7 research outputs found
Etude du reseau idiotypique fonctionnel, ses composants et leurs interactions
- Publication venue
- Publication date
- 01/01/1984
- Field of study
SIGLECNRS-CDST / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
Mecanismes cellulaires et moleculaires de la proliferation et de la differenciation des cellules #gamma##delta# murines au cours du developpement
- Author
- Publication venue
- Publication date
- 01/01/1993
- Field of study
SIGLEAvailable from INIST (FR), Document Supply Service, under shelf-number : AR 16482 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueMinistere de l'Enseignement Superieur et de la Recherche, 75 - Paris (France)FRFranc
La reaction croisee entre le motif allotypique Aa1 des immunoglobulines du lapin et les anticorps diriges contre le motif allotypique Aa3: Participation des variantes de la specificite Aa1 a cette reaction croisee
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial
- Author
- ADER Florence
- AKINOSOGLOU Karolina
- BALLY Isabelle
- BANO Jesus Rodriguez
- BELHADI Drifa
- BELKHIR Leila
- BERGAUD Nathalie
- BILLARD Nicolas
- BOTELHO-NEVERS Elisabeth
- BOUSCAMBERT-DUCHAMP Maude
- BURDET Charles
- CABIE Andre
- CARCELAIN Guislaine
- CAZENAVE-ROBLOT France
- CLEVENBERGH Philippe
- COSTAGLIOLA Dominique
- COUFFIN-CADIERGUES Sandrine
- COURJON Johan
- DALGARD Olav
- DANION Francois
- DE CASTRO Nathalie
- DECHANET Aline
- DELMAS Christelle
- DERGAN-DYLON Sebastian
- DESTRAS Gregory
- DIALLO Alpha
- DISCOVERY STUDY Group
- ESPEROU Helene
- EUSTACE Joe
- FAURE Emmanuel
- FOUGEROU-LEURENT Claire
- GALLIEN Sebastien
- GAROT Denis
- GAYMARD Alexandre
- GOEHRINGER Francois
- GOUSSEFF Marie
- GREIL Richard
- GUEDJ Jeremie
- HAJDU Edit
- HALANOVA Monika
- HAN Thi-Hong-Lien
- HITES Maya
- JAMARD Simon
- JOSSET Laurence
- KALIF Ouifiya
- KOTANIDOU Anastasia
- LACOMBE Karine
- LANTERNIER Fanny
- LAPIQUE Eva Larranaga
- LESCURE Xavier
- LETURNIER Paul
- LEVEAU Benjamin
- LOUBET Paul
- MALVY Denis
- MARTIN-BLONDEL Guillaume
- MASSONNAUD Clement R
- MENTRE France
- MERCIER Noemie
- MESTRE Soizic Le
- METOIS Anabelle
- MOING Vincent Le
- NORET Marion
- PAIVA Jose-Artur
- PEIFFER-SMADJA Nathan
- PIEKARSKA Anna
- PIROTH Lionel
- POIGNARD Pascal
- REIGNIER Jean
- RIISE Anne Ma Dyrhol
- ROGER Claire
- ROUVEIX-NORDON Elisabeth
- SELLIER Pierre
- SILVA Susana
- STAUB Therese
- TERZIC Vida
- THIERY Guillaume
- TOLSMA Violaine
- TONBY Kristian
- TRABAUD Mary-Anne
- TROJANEK Milan
- TROSEID Marius
- TSIODRAS Sotirios
- TUBIANA Sarah
- UNAL Serhat
- VARDON-BOUNES Fanny
- VISEE Clotilde
- YAZDANPANAH Yazdan
- Publication venue
- WB Saunders
- Publication date
- 16/02/2024
- Field of study
International audienc
High Risk of Anal and Rectal Cancer in Patients With Anal and/or Perianal Crohn’s Disease
- Author
- Abdelli Naceur
- Abitbol Vered
- Abramowitz Laurent
- Afchain Pauline
- Agard Dominique
- Aillet Luc
- Alamdari Afchine
- Algard Michèle
- Allez Matthieu
- Allez Matthieu
