Prevalence of Hepatitis B and C virus infection among alcoholic individuals: importance of screening and vaccination

Drug users have been reported to have an increased risk for acquisition of viral hepatitis. This study aims to evaluate the prevalence of HBV and HCV infection and usefulness of saliva for HBsAg and anti-HCV detection in alcoholic patients.A total of 90 alcoholic patients were recruited in 2013. HBsAg and anti-HCV were tested in serum and saliva, anti-HBc and anti-HBs were tested in serum using commercial enzyme immunoassays (EIA).Using serum samples, anti-HCV, HBsAg, anti-HBc and anti-HBs prevalences were 5.6%, 0%, 15.7%, and 29.2%. HBsAg detection in saliva showed 100% of specificity and anti-HCV detection demonstrated 100% of sensitivity and 94.7% of specificity. Low prevalence of HBV and high prevalence of anti-HCV were found and reinforced the recommendation of HBV vaccination to avoid the acute and chronic cases and HCV screening in this group to identify cases for antiviral therapy. Saliva samples could be used for anti-HCV detection in this population, what could increase the diagnosis access

Efeitos agudos de diferentes métodos de alongamento de músculos antagonistas no volume total de treino de agonistas

Introdução: alguns estudos contemporâneos elucidam que os exercícios de alongamento, quando aplicados nos músculos antagonistas, podem promover melhoras no desempenho muscular dos músculos agonistas. Objetivo: investigar os efeitos agudos de diferentes métodos de alongamento de músculos antagonistas no volume total de treino (VTT) no exercício cadeira extensora. Materiais e métodos: A amostra foi composta por 12 mulheres (28.6 ± 4.66 anos de idade; 164 ± 0.05 cm de estatura; 59.2 ± 6.50 kg de massa corporal) recreacionalmente treinadas. A entrada nos protocolos experimentais foi randomizada e realizada em quatro dias distintos; 1) protocolo tradicional (GTRAD) - sem alongamento prévio e execução da cadeira extensora; 2) protocolo alongamento estático e posterior execução da cadeira extensora (GAE); 3) protocolo alongamento dinâmico e posterior execução da cadeira extensora (GAD); 4) protocolo alongamento FNP e posterior execução da cadeira extensora (GFNP). Resultados: não foram observadas diferenças significativas entre os grupos experimentais quando a significância foi ajustada pela correção de Bonferroni (p>0.05). Conclusão: sugere-se que treinadores e profissionais de condicionamento físico utilizem os exercícios de alongamento, como parte integrante de uma sessão de TF, com o intuito de treinar força e flexibilidade na mesma sessão de treino, sem efeitos deletérios no VTT

Energetic and Economic Analysis of Spineless Cactus Biomass Production in the Brazilian Semi-arid Region

The Brazilian semi-arid region is marked by a variable spatial-temporal rainfall distribution, concentrated over a 3 to 4 month season. Limited water availability is the main obstacle to the production of forage plants of C3 metabolism (such as corn and soybeans) and C4 metabolism (such as sugarcane), as well as livestock. To mitigate this forage supply, the spineless cactus (SC) has been cultivated in the region, producing high biomass amounts in this harsh environment. Recently, this remarkable capacity to produce biomass has drawn the attention of the renewable energy sector, supported by recent studies demonstrating the feasibility of its biomass as a raw material for bioenergy production. However, before moving to commercial scale, it is necessary to demonstrate that large-scale production has energy and economic viability for clean energy investors. Thus, the objective of this article was to analyze the energetic and economic viability of forage cactus cultivation systems in the Brazilian semi-arid region. The data used were extracted from the literature, based on forage production. For the energy evaluation, the energy balance was performed and the energy efficiency, energy productivity, specific energy, and net energy metrics were applied. The financial feasibility analysis used the Net Present Value (NPV) and Internal Rate of Return (IRR). The energy balance revealed that the SC cultivation is viable for biomass commercial-scale production, with an energy efficiency of 3.36, an energy productivity of 0.25 kg MJ−1, a specific energy of 13.5 MJ kg−1, and an energy balance of 127,348 MJ ha−1. For the economic aspect, considering an attractive minimum rate of return of 8%, production also proved to be viable, in a time horizon of three years. The Net Present Value and IRR metrics were USD 2196 and the IRR was 46%, respectively. The results found are important to encourage new investments in rural properties in the semi-arid region, and cultivation in new areas proved to be an efficient alternative from an energy and economic point of view, in addition to collaborating for the energy transition to sustainable sources and in the mitigation of regional environmental impacts

Energetic and Economic Analysis of Spineless Cactus Biomass Production in the Brazilian Semi-arid Region

