Does alexithymia have a mediating effect between impulsivity and emotional-behavioral functioning in adolescents with binge eating disorder?

Objective: Binge eating Disorder (BeD) has recently been included in the Dsm-5. like many other eating disorder symptoms, BED is often present in adolescence. No studies have specifically investigated the influence of impulsivity and alexithymia on the emotional-behavioural functioning of adolescents diagnosed with BeD. Method: in this study, we recruited n = 162 adolescents (age range: 14-18) and divided them into two groups: 78 adolescents diagnosed with BeD, according to the Dsm-5 criteria (group A), and 84 healthy controls (group B). participants completed the youth self-report (ysr/11-18), the toronto Alexithymia scale (tAs-20) and the Barratt impulsiveness scale (Bis-11). Results: the results showed that group A had higher scores of alexithymia, impulsivity and maladaptive emotionalbehavioural functioning than Group B. Furthermore, alexithymia had a mediating effect on the relationship between impulsivity and emotional-behavioural functioning. Conclusions: These results allow us to hypothesise that alexithymia is a key variable influencing the emotional and behavioural problems of adolescents affected by BED. Our data confirms the previous studies underlining the association of impulsivity and alexithymia with the diagnosis of BeD in adolescents, and our study contributes to the previous literature, emphasising the central role of alexithymia in the mediating effect between impulsivity and emotional and behavioural problems. these results suggest the importance of promoting prevention and treatment polices focused on alexithymia

Contact between the components of a knee prosthesis: numerical and experimental study

The aim of this work is the analysis of the contact area in a knee prosthesis using two different approaches. In particular, the interface between the femoral component and the polyethylene insert has been studied both numerically and experimentally. The interest in studying the contact area is related to the fact that the wear of the polyethylene insert, due to the high contact pressures, represents one of the major causes of failure of the total knee prosthesis. The possibility to evaluate the contact area at different loads and mutual position between femur and tibia is, therefore, of fundamental importance to study the service life of a prosthesis and to improve its performance. The finite element numerical approach has required the acquisition, through reverse engineering, and CAD modelling of the prosthetic components. Then the FEM simulations have been developed considering two different load conditions. In order to compare the calculated data, the same load configurations have been used for experimental tests based on ultrasonic method. In this case, some preliminary tests were required to calibrate the system depending on the particular characteristics of materials, geometries and surface finish of the prosthesis.The results show a good correlation between the data obtained with the two different approaches and, consequently, a good level of reliability of the procedures developed for the numerical and experimental evaluation of the contact area. The numerical procedure can be used to determine the area for different angles and loads, but especially in the design phase. The ultrasonic technique can be used to validate the numerical data

Contact between the components of a knee prosthesis: numerical and experimental study

The aim of this work is the analysis of the contact area in a knee prosthesis using two different approaches. In particular, the interface between the femoral component and the polyethylene insert has been studied both numerically and experimentally. The interest in studying the contact area is related to the fact that the wear of the polyethylene insert, due to the high contact pressures, represents one of the major causes of failure of the total knee prosthesis. The possibility to evaluate the contact area at different loads and mutual position between femur and tibia is, therefore, of fundamental importance to study the service life of a prosthesis and to improve its performance. The finite element numerical approach has required the acquisition, through reverse engineering, and CAD modelling of the prosthetic components. Then the FEM simulations have been developed considering two different load conditions. In order to compare the calculated data, the same load configurations have been used for experimental tests based on ultrasonic method. In this case, some preliminary tests were required to calibrate the system depending on the particular characteristics of materials, geometries and surface finish of the prosthesis.The results show a good correlation between the data obtained with the two different approaches and, consequently, a good level of reliability of the procedures developed for the numerical and experimental evaluation of the contact area. The numerical procedure can be used to determine the area for different angles and loads, but especially in the design phase. The ultrasonic technique can be used to validate the numerical data

An Ion Exchange Membrane Crystallisation reactor for Magnesium recovery from brines

CrIEM technology is a novel ion exchange application that allows reactive crystallization for separation of valuable species (e.g. Mg from brines) with a large flexibility in the choice of reactants

New & Noteworthy, June 2018

Contents include: Letters from the past and current presidents; ECD Travel Grant Recipients: Responses from their first conference; Conference Spotlights: Dramaturgs & #METOO: A Conference Report; Call for translators.https://soundideas.pugetsound.edu/lmdanewsletter/1001/thumbnail.jp

Novel Metabolites in Phenanthrene and Pyrene Transformation by Aspergillus-Niger

Fil: Sack, Ute. Institute of Microbiology. Friedrich Schiller University; GermanyFil: Heinze, Thomas M.. National Center for Toxicological Research, Food and Drug Administration. Arkansas; ArgentinaFil: Deck, Joanna. National Center for Toxicological Research, Food and Drug Administration. Arkansas; ArgentinaFil: Cerniglia, Carl E.. National Center for Toxicological Research, Food and Drug Administration. Arkansas; ArgentinaFil: Cazau, María Cecilia. Institute of Botany. University of La Plata; ArgentinaFil: Fritsche, Wolfgang. Institute of Microbiology. Friedrich Schiller University; German

Involvement of DAT1 gene on internet addiction. Cross-correlations of methylation levels in 5'-utr and 3’-UTR genotypes, interact with impulsivity and attachment-driven quality of relationships

