Analysis of second harmonic generation in photonic-crystal-assisted waveguides

We study second harmonic generation in a planar dielectric waveguide having a low-index, polymer core layer, bounded by two multilayer stacks. This geometry allows exceptionally strong confinement of the light at the fundamental wavelength inside the core region with virtually zero net propagation losses for distances that exceed several centimeters, provided material and scattering losses are neglected. A phase-matched configuration of the waveguide is reported in which the pump signal is the lowest-order mode of the waveguide, and the generated second harmonic signal corresponds to the third propagation mode of the waveguide. Using a polymer waveguide core, having chi(2)=100 pm/V, we predict a conversion efficiency of approximately 90% after a propagation distance of 2 mm, using peak pump intensities inside the core of the waveguide of 1.35 GW/cm^2. If the waveguide core contains polymer layers with different glass transition temperatures, the layers can be poled independently to maximize the overlap integral, and similar pump depletions may be achieved over a distance of approximately 500 microns.Comment: 20 pages, 7 figures, 330k

Second and Third Harmonic Generation in Metal-Based Nanostructures

We present a new theoretical approach to the study of second and third harmonic generation from metallic nanostructures and nanocavities filled with a nonlinear material, in the ultrashort pulse regime. We model the metal as a two-component medium, using the hydrodynamic model to describe free electrons, and Lorentz oscillators to account for core electron contributions to both the linear dielectric constant and to harmonic generation. The active nonlinear medium that may fill a metallic nanocavity, or be positioned between metallic layers in a stack, is also modeled using Lorentz oscillators and surface phenomena due to symmetry breaking are taken into account. We study the effects of incident TE- and TM-polarized fields and show that a simple re-examination of the basic equations reveals additional exploitable dynamical features of nonlinear frequency conversion in plasmonic nanostructures.Comment: 33 pages, including 11 figures and 74 references; corrected affiliations and some typo

Expanded Total Equivalent Warming Impact analysis on experimental standalone fresh-food refrigerator

The stand-alone refrigerators for fresh food storage represent a large part of supermarket refrigeration equip-ment. In these devices, the usage of refrigerants with low Global Warming Potential allows the mitigation of the direct emissions due to refrigerant leakages. In contrast, the indirect emissions in these components are highly dependent on the refrigerant charge, leakage, and equivalent emission factors related to the electricity pro-duction mix. The most used index to evaluate the environmental impact of refrigerators is the Total Equivalent Warming Impact. Despite that this index presents limits on the fixed evaluation of many parameters such as refrigerant charge, electricity consumption and, electricity emission factor. Otherwise in this study, an accurate evaluation of refrigerators emissions has been realised by using the innovative Expanded Total Equivalent Warming Impact method to an experimental stand-alone refrigerator by using a dynamic approach to evaluate direct and indirect contributions. The environmental analysis considers four different refrigerants and four different countries of location. The results show that the indirect emissions due to electricity consumption cover the highest share of emissions. In addition, the operating years affected by low refrigerant charges are respon-sible for emissions by greater than 25% compared to other ones. The hourly equivalent emissions due to elec-tricity consumption in countries characterized by an electricity generation mix mainly based on renewable and/ or nuclear plants show an indirect environmental impact up to 5 times lower than countries with a natural gas -based electricity production mix. The study also defines new strategies to reduce the environmental impact of the stand-alone refrigerator such as the use of photovoltaic systems combined with this technology or earlier maintenance processes that could determine an equivalent emission saving of up to 38%

Singularity-driven Second and Third Harmonic Generation in a {\epsilon}-near-zero nanolayer

We show a new path to {\epsilon}~0 materials without resorting to metal-based metamaterial composites. A medium that can be modeled using Lorentz oscillators usually displays {\epsilon}=0 crossing points, e.g. {\epsilon}=0 at {\lambda}~7{\mu}m and 20{\mu}m for SiO2 and CaF2, respectively. We show that a Lorentz medium yields a singularity-driven enhancement of the electric field followed by dramatic lowering of thresholds for a plethora of nonlinear optical phenomena. We illustrate the remarkable enhancement of second and third harmonic generation in a layer of {\epsilon}~0 material 20nm thick, and discuss the role of nonlinear surface sources

Monitoring multiple myeloma by idiotype-specific peptide binders of tumor-derived exosomes.