The Brazilian semi-arid region is marked by a variable spatial-temporal rainfall distribution, concentrated over a 3 to 4 month season. Limited water availability is the main obstacle to the production of forage plants of C3 metabolism (such as corn and soybeans) and C4 metabolism (such as sugarcane), as well as livestock. To mitigate this forage supply, the spineless cactus (SC) has been cultivated in the region, producing high biomass amounts in this harsh environment. Recently, this remarkable capacity to produce biomass has drawn the attention of the renewable energy sector, supported by recent studies demonstrating the feasibility of its biomass as a raw material for bioenergy production. However, before moving to commercial scale, it is necessary to demonstrate that large-scale production has energy and economic viability for clean energy investors. Thus, the objective of this article was to analyze the energetic and economic viability of forage cactus cultivation systems in the Brazilian semi-arid region. The data used were extracted from the literature, based on forage production. For the energy evaluation, the energy balance was performed and the energy efficiency, energy productivity, specific energy, and net energy metrics were applied. The financial feasibility analysis used the Net Present Value (NPV) and Internal Rate of Return (IRR). The energy balance revealed that the SC cultivation is viable for biomass commercial-scale production, with an energy efficiency of 3.36, an energy productivity of 0.25 kg MJ−1, a specific energy of 13.5 MJ kg−1, and an energy balance of 127,348 MJ ha−1. For the economic aspect, considering an attractive minimum rate of return of 8%, production also proved to be viable, in a time horizon of three years. The Net Present Value and IRR metrics were USD 2196 and the IRR was 46%, respectively. The results found are important to encourage new investments in rural properties in the semi-arid region, and cultivation in new areas proved to be an efficient alternative from an energy and economic point of view, in addition to collaborating for the energy transition to sustainable sources and in the mitigation of regional environmental impacts

Osmoregulators in Hymenaea courbaril and Hymenaea stigonocarpa under water stress and rehydration

The objective of this work was to evaluate the effect of different water deficiency and rehydration levels on the concentrations of osmoregulators in two plant species (Hymenaea courbaril and H. Stigonocarpa) in the Amazon. We adopted a 2 × 5 × 5 factorial system, referring to 2 species (H. courbaril and H. stigonocarpa) and 5 stages of hydration and rehydration. The five hydration and rehydration stages were established in: (1) Control treatment E0; (2) Plants with 13 days of stress after incubation—E13; (3) Plants with 26 days of stress E26; (4) The plants that were established after 26 days after incubation and rehydrated for two days (RD2); (5) rehydrated for two days (RD4). The plants that were established after 26 days after incubation and rehydrated for four days. The experiment totaled fifty young plants with five replicates. Biochemical measurements were performed at the beginning of the experiment (E0) at 13 (E13) and 26 (E26) days after the water stress, in which the plants were rehydrated, repeating the analyses after two (RD2) and four (RD4) days. Both species increased the sucrose concentration by 18%, with a decrease of 52% in starch content. The RD4 time presented the highest mean starch concentration (0.19 mmol g−1 of the residue for H. courbaril and 0.27 mmol g−1 of residue for H. stigonocarpa). Increased proline concentrations were recorded for controls until RD2 for both species. For glycine betaine, the highest increases in treatments E26 and RD2 were observed for the H. courbaril species. Our rehydration period was not sufficient for total recovery of pre-stress concentrations of all studied solutes

Effects of Standardized Brazilian Green Propolis Extract (EPP-AF®) on Inflammation in Haemodialysis Patients: A Clinical Trial

Background. Patients on haemodialysis (HD) present a significant inflammatory status, which has a pronounced negative impact on their outcomes. Propolis is a natural resin with anti-inflammatory and immunomodulatory properties. We assessed the safety and impact of a standardized Brazilian green propolis extract (EPP-AF®) on the inflammatory status in patients under conventional HD. Methods. Patients were assigned to receive 200 mg/day of EPP-AF® for 4 weeks followed by 4 weeks without the drug, and changes in plasma levels of interleukins (ILs), interferon gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α), and high-sensitivityc-reactive protein (HsCRP) were measured. A heatmap was used to illustrate trends in data variation. Results. In total, 37 patients were included in the final analysis. Patients presented an exacerbated inflammatory state at baseline. During EPP-AF® use, there was a significant reduction in IFN-γ (p=0.005), IL-13 (p=0.04 2), IL-17 (p=0.039), IL-1ra (p=0.008), IL-8 (p=0.009), and TNF-α (p < 0.001) levels compared to baseline, and significant changes were found in Hs-CRP levels. The heatmap demonstrated a pattern of pronounced proinflammatory status at baseline, especially in patients with primary glomerulopathies, and a clear reduction in this pattern during the use of EPP-AF®. There was a tendency to maintain this reduction after suspension of EPP-AF®. No significant side effects were observed. Conclusion. Patients under haemodialysis presented a pronounced inflammatory status, and EPP-AF® was demonstrated to be safe and associated with a significant and maintained reduction in proinflammatory cytokines in this population. This trial is registered with Clinicaltrials.gov NCT04072341