Disturbing the Universe – Summary of BEACH 2008

Results and perspectives in heavy flavour physics research, presented at the 2008 edition of the International Conference on Beauty, Charm and Hyperons held in Columbia (SC, USA), are briefly reviewed

Fruit Flies Provide New Insights in Low-Radiation Background Biology at the INFN Underground Gran Sasso National Laboratory (LNGS)

Deep underground laboratories (DULs) were originally created to host particle, astroparticle or nuclear physics experiments requiring a low-background environment with vastly reduced levels of cosmic-ray particle interference. More recently, the range of science projects requiring an underground experiment site has greatly expanded, thus leading to the recognition of DULs as truly multidisciplinary science sites that host important studies in several fields, including geology, geophysics, climate and environmental sciences, technology/instrumentation development and biology. So far, underground biology experiments are ongoing or planned in a few of the currently operating DULs. Among these DULs is the Gran Sasso National Laboratory (LNGS), where the majority of radiobiological data have been collected. Here we provide a summary of the current scenario of DULs around the world, as well as the specific features of the LNGS and a summary of the results we obtained so far, together with other findings collected in different underground laboratories. In particular, we focus on the recent results from our studies of Drosophila melanogaster, which provide the first evidence of the influence of the radiation environment on life span, fertility and response to genotoxic stress at the organism level. Given the increasing interest in this field and the establishment of new projects, it is possible that in the near future more DULs will serve as sites of radiobiology experiments, thus providing further relevant biological information at extremely low-dose-rate radiation. Underground experiments can be nicely complemented with above-ground studies at increasing dose rate. A systematic study performed in different exposure scenarios provides a potential opportunity to address important radiation protection questions, such as the dose/dose-rate relationship for cancer and non-cancer risk, the possible existence of dose/dose-rate threshold(s) for different biological systems and/or end points and the possible role of radiation quality in triggering the biological response

Four-qubit entangled symmetric states with positive partial transpositions

We solve the open question of the existence of four-qubit entangled symmetric states with positive partial transpositions (PPT states). We reach this goal with two different approaches. First, we propose a half-analytical-half-numerical method that allows to construct multipartite PPT entangled symmetric states (PPTESS) from the qubit-qudit PPT entangled states. Second, we adapt the algorithm allowing to search for extremal elements in the convex set of bipartite PPT states [J. M. Leinaas, J. Myrheim, and E. Ovrum, Phys. Rev. A 76, 034304 (2007)] to the multipartite scenario. With its aid we search for extremal four-qubit PPTESS and show that generically they have ranks (5,7,8). Finally, we provide an exhaustive characterization of these states with respect to their separability properties.Comment: 5+4 pages, improved version, title slightly modifie

Geomatics for Integrated Coastal Zone Management: multitemporal shoreline analysis and future regional perspective for the Portuguese Central Region

Shoreline mapping and change detection are critical for Integrated Coastal Zone Management (ICZM) and all that it represents. This research utilized previous studies that combined both Remote Sensing and Geographical Information System (GIS) techniques to assess, map and forecast shoreline evolution from short-term perspectives. The study area is located in the central region of Portugal, between the counties of Ovar and Marinha Grande (circa 140 km) and the time period assessed was from 1984 to 2011. Historical data were used to calculate advance and retreat rates in order to support environmental scenarios for the Portuguese Central Region’s Coastal Management Plan. To ensure accuracy, a repeatable procedure was validated using Landsat TM and ETM+ satellite images, which were subsequently enhanced and elaborated by Remote Sensing analyses to detect and extract shorelines. They were subsequently integrated within an Esri ArcGIS software application (DSAS - Digital Shoreline Analysis System) to determine and predict rates of coastline change. Graphical DSAS plots identified coastline phases and shifts and were used to simulate the 2022 coastline scenario. These results will be integrated into the Coastal Zone Management Plan (Horizon – 2022). Importantly this methodological planning approach provides visual coastline change information for regional decision-makers and stakeholders

A cloud-based healthcare infrastructure for neonatal intensive-care units

Intensive medical attention of preterm babies is crucial to avoid short-term and long- term complications. Within neonatal intensive care units (NICUs), cribs are equipped with electronic devices aimed at: monitoring, administering drugs and supporting clinician in making diagnosis and offer treatments. To manage this huge data flux, a cloud-based healthcare infrastructure that allows data collection from different devices (i.e., patient monitors, bilirubinometers, and transcutaneous bilirubinometers), storage, processing and transferring will be presented. Communication protocols were designed to enable the communication and data transfer between the three different devices and a unique database and an easy to use graphical user interface (GUI) was implemented. The infrastructure is currently used in the “Women’s and Children’s Hospital G.Salesi” in Ancona (Italy), supporting clinicians and health opertators in their daily activities

Reorganization of interaction networks modulates the persistence of species in late successional stages

