Global Stability Analysis of Healthy Situation for a Coupled Model of Healthy and Cancerous Cells Dynamics in Acute Myeloid Leukemia

In this paper we aim to study the global stability of a coupled model of healthy and cancerous cells dynamics in healthy situation of Acute Myeloid Leukemia. We also clarify the effect of interconnection between healthy and cancerous cells dynamics on the global stability The interconnected model is obtained by transforming the PDE-based model into a nonlinear distributed delay system. Using Lyapunov approach, we derive necessary and sufficient conditions for global stability for a selected equilibrium point of particular interest (healthy situation). Simulations are conducted to illustrate the obtained results

F-term Braneworld inflation in Light of Five-year WMAP observations

We consider a supersymmetric hybrid inflation in the framework of the Randall-Sundrum type II Braneworld model. We drive an analytical expression for the scalar potential and find that the F-term dominates hybrid inflation process. We show that for some value of Brane tension we can eliminate the fine tuning problem related to coupling constant k of the potential: We also calculate all known spectrum inflation parameters and show that observational bounds from WMAP5, BAO and SN observations are satisfied.Comment: 7 pages, no figure

On Chaplygin Gas Braneworld Inflation with Monomial Potential

In this paper we study the Chaplygin gas model as a candidate for inflation in the framework of the Randall Sundrum type-II braneworld model. We consider the original and generalized Chaplygin gas model in the presence of monomial potential. The inflationary spectrum perturbation parameters are reformulated and evaluated in the high-energy limit and we found that they depend on several parameters. We also showed that these perturbation parameters are widely compatible with the recent Planck data for a particular choice of the parameters space of the model. A suitable observational central value of $n_{s}\simeq$ $0.965$ is also obtained in the case of original and generalized Chaplygin gas.Comment: 7 figures. arXiv admin note: text overlap with arXiv:0805.1005 by other author

Intelligent IT Governance Platform: Strategic level

The objective of this work is the implementation of a new IT governance platform adaptable to any type of Information system architecture and any kind of business. The proposed platform is intelligent and independent to understand the business needs continuously changing, is distributed to involve all stakeholders and heterogeneous components, and scalable to accumulate the know-how of the company's IT Governance through a learning asset

Empirical Study on the Status of Moroccan Information Systems and Proposition of Approach for Choice of Best Practices for Good IT Governance

Today, the function of the chief information officer (CIO) has become part of the flow charts of many Moroccan companies [1]. Based on this statement, we did an empirical study in the first part of this work on the state of information systems (IS) Moroccan to know their strengths and weaknesses. The aim of the second part is to propose an approach based on the IT (information technology) frameworks helping CIOs to form their own repository of good practices to be applied in order to have good IT governance

Empirical Study: Moroccan Information systems specificities for better IT Governance

The spread of information systems (IS) use has become an essential criterion for judging today's overall development level of a country and its attractiveness for capital and investment. Many International rankings evaluate the performance of different countries at this level. And Morocco occupies a disappointing position compared to its potential. Paradoxically, Morocco is lagging behind, although in the telecom sector, it is ahead of many developing countries, Thus, in 2015, the index NRI (Networked Readiness Index), measuring the preparation of an economy to make effective use of new information technologies (IT) published by the World Economic Forum, ranks Morocco in the 87th place. Indeed, with the exception of large companies that have implemented a set of tools to automate the process, a large number of SMEs and SMIs are very late as far as IT use is concerned. It means that IS in Morocco is still unable to achieve business perspectives for benefits and processes optimization. The aim of this article is to understand the particularities of Moroccan IS to understand the week points to correct in order to govern well enterprise Information technologies

Análise de componentes principais no estudo da diversidade genética de caprinos.

Analisou-se dados biométricos de raças exóticas Toggenbourg, Saanen, Anglonubiana, Alpina e Boer. No Marrocos, foram amostrados caprinos locais Drâa, Zagora e Rhâali. Mensurou-se altura de cernelha (AC), altura da maçã do peito ao chão (AP) e comprimento de orelha (CO). A profundidade torácica foi calculada (AC-AP) e foram estabelecidos índices entre duas medidas corporais. As variáveis foram submetidas à análise de componentes principais (ACP) através do programa SAS v. 9.0. Do total de sete componentes, os dois primeiros foram suficientes para acumular 74,87% da variância total dos dados. Na representação gráfica da distribuição dos indivíduos, observou-se que Toggebourg, Saanen e Alpina ocuparam apenas os quadrantes esquerdos e Zagora apenas nos quadrantes direitos. Drâa ocupou os quadrantes superiores. Apresentaram menos identidade as populações de Rhâali, Boer e Anglo-nubiana, cujos indivíduos se dispersaram entre ambos os quadrantes inferiores e o superior direito. Estes resultados estão de acordo com o histórico e a distribuição geográfica das raças, alertam para a necessidade de outros estudos sobre os caprinos marroquinos. Os resultados da ACP foram consistentes, permitindo preconizá-la como uma técnica auxiliar em estudos futuros

A generalized empirical interpolation method : application of reduced basis techniques to data assimilation

In an effort to extend the classical lagrangian interpolation tools, new interpolating methods that use general interpolating functions are explored. The method analyzed in this paper, called Generalized Empirical Interpolation Method (GEIM), belongs to this class of new techniques. It generalizes the plain Empirical Interpolation Method by replacing the evaluation at interpolating points by application of a class of interpolating linear functions. The paper is divided into two parts: first, the most basic properties of GEIM (such as the well-posedness of the generalized interpolation problem that is derived) will be analyzed. On a second part, a numerical example will illustrate how GEIM, if considered from a reduced basis point of view, can be used for the real-time reconstruction of experiments by coupling data assimilation with numerical simulations in a domain decomposition framework

Microbial ligand costimulation drives neutrophilic steroid-refractory asthma

Funding: The authors thank the Wellcome Trust (102705) and the Universities of Aberdeen and Cape Town for funding. This research was also supported, in part, by National Institutes of Health GM53522 and GM083016 to DLW. KF and BNL are funded by the Fonds Wetenschappelijk Onderzoek, BNL is the recipient of an European Research Commission consolidator grant and participates in the European Union FP7 programs EUBIOPRED and MedALL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD