Protection contre les crues et renaturation de la Drance à Martigny - Du barrage filtrant de La Condémine au pont de Courvieux

La Ville de Martigny en Valais a été victime à plusieurs reprises de débordements de la Drance, occasionnés par des débâcles glaciaires et des crues à fort charriage. Pour remédier à cette situation de risque important, un projet d’aménagement du cours d’eau et de ses abords a été développé. Outre la protection contre les crues, le projet vise des objectifs de renaturation, particulièrement difficiles à mettre en oeuvre dans le contexte urbain. Les principes de dimensionnement sont clairement définis et les principales mesures proposées sont passées en revue. Elles concernent en particulier la gestion sédimentaire grâce à un dépotoir contrôlé par un barrage filtrant, le rétablissement de la libre migration piscicole, l’approfondissement du lit sur quelque 1‘500 m pour permettre le libre transit sous les nombreux ponts concernés, la stabilisation du lit et des berges, la surélévation adéquate des digues selon un concept de débordement différencié en cas de surcharge, la protection des ponts susceptibles d’être mis en charge et de leurs fondations ainsi que le concept d’élargissement du lit sur le secteur aval de la Drance avant son raccordement au Rhône. La réalisation de l’ensemble des travaux est planifiée sur 7 ans, à partir de 2018

First results of Waterborne Geophysical surveys around the Malpasso site (Tuoro sul Trasimeno, Italy) for geological and archeological characterization

With the aims of both reconstructing the geological setting of the area around the Malpasso site and to eventually find some localized remains of the battle we carried out several waterborne geophysical surveys on the area. Adopted methodologies were: magnetic surveys, seismic reflection Chirp Sonar surveys and Continuous Vertical Electric Soundings (CVES) profiles

Il cimitero ebraico di Gradisca d'Isonzo

Curatela di un volume della collana Corpus Epitaphiorum Hebraicorum Italiae che riguarda il cimitero ebraico di Gradisca d'Isonzo, istituito nella contea principesca di Gorizia e Gradisca nel periodo dell'appartenenza all'Impero asburgico, unico attualmente in uso nel Goriziano, che comprende la storia del contesto e delle famiglie, la riproduzione di fotografie storiche e attuali delle lapidi con la loro traduzione in italiano

The impact of anastomotic leak on long-term oncological outcomes after low anterior resection for mid-low rectal cancer: extended follow-up of a randomised controlled trial

The impact of anastomotic leaks (AL) on oncological outcomes after low anterior resection for mid-low rectal cancer is still debated. The aim of this study was to evaluate overall survival (OS), disease-free survival (DFS), and local and distant recurrence in patients with AL following low anterior resection

Microbiota analysis and microbiological hazard assessment in poultry carcasses from conventional and antibiotic free farms

The aim of this study was to assess microbiota and microbiological hazards in poultry carcasses from animals reared in conventional (n=15) and antibiotic free (n=15) farms. An aliquot of neck and breast skin was obtained from each individual carcass at the end of the refrigeration tunnel and submitted to DNA extraction. Total DNA was sequenced in the 16S rRNA and reads analysed with MG-RAST to classify the colonising bacteria up to the genus level and compare each taxonomic group in terms of mean relative frequency of abundance in conventional and antibiotic free carcasses. Firmicutes displayed abundances always higher than 38% but did not show statistically significative differences between conventional and antibiotic free carcasses. On the contrary, Bacteroidetes and Actinobacteria were significantly higher in antibiotic free then conventional carcasses (21.57 vs 10.95%; 19.29 vs 12.05%), whereas Proteobacteria were higher in the latter (33.19 vs 19.52%). The genera significantly higher in antibiotic free than conventional carcasses were Chryseobacterium (10.07 vs 1.94%), Rothia (3.08 vs 0.77%) and Micrococcus (1.12 vs 0.16%), while Shewanella was significantly higher in conventional carcasses (1.38 vs 0.26%). Among Firmicutes, the genera significantly higher in conventional carcasses were Ureibacillus (1.45 vs 0.11%) and Bacillus (3.28 vs 0.56%). The higher abundance of Proteobacteria in conventional carcasses might suggest that hygienic conditions in conventional farms are worse than antibiotic free farms. However, from a food safety point of view, Salmonella was not detected in both kinds of carcasses and the Campylobacter mean relative frequency of abundance was always lower than 0.4%

Local Structure and Magnetism of Fe2O3 Maghemite Nanocrystals: The Role of Crystal Dimension

