Modelo de gestión basado en la Metodología ITIL V3 para el servicio de Help Desk orientada al soporte técnico de la unidad de ti de la Empresa Eléctrica Regional Norte S.A. Emelnorte

Desarrollar un modelo de gestión basado en la metodología ITIL V3 para el servicio de Help Desk orientada al soporte técnico de la unidad de TI de la Empresa Eléctrica Regional Norte S.A. EMELNORTE.La Dirección de TIC’s de la empresa eléctrica EMELNORTE S.A. detectó inconsistencias respecto al registro de los servicios prestados a los empleados dentro de la empresa, contaba con un Help Desk mismo que se usó poco tiempo porque se evidenció tiempos excesivos en la atención de los requerimientos, buscando una alternativa que ayude mejorar los servicios. Para solventar estas inconsistencias se optó por la implementación la metodología ITIL V3 para la gestión de servicios de la dirección de TIC’s, iniciando con un levantamiento del proceso de atención de requerimientos y posteriormente se desarrolló e implementó una nueva aplicación de Help Desk. Para la implementación de ITIL V3 el modelo de gestión de servicios se adaptó a las necesidades de la Dirección TIC’s de la empresa EMELNORTE, generando acuerdos de nivel de servicios (SLA). Para el desarrollo de la aplicación web se utilizó Java como lenguaje de programación, Eclipse como entorno de desarrollo, Oracle como base de datos, Wifly como servidor, con la estructura modelo, vista, controlador (MVC) y la metodología Scrum. Para finalizar, se aplicó la encuesta CSUQ para validar la usabilidad de la aplicación web, se empleó la fórmula de correspondencia de SCUQ a SUS para obtener la puntuación según la escala de valores de SUS, dando como resultado del 92.44% de satisfacción de los usuarios encuestados.Ingenierí

La situación de los incendios en el Valle del Tiétar

The Valley of the Tiétar (Ávila) it is one of the spaces inside the peninsular geography that shows a bigger number of forest fires. The topographical and climatic conditions, next to an inadequate politics of reforestations and other more recent threats as the development urbanístico and of new infrastructures for the transport, they are the biggest problems to those that it faces this space considered by many as an ecological treasure. It demonstrates it to it being declared as Area of Special Protection for the Ave (ZEPA) and I eat Place of Community Interest (LIC)

Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice

DNA double strand breaks are the most cytotoxic lesions that can occur on the DNA. They can be repaired by different mechanisms and optimal survival requires a tight control between them. Here we uncover protein deneddylation as a major controller of repair pathway choice. Neddylation inhibition changes the normal repair profile toward an increase on homologous recombination. Indeed, RNF111/UBE2M-mediated neddylation acts as an inhibitor of BRCA1 and CtIP-mediated DNA end resection, a key process in repair pathway choice. By controlling the length of ssDNA produced during DNA resection, protein neddylation not only affects the choice between NHEJ and homologous recombination but also controls the balance between different recombination subpathways. Thus, protein neddylation status has a great impact in the way cells respond to DNA breaks.España , Ministerio de Economía y Competitividad SAF2010-1487

Commonly Used External TAM Variables in e-Learning, Agriculture and Virtual Reality Applications

In recent years information and communication technologies (ICT) have played a significant role in all aspects of modern society and have impacted socioeconomic development in sectors such as education, administration, business, medical care and agriculture. The benefits of such technologies in agriculture can be appreciated only if farmers use them. In order to predict and evaluate the adoption of these new technological tools, the technology acceptance model (TAM) can be a valid aid. This paper identifies the most commonly used external variables in e-learning, agriculture and virtual reality applications for further validation in an e-learning tool designed for EU farmers and agricultural entrepreneurs. Starting from a literature review of the technology acceptance model, the analysis based on Quality Function Deployment (QFD) shows that computer self-efficacy, individual innovativeness, computer anxiety, perceived enjoyment, social norm, content and system quality, experience and facilitating conditions are the most common determinants addressing technology acceptance. Furthermore, findings evidenced that the external variables have a different impact on the two main beliefs of the TAM Model, Perceived Usefulness (PU) and Perceived Ease of Use (PEOU). This study is expected to bring theoretical support for academics when determining the variables to be included in TAM extensions

Validation of a TAM Extension in Agriculture: Exploring the Determinants of Acceptance of an e-Learning Platform

