Glass Ceiling Commission - The Impact of the Glass Ceiling and Structural Change on Minorities and Women

Glass Ceiling ReportGlassCeilingBackground12StructuralChange.pdf: 9391 downloads, before Oct. 1, 2020

The Indianapolis Foundation Library Partners

In 1989 an anonymous bequest of nearly $15 million was made to The Indianapolis Foundation, creating the Library Fund, which would be used to support Marion County libraries. This group, which would come to be called The Indianapolis Foundation Library Partners, was made up of the Indianapolis Marion County Public Library (IMCPL); the libraries of all of the public, private, and parochial high schools in Marion County; and the libraries of Indiana University Purdue University Indianapolis (IUPUI), Marian College, and the University of Indianapolis. The donor stipulated that that The Indianapolis Foundation “shall give preference to projects which cannot be met by the operating budgets of the recipient institutions.” Further, the donor expressed a hope that, “in exercising its discretion, the Foundation will emphasize provision of books and other library materials rather than the employment of personnel and the construction of buildings.” Thus the proceeds of the Library Fund were to be used for new, innovative, and collaborative projects. Core library operation expenses and building projects were excluded. This remarkable gift created a resource, now valued at approximately$25 million and producing approximately $1.25 million a year, that is truly unique. Since its beginning in 1989, the Library Fund has made over$16 million in grants to Marion County libraries. This resource in turn fostered a collaborative environment among the libraries and librarians in Marion County that is also unique. In this article we describe the history of The Indianapolis Foundation Library Partners, its current programs, and its growth over the years

The Future of Healthcare Delivery: IPE/IPP Audiology and Nursing Student/Faculty Collaboration to Deliver Hearing Aids to Vulnerable Adults via Telehealth

A multi-departmental, two-city initiative to provide hearing aid service via a telepractice approach was developed whereby nursing and auditory students with supervisory faculty used AV conferencing for training and interaction with referred patients. Located in two cities, 21 nursing and 15 doctoral level audiology students met virtually, and students received teleaudiology education and practicum with interprofessional education and practice components. Nursing students in one city and a supervising faculty in another city could interact with providers and patients in both cities to provide hearing care. The teleaudiology project delivered hearing health care services, including fitting of digital mini hearing aids, to 181 patients over 29 months of the project. During that time period, 205 total patients were referred to the teleaudiology clinic. Over 90% of these patients, as assessed by either patient teleaudiology clinic visits or telephone follow-up, successfully wore their hearing aids. Students administered selected published surveys related to patient outcomes both pre and post fitting. Patients reported significant hearing handicap reduction and were very satisfied with the teleaudiology mode of digital hearing aid and hearing health care service delivery. The experience provided interprofessional pre-service exposure to cutting edge technology and an innovative delivery system for future members of the healthcare workforce

Evidence for B cell exhaustion in chronic graft-versus-host disease

Chronic graft-versus-host disease (cGvHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (HSCT). A number of studies support a role for B cells in the pathogenesis of cGvHD. In this study, we report the presence of an expanded population of CD19+CD21− B cells with features of exhaustion in the peripheral blood of patients with cGvHD. CD21− B cells were significantly increased in patients with active cGvHD compared to patients without cGvHD and healthy controls (median 12.2 versus 2.12 versus 3%, respectively; p < 0.01). Compared with naïve (CD27−CD21+) and classical memory (CD27+CD21+) B cells, CD19+CD21− B cells in cGvHD were CD10 negative, CD27 negative and CD20hi, and exhibited features of exhaustion, including increased expression of multiple inhibitory receptors such as FCRL4, CD22, CD85J, and altered expression of chemokine and adhesion molecules such as CD11c, CXCR3, CCR7, and CD62L. Moreover, CD21− B cells in cGvHD patients were functionally exhausted and displayed poor proliferative response and calcium mobilization in response to B-cell receptor triggering and CD40 ligation. Finally, the frequencies of circulating CD21− B cells correlated with cGvHD severity in patients after HSCT. Our study further characterizes B cells in chronic cGVHD and supports the use of CD21−CD27−CD10− B cell frequencies as a biomarker of disease severity

Ökonomie des Opfers. Literatur im Zeichen des Suizids

Warum bleibt im Gedächtnis nur, was nicht aufhört, weh zu tun, wie Nietzsche einmal gesagt hat? Der vorliegende Sammelband sucht Antworten darauf – im Werk und im Suizid von Autoren wie Heinrich von Kleist, Virginia Woolf, Yukio Mishima, Anne Sexton, Hermann Burger und David Foster Wallace. Es scheint einen fatalen Zusammenhang zu geben zwischen Dichtung, die den Erwartungshorizont der Zeitgenossen sprengt, und dem Suizid des Dichters – einen fatalen Zusammenhang auch von Suizid und Nachruhm eines Autors. Von individuellen Leiden abgesehen gilt: Wer monströs als Subjekt aus der Geschichte verschwindet, taucht irgendwann als Objekt von Geschichten wieder auf, erreicht Aufmerksamkeit in Nachrufen, Erzählungen, mündlicher und schriftlicher Historiografie. Dergestalt paradox ist die Ökonomie des Selbstopfers, in der sich auch eine vorgängige Anökonomie verbergen kann

Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA

Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Aquatic Toxicology 159 (2015): 156-166, doi:10.1016/j.aquatox.2014.12.017.Atlantic killifish (Fundulus heteroclitus) thrive in New Bedford Harbor (NBH), MA, highly contaminated with polychlorinated biphenyls (PCBs). Resident killifish have evolved tolerance to dioxin-like (DL) PCBs, whose toxic effects through the aryl hydrocarbon receptor (AhR) are well studied. In NBH, non-dioxin like PCBs (NDL PCBs), which lack activity toward the AhR, vastly exceed levels of DL congeners yet how killifish counter NDL toxic effects has not been explored. In mammals and fish, NDL PCBs are potent activators of ryanodine receptors (RyR), Ca2+ release channels necessary for a vast array of physiological processes. In the current study we compared the expression and function of RyR related pathways in NBH killifish with killifish from the reference site at Scorton Creek (SC, MA). Relative to the SC fish, adults from NBH displayed increased levels of skeletal muscle RyR1 protein, and increased levels of FK506-binding protein 12 kDa (FKBP12), an accessory protein essential for NDL PCB-triggered changes in RyR channel function. In accordance with increased RyR1 levels, NBH killifish displayed increased maximal ligand binding, increased maximal response to Ca2+ activation and increased maximal response to activation by the NDL PCB congener PCB 95. Compared to SC, NBH embryos and larvae had increased levels of mtor and ryr2 transcripts at multiple stages of development, and generations, while levels of serca2 were decreased at 9 days post-fertilization in the F1 and F2 generations. These findings suggest that there are compensatory and heritable changes in RyR mediated Ca2+ signaling proteins or potential signaling partners in NBH killifish.Funding was provided through the NIEHS Superfund Research Program UC Davis (INP and EBF; P42-ES004699) and Boston University (JJS and JVG; P42-ES007381). Support was supplied via the UC Davis NHLBI Training Grant (T32-HL086350, EBF). Additional support came from NIEHS 1R01-ES014901, 1R01-ES017425, the UC Davis Center for Children’s Environmental Health (1P01-ES011269, U.S. Environmental Protection Agency Grant 8354320), and an unrestricted JB Johnson Foundation gift grant.2015-12-1

Arsenic Trioxide with Ascorbic Acid and High-Dose Melphalan: Results of a Phase II Randomized Trial

AbstractArsenic trioxide (ATO) is synergistic with ascorbic acid (AA) and melphalan against myeloma both in vitro and in vivo. The aim of this randomized phase II trial was to determine the safety and efficacy of a combination of ATO, melphalan, and AA as preparative regimen in 48 patients undergoing autologous hematopoietic stem cell transplantation (ASCT) for multiple myeloma (MM). Forty-eight patients received melphalan 200 mg/m2 i.v. over 2 days and AA 1000 mg i.v. over 7 days in 3 treatment arms: no ATO (arm 1), ATO 0.15 mg/kg i.v. × 7 days (arm 2), and ATO 0.25 mg/kg i.v. × 7 days (arm 3). No dose-limiting toxicity, engraftment failure, or nonrelapse mortality (NRM) was seen in the first 100 days post-ASCT. Complete responses (CR) were seen in 12 of 48 patients (25%), with an overall response rate (ORR = CR + PR) of 85%. Median progression-free survival (PFS) was 25 months; median overall survival (OS) has not yet been reached. There was no significant difference in CR, PFS, or OS among the 3 treatment arms, and no adverse effect of ATO on melphalan pharmacokinetics. Addition of ATO + AA to high-dose melphalan is safe and well tolerated as a preparative regimen for MM

An Academic Writing Curriculum and Materials for A1-B2-Level Learners in a Turkish University’s English Language Preparatory Program

This IPP combines a literature review and a materials development project. The literature review outlines and supports the approach taken throughout the curriculum and the materials that were developed. First, it lays out the nature of Turkish universities’ ELPP’s; then, it deals with the basic philosophy of the curriculum including individualization and standardization, the role of joy in education, the necessity for an integration of skills in teaching academic writing, the use of models, and the necessity and purpose of feedback. In the second half of the literature review, the key features of academic writing are discussed in advance of showing how to teach them. Recommendations are also given for testing the validity of the approach taken and for additional areas that should be studied. These are followed by a demonstration lesson where the principles are shown in action. Finally, the entire 32-week curriculum is presented, showing how this philosophy can be actualized in lesson planning, materials, and handouts