First detection of triply-deuterated methanol

We report the first detection of triply-deuterated methanol, with 12 observed transitions, towards the low-mass protostar IRAS 16293-2422, as well as multifrequency observations of 13CH3OH, used to derive the column density of the main isotopomer CH3OH. The derived fractionation ratio [CD3OH]/[CH3OH] averaged on a 10'' beam is 1.4%. Together with previous CH2DOH and CHD2OH observations, the present CD3OH observations are consistent with a formation of methanol on grain surfaces, if the atomic D/H ratio is 0.1 to 0.3 in the accreting gas. Such a high atomic ratio can be reached in the frame of gas-phase chemical models including all deuterated isotopomers of H3+.Comment: Accepted by A&

Features of the Higher Education for the Circular Economy: The Case of Italy

The higher education system plays a critical role in supporting the transition towards a circular economy (CE). It helps create business leaders and policymakers having appropriate skills, competences, and consciousness referring to the CE challenges. Nevertheless, few studies have specifically investigated how the higher education system is addressing the CE, how the current academic offering is integrating the CE principles, and which skills and competences are currently provided. This paper overcomes these limitations by investigating the current offering of the higher education for the CE in Italy. We analyze the academic programs, courses, and modules at different levels of 49 Italian universities and, by means of a detailed classification of the learning outcomes, provide a clear picture of the knowledge, skills, and competences offered by the CE education. We finally discuss implications of our findings concerning the development of CE education and CE jobs

The influence of permeability through bacterial porins in whole-cell compound accumulation

The lack of new drugs for Gram-negative pathogens is a global threat to modern medicine. The complexity of their cell envelope, with an additional outer membrane, hinders internal accumulation and thus, the access of molecules to their targets. Our limited understanding of the molecular basis for compound influx and efflux from these pathogens is a major bottleneck for the discovery of effective antibacterial compounds. Here we analyse the correlation between the whole-cell compound accumulation of ~200 molecules and their predicted porin permeability coefficient (influx), using a recently developed scoring function. We found a strong linear relationship (74%) between the two, confirming porins key in compound uptake in Gram-negative bacteria. The analysis of this unique dataset aids to better understand the molecular descriptors behind whole-cell accumulation and molecular uptake in Gram-negative bacteria

ISO-LWS observations of IRAS16293-2422

We obtained LWS grating spectra toward IRAS 16293-2422 and the surrounding region, which covers the entire extent of the molecular outflow. The LWS spectra show that the region is relatively uncontaminated by PhotoDissociationRegion (PDR)-like emission, showing only a weak diffuse CII emission. The on-source spectrum revealed the presence of the OI(63μm) line and several lines from CO, H2O and OH molecules. In this work we derive the macroscopic quantities associated with the UV-illuminated emitting gas which surrounds IRAS16293-2422 and compare it with previous studies. We show that the molecular lines originate in a hot (~1600 K), dense (~ 3·104cm-3) and extended (~ 8·1016cm) region, that we interprete as the shock of the wind impacting obliquely with the walls of the cavity created by the wind itself. The OI(63μm) line observed by the Kuiper Airborne Observatory (KAO: Ceccarelli et al. 1997a) at ~ 1.2·1017cm west from the central source is hence interpreted as the head of the shock where the wind strikes the ambient gas. Finally we speculate that the OI(63μm) line emission seen on-source originates in the collapsing envelope that surrounds the central object(s

Detection of doubly-deuterated methanol in the solar-type protostar IRAS16293-2422

We report the first detection of doubly-deuterated methanol (CHD2OH), as well as firm detections of the two singly-deuterated isotopomers of methanol (CH2DOH and CH3OD), towards the solar-type protostar IRAS16293-2422. From the present multifrequency observations, we derive the following abundance ratios: [CHD2OH]/[CH3OH] = 0.2 +/- 0.1, [CH2DOH]/[CH3OH] = 0.9 +/- 0.3, [CH3OD]/[CH3OH] = 0.04 +/- 0.02. The total abundance of the deuterated forms of methanol is greater than that of its normal hydrogenated counterpart in the circumstellar material of IRAS16293-2422, a circumstance not previously encountered. Formaldehyde, which is thought to be the chemical precursor of methanol, possesses a much lower fraction of deuterated isotopomers (~ 20%) with respect to the main isotopic form in IRAS16293-2422. The observed fractionation of methanol and formaldehyde provides a severe challenge to both gas-phase and grain-surface models of deuteration. Two examples of the latter model are roughly in agreement with our observations of CHD2OH and CH2DOH if the accreting gas has a large (0.2-0.3) atomic D/H ratio. However, no gas-phase model predicts such a high atomic D/H ratio, and hence some key ingredient seems to be missing.Comment: 5 pages, 3 figure

