Attitudes and opinions of Head Start trainees toward children and selected training procedures as reflected in group discussions

Call number: LD2668 .R4 1967 S94

Seroprevalence of Human Brucellosis in a Rural Area of Western Anatolia, Turkey

This study was conducted to determine the seroprevalence of human brucellosis and identify the potential risk factors in a rural area of Western Anatolia, Turkey. A simple random-sampling method was used for identifying 1,052 subjects for the study. Blood samples, collected from all the subjects, were studied following the methods of Rose Bengal slide agglutination and standard tube agglutination tests. One thousand and one samples (95.2%) were seronegative, and 51 (4.8%) were seropositive. There was a statistically significant correlation between seropositivity and age, sex, consuming fresh cheese and cream made from unboiled milk (p values 0.005, 0.019, <0.001, and <0.001 respectively). Seropositivity was not related to educational level (0.270). It is concluded that pasteurization of milk and dairy products and education regarding eating habits must be pursued for eradication of human brucellosis from rural areas. The findings of the study suggest that human brucellosis is still an important public-health problem in the western Anatolia region of Turkey, especially in rural areas

Synthesis, characterization, electrochemical and spectroscopic studies of two new heteroleptic Ru(II) polypyridyl complexes

WOS: 000247195800020New [Ru(L1)(H(2)dcbpy)(NCS)(2)] [K30] and [Ru(L2)(H(2)dcbpy)(NCS)(2]) [K27] complexes were synthesized in a one-pot reaction starting from [RuCl2(p-cymene)](2), where the ligands (H2dcbpy = 4,4'-dicarboxy-2,2'-bipyridine, L1 = 4,5-diazafluoren-9-one, and L2 = 1, 10-phenanthroline-5,6-dione) are introduced sequentially. The resulting complexes were characterized by UV-vis, emission, IR, TGA, NMR, elemental analysis and cyclic voltammetry. The absorption and emission maxima of the two complexes are very similar to one another. The low-energy MLCT absorption maxima of the complexes appear at 524 nm, and the luminescence consists of a single band with a maximum at 700 and 720 nm, respectively, in DMF solution at 298 K. The electrochemical behaviors of the complexes have been studied in CH3CN by cyclic voltammetry. The LUMO energy levels of K27 and K30 were determined as -4.01 and -3.86 eV, respectively. The thermogravimetric analyses (TGA) of the prepared complexes show that the dyes are stable up to about 220 degrees C. Photodecompositions of the complexes in solution were studied in both ethanol and DMF solvents with a steady-state spectrofluori meter in time-based mode. The photostability of the compounds in DMF was found to increase twice in comparison to ethanol. Fluorescence quenching experiments of the one simple derivative of PDIs (N,N'-bis(I-ethylpropyl)perylene-3,4,9,10-tetracarboxylic acid (EP-PDI)) in DMF were studied vs. increasing K27 and K30 concentrations to monitor donor/acceptor capability. The rate constants (k(q)) of EP-PDI for each complex, K27 and K30, were determined as 7.72 x 10(12) and 6.52 x 10(12) M-1 s(-1), respectively. In addition, the free energies of exothermic photo-electron transfer (ET) processes between EP-PDI and complexes K27 and K30 were calculated to be -62.3 and -57.9 kcal mol(-1), respectively. (C) 2006 Elsevier Ltd. All rights reserved

Anti-Toxoplasma gondii Antibodies in Patients With Schizophrenia—Preliminary Findings in a Turkish Sample

Schizophrenia is a serious neuropsychiatric disease of uncertain etiology. We investigated the seropositivity rate for anti-Toxoplasma IgG and IgM antibodies by enzyme-linked immunosorbent assay (ELISA) in patients with schizophrenia to ascertain a possible relationship between Toxoplasma gondii and schizophrenia. We selected 100 patients with schizophrenia, 50 with depressive disorder, and 50 healthy volunteers to investigate the seropositivity rate of anti-Toxoplasma antibodies by ELISA. The seropositivity rate for anti-Toxoplasma IgG antibodies among schizophrenia patients (66%) was significantly higher than among patients with depressive disorder or healthy volunteers (P < .01). Thus, there might be a causal relationship between toxoplasmosis and the etiology of schizophrenia

Unveiling the catalytic nature of palladium-N-heterocyclic carbene catalysts in the alpha-alkylation of ketones with primary alcohols

We report herein the synthesis of four new Pd-PEPPSI complexes with backbone-modified N-heterocyclic carbene (NHC) ligands and their application as catalysts in the alpha-alkylation of ketones with primary alcohols using a borrowing hydrogen process and tandem Suzuki-Miyaura coupling/alpha-alkylation reactions. Among the synthesized Pd-PEPPSI complexes, complex 2c having 4-methoxyphenyl groups at the 4,5-positions and 4-methoxybenzyl substituents on the N-atoms of imidazole exhibited the highest catalytic activity in the alpha-alkylation of ketones with primary alcohols (18 examples) with yields reaching up to 95%. Additionally, complex 2c was demonstrated to be an effective catalyst for the tandem Suzuki-Miyaura-coupling/alpha-alkylation of ketones to give biaryl ketones with high yields. The heterogeneous nature of the present catalytic system was verified by mercury poisoning and hot filtration experiments. Moreover, the formation of NHC-stabilized Pd(0) nanopArticles during the alpha-alkylation reactions was identified by advanced analytical techniques.We are grateful to the Ege University Scientific Research Projects Coordination (FYL-2019-21171) and the Turkish Academy of Science (TUBA) for the financial support. M. O. thanks the Turkiye Scholarships for the fellowship. Z. E. thanks to the Council of Higher Education of Turkey for 100/2000 CoHE Doctoral Scholarship and TUBITAK 2211/C National Ph.D. Scholarship Program in the Priority Fields in Science and Technology.Ege University Scientific Research Projects Coordination [FYL-2019-21171]; Turkish Academy of Science (TUBA); Turkiye Scholarships; Council of Higher Education of Turkey; TUBITAK 2211/C National Ph.D. Scholarship Program in the Priority Fields in Science and Technolog

