Molecular characterization of human gastric mucosa by HR-MAS Magnetic Resonance Spectroscopy

The present study was aimed at identifying themolecular profile characteristic of the healthy humangastric mucosa.Ex vivo HR-MAS magnetic resonance spectroscopy performed at 9.4 Tesla (400.13 MHz for 1H) on gastric specimens collected during endoscopy, permits the identification of more than forty species giving a detailed picture of the biochemical pattern of the gastric tissues. These preliminary data will be used for a comparison with gastric preneoplastic and neoplastic situations. Moreover, the full knowledge of the biochemical pattern of the healthy gastrictissues is the necessary presupposition for the application of magnetic resonance spectroscopy directly in vivo

Pulmonary metastasis: very late relapse of testicular embryonal carcinoma

Testicular carcinoma recurrences represent a rare finding (1-6% in non-seminomatous germ cell tumours). However, cases of recurrence have been described many years later. We report a case of late recurrence of embryonic testicular carcinoma, after 26 years, with pulmonary metastases. Following evidence of increase of alpha-fetoprotein (AFP), the patient underwent a total body computed tomography scan that exhibited two pulmonary nodules, one in upper left lobe and other in left hilar region with multiple mediastinal and retrocrural lymph node enlargements All consolidations showed increased sugar uptake value at PET CT. Biopsies of lung consolidations confirmed diagnosis of recurrence of testicular carcinoma

El legado de la poesía tradicional hispánica en el cancionero popular argentino y su inclusión en el aula de ELSE

La literatura es un material cultural auténtico y un recurso valioso para el aprendizaje de una lengua. Por este motivo, representa un elemento altamente funcional para la enseñanza en el aula de español como lengua segunda y extranjera (ELSE), útil para comprender el funcionamiento de la lengua dentro de los contextos socioculturales en los que esta se emplea como medio de comunicación. En este sentido, la literatura es fuente de ejemplos gramaticales y da cuenta de diferentes usos de la lengua, así como constituye un reservorio cultural que transmite elementos del contexto social en el que se desarrolla la lengua meta que se está adquiriendo. Además, la literatura se consolida como uno de los medios que enuncian y difunden la variedad de la lengua estándar de una sociedad, así como puede dar acogida a otras variedades lingüísticas regionales y a jergas específicas que conviven en el interior de una comunidad.Facultad de Humanidades y Ciencias de la Educació

“Las faldas se levantan”: presencia de la figura femenina en la copla popular del carnaval del Norte argentino

El carnaval es una fiesta popular introducida en América en el periodo de la conquista española. Con un formato típicamente europeo, a través de los siglos este modo de celebración empieza antes de la Cuaresma cristiana. Martos Martos (2001) señala que “la palabra carnaval proviene de la expresión latina carnelevare, luego modificada a carnevale, que quiere decir ‘sin carne’, ‘dejar la carne’, en referencia al periodo ritual de abstinencia y rigores para el cuerpo que suponía la Cuaresma” (p. 30). Es una festividad que nació en la Edad Media a partir de la imposición de la religión cristiana en el continente; estos festejos comenzaron con la celebración de la vida y los abusos previos al ayuno que se debía hacer antes de la Semana Santa. Es por estos motivos que en el carnaval priman los excesos de los objetos y comportamientos considerados “mundanos” como la bebida y la comida, y a ello se suman los colores de las ropas y de las decoraciones, los bailes, los encuentros y las diferentes artes muchas veces censuradas por la Iglesia.Facultad de Humanidades y Ciencias de la Educació

Cultura popular y cultura letrada: lo erótico como clave de lectura en Retrato de la Lozana andaluza de Francisco Delicado

Retrato de la Lozana andaluza, publicado originalmente en 1528 de manera anónima en Roma, relata las aventuras de Aldonza Lorenzo, luego conocida como Lozana, durante su estadía en Roma hasta los años previos al Saco de Roma en 1527. En dicha ciudad Lozana ejerce, entre otros oficios, el de prostituta, lo cual le da acceso a los más variados escenarios y a personas de todas las clases sociales. Su autor, Francisco Delicado, también contó para la elaboración de la obra con una posición privilegiada en el contexto cultural de la Roma del Renacimiento, ciudad a la que llegó expulsado de España alrededor del año 1492, tras el edicto de Granada promulgado por los Reyes Católicos, que establecía la expulsión de los judíos de España. Luego, en Venecia, se desempeñó como editor y corrector de imprenta. A estas coordenadas geográfico-culturales se suma el gran interés del clérigo por la lengua. Además de intervenir activamente en los debates del momento sobre cuál debe ser el español que unifique a España, Delicado tiene un gran interés —que deja claro en su actividad como editor— en cómo debe leerse, pronunciarse e interpretarse el español en Italia, por lo cual el recorrido de Lozana por la plurilingüe Roma hace de la obra un texto de gran valor como documento filológico.Facultad de Humanidades y Ciencias de la Educació