The B1 shock in the L1157 outflow as seen at high spatial resolution

We present high spatial resolution (750 AU at 250 pc) maps of the B1 shock in the blue lobe of the L1157 outflow in four lines: CS (3-2), CH3OH (3_K-2_K), HC3N (16-15) and p-H2CO (2_02-3_01). The combined analysis of the morphology and spectral profiles has shown that the highest velocity gas is confined in a few compact (~ 5 arcsec) bullets while the lowest velocity gas traces the wall of the gas cavity excavated by the shock expansion. A large velocity gradient model applied to the CS (3-2) and (2-1) lines provides an upper limit of 10^6 cm^-3 to the averaged gas density in B1 and a range of 5x10^3< n(H2)< 5x10^5 cm^-3 for the density of the high velocity bullets. The origin of the bullets is still uncertain: they could be the result of local instabilities produced by the interaction of the jet with the ambient medium or could be clump already present in the ambient medium that are excited and accelerated by the expanding outflow. The column densities of the observed species can be reproduced qualitatively by the presence in B1 of a C-type shock and only models where the gas reaches temperatures of at least 4000 K can reproduce the observed HC3N column density.Comment: 13 pages, 12 figure

Deuterium fractionation on interstellar grains studied with modified rate equations and a Monte Carlo approach

The formation of singly and doubly deuterated isotopomers of formaldehyde and of singly, doubly, and multiply deuterated isotopomers of methanol on interstellar grain surfaces has been studied with a semi-empirical modified rate approach and a Monte Carlo method in the temperature range 10-20 K. Agreement between the results of the two methods is satisfactory for all major and many minor species throughout this range. If gas-phase fractionation can produce a high abundance of atomic deuterium, which then accretes onto grain surfaces, diffusive surface chemistry can produce large abundances of deuterated species, especially at low temperatures and high gas densities. Warming temperatures will then permit these surface species to evaporate into the gas, where they will remain abundant for a considerable period. We calculate that the doubly deuterated molecules CHD2OH and CH2DOD are particularly abundant and should be searched for in the gas phase of protostellar sources. For example, at 10 K and high density, these species can achieve up to 10-20% of the abundance of methanol.Comment: 27 pages, 3 figures, Planetary and Space Science, in pres

Is the far border of the Local Void expanding?

According to models of evolution in the hierarchical structure formation scenarios, voids of galaxies are expected to expand. The Local Void (LV) is the closest large void, and it provides a unique opportunity to test observationally such an expansion. It has been found that the Local Group, which is on the border of the LV, is running away from the void center at ~260 km/s. In this study we investigate the motion of the galaxies at the far-side border of the LV to examine the presence of a possible expansion. We selected late-type, edge-on spiral galaxies with radial velocities between 3000 km/s and 5000 km/s, and carried out HI 21 cm line and H-band imaging observations. The near-infrared Tully-Fisher relation was calibrated with a large sample of galaxies and carefully corrected for Malmquist bias. It was used to compute the distances and the peculiar velocities of the LV sample galaxies. Among the 36 sample LV galaxies with good quality HI line width measurements, only 15 galaxies were selected for measuring their distances and peculiar velocities, in order to avoid the effect of Malmquist bias. The average peculiar velocity of these 15 galaxies is found to be -419+208-251 km/s, which is not significantly different from zero. Due to the intrinsically large scatter of Tully-Fisher relation, we cannot conclude whether there is a systematic motion against the center of the LV for the galaxies at the far-side boundary of the void. However, our result is consistent with the hypothesis that those galaxies at the far-side boundary have an average velocity of ~260 km/s equivalent to what is found at the position of the Local Group.Comment: 15 pages, 6 figures, and 4 tables. Accepted for publication in A&