Identifying spatial clustering of diarrhoea among children under 5 years across 707 districts in India: a cross sectional study

Abstract Background Diarrhoea is one of the leading reasons for under-five child mortality and morbidity across the globe and especially in low- and middle-income countries like India. The present study aims to investigate and identify the spatial clustering and the factors associated with diarrhoea across 707 districts of different states in India. Methods This study used National Family Health Survey-4 & 5 (2015–16 & 2019–21) data in India. Spatial analysis software i.e., ArcGIS and GeoDa including Moran’s statistics have been applied to detect the spatial prevalence and auto-correlation of diarrhoea among neighbourhood districts. Bivariate analysis with a chi-square test and logistic regression has been performed to identify the factors associated with the morbidity condition. Results The result shows out of 2,23,785 children, 7.3 percent children suffer from diarrhoea in India. The prevalence is highest in Bihar (13.7%) and lowest in Lakshadweep (2.3%). Around 33 percent of districts have reported more than the national average level of diarrhoea prevalence. The study also found a medium to high level of autocorrelation with 0.41 Moran’s Index value and detected 69 hot-spots districts mostly from Maharashtra, Bihar, Odisha, and Gujarat. The study has also found, with an increase in children’s age as well as mother's age the prevalence of the disease decreases. The prevalence is more among male children than females. Underweight [OR = 1.08, 95% CI (1.03–1.13)] children have a greater risk of suffering from diarrhoeal diseases. The odds of children living in a pucca house [OR = 0.89, 95% CI (0.68–1.16)] are less likely to suffer from diarrhoea. On the other hand, rich economic status [OR = 0.91, 95% CI (0.86–0.97)], reduce the risk of such morbid conditions. Conclusion The study recommends targeting the hot-spot districts with high prevalence areas, and district-level interventions by improving housing type and child nutrition status, which can help to prevent diarrhoeal diseases among children in India. Thus, the identification of hotspot districts and suggested policy interventions by the current study can help to prevent childhood mortality and morbidity, as well as to achieve the target given by Sustainable development Goals 3.2

Supplemental Material, sj-pdf-1-fnb-10.1177_03795721241234086 - Spatial Clustering of Malnutrition and Anemia Among Reproductive Women and Its Associated Risk Factors in India: Evidence From National Family Health Survey-5

Supplemental Material, sj-pdf-1-fnb-10.1177_03795721241234086 for Spatial Clustering of Malnutrition and Anemia Among Reproductive Women and Its Associated Risk Factors in India: Evidence From National Family Health Survey-5 by Koustav Ghosh, Atreyee Sinha Chakraborty, Banashri Haloi and Sofia Zakir in Food and Nutrition Bulletin</p

Supplemental Material, sj-pdf-2-fnb-10.1177_03795721241234086 - Spatial Clustering of Malnutrition and Anemia Among Reproductive Women and Its Associated Risk Factors in India: Evidence From National Family Health Survey-5

Supplemental Material, sj-pdf-2-fnb-10.1177_03795721241234086 for Spatial Clustering of Malnutrition and Anemia Among Reproductive Women and Its Associated Risk Factors in India: Evidence From National Family Health Survey-5 by Koustav Ghosh, Atreyee Sinha Chakraborty, Banashri Haloi and Sofia Zakir in Food and Nutrition Bulletin</p

Establishment of Repeated In Vitro Exposure System for Evaluating Pulmonary Toxicity of Representative Criteria Air Pollutants Using Advanced Bronchial Mucosa Models

There is mounting evidence that shows the association between chronic exposure to air pollutants (particulate matter and gaseous) and onset of various respiratory impairments. However, the corresponding toxicological mechanisms of mixed exposure are poorly understood. Therefore, in this study, we aimed to establish a repeated exposure setting for evaluating the pulmonary toxicological effects of diesel exhaust particles (DEP), nitrogen dioxide (NO2), and sulfur dioxide (SO2) as representative criterial air pollutants. Single, combined (DEP with NO2 and SO2), and repeated exposures were performed using physiologically relevant human bronchial mucosa models developed at the air&ndash;liquid interface (bro-ALI). The bro-ALI models were generated using human primary bronchial epithelial cells (3&ndash;4 donors; 2 replicates per donor). The exposure regime included the following: 1. DEP (12.5 &micro;g/cm2; 3 min/day, 3 days); 2. low gaseous (NO2: 0.1 ppm + SO2: 0.2 ppm); (30 min/day, 3 days); 3. high gaseous (NO2: 0.2 ppm + SO2: 0.4 ppm) (30 min/day, 3 days); and 4. single combined (DEP + low gaseous for 1 day). The markers for pro-inflammatory (IL8, IL6, NFKB, TNF), oxidative stress (HMOX1, GSTA1, SOD3,) and tissue injury/repair (MMP9, TIMP1) responses were assessed at transcriptional and/ or secreted protein levels following exposure. The corresponding sham-exposed samples under identical conditions served as the control. A non-parametric statistical analysis was performed and p &lt; 0.05 was considered as significant. Repeated exposure to DEP and single combined (DEP + low gaseous) exposure showed significant alteration in the pro-inflammatory, oxidative stress and tissue injury responses compared to repeated exposures to gaseous air pollutants. The study demonstrates that it is feasible to predict the long-term effects of air pollutants using the above explained exposure system

Novel Mullite Coated Ni-Zn-Cu-Ferrite Nanocomposite: Study of their Magnetic and Polarization Response and Application in Multiferroics

Novel multiferroic nanocomposite fabricated by Ni–Zn–Cu-ferrite (NZCF)-mullite is reported in this article. The crystallographic phases are confirmed by X-ray diffraction. The static magnetic properties are measured for both bare NZCF and mullite encapsulated NZCF nanocomposite which show the successful retention of the magnetic behaviors of the nanocomposites even at higher annealing temperature of 1200 °C. The dielectric response is estimated and high value of dielectric constant (∼210.7 at 100 Hz) is observed for the mullite encapsulated NZCF nanocomposite due to the formation of interfacial polarization in the nanocomposite. The temperature dependent dielectric response suggests the presence of dielectric polarization in the NZCF-mullite nanocomposite. Magnetocapacitance (MC) study of the NZCF-mullite nanocomposite sample is observed at room temperature (RT). The observed MC and its variation with magnetic field confirm the presence of strong interactions between the magnetic and ferroelectric order parameters in the nanocomposite sample