Osteomielitis vertebral cervical como complicación de cirugía faríngea: a propósito de un caso

Se presenta un caso de un a enferma de 59 años, diabética, afecta de un a osteomielitis vertebral cervical por Candida Albicans. La vía de infección fué la persistencia durante varios meses de unos tutores, colocados tras la resección de un a estenosis nasofaríngea , que impactaban sobre la cara anterior de la vértebra C3. El desarrollo insidioso y la ausencia de un cuadro clínico específico fué la causa del retraso diagnóstico.A 5 9 yea r ol d woma n wit h diabete s mellitu s presente d a cervica l vertebra l osteomyelitis du e t o Candid a Albicans. Th e chroni c implantatio n o f dilatio n tube s followin g th e resectio n o f a nasopharyngea l stenosis wa s th e mod e o f infection . Th e insidiou s an d prolonge d onse t an d n o specifica l clinica l pictur e wer e t h e caus e o f dela y i n th e diagnosi

Biomass-derived carbons physically activated in one or two steps for CH4/CO2 separation

The present study aims at evaluating the suitability of producing activated carbons (ACs) derived from wheat straw by a one-step synthesis approach, as an alternative to more conventional two steps production processes (i.e., pyrolysis and subsequent activation). The performance of the produced ACs, in one or two steps, as sustainable and selective CO2 adsorbents for CH4/CO2 separation is compared. In addition, the influence of pyrolysis conditions on the properties of the resulting two-step ACs is carefully analyzed. We show that the biochar-based precursors of ACs presenting the best textural properties were obtained under mild conditions of maximum temperature and absolute pressure during pyrolysis. The one-step ACs were fully comparable —in terms of textural properties as well as CO2 uptake and selectivity— to those produced by the more conventional two-step synthesis process. In addition, results obtained from breakthrough curve simulations highlight that the best AC in terms of CH4 recovery under dynamic conditions was produced by a one-step activation. Therefore, the one-step process appears to be as an attractive route for the production of engineered carbon materials, which can lead to significant cost savings in large-scale production systems

The dynamics over the next few years of the Spanish mobile telecommunications market share: a mathematical modelling approach

This is an author's accepted manuscript of an article published in: “Mathematical and Computer Modelling of Dynamical Systems: Methods, Tools and Applications in Engineering and Related Sciences"; Volume 20, Issue 6, 2014; copyright Taylor & Francis; available online at: http://dx.doi.org/10.1080/13873954.2013.843572Taking into account available data from 2002 to 2009 about the market share percentages of the Spanish mobile telecommunications service providers, a dynamic diffusion model to study the evolution of the clients’ change between the different companies during the period 2010–2016 is proposed. The constructed model provides a tool for forecasting short-term trends about the customers’ preferences with respect to mobile network operators taking into account both, autonomous decisions due to direct marketing and advertising strategies, and also decisions adopted through interaction via social influence. The model can provide insights to companies for designing strategies in order to gain market share.This work has been partially supported by the FIS PI-10/01433; the Spanish Government and European Regional Development Fund (FEDER) [grant number MTM2009-08587]; and the Universitat Politecnica de Valencia [grant number PAID06-11-2070].Cervelló Royo, RE.; Cortés, J.; Santonja, F.; Villanueva Micó, RJ. (2014). The dynamics over the next few years of the Spanish mobile telecommunications market share: a mathematical modelling approach. Mathematical and Computer Modelling of Dynamical Systems. 20(6):557-565. https://doi.org/10.1080/13873954.2013.843572S557565206Gruber, H. (1999). An investment view of mobile telecommunications in the European Union. Telecommunications Policy, 23(7-8), 521-538. doi:10.1016/s0308-5961(99)00042-7Cortés, J.-C., Lombana, I.-C., & Villanueva, R.-J. (2010). Age-structured mathematical modeling approach to short-term diffusion of electronic commerce in Spain. Mathematical and Computer Modelling, 52(7-8), 1045-1051. doi:10.1016/j.mcm.2010.02.030Gruber, H. (2001). Competition and innovation. Information Economics and Policy, 13(1), 19-34. doi:10.1016/s0167-6245(00)00028-7Gruber, H., & Verboven, F. (2001). The diffusion of mobile telecommunications services in the European Union. European Economic Review, 45(3), 577-588. doi:10.1016/s0014-2921(00)00068-4Bettencourt, L. (1997). Customer voluntary performance: Customers as partners in service delivery. Journal of Retailing, 73(3), 383-406. doi:10.1016/s0022-4359(97)90024-5Herrera-González, F., & Castejón-Martín, L. (2009). The endless need for regulation in telecommunication: An explanation. Telecommunications Policy, 33(10-11), 664-675. doi:10.1016/j.telpol.2009.07.001Santonja, F.-J., Morales, A., Villanueva, R.-J., & Cortés, J.-C. (2012). Analysing the effect of public health campaigns on reducing excess weight: A modelling approach for the Spanish Autonomous Region of the Community of Valencia. Evaluation and Program Planning, 35(1), 34-39. doi:10.1016/j.evalprogplan.2011.06.00

Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: A systematic review.

This systematic review aimed to investigate immune-inflammatory and hypothalamic-pituitary-adrenal (HPA) axis biomarkers in individuals with non-specific low back pain (NSLBP) compared to healthy control. The search was performed in five databases until 4 November 2021. Two reviewers independently conducted screenings, data extraction, risk of bias, and methodological quality assessment of 14 unique studies. All studies reported the source of the fluid analyzed: nine studies used serum, two used plasma, one used serum and plasma, and two studies used salivary cortisol. We found preliminary and limited evidence (only one study for each biomarker) of increased levels in growth differentiation factor 15 (GDF-15), interleukin-23 (IL-23), transforming growth factor-beta (TGF-β), and soluble tumor necrosis factor receptor 1 (sTNF-R1) in NSLBP. Inconsistent and limited evidence was identified for interleukin-10 (IL-10). Although C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) levels appear to increase in NSLBP, only one study per each biomarker reported statistically significant differences. Interleukin-1 beta (IL-1β), interleukin-17 (IL-17), interferon gamma (IFN-γ), and high-sensitivity CRP (hsCRP) showed no significant differences. Regarding cortisol, one study showed a significant increase and another a significant decrease. More robust evidence between GDF-15, IL-23, TGF-β, and sTNF-R1 with NSLBP is needed. Moreover, contrary to the findings reported in previous studies, when comparing results exclusively with healthy control, insufficient robust evidence for IL-6, TNF-α, and CRP was found in NSLBP. In addition, cortisol response (HPA-related biomarker) showed a dysregulated functioning in NSLBP, with incongruent evidence regarding its directionality. Therefore, our effort is to find adjusted evidence to conclude which immune-inflammatory and HPA axis biomarkers are altered in NSLBP and how much their levels are affected

Social inequities in the impact of COVID-19 lockdown measures on the mental health of a large sample of the Colombian population (PSY-COVID study)

The identification of general population groups particularly vulnerable to the impact of COVID-19 lockdown measures on mental health and the development of healthcare policies are priority challenges in the current and future pandemics. This study aimed to identify the personal and social determinants of the impact of COVID-19 lockdown measures on mental health in a large sample of the Colombian population. In this cross-sectional study, an anonymous online survey was answered by 18,061 participants from the general population residing in Colombia during the first wave of the COVID-19 outbreak (from 20 May to 20 June 2020). The risk of depression, anxiety, and somatization disorders were measured using the Patient Health Questionnaire (PHQ-2), Generalized Anxiety Disorder Scale (GAD-2), and Somatic Symptom Questionnaire (SSQ-5), respectively. Overall, 35% of participants showed risk of depression, 29% of anxiety, and 31% of somatization. According to the analysis of social determinants of health, the most affected groups were people with low incomes, students, and young adults (18-29 years). Specifically, low-income young females were the most at-risk population group. These findings show how the lockdown measures affected the general population's mental health in Colombia and highlight some social risk factors in health