- Alpérine Michel
- Altman Claude
- Andréani Tony
- Arab Kamel
- Arnoux Jean Pierre
- Arotçarena Ramuntxo
- Arpurt Jean Pierre
- Attar Alain
- Auby Dominique
- Audan Alain
- Audebert Michel
- Auroux Jean
- Aygalenq Philippe
- Bader Robert
- Baetz Andre
- Balavoine Yvon
- Barbereau Didier
- Barbieux Jean Pierre
- Bardoux Nicolas
- Barjonet Georges
- Baron Philippe
- Baroni Jean-Luc
- Barouk Jerome
- Barraya Remy
- Barre Bruno
- Barré Philippe
- Battistelli Daniel
- Baty Vincent
- Baudet Anne
- Baumer Philippe
- Bauret Paul
- Beau Philippe
- Beaugerie Laurent
- Beaugerie Laurent
- Beaulieu Sandrine
- Bedenne Laurent
- Bellaiche Guy
- Bellaiche Marc
- Bellanger Jérôme
- Benamouzig Robert
- Benchaa Benabdallah
- Benfiguig Kader
- Benfredj Paul
- Bensaude Raoul-Jacques
- Berthelemy Philippe
- Bertrand Hugues
- Bezet Alexis
- Bineau Catherine
- Bion Eric
- Bismuth Michaël
- Blain Antoine
- Blanc Georges
- Blanchi Alain
- Blanquart Alain
- Blazquez Martine
- Bloch Francis
- Blondel Fabienne
- Blondelot Jean-Pierre
- Blondon Hugues
- Boehm Christian
- Bohon Philippe
- Boiffin Franck
- Bolze Jean-Louis
- Bommelaer Gilles
- Bonaz Bruno
- Bonjean Philippe
- Bonneau Gilles
- Bonnet-Eymard Pierre-Olivier
- Bonniaud Pierre
- Bonny Corinne
- Bord Pierre
- Borel Isabelle
- Bories Jean-Marc
- Boruchowicz Arnaud
- Bottlaender Jacques
- Bougnol Michel
- Bouhnik Yoram
- Bouhot Florence
- Boulant James
- Boulay Guy
- Bounin Pierre-André
- Bourbon Pierre
- Bourgeaux Claude
- Bourreille Arnaud
- Boustière Christian
- Boutin Jean
- Boutroux Dominique
- Bouygues Martin
- Bouyssou Philippe
- Boyer-Darrigrand Nathalie
- Brazier Franck
- Bretagnolle Philippe
- Breton Anne
- Brichard Jean Michel
- Bridoux-Henno Laure
- Bronstein Jean Ariel
- Broyer Joel
- Brun Marc
- Brézault Catherine
- Bulois Philippe
- Caby Christine Meicler
- Cadiot Guillaume
- Calabet Jean
- Canet Bernard
- Capelle Philippe
- Capony Patrice
- Carbonnel Franck
- Carles Bertrand
- Carlier-Bandu Martine
- Carpentier Stephane
- Carrat Fabrice
- Carre Dominique
- Carwana Alain
- Cassan Philippe
- Casteur Alban
- Cattan Philippe
- Cattan Stéphane
- Cavicchi Maryan
- Cayla Jean-Michel
- Cazalbou Claude
- Cazals Jean Brice
- Cazenave Jean Louis
- Cemachovic Israël
- Cerbelaud Philippe
- Certin Michel
- Chabry Bernard
- Chamouard Patrick
- Champigneulle Bruno
- Chapoutot Christian
- Charachon Antoine
- Chardonnal Gérard
- Charneau Jacky
- Charpin Serge
- Chatrenet Philippe
- Chaussade Stanislas
- Chavaillon Annick
- Chayette Claude
- Cholet Franck
- Christidis Christos
- Chryssostalis Ariane
- Claude Pierre
- Claudez Hubert
- Claviere Christophe
- Codjovi Philippe
- Coffin Benoit
- Coffin Jean-Charles
- Collin Catherine
- Colombel Jean-Frédéric
- Colombel Jean-Frédéric
- Colson Jean Louis
- Combes Rémi
- Combet Francois
- Comte Jean-Marc
- Constantini Denis
- Contou Jean-François
- Corallo Jacques
- Cordet Frederic
- Cordier-Collet Mariepierre
- Corrieri-Baizeau Céline
- Cortot Antoine
- Cosnes Jacques