Internet influences our communication, social and work interactions, entertainment, and many other aspects of life. Even if the original purpose was to simplify our lives, an excessive and/or maladaptive use of it may have negative consequences. The dopamine transporter (DAT1) gene was studied in relation to addictions, including excessive use of the Internet. The crucial role of DAT1 was previously underlined in modulating emotional aspects, such as affiliative behaviors. The present research follows a new approach based on cross-correlation between (de)methylation levels in couples of CpG loci, as previously shown. We investigated the possible relationships between Internet addiction, impulsivity, quality of attachment, DAT1 genotypes (from the 3′-untranslated region (UTR) variable number of tandem repeats (VNTR) poly-morphism), and the dynamics of methylation within the 5’-UTR of the DAT1 gene. From a normative sample of 79 youths, we extrapolated three subgroups a posteriori, i.e., one “vulnerable” with high Internet Addiction Test (IAT) scores (and high Barrat Impulsivity Scale (BIS) scores; n = 9) and two “controls” with low BIS scores and 10/10 vs. 9/x genotype (n = 12 each). Controls also had a “secure” attachment pattern, while genotypes and attachment styles were undistinguished in the vulnerable subgroup (none showed overt Internet addiction). We found a strongly positive correlation in all groups between CpG2 and CpG3. An unsuspected relationship between the 3’-UTR genotype and a 5’-UTR intra-motif link was revealed by CpG5–CpG6 comparison. The negative correlation between the CpG3–CpG5 positions was quite significant in the control groups (both with genotype 10/10 and with genotype 9/x), whereas a tendency toward positive correlation emerged within the high IAT group. In conclusion, future attention shall be focused on the intra-and inter-motif interactions of methylation on the CpG island at the 5′-UTR of DAT1

A latent profile approach for the study of internet gaming disorder, social media addiction, and psychopathology in a normative sample of adolescents

Background: For a small minority of individuals, the overuse of digital technologies has been associated with negative factors, including psychological distress and psychopathological symptoms. Two technology-based addictions – internet gaming disorder (IGD) and social media addiction (SMA) – have been found to be related to comorbid disorders and impulsivity especially in adolescents and emerging adults’ populations, but results in this field are inconclusive. Purpose: Using the latent profile analysis (LPA), this study identified different profiles of adolescents characterized by unique patterns of psychopathological risks, and similar levels of impulsivity, IGD, and SMA. Participants and methods: A total of 643 participants (312 males; Mage =16.02 years) were divided into three age groups (early, mid-, and late adolescence). They completed a battery of scales comprising: Internet Gaming Disorder Scale–Short Form, Bergen Social Media Addiction Scale, Barratt Impulsiveness Scale for Adolescents, and Symptom Checklist-90-R. Results: LPAs revealed distinct profiles across early, mid- and late adolescence with regards to the psychopathological variables taken into account. Specifically, only two profiles were identified in the 14–15 year age group, whereas three profiles emerged in the 16–17 year age group. Conclusion: This study highlighted that the profiles identified in each age group differed in terms of psychopathological risk (low, medium and high), showing instead similar (and non-clinical) scores in technology-based addictions and impulsivity. Results could be useful in designing prevention and intervention programs in youth showing similar patterns for technology-based addictions, but different levels of psychopathological symptoms

Epidermal Growth Factor Receptor Inhibition Modulates the Microenvironment by Vascular Normalization to Improve Chemotherapy and Radiotherapy Efficacy

Background: Epidermal growth factor receptor (EGFR) inhibitors have shown only modest clinical activity when used as single agents to treat cancers. They decrease tumor cell expression of hypoxia-inducible factor 1-a (HIF-1a) and vascular endothelial growth factor (VEGF). Hypothesizing that this might normalize tumor vasculature, we examined the effects of the EGFR inhibitor erlotinib on tumor vascular function, tumor microenvironment (TME) and chemotherapy and radiotherapy sensitivity. Methodology/Principal Findings: Erlotinib treatment of human tumor cells in vitro and mice bearing xenografts in vivo led to decreased HIF-1a and VEGF expression. Treatment altered xenograft vessel morphology assessed by confocal microscopy (following tomato lectin injection) and decreased vessel permeability (measured by Evan’s blue extravasation), suggesting vascular normalization. Erlotinib increased tumor blood flow measured by Power Doppler ultrasound and decreased hypoxia measured by EF5 immunohistochemistry and tumor O2 saturation measured by optical spectroscopy. Predictin

Assessment of the Italian version of the Internet Disorder Scale (IDS-15)

Much research has focused on the validation of psychometric tools assessing Internet addiction. One of the newest measures is the Internet Disorder Scale (IDS-15) based on the modified IGD criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). This study aimed at investigating the psychometric properties of the Italian version of the IDS-15 by examining the construct and the concurrent and the criterion-related validity and by identifying the taxonomy and the patterns of Internet users. A sample of 471 participants (Mage = 24.72 years, SD = 8.66; 256 males) was recruited from secondary schools, universities, and gaming halls. Confirmatory factor analyses supported the four-dimensional second-order structure and the three levels of the measurement invariance across gender. The reliability and the validity of the scale were confirmed, and the LPAs provided four classes of Internet users on the basis of the scores obtained in all four dimensions of the scale. The psychometric robustness of the Italian version of the IDS-15 was clearly demonstrated. Cross-cultural research should expand and generalize the present findings