Supporting education and training initiatives has been identified as an effective way to address Sustainable Development Challenges. In this sense, e-learning stands out as one of the most viable alternatives considering its advantages in terms of resources, time management, and geographical location. Understanding the reasons that move users to adopt these technologies is critical for achieving the desired social objectives. The Technology Acceptance Model (TAM) provides valuable guidelines to identify the variables shaping users’ acceptance of innovations. The present study aims to validate a TAM extension designed for FARMER 4.0, an e-learning application in the agricultural sector. Findings suggest that content quality (CQ) is the primary determinant of farmers’ and agricultural entrepreneurs’ perception of the tool’s usefulness (PU). Furthermore, experience (EXP) and self-efficacy (SE) shape potential users’ perceptions about ease of use (PEOU). This study offers helpful insight into the design and development of e-learning applications in the farming sector and provides empirical evidence of TAM’s validity to assess technology acceptance

DNA end resection requires constitutive sumoylation of CtIP by CBX4

DNA breaks are complex DNA lesions that can be repaired by two alternative mechanisms: non-homologous end-joining and homologous recombination. The decision between them depends on the activation of the DNA resection machinery, which blocks non-homologous end-joining and stimulates recombination. On the other hand, post-translational modifications play a critical role in DNA repair. We have found that the SUMO E3 ligase CBX4 controls resection through the key factor CtIP. Indeed, CBX4 depletion impairs CtIP constitutive sumoylation and DNA end processing. Importantly, mutating lysine 896 in CtIP recapitulates the CBX4-depletion phenotype, blocks homologous recombination and increases genomic instability. Artificial fusion of CtIP and SUMO suppresses the effects of both the non-sumoylatable CtIP mutant and CBX4 depletion. Mechanistically, CtIP sumoylation is essential for its recruitment to damaged DNA. In summary, sumoylation of CtIP at lysine 896 defines a subpopulation of the protein that is involved in DNA resection and recombination

Representaciones sociales de la pedagogía en docentes de la Universidad del Magdalena.

La pedagogía como ciencia dedicada al estudio de la educación, es capaz de articular los aportes de otras disciplinas contribuyendo a su evolución. Su abordaje teórico ha tenido lugar desde perspectivas históricas, sociológicas, psicológicas; la importancia de la disciplina es denotada desde los ámbitos cognitivos, sociales, culturales, académicos, práctica docente, relación estudiante-docente, entre otros; al mismo tiempo como proceso social transformador de individuos asume un papel protagónico en las aulas de clase de cualquier nivel educativo. Así, como otros constructos de la ciencia, la pedagogía avanza por un desarrollo en la apropiación del concepto por parte de las comunidades sociales organizándose en un esquema común que dispondrá las actitudes de las personas frente a esta (Lacolla, 2005). Por su parte, la representación social es definida como un referente real en la que confluyen aspectos psicológicos y sociológicos, las cuales provienen de un trasfondo cultural común de la sociedad (Moscovici, 1976 citado en Villamil & Puerto, 2004). El estudio de éstas han sido de gran utilidad dentro del campo de la salud y la educación, pues han permitido obtener una concepción socialmente compartida sobre los diferentes objetos de estudio, además de proporcionar una teoría psicosocial de la organización jerárquica del pensamiento social (Esser & Rojas, 2006). En este estudio se investigará la Representación Social [1] de la pedagogía que tienen los docentes de la Universidad del Magdalena; se supone que estas representaciones de génesis sociocultural determinan el papel y el modo de actuar del docente para con sus estudiantes, dejando vislumbrar conceptos que se han construido y estructurado en la experiencia personal-colectiva en la interacción con el otro, que en últimas se pone en función de los estudiantes en la práctica áulica que cada docente universitario lleva a cabo, dejando de manifiesto la organización y la influencia que tiene el pensamiento social en el individuo en las diferentes interacciones sociales que se dan entre estos. Por lo anterior, el estudio de la representación social como referente teórico y epistemológico, serán el punto de partida para entender la dinámica de las interacciones sociales de los docentes, que adquiere gran significado en el interior del aula, reconociendo la importancia de los constructos cognitivos cuando estos influyen en el comportamiento humano, que se estimulan constantemente en el común de lo cotidiano en las distintas opiniones, conceptos, actitudes e intereses, que cada uno posee, dando rienda suelta al avance, a la construcción y a la reconstrucción constante del saber-hacer pedagógico, sirviendo de insumo real en la mejora continua de las prácticas que se llevan a cabo en el día a día con los estudiantes universitarios; propendiendo alcanzar la calidad en la educación que la sociedad del siglo XXI ha reclamado desde los distintos organismos internacionales, nacionales y locales