- Coton Thierry
- Cottereau Jean
- Coupier Dominique
- Courat Laurent
- Coutarel Pierre
- Croguennec Bernard
- Cuillerier Emmanuel
- Cuissard Laurent
- Cézard Jean Pierre
- d'Abravanel Pascale
- d'Abrigeon Gilles
- Dabadie Alain
- Dadamessi Innocenti
- Dall'Osto Hélène
- Danis Jacques
- Danne Odile
- Dapoigny Michel
- Darsouni Riad
- Dartois-Hoguin Michele
- David Benoit
- David Dominique
- David Xavier-Richard
- de Fleury Patrice
- de la Lande Philippe
- de Laguierce Isabelle Duval
- de Lustrac Mercédes
- de Montigny Stéphanie
- de Saint Louvent Patrick
- Debenes Bernard
- Decroix Bruno
- Delanoe Christophe
- Delaperriere Nadege
- Delasalle Patrick
- Delbende Bruno
- Delchier Jean-Charles
- Delon Bernard
- Deltombe Bernard
- Denoyel Philippe
- Dentant Lionel
- Deplaix Philippe
- Derreveaux Philippe
- Dervichian Michel
- Desaint Benoit
- Desbazeille François
- Deschamps Jean-Paul
- Desreumaux Pierre
- Desseaux Gerard
- Desurmont Philippe
- Devulder Franck
- Dewannieux Jacques
- Diacono Michel
- Dib Nina
- Dieterling Paul
- Dieumegard Barbara
- Diez Jean-Lucien
- Dorval Etienne
- Doubremelle Marie
- Dramard Jean-Michel
- Druart Francois
- Dubern Béatrice
- Dubois Philippe
- Dubroca Jeanne
- Dubuc-Rey Nathalie
- Duché Mathieu
- Duclos Bernard
- Dumortier Jérôme
- Dupas Jean Louis
- Dupont Gossart Anne-Claire
- Dupuy J-François
- Dupuychaffray Jean-Pierre
- Durget Alain
- Durous Eric
- Duruy Marc
- D’almagne Hélène
- D’aubigny Nicolas Drouët
- Ecuer Stéphane
- Edouard André
- Elie-Legrand Marie-Claire
- Emery Philippe
- Emery Yves
- Empinet Olivier
- Escartin Michel -Pierre
- Estable Patrick
- Etienney Isabelle
- Evard Daniel
- Even Philippe
- Fallourd Philippe
- Faroux Roger
- Fatisse Abdelaziz
- Faucheron Jean-Luc
- Fauchot Olivier
- Faure Patrick
- Fayemendy Laurent
- Fein Francine
- Ferbus Dominique Chaslin
- Filippi Jérôme
- Fiorucci Robert
- Florent Christian
- Flourié Bernard
- Fléjou Jean-François
- Foltz Marc
- Fontenelle Patrick
- Fourdan Olivier
- Fourgeaud Jean-Luc
- Fournier Régis
- Fratini Gérard
- Galindo Georges
- Galmiche Jean-Paul
- Ganne Nathalie
- Gargot Dany
- Garnier Thierry
- Garret Marc
- Gatineau-Sailliant Gilles
- Gauchet Jean-Michel
- Gaudy Daniele
- Gauffeny Benoit
- Gautier-Jubé Florence
- Gaye-Bareyt Eric
- Gazut Valérie
- Geagea Edmond
- Gehrke Nathalie Mallier
- Gelsi Eve
- Gendre Jean-Pierre
- Genes Julien
- Gerbal Jean-Luc
- Gerosa Yves
- Gillion Jean Marie
- Ginies Jean-Louis
- Girardet Jean-Philippe
- Glibert André
- Godeberge Béatrice
- Godeberge Philippe
- Goldfain Denis
- Gonot Olivier
- Gornet Jean-Marc
- Gotlib Jean Pierre
- Gottrand Frédéric
- Gouilloud Sylvie
- Grandmaison Brigitte
- Granveau Antoine
- Greco Fernand
- Greff Michel
- Grimprel Hubert
- Grinholtz Alain
- Gros Pascal
- Guedon Claire
- Guegan Martine
- Guemene Jean-Marc
- Guez Chantal
- Guillan Jacques
- Guilleminet Christian
- Gury Bruno
- Hagège Hervé
- Hamm Romain
- Hamon Jean-François
- Hartwig Johannes
- Haëm Jacques
