74 research outputs found
On Barreira-Valls polynomial stability of evolution operators in Banach spaces
Our main objective is to consider a concept of nonuniform behavior and obtain appropriate versions of the well-known stability due to R. Datko and L. Barbashin. This concept has been considered in the works of L. Barreira and C. Valls. Our approach is based on the extension of techniques for exponential stability to the case of polynomial stability
Disparities and relative risk ratio of preterm birth in six Central and Eastern European centers
Aim To identify characteristic risk factors of preterm birth
in Central and Eastern Europe and explore the differences
from other developed countries.
Method Data on 33 794 term and 3867 preterm births
(<37 wks.) were extracted in a retrospective study between
January 1, 2007 and December 31, 2009. The study took
place in 6 centers in 5 countries: Czech Republic, Hungary
(two centers), Romania, Slovakia, and Ukraine. Data on historical
risk factors, pregnancy complications, and special
testing were gathered. Preterm birth frequencies and relevant
risk factors were analyzed using Statistical Analysis
System (SAS) software.
Results All the factors selected for study (history of smoking,
diabetes, chronic hypertension, current diabetes,
preeclampsia, progesterone use, current smoking, body
mass index, iron use and anemia during pregnancy), except
the history of diabetes were predictive of preterm
birth across all participating European centers. Preterm
birth was at least 2.4 times more likely with smoking (history
or current), three times more likely with preeclampsia,
2.9 times more likely with hypertension after adjusting for
other covariates. It had inverse relationship with the significant
predictor body mass index, with adjusted risk ratio of
0.8 to 1.0 in three sites. Iron use and anemia, though significant
predictors of preterm birth, indicated mixed patterns
for relative risk ratio.
Conclusion Smoking, preeclampsia, hypertension and
body mass index seem to be the foremost risk factors of
preterm birth. Implications of these factors could be beneficial
for design and implementation of interventions and
improve the birth outcome
IL-7/IL-7R gene variants impact circulating IL-7/IL-7R homeostasis and ART-associated immune recovery status
Altres ajuts: This study would not have been possible without the collaboration of all the patients and medical and nursing staff who have taken part in the project. This work was supported by Gilead Fellowship Program GLD14/293 and GLD17/00299 and Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (Proyecto de Investigación de Excelencia; CTS2593). YMP and ERM are supported by the Servicio Andaluz de Salud through Programa Nicolás Monardes (C-0013/17 and C-0032/17, respectively). We are also grateful to GESIDA for ''Premio para Jóvenes Investigadores 2019'' to AR. Authors greatly appreciate the comments and criticisms of the anonymous reviewers that greatly helped to improve the manuscript.A relationship between polymorphisms in genes encoding interleukin 7 (IL-7) and its cellular receptor (IL-7R) and antiretroviral therapy (ART)-associated immune recovery in HIV subjects has been previously reported. However, details of this relationship remain unclear, and the association of these polymorphisms with circulating IL-7/IL-7R levels is scarce. Here, we explored whether IL-7/IL-7R axis was associated with quantitative CD4 T-cell recovery in HIV-infected subjects. IL-7/IL-7R polymorphisms were assessed by genotyping, and multiple inheritance models were used to estimate both, their association with low pre-ART CD4 T-cell counts and incomplete immune recovery status after 48 weeks of suppressive ART. Integrated data from genetic variants association and soluble plasma IL-7/IL-7R quantification suggest that IL-7/IL-7R genotype expression could alter the homeostatic balance between soluble and membrane-bound receptors. The haplotype analyses indicates that allele combinations impacts pre-ART circulating CD4 T-cell counts, immune recovery status and the absolute increment of CD4 T-cell counts. The knowledge about how IL-7/IL-7R axis is related to quantitative CD4 T-cell recovery and immune recovery status after initiating ART could be useful regarding T-cell reservoirs investigations in HIV subjects
2015/16 seasonal vaccine effectiveness against hospitalisation with influenza a(H1N1)pdm09 and B among elderly people in Europe: Results from the I-MOVE+ project
We conducted a multicentre test-negative caseâ\u80\u93control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged â\u89¥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders. We included 355 influenza A(H1N1)pdm09 cases, 110 influenza B cases, and 1,274 controls. Adjusted IVE against influenza A(H1N1)pdm09 was 42% (95% confidence interval (CI): 22 to 57). It was 59% (95% CI: 23 to 78), 48% (95% CI: 5 to 71), 43% (95% CI: 8 to 65) and 39% (95% CI: 7 to 60) in patients with diabetes mellitus, cancer, lung and heart disease, respectively. Adjusted IVE against influenza B was 52% (95% CI: 24 to 70). It was 62% (95% CI: 5 to 85), 60% (95% CI: 18 to 80) and 36% (95% CI: -23 to 67) in patients with diabetes mellitus, lung and heart disease, respectively. 2015/16 IVE estimates against hospitalised influenza in elderly people was moderate against influenza A(H1N1)pdm09 and B, including among those with diabetes mellitus, cancer, lung or heart diseases
THE AND INFRARED BANDS OF
1. H. Bürger, H. Beckers, and J. Kauppinen. J. Mol. Spectrosc. 108, 215 (1984) 2. A. Ceausu, G. Graner, H. Bürger, E.B. Mkalhri, J. Ccaleou and A. G. Lesarri, J. Mol. Spectrosc, (1995) (in press).Author Institution: associé aux Universités P. et M. Curie et Paris. Sud, Bât 350, Campus d'Orsay. 91405 Orsay, France.; Universität Gesamthochschule, FB9, 42097 Wappertal, Germany.; J. Heyrovsky Institute of Physical Chemistry, Dolejskova 3, 18223 Praha 8. Czech Republic.The and (E) fundamental bands of isotopically pure Br, centered at 929.752 and respectively have been analyzed from a high resolution Fourier transform spectrum in order to improve a former . These two bands strongly interact through a X-Y Coriolis resonance. We also included in the model the weak Coriolis resonance between and , with a crossing near and K = 14, the r-type resonance between and of , with a crossing at J = 58 and the accidental resonance between the levels of and of . We made a global fit of 4200 wavenumbers for and and 630 upper state energies of , deduced from previously transitions of and of . A few perturbation allowed transitions were also included in the fit, which gives a s. d. on residuals better than . A set of molecular parameters for all levels involved will be reported
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