Wellbeing indicators affecting female entrepreneurship in OECD countries

[EN] The objective of this research is to know which wellbeing indicators, such as work-life balance, educational level, income or job security, are related to the rate of female entrepreneurship in 29 OECD countries. In addition, these countries have been classified according to the motivation of the entrepreneur either by necessity or by opportunity. The empiric study is focused on 29 OECD countries covering the different geographic areas (Western Europe, Central and Eastern Europe, Middle East, etc.) Due to the fact that the sample is relatively small, it is essential to use a selective approach when selecting the causal conditions. To this end, fsQCA is the most appropriate methodology for such a small data set. A total of 5 variables have been used: an independent variable (female TEA ratio), and four dependent variables (work life balance, educational level, sustainable household income and job security). Data measuring female TEA ratio have been obtained from Global Entrepreneur Monitor (GEM in Global report, 2015) data base, while data measuring wellbeing dimensions were taken from the Better Life Index (OECD in How¿s life? Measuring wellbeing, 2015. http://www.oecdbetterlifeindex.org). The results of this piece of research show that countries with high sustainable household income together with high level of education achieves high female entrepreneurship ratio with both, a good work-life balance (despite of a high unemployment probability), or a high labour-personal imbalance (in this latter, with a low probability of unemployment).This work has been funded by the R + D project for emerging research groups with reference (GVA) GV/2016/078.Ribes-Giner, G.; Moya Clemente, I.; Cervelló Royo, RE.; Perelló Marín, MR. (2019). Wellbeing indicators affecting female entrepreneurship in OECD countries. 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Long-term adherence to IFN beta-1a treatment when using rebismart1device in patients with relapsing-remitting multiple sclerosis

The effectiveness of disease-modifying drugs in the treatment of multiple sclerosis is associated with adherence. RebiSmart® electronic device provides useful information about adherence to the treatment with subcutaneous (sc) interferon (IFN) ß-1a (Rebif®). The aim of the study was to determine long-term adherence to this treatment in patients with relapsing- remitting multiple sclerosis (RRMS). This retrospective multicentre observational study analysed 258 patients with RRMS who were receiving sc IFN ß-1a (Rebif®) treatment by using RebiSmart® until replacement (36 months maximum lifetime) or treatment discontinuation. Adherence was calculated with data (injection dosage, time, and date) automatically recorded by RebiSmart®. Patients in the study had a mean age of 41 years with a female proportion of 68%. Mean EDSS score at start of treatment was 1.8 (95% CI, 1.6-1.9). Overall adherence was 92.6%(95% CI, 90.6-94.5%). A total of 30.2% of patients achieved an adherence rate of 100%, 80.6% at least 90%, and only 13.2% of patients showed a suboptimal adherence (<80%). A total of 59.9% of subjects were relapse-free after treatment initiation. Among 106 subjects (41.1%) who experienced, on average, 1.4 relapses, the majority were mild (40.6%) or moderate (47.2%). Having experienced relapses from the beginning of the treatment was the only variable significantly related to achieving an adherence of at least 80% (OR = 3.06, 1.28-7.31). Results of this study indicate that sc IFN ß-1a administration facilitated by RebiSmart® could lead to high rates of adherence to a prescribed dose regimen over 36 months

Human Endometrial Side Population Cells Exhibit Genotypic, Phenotypic and Functional Features of Somatic Stem Cells

During reproductive life, the human endometrium undergoes around 480 cycles of growth, breakdown and regeneration should pregnancy not be achieved. This outstanding regenerative capacity is the basis for women's cycling and its dysfunction may be involved in the etiology of pathological disorders. Therefore, the human endometrial tissue must rely on a remarkable endometrial somatic stem cells (SSC) population. Here we explore the hypothesis that human endometrial side population (SP) cells correspond to somatic stem cells. We isolated, identified and characterized the SP corresponding to the stromal and epithelial compartments using endometrial SP genes signature, immunophenotyping and characteristic telomerase pattern. We analyzed the clonogenic activity of SP cells under hypoxic conditions and the differentiation capacity in vitro to adipogenic and osteogenic lineages. Finally, we demonstrated the functional capability of endometrial SP to develop human endometrium after subcutaneous injection in NOD-SCID mice. Briefly, SP cells of human endometrium from epithelial and stromal compartments display genotypic, phenotypic and functional features of SSC