Reduction Arguments for Geometric Inequalities Associated With Asymptotically Hyperboloidal Slices

We consider several geometric inequalities in general relativity involving mass, area, charge, and angular momentum for asymptotically hyperboloidal initial data. We show how to reduce each one to the known maximal (or time symmetric) case in the asymptotically flat setting, whenever a geometrically motivated system of elliptic equations admits a solution.Comment: 30 pages; final versio

Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity.

Developmental enhancers integrate graded concentrations of transcription factors (TFs) to create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) enhancer which drives a sharp expression pattern in the Drosophila blastoderm embryo in response to the transcriptional activator Bicoid (Bcd). We systematically interrogate cis and trans factors that influence the shape and position of expression driven by HbP2, and find that the prevailing model, based on pairwise cooperative binding of Bcd to HbP2 is not adequate. We demonstrate that other proteins, such as pioneer factors, Mediator and histone modifiers influence the shape and position of the HbP2 expression pattern. Comparing our results to theory reveals how higher-order cooperativity and energy expenditure impact boundary location and sharpness. Our results emphasize that the bacterial view of transcription regulation, where pairwise interactions between regulatory proteins dominate, must be reexamined in animals, where multiple molecular mechanisms collaborate to shape the gene regulatory function

Adenosquamous Carcinoma of Extrahepatic Bile Duct: A Case Report

Most malignant tumors originating from the biliary tract are adenocarcinomas, and adenosqamous carcinoma of Klatskin's tumor is a very rare finding. An 83-yr-old man was admitted to our hospital because of jaundice. The abdominal computed tomography and magnetic resonance cholangiopancreatography revealed wall thickening and luminal stenosis of both the intrahepatic duct confluent portion and the common hepatic duct. These findings were compatible with Klatskin's tumor, Bismuth type III. Considering the patient's old age, palliative combined modality therapy was performed. After percutaneous transhepatic biliary drainage, biopsy was performed via percutaneous transhepatic cholangioscopy. The histopathologic findings showed adenosquamous carcinoma. External radiotherapy and intraluminal brachytherapy through the endobiliary Y-type stent were then done. Nine months after the radiotherapy, the laboratory findings and the abdominal computed tomography revealed biliary obstruction and progressive hepatic metastasis. The combined modality therapy of external radiotherapy, intraluminal brachytherapy and stenting assisted him to live a normal life until he finally experienced biliary obstruction

A foreign body response-on-a-chip platform

Understanding the foreign body response (FBR) and desiging strategies to modulate such a response represent a grand challenge for implant devices and biomaterials. Here, the development of a microfluidic platform is reported, i.e., the FBR?on?a?chip (FBROC) for modeling the cascade of events during immune cell response to implants. The platform models the native implant microenvironment where the implants are interfaced directly with surrounding tissues, as well as vasculature with circulating immune cells. The study demonstrates that the release of cytokines such as monocyte chemoattractant protein 1 (MCP?1) from the extracellular matrix (ECM)?like hydrogels in the bottom tissue chamber induces trans?endothelial migration of circulating monocytes in the vascular channel toward the hydrogels, thus mimicking implant?induced inflammation. Data using patient?derived peripheral blood mononuclear cells further reveal inter?patient differences in FBR, highlighting the potential of this platform for monitoring FBR in a personalized manner. The prototype FBROC platform provides an enabling strategy to interrogate FBR on various implants, including biomaterials and engineered tissue constructs, in a physiologically relevant and individual?specific manner

The Student Movement Volume 108 Issue 1: \u2723 and me: Welcome to the AU Family!

HUMANS Babbling at the Crayon Box, Anneliese Tessalee Dorm Sweet Dorm, Savannah Tyler Surviving Freshman Year 101, Colin Cha ARTS & ENTERTAINMENT AU\u27s Reception of Barbie , Amelia Stefanescu Hey, How Was Your Summer? , Nailea Soto Sewing as an Art Form: My Experience as a First-Time Formal Dressmaker, Daena Holbrook Shadow & Bone: Reentering the Grishaverse, Madison Vath NEWS Another Generation, Another Convocation, Melissa Moore Canada\u27s Fiery Struggle: The Ongoing Battle Against Wildfires, Brendan Oh Labor Day, the Writers\u27 Strikes, and Fairness, Nathaniel Miller IDEAS Antibiotic Resistance, Sumin Lee Chapel Credits: Fair or Unfair?, Corinna Bevier From Flowers to Fires: Does Climate Change Rhetoric Need to Change?, Bella Hamann Suicide Prevention Month and the Power of Support, Reagan Westerman PULSE All That and Then Summer, Lexie Dunham Food Near AU, Alyssa Caruthers Mirror, Mirror on the Wall, is There a Fairest of Them All?, Anna Rybachek Social Media Fasts, Rodney Bell II LAST WORD You Are a God Who Sees Me, Chris Ngugihttps://digitalcommons.andrews.edu/sm-108/1000/thumbnail.jp