Seroprevalence of Human Brucellosis in a Rural Area of Western Anatolia, Turkey

This study was conducted to determine the seroprevalence of human brucellosis and identify the potential risk factors in a rural area of Western Anatolia, Turkey. A simple random-sampling method was used for identifying 1,052 subjects for the study. Blood samples, collected from all the subjects, were studied following the methods of Rose Bengal slide agglutination and standard tube agglutination tests. One thousand and one samples (95.2%) were seronegative, and 51 (4.8%) were seropositive. There was a statistically significant correlation between seropositivity and age, sex, consuming fresh cheese and cream made from unboiled milk (p values 0.005, 0.019, <0.001, and <0.001 respectively). Seropositivity was not related to educational level (0.270). It is concluded that pasteurization of milk and dairy products and education regarding eating habits must be pursued for eradication of human brucellosis from rural areas. The findings of the study suggest that human brucellosis is still an important public-health problem in the western Anatolia region of Turkey, especially in rural areas

The effects of caspofungin and voriconazole in an experimental fungal infection of the ear due to Aspergillus

The purpose of the study was to evaluate the effectiveness of caspofungin and voriconazole in the treatment of experimental Aspergillus otits media in an experimental rabbit model. A total of 30 New Zealand white rabbits were divided into four treatment groups and one control group. The rabbits were immunosuppressed by cyclophosphamide and triamcinolone acetonide. The right ear of each rabbit was infected by an injection of the inoculum of 0.1 ml (8.6 x 103 CFU/0.1 ml) of Aspergillus fumigatus into the middle ear cavity. At 72 h after the inoculation, amphotericin B 1 mg/kg per day (n = 6), itraconazole 10 mg/kg per day (n = 6), voriconazole 10 mg/kg per day (n = 6) and caspofungin 5 mg/kg per day (n = 6) were injected to each treatment group. No antifungal drug was administered to the control group (n = 6). Clinical and histopathological examination scores and microbiological analysis of middle ear mucosa were compared.There was statistically significant difference in the clinical scores, histopathological scores, and mean CFU/g between the treatment and control groups (P < 0.05). There was no statistically significant difference among the treatment groups in the clinical and histopathological scores, whereas there was statistically significant difference in the mean CFU/g (P < 0.05). The mean CFU/g of amphotericin B and caspofungin groups were similar and both were lower than the itraconazole and voriconazole groups. Also, the mean CFU/g of voriconazole group was lower than the itraconazole group (P < 0.05). Caspofungin and voriconazole were demonstrated at least as effective as amphotericin B and itraconazole. We suggest that caspofungin and voriconazole may be considered for the treatment of fungal infection of the ear

A Monostyryl Boradiazaindacene (BODIPY)-based lanthanide-free colorimetric and fluorogenic probe for sequential sensing of copper (II) ions and dipicolinic acid as a biomarker of bacterial endospores

A new catechol-substituted monostyryl boradiazaindacene (BODIPY)-based lanthanide-free colorimetric and fluorogenic probe was developed for the sequential detection of Cu2+ ions and dipicolinic acid (DPA), a distinctive biomarker of bacterial endospores, with high sensitivity and selectivity. In the presence of Cu2+ ions, the blue solution of the probe changes to cyan and the fluorescence is quenched, however, the cyan color changes to blue immediately and the fluorescence is restored on contact with DPA, resulting from competitive binding of DPA that interact with Cu2+ ions. A practical application by using Geobacillus stearothermophilus spores was further studied and as low as 1.0 x 10(5) spores were detected

Synthesis and catalytic activity of ruthenium(II) complexes containing pyridine-based tridentate triamines ('NNN') and pyridine carboxylate ligands (NO)

WOS: 000308696200037The reaction of [(p-cymene)RuCl2](2) with K[NOa-b] (NO- = 2-picolinate, a or 2-quinaldinate, b) gave neutral [(p-cymene)RuCl(NOa-b)] (1a-b), complexes which were treated with pyridine-based meridional triamine ligands ('NNN') to create complexes of the type [RuCl(NOa-b)('NNN')] (2a: 'N = N-d, NOa(-) = 2-picolinato; 2b: 'N = N-d, NOb- = 2-quinaldinato; 3a: 'N = N-b, NOa- = 2-picolinato; 3b: 'N = N-b, NOb- = 2-quinaldinato; 4a: 'N = N-p, NOa- = 2-picolinato; 4b: 'N = N-p, NOb- = 2-quinaldinato). The new compounds were characterized by elemental analysis, IR and NMR spectroscopy and, 1b was studied by single crystal X-ray diffraction. The complexes 1-4 have been employed as catalysts for the transfer hydrogenation (TH) of acetophenone derivatives to secondary alcohols in the presence of KOH using 2-propanol as a hydrogen source at 82 degrees C. The highest catalytic activity was obtained with 3a. (C) 2012 Elsevier B. V. All rights reserved.Scientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [107T808]; TUBA (Turkish Academy of Science)Turkish Academy of SciencesThis research has been supported by The Scientific and Technical Research Council of Turkey (TUBITAK) (Project No: 107T808). B.C. also thank to TUBA (Turkish Academy of Science) for financial support