Catalytic Performance and Electrophoretic Behavior of an Yttrium-Organic Framework Based on a Tricarboxylic Asymmetric Alkyne

A new Y-based metal-organic framework (MOF) GR-MOF-6 with a chemical formula of {[YL(DMF)2]·(DMF)}n {H3L = 5-[(4-carboxyphenyl)ethynyl] isophthalic acid; DMF = N,N-dimethylformamide} has been prepared by a solvothermal route. Structural characterization reveals that this novel material is a three-dimensional MOF in which the coordination of the tritopic ligand to Y(III) metal ions leads to an intercrossing channel system extending over three dimensions. This material has proven to be a very efficient catalyst in the cyanosilylation of carbonyls, ranking second in catalytic activity among the reported rare earth metal-based MOFs described so far but with the lowest required catalyst loading. In addition, its electrophoretic behavior has been studied in depth, providing a zero-charge point between pH 4 and 5, a peak electrophoretic mobility of -1.553 μm cm V-1 s-1, and a ζ potential of -19.8 mV at pH 10.This research has been funded by the State Research Agency (Grants RTC-2016-5239-2, CTQ2017-84334-R, PGC2018-102052-A-C22, and PGC2018-102052-B-C21) of the Spanish Ministry of Science, Innovation and Universities, the European Union [European Regional Development Fund (ERDF)], and Junta de Andalucía (FQM-376 and FQM-394). S.R. acknowledges the Juan de la Cierva Incorporación Fellowship (Grant Agreement IJC2019-038894-I)

PET-CT in anaplastic thyroid carcinoma and other aggressive histological subtypes

[EN]Introduction and objective: The aggressive histological subtypes of thyroid cancer are less common and have a worse prognosis than well –differentiated ones (DTC). The most important aggressive subtypes are Hürtle cell carcinoma (CHH), anaplasic and poorly differentiated carcinoma. In this review, we are going to evaluate the role of PET-CT, especially with 18F-FDG, in these aggressive histological lines, as well as in aggressive subtypes of DTC (tall cells, diffuse sclerosing…) and in radioiodine-refractory differentiated thyroid carcinoma. Synthesis: Although the main indication for 18F-FDG PET in thyroid cancer is suspected recurrence, in patients with DTC with elevated serum thyroglobulin and radioiodine-negative whole-body scan (WBS), this technique has increasing applications in DTC. Likewise, 18F-FDG PET is also an efficient diagnostic tool in the study of anaplastic carcinoma, poorly differentiated and other aggressive lines It is recommended, in current clinical guidelines, as part of the initial staging in anaplastic, poorly differentiated, and invasive HCC. And it is increasingly used in other indications such as prognostic assessment, evaluation of treatment response, and even during the follow-up of high-risk patients. It is recommended, in current clinical guidelines, as part of the initial staging in anaplastic, poorly differentiated, and invasive HCC. And it is increasingly used in other indications such as prognostic assessment, evaluation of treatment response, and even during the follow-up of high-risk patients. The use of other PET tracers, such as 68Ga-PSMA and 68Ga-DOTATATE have not clearly demonstrated their clinical benefit over 18F-FDG. They are usually limited to cases in which it is necessary to assess the density of somatostatin analogs and PSMA receptors prior to metabolic therapy. Conclusions: 18F-FDG PET-CT is the most effective functional diagnostic technique in the study of poorly differentiated and aggressive thyroid neoplasms, since they show little or no avidity for radioiodine and however high affinity for 18F-FDG. The role of other PET tracers for the evaluation of these tumors is promising, although it still needs studies with a larger number of patients. t is recommended, in current clinical guidelines, as part of the initial staging in anaplastic, poorly differentiated, and invasive HCC. And it is increasingly used in other indications such as prognostic assessment, evaluation of treatment response, and even during the follow-up of high-risk patients. 18F-FDG PET-CT is the most effective functional diagnostic technique in the study of poorly differentiated and aggressive thyroid neoplasms, since they show little or no avidity for radioiodine and however high affinity for 18F-FDG. The role of other PET tracers for the evaluation of these tumors is promising, although it still needs studies with a larger number of patients

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum