment and outgrowth in vitro, in vivo implantation by embryo transfer, and early embryonic development in an animal model. Blastocysts treated with 50 μM DHLA exhibited significantly increased apoptosis and a corresponding decrease in total cell number. Notably, the implantation success rates of blastocysts pretreated with DHLA were lower than that of their control counterparts. Moreover, in vitro treatment with 50 μM DHLA was associated with increased resorption of post-implantation embryos and decreased fetal weight. Data obtained using an in vivo mouse model further disclosed that consumption of drinking water containing 100 μM DHLA led to decreased early embryo development, specifically, inhibition of development to the blastocyst stage. However, it appears that concentrations of DHLA lower than 50 μM do not exert a hazardous effect on embryonic development. Our results collectively indicate that in vitro and in vivo exposure to concentrations of DHLA higher than 50 μM DHLA induces apoptosis and retards early pre- and post-implantation development, and support the potential of DHLA to induce embryonic cytotoxicity
Spin configuration of top quark pair production with large extra dimensions at photon-photon colliders
Top quark pair production at photon-photon colliders is studied in low scale
quantum gravity scenario. From the dependence of the cross sections on the spin
configuration of the top quark and anti-quark, we introduce a new observable,
top spin asymmetry. It is shown that there exists a special top spin basis
where with the polarized parent electron beams the top spin asymmetry vanishes
in the standard model but retains substantial values with the large extra
dimension effects. We also present lower bounds of the quantum gravity scale
from total cross sections with various combinations of the laser,
electron beam, and top quark pair polarizations. The measurements of the top
spin state with unpolarized initial beams are
shown to be most effective, enhancing by about 5% the bounds with respect
to totally unpolarized case.Comment: 18 pages, 4 figures, ReVTe
Performance evaluation of flexible manufacturing systems under uncertain and dynamic situations
The present era demands the efficient modelling of any manufacturing system to enable it to cope with unforeseen situations on the shop floor. One of the complex issues affecting the performance of manufacturing systems is the scheduling of part types. In this paper, the authors have attempted to overcome the impact of uncertainties such as machine breakdowns, deadlocks, etc., by inserting slack that can absorb these disruptions without affecting the other scheduled activities. The impact of the flexibilities in this scenario is also investigated. The objective functions have been formulated in such a manner that a better trade-off between the uncertainties and flexibilities can be established. Consideration of automated guided vehicles (AGVs) in this scenario helps in the loading or unloading of part types in a better manner. In the recent past, a comprehensive literature survey revealed the supremacy of random search algorithms in evaluating the performance of these types of dynamic manufacturing system. The authors have used a metaheuristic known as the quick convergence simulated annealing (QCSA) algorithm, and employed it to resolve the dynamic manufacturing scenario. The metaheuristic encompasses a Cauchy distribution function as a probability function that helps in escaping the local minima in a better manner. Various machine breakdown scenarios are generated. A ‘heuristic gap’ is measured, and it indicates the effectiveness of the performance of the proposed methodology with the varying problem complexities. Statistical validation is also carried out, which helps in authenticating the effectiveness of the proposed approach. The efficacy of the proposed approach is also compared with deterministic priority rules
Conserved cosmological structures in the one-loop superstring effective action
A generic form of low-energy effective action of superstring theories with
one-loop quantum correction is well known. Based on this action we derive the
complete perturbation equations and general analytic solutions in the
cosmological spacetime. Using the solutions we identify conserved quantities
characterizing the perturbations: the amplitude of gravitational wave and the
perturbed three-space curvature in the uniform-field gauge both in the
large-scale limit, and the angular-momentum of rotational perturbation are
conserved independently of changing gravity sector. Implications for
calculating perturbation spectra generated in the inflation era based on the
string action are presented.Comment: 5 pages, no figure, To appear in Phys. Rev.
Universal conductance enhancement and reduction of the two-orbital Kondo effect
We investigate theoretically the linear and nonlinear conductance through a
nanostructure with two-fold degenerate single levels, corresponding to the
transport through nanostructures such as a carbon nanotube, or double dot
systems with capacitive interaction. It is shown that the presence of the
interaction asymmetry between orbits/dots affects significantly the profile of
the linear conductance at finite temperature, and, of the nonlinear
conductance, particularly around half-filling, where the two-particle Kondo
effect occurs. Within the range of experimentally feasible parameters, the
SU(4) universal behavior is suggested, and comparison with relevant experiments
is made.Comment: 10 pages, 16 figure
Surgical Treatment of Non-Small Cell Lung Cancer with Isolated Synchronous Brain Metastases
This study is a retrospective examination of our experiences with patients who underwent treatment of isolated synchronous brain metastases coupled with primary non-small cell lung cancer. From January 1995 to June 2004, 12 patients presented with isolated synchronous brain metastases coupled with primary non-small cell lung cancer. The patient was comprised of 8 men and 4 women. The median age was 52 yr, in a range of 32 to 75 yr. Median follow-up duration was 10.6 months, in a range of 2 to 55.8 months. Recurrence developed in 7 patients, and the median interval from 1st treatment to recurrence was 4.5 months (2.8-6.5 months). The overall 1-yr survival rate was 61.7%. The 1-yr survival rates for pathologic N0 and N1 cases were 75% and 66.7%, respectively. The median survival duration for pathologic N2 was 6.2 months (95% CI, 4.8-7.5 months). The 1-yr survival rate for cases of single brain metastasis was 75%. Based on our current observations, we could speculate that aggressive management of primary non-small cell lung cancer and isolated synchronous brain metastases was beneficial in a selected group of patients, as long as the brain lesions and pulmonary lesions were limited or resectable
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