Ecological interaction networks constantly reorganize as interspecific interactions change across successional stages and environmental gradients. This reorganization can also be associated with the extent to which species change their preference for types of niches available in their local sites. Despite the pervasiveness of these interaction changes, previous studies have revealed that network reorganizations have a minimal or insignificant effect on global descriptors of network architecture, such as connectance, modularity and nestedness. However, little is known about whether these reorganizations may have an effect on community dynamics and composition.To answer the question above, we study the multi-year dynamics and reorganization of plant–herbivore interaction networks across secondary successional stages of a tropical dry forest. We develop new quantitative tools based on a structural stability approach to estimate the potential impact of network reorganization on species persistence. Then, we investigate whether this impact can explain the likelihood of persistence of herbivore species in the observed communities.We find that resident (early-arriving) herbivore species increase their likelihood of persistence across time and successional stages. Importantly, we demonstrate that, in late successional stages, the reorganization of interactions among resident species has a strong inhibitory effect on the likelihood of persistence of colonizing (late-arriving) herbivores.These findings support earlier predictions suggesting that, in mature communities, changes of species interactions can act as community-control mechanisms (also known as priority effects). Furthermore, our results illustrate that the dynamics and composition of ecological communities cannot be fully understood without attention to their reorganization processes, despite the invariability of global network properties

Detection of tet(M) gene from raw milk by rapid DNA extraction followed by a two-step PCR with nested primers.

The likelihood that milk and milk products may act as a vehicle for antibiotic-resistant bacterial genes has become a concern to the food industry and a public health issue, and the demand for rapid tests has increased. The purity of DNA extracted from food samples is a key issue in the sensitivity and usefulness of biological analyses, such as PCR for pathogens and nonpathogens. A rapid, phenol-chloroform free method based on a modification of a sodium iodide DNA extraction, followed by a two-step PCR was developed for direct detection of the tet(M) gene in milk samples within a single working day. This study compares the proposed method with a traditional phenol solvent extraction method and with a commercial kit (QIAamp DNA blood mini kit, Qiagen). The three DNA extraction methods were used to ensure access to the tet(M) gene from 1 ml of raw milk, inoculated with a strain of Enterococcus faecalis, which carries the tet(M) gene. The proposed method, followed by a two-step PCR with nested primers specific for the tet(M) gene, was able to reach a detection limit below 10 CFU/ml in less than 4 h, including the two amplification cycles, thus outperforming in sensitivity and rapidity both the traditional and the commercial method

Prevalence of Johne\u27s-disease infections in Umbria, Italy

Ukupno 788 uzoraka seruma uzetih od mliječnih goveda u Umbriji, Italija, ispitano je na prisustvo antitijela na Mycobacterium avium subsp. paratuberculosis (MAP) pomoću komercijalnog ELISA testa (imunoenzimski test). Uzorkovane životinje uzgajane su na 19 farmi iz središnjeg dijela pokrajine Umbrije (okruzi Perugia i Assisi). Koristeći graničnu vrijednost za pozitivan test prema preporuci proizvođača, utvrđene su 44 pozitivne životinje (5,6%). Na temelju osjetljivosti i specifičnosti ELISA testa koje navodi proizvođač, izračunato je da je ukupna učestalost bolesti u mliječnih goveda u Umbriji ustvari iznosila 9,7% (granice pouzdanosti 99%, 7,0%, 12,4%).A total of 788 serum samples from dairy cattle in Umbria, Italy, were tested for the presence of antibodies to Mycobacterium avium subspecies paratuberculosis (MAP) using a commercial enzyme-linked immunosorbent assay (ELISA) kit. The sampled animals came from 19 herds representative of the central area of the Umbria County (Perugia and Assisi districts). Using the manufacturers suggested cut-off for a positive test, 44 animals (5.6%) were positive. Using the sensitivity and specificity claimed by the manufacturer of the ELISA kit, the true prevalence in Umbria dairy cattle overall was calculated as 9.7% (99% CI, 7.0%, 12.4%).Insgesamt 788 Serummuster, genommen von Milchrindvieh in Umbria/Italien, wurden auf Anwesenheit von Antikörpern auf Mycobacterium avium subsp. Paratuberculosis (MAP) mit Hilfe von kommerziellem ELISA Test (Immunoenzymtest) geprüft. Die gemusterten Tiere wurden auf 19 Farmen in mittlerem Teil der Provinz Umbria (Kreise Perugia und Assisi) gezüchtet. Nach Anweisung des Herstellers benutzte man den Grenzwert für positiven Test, so wurden 44 positive Tiere (5,6 %) festgestellt. Auf Grund der Empfindlichkeit und der Spezifität des ELISA Testes, die der Hersteller anführt, wurde ausgerechnet, dass die gesamte Häufigkeit der Krankheit bei Milchrindvieh in Umbria wirklich 9,7 % betrug (Grenzen der Zuversichtlichkeit 99 %, 7,0 %, 12,4 %).E’ stata valutata la prevalenza dell’enterite paratubercolare in alcuni allevamenti di bovini da latte in Umbria. Allo scopo č stato effettuato uno screening tramite test ELISA che consente l’individuazione di animali con immunitŕ umorale nei confronti di MAP (Mycobacterium avium complex). Il test ELISA ha messo in evidenza una prevalenza variabile nelle aziende saggiate, con una media complessiva del 5.6% ed una prevalenza vera nella regione del 9.7% (limiti fiduciari 99%, 7.0%, 12.4%)