Abstract Tumor-derived exosomes (TDEs) play a pivotal role in tumor establishment and progression, and are emerging biomarkers for tumor diagnosis in personalized medicine. To date, there is a lack of efficient technology platforms for exosome isolation and characterization. Multiple myeloma (MM) is an incurable B-cell malignancy due to the rapid development of drug-resistance. MM-released exosomes express the immunoglobulin B-cell receptor (Ig-BCR) of the tumor B-cells, which can be targeted by Idiotype-binding peptides (Id-peptides). In this study, we analyzed the production of MM-released exosomes in the murine 5T33MM multiple myeloma model as biomarkers of tumor growth. To this end, we selected Id-peptides by screening a phage display library using as bait the Ig-BCR expressed by 5T33MM cells. By FACS, the FITC-conjugated Id-peptides detected the MM-released exosomes in the serum of 5T33MM-engrafted mice, levels of which are correlated with tumor progression at an earlier time point compared to serum paraprotein. These results indicate that Id-peptide-based recognition of MM-released exosomes may represent a very sensitive diagnostic approach for clinical evaluation of disease progression

Second harmonic generation from metallo-dielectric multilayer photonic band gap structures

We experimentally and theoretically investigate the second order nonlinear optical response of metallo-dielectric multilayer structures composed of Ag and Ta2O5 layers, deposited by magnetron sputtering. Second harmonic generation measurements were performed in reflection mode as a function of incidence angle, using femtosecond pulses originating from a Ti:Sapphire laser system tuned at 800 nm. The dependence of the generated signal was investigated as a function of pump intensity and polarization state. Our experimental results show that the conversion efficiency from a periodic metallo-dielectric sample may be enhanced by at least a factor of 30 with respect to the conversion efficiency from a single metal layer, thanks in part to the increased number of active surfaces, pump field localization and penetration inside the metal layers. The conversion efficiency maximum shifts from 70 degrees for the single silver layer down to approximately 55 degrees for the stack. The experimental results are found to be in good agreement with calculations based on coupled Maxwell-Drude oscillators under the action of a nonlinear Lorentz force term

Administration of Linoleoylethanolamide Reduced Weight Gain, Dyslipidemia, and Inflammation Associated with High-Fat-Diet-Induced Obesity

Acylethanolamides (NAEs) are bioactive lipids derived from diet fatty acids that modulate important homeostatic functions, including appetite, fatty acid synthesis, mitochondrial respiration, inflammation, and nociception. Among the naturally circulating NAEs, the pharmacology of those derived from either arachidonic acid (Anandamide), oleic acid (OEA), and palmitic acid (PEA) have been extensively characterized in diet-induced obesity. For the present work, we extended those studies to linoleoylethanolamide (LEA), one of the most abundant NAEs found not only in plasma and body tissues but also in foods such as cereals. In our initial study, circulating concentrations of LEA were found to be elevated in overweight humans (body mass index (BMI, Kg/m) > 25) recruited from a representative population from the south of Spain, together with AEA and the endocannabinoid 2-Arachidonoyl glycerol (2-AG). In this population, LEA concentrations correlated with the circulating levels of cholesterol and triglycerides. In order to gain insight into the pharmacology of LEA, we administered it for 14 days (10 mg/kg i.p. daily) to obese male Sprague Dawley rats receiving a cafeteria diet or a standard chow diet for 12 consecutive weeks. LEA treatment resulted in weight loss and a reduction in circulating triglycerides, cholesterol, and inflammatory markers such as Il-6 and Tnf-alpha. In addition, LEA reduced plasma transaminases and enhanced acetyl-CoA-oxidase (Acox) and Uncoupling protein-2 (Ucp2) expression in the liver of the HFD-fed animals. Although the liver steatosis induced by the HFD was not reversed by LEA, the overall data suggest that LEA contributes to the homeostatic signals set in place in response to diet-induced obesity, potentially contributing with OEA to improve lipid metabolism after high fat intake. The anti-inflammatory response associated with its administration suggests its potential for use as a nutrient supplement in non-alcoholic steatohepatitis.Juan Decara holds a “Miguel Servet” (CP21/00021) research contract from the Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III (ISCIII), cofunded by European Social Fund, “Investing in your future”, Gobierno de España. The present work was funded by Instituto de Salud Carlos III (ISCIII), Ministerio de Ciencia e Innovación; European Regional Development Funds Euro- pean Union (ERDF-EU) grants “Proyectos de Investigación en Salud” PI19/01577 and PI22/00427; Proyectos de investigación en salud (PI-0139-2018) Consejería de Salud y Familias, Junta de An- dalucía, Proyecto de Investigación en Salud; grant for international postdoctoral stay “Jose Castillejo” Program (Grant CAS15/00257), Ministerio de Educación Cultura y Deporte, Gobierno de España. The funders had no role in the design of the study; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication

Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis (the BiCARB trial)? Study protocol for a randomized controlled trial

Date of acceptance: 01/07/2015 © 2015 Witham et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Acknowledgements UK NIHR HTA grant 10/71/01. We acknowledge the financial support of NHS Research Scotland in conducting this trial.Peer reviewedPublisher PD