The Student Movement Volume 108 Issue 8: Conducting Us Into The Season

HUMANS Eating Healthier at Andrews, Brooklyn Anderson Honors Research with Shania Watts, Grace No Social Media: Is It Really Social?, Colin Cha ARTS & ENTERTAINMENT Journey to the Marvelous God - A double conducting recital, Aiko J. Ayala Rios Love, Murder, and Secrets: A Night At The MSU French Film Festival, Amelia Stefanescu What To Do About National Clean Out Your Refrigerator Day, Nate Miller Places to Go: The Lake Michigan College Mendel Center, Madison Vath NEWS Argentina Election Article, Regan McCain Qualitative Research Writing Group: Your Research Accountability Partner, Melissa Moore Self-Driving Taxis, Katie Davis Students\u27 reactions to Andrews\u27s National Ranking, Kiheon Chung Upcoming Winter Events, Melissa Moore IDEAS Morally Gray, Katie Davis Red and Green Flags, Ruben Colón Remembering Matthew Perry, Corinna Bevier SDAs and The Big Bang: A Survey, Erin Beers Shoot Your Shot - Or Maybe Not?, Regan Westerman PULSE Burnout vs. Laziness: What\u27s The Difference?, Lexie Dunham How Habits Happen, Anna Rybachek The Mauricio Fund, Elianna Fisher LAST WORD Reality for a Second-Generation Immigrant, Gio Leehttps://digitalcommons.andrews.edu/sm-108/1007/thumbnail.jp

Ankle-Foot Orthosis Made by 3D Printing Technique and Automated Design Software

We described 3D printing technique and automated design software and clinical results after the application of this AFO to a patient with a foot drop. After acquiring a 3D modelling file of a patient’s lower leg with peroneal neuropathy by a 3D scanner, we loaded this file on the automated orthosis software and created the “STL” file. The designed AFO was printed using a fused filament fabrication type 3D printer, and a mechanical stress test was performed. The patient alternated between the 3D-printed and conventional AFOs for 2 months. There was no crack or damage, and the shape and stiffness of the AFO did not change after the durability test. The gait speed increased after wearing the conventional AFO (56.5 cm/sec) and 3D-printed AFO (56.5 cm/sec) compared to that without an AFO (42.2 cm/sec). The patient was more satisfied with the 3D-printed AFO than the conventional AFO in terms of the weight and ease of use. The 3D-printed AFO exhibited similar functionality as the conventional AFO and considerably satisfied the patient in terms of the weight and ease of use. We suggest the possibility of the individualized AFO with 3D printing techniques and automated design software

White paper: Research Challenges at the Intersection of Energy and Equity in the Energy Transition

Summary report from NSF2026: Conference Workshops to Identify Research Challenges at the Intersection of Energy and Equity in the Energy Transitio

Brunner's Gland Hyperplasia: Treatment of Severe Diffuse Nodular Hyperplasia Mimicking a Malignancy on Pancreatic-Duodenal Area

Brunner's gland hyperplasia is a benign tumor of the duodenum and it is rarely associated with clinical symptoms. We report on a 64-yr-old man with Brunner's gland hyperplasia who had undergone a duodenocephalo-pancreatectomy. The reason is that he presented upper gastrointestinal obstructive symptoms and the esophagogastroduodenoscopic finding revealed the lesion to be an infiltrating type mass on the second portion of the duodenum with luminal narrowing. An abdominal computed tomography showed a 2.5 cm-sized mass in the duodenal second portion with a suspicious pancreatic invasion and 7 mm-sized lymph node around the duodenum. Duodenocephalopancreatectomy was successfully performed. Histological examination revealed a Brunner's gland hyperplasia. The final diagnosis was the coexistence of Brunner's gland hyperplasia and pancreatic heterotopia with a pancreatic head invasion. The literature on Brunner's gland hyperplasia is reviewed

Enabling an Equitable Energy Transition Through Inclusive Research

Comprehensive and meaningful inclusion of marginalized communities within the research enterprise will be critical to ensuring an equitable, technology-informed, clean energy transition. We provide five key action items for government agencies and philanthropic institutions to operationalize the commitment to an equitable energy transition