Application of Proteomics and Peptidomics to COPD

Chronic obstructive pulmonary disease (COPD) is a complex disorder involving both airways and lung parenchyma, usually associated with progressive and poorly reversible airflow limitation. In order to better characterize the phenotypic heterogeneity and the prognosis of patients with COPD, there is currently an urgent need for discovery and validation of reliable disease biomarkers. Within this context, proteomic and peptidomic techniques are emerging as very valuable tools that can be applied to both systemic and pulmonary samples, including peripheral blood, induced sputum, exhaled breath condensate, bronchoalveolar lavage fluid, and lung tissues. Identification of COPD biomarkers by means of proteomic and peptidomic approaches can thus also lead to discovery of new molecular targets potentially useful to improve and personalize the therapeutic management of this widespread respiratory disease

Entanglement Content of Quantum Particle Excitations I. Free Field Theory

We evaluate the entanglement entropy of a single connected region in excited states of one-dimensional massive free theories with finite numbers of particles, in the limit of large volume and region length. For this purpose, we use finite-volume form factor expansions of branch-point twist field two-point functions. We find that the additive contribution to the entanglement due to the presence of particles has a simple "qubit" interpretation, and is largely independent of momenta: it only depends on the numbers of groups of particles with equal momenta. We conjecture that at large momenta, the same result holds for any volume and region lengths, including at small scales. We provide accurate numerical verifications

Aerosol delivery through high-flow nasal therapy: Technical issues and clinical benefits

High-flow nasal cannula (HFNC) therapy is an oxygen delivery method particularly used in patients affected by hypoxemic respiratory failure. In comparison with the conventional “low flow” oxygen delivery systems, it showed several important clinical benefits. The possibility to nebulize drugs via HFNC represents a desirable medical practice because it allows the administration of inhaled drugs, mostly bronchodilators, without the interruption or modification of the concomitant oxygen therapy. HFNC, by itself has shown to exert a small but significant bronchodilator effect and improves muco-ciliary clearance; thus, the nebulization of bronchodilators through the HFNC circuit may potentially increase their pharmacological activity. Several technical issues have been observed which include the type of the nebulizer that should be used, its position within the HFNC circuit, and the optimal gas flow rates to ensure an efficient drug delivery to the lungs both in “quiet” and “distressed” breathing patterns. The aim of this review has been to summarize the scientific evidence coming from “in vitro” studies and to discuss the results of “in vivo” studies performed in adult subjects, mainly affected by obstructive lung diseases. Most studies seem to indicate the vibrating mesh nebulizer as the most efficient type of nebulizer and suggest to place it preferentially upstream from the humidifier chamber. In a quite breathing patterns, the inhaled dose seems to increase with lower flow rates while in a “distressed” breathing pattern, the aerosol delivery is higher when gas flow was set below the patient’s inspiratory flow, with a plateau effect seen when the gas flow reaches approximately 50% of the inspiratory flow. Although several studies have demonstrated that the percentage of the loaded dose nebulized via HFNC reaching the lungs is small, the bronchodilator effect of albuterol seems not to be impaired when compared to the conventional inhaled delivery methods. This is probably attributed to its pharmacological activity. Prospective and well-designed studies in different cohort of patients are needed to standardize and demonstrate the efficacy of the procedure

H-Prune through GSK-3β interaction sustains canonical WNT/β-catenin signaling enhancing cancer progression in NSCLC.

H-Prune hydrolyzes short-chain polyphosphates (PPase activity) together with an hitherto cAMP-phosphodiesterase (PDE), the latest influencing different human cancers by its overexpression. H-Prune promotes cell migration in cooperation with glycogen synthase kinase-3 (Gsk-3β). Gsk-3β is a negative regulator of canonical WNT/β-catenin signaling. Here, we investigate the role of Gsk-3β/h-Prune complex in the regulation of WNT/β-catenin signaling, demonstrating the h-Prune capability to activate WNT signaling also in a paracrine manner, through Wnt3a secretion. In vivo study demonstrates that h-Prune silencing inhibits lung metastasis formation, increasing mouse survival. We assessed h-Prune levels in peripheral blood of lung cancer patients using ELISA assay, showing that h-Prune is an early diagnostic marker for lung cancer. Our study dissects out the mechanism of action of h-Prune in tumorigenic cells and also sheds light on the identification of a new therapeutic target in non-small-cell lung cancer

Patient and physician perspectives on biological treatment in severe asthma: a Severe Asthma Network Italy survey

: Patients with severe asthma perceive beneficial effects of biologics and good self-reported adherence to treatment, even when self-administered at home https://bit.ly/48vP70w