Here we report on the impact of reducing the crystalline size on the structural and magnetic properties of γ-Fe2O3 maghemite nanoparticles. A set of polycrystalline specimens with crystallite size ranging from ~2 to ~50 nm was obtained combining microwave plasma synthesis and commercial samples. Crystallite size was derived by electron microscopy and synchrotron powder diffraction, which was used also to investigate the crystallographic structure. The local atomic structure was inquired combining pair distribution function (PDF) and X-ray absorption spectroscopy (XAS). PDF revealed that reducing the crystal dimension induces the depletion of the amount of Fe tetrahedral sites. XAS confirmed significant bond distance expansion and a loose Fe-Fe connectivity between octahedral and tetrahedral sites. Molecular dynamics revealed important surface effects, whose implementation in PDF reproduces the first shells of experimental curves. The structural disorder affects the magnetic properties more and more with decreasing the nanoparticle size. In particular, the saturation magnetization reduces, revealing a spin canting effect. Moreover, a large effective magnetic anisotropy is measured at low temperature together with an exchange bias effect, a behavior that we related to the existence of a highly disordered glassy magnetic phase

GRB Afterglows with Energy Injection from a spinning down NS

We investigate a model for the shallow decay phases of Gamma-ray Burst (GRB) afterglows discovered by Swift/XRT in the first hours following a GRB event. In the context of the fireball scenario, we consider the possibility that long-lived energy injection from a millisecond spinning, ultramagnetic neutron star (magnetar) powers afterglow emission during this phase. We consider the energy evolution in a relativistic shock subject to both radiative losses and energy injection from a spinning down magnetar in spherical symmetry. We model the energy injection term through magnetic dipole losses and discuss an approximate treatment for the dynamical evolution of the blastwave. We obtain an analytic solution for the energy evolution in the shock and associated lightcurves. To fully illustrate the potential of our solution we calculate lightcurves for a few selected X-ray afterglows observed by Swift and fit them using our theoretical lightcurves. Our solution naturally describes in a single picture the properties of the shallow decay phase and the transition to the so-called normal decay phase. In particular, we obtain remarkably good fits to X-ray afterglows for plausible parameters of the magnetar. Even though approximate, our treatment provides a step forward with respect to previously adopted approximations and provides additional support to the idea that a millisecond spinning (1-3 ms), ultramagnetic (B$\sim 10^{14}-10^{15}$ G) neutron star loosing spin energy through magnetic dipole radiation can explain the luminosity, durations and shapes of X-ray GRB afterglows.Comment: 7 pages, 2 figures, submitted to Astronomy & Astrophysics - referee's comments include

Rationale and design of MILES-3 and MILES-4 studies: two randomized phase III trials comparing single-agent chemotherapy versus cisplatin-based doublets in elderly patients with advanced non-small cell lung cancer

BACKGROUND: Platinum-based chemotherapy is the cornerstone of treatment of advanced non-small-cell lung cancer (NSCLC) patients, but the efficacy of adding cisplatin to single-agent chemotherapy remains to be demonstrated in prospective phase III trials dedicated to elderly patients. Furthermore, the superiority of cisplatin/pemetrexed over cisplatin/gemcitabine in non-squamous NSCLC has not been confirmed prospectively. We present the rationale and design of two open-label, multicenter, randomized phase III trials for elderly patients with advanced NSCLC∶ Multicenter Italian Lung cancer in the Elderly Study (MILES)-3 and MILES-4. The aim is to evaluate the efficacy of adding cisplatin to single-agent chemotherapy (both trials) and the efficacy of pemetrexed versus gemcitabine in non-squamous tumors (MILES-4). PATIENTS AND METHODS: Both trials are dedicated to first-line therapy of patients older than 70 years with advanced NSCLC, ECOG performance status 0-1. In the MILES-3 trial, patients are randomized in a 1∶1 ratio to gemcitabine or cisplatin/gemcitabine. In the MILES-4 study patients with non-squamous histology are randomized, in a factorial design with 1∶1∶1∶1 ratio, to four arms: gemcitabine (A), cisplatin/gemcitabine (B), pemetrexed (C), cisplatin/pemetrexed (D). Two comparisons are planned∶ A+C vs B+D to test the role of cisplatin; A+B vs C+D to test the role of pemetrexed. Primary endpoint of both trials is overall survival. Secondary and exploratory endpoints include progression-free survival, response rate, toxicity, and quality of life. CONCLUSIONS: MILES-3 and MILES-4 results will add important evidence about the role of cisplatin-based doublets and pemetrexed in the first-line therapy of elderly patients with advanced NSCLC

The Genome of the Zoonotic Malaria Parasite Plasmodium simium Reveals Adaptions to Host-switching

Oral Session