- Hecquet Geneviève
- Helbert Thierry
- Helie Ludovic
- Henry Gerard
- Heresbach Denis
- Hervé Sophie
- Heyries Laurent
- Hochain Patrick
- Houard Xavier
- Houcke Philippe
- Howaizi Mehran
- Hubert Gilles
- Huc Denis
- Hugot Jean-Pierre
- Humeau Benoit
- Hébuterne Xavier
- Iglicki Franck
- Imani Kamran
- Ink Olivier
- Jacques Christian
- Jaillet Jean-Claude
- Janin-Manificat Raoul
- Jean Francois
- Jian Raymond
- Jost Béatrice
- Jouet Pauline
- Jouffre Claude
- Jouve Jean-Louis
- Julien Pierre-Emile
- Jullien Monique
- Justum Anne-Marie
- Kaassis Mehdi
- Kalt Philippe
- Kerlirzin Anne
- Kezachian Gilles
- Khaddari Saïd
- Khouri Elie
- Kirchgesner Julien
- Koch Stéphane
- Kunkel Daniel
- Kurtz Thierry
- Kusielewicz Daniel
- l'Hirondel Christian
- Labarriere Damien
- Labat-Labourdette Jacques
- Labérenne Jean-Eric
- Lafarge Jocelyne
- Lagarrigue Cécile
- Lagier Emmanuel
- Lagneau Marion
- Laharie David
- Lamouliatte Hervé
- Lamy Philippe
- Landau Alain
- Lang Francoise
- Languepin Jeanne
- Lapalus Marie-George
- Laplane Bertrand
- Lariviere Isabelle Loury
- Larvol Loic
- Lascar Gilles
- Latrive Jean-Paul
- Le Bihan Monique
- Le Bourgeois Philippe
- Le Couteulx Christian
- Le Dréau Gérard
- Le Floch Isabelle Joly
- Le Gall Bruno
- Le Gall Ronan
- Le Genissel Henri
- Le Marchand Pierre
- Le Mercier Yvon
- Le Sidaner Anne
- Le Tallec Francois
- Lederman Emmanuel
- Lefebvre Jean
- Legrand Christophe
- Lelouch Stéphane
- Lemière Sébastien
- Lenaerts Catherine
- Lenormand Frédéric
- Lentini Franck
- Leprince Eric
- Lerebours Eric
- Leroi Henri
- Leroy Olivier
- Lesage Xavier
- Lescut Dominique
- Lesur Gilles
- Leurent Bruno
- Leveque Anne-Marie
- Levoir Damien
- Levy Patrick
- Lhopital François
- Liebaert Marie Pierre
- Lillo Philippe
- Locher Christophe
- Lochum Sylvain
- Loeb Christian
- Loison Patrick
- Lombard Frédéric
- Lons Thierry
- Lucidarme Damien
- Luneau Fabrice
- Lémann Marc
- Léostic Didier
- Lévy Philippe
- Macaigne Gilles
- Madonia Patrick
- Maechel Henri
- Magois Hervé
- Maignan Philippe
- Maille Francois
- Mallet Anne Courillon
- Mallet Laurent
- Mamou Patrick
- Marcato Norma
- Marchal Jean Luc
- Marinier Evelyne
- Marois Francis
- Maroy Bernard
- Marteau Philippe
- Martin Jacques
- Masliah Claude
- Mathieu Stéphane
- Mathonnet Muriel
- Maurage Chantal
- Medini Abdelkrim
- Menat Jean Philippe
- Merite François
- Mesnard Bruno
- Messing Bernard
- Metman Etienne-Henry
- Meurisse Franck
- Meurisse Jean-Jacques
- Meyran Emmanuel
- Michaud Laurent
- Michaudel Gilles
- Michiels Christophe
- Migairou Jean-Luc
- Miguet Mathieu
- Minault Sophie
- Mineur Alexandra
- Minier Gilles
- Mion François
- Missonnier Gilles
- Mockly Jean Francois
- Moindrot Henri
- Moitry Alain
- Molard Bruno Richard
- Monnin Jean-Luc
- Monsch Jean-Marie
- Moraillon Armand
- Morali Alain
- Moreau Jacques
- Moreau Pierre
- Moreau Xavier
- Morin Thierry
- Mornet Martine
- Mougenel Jean Louis
- Mourrut Christian
- Mouterde Olivier
- Mouton Pascal
- Mozer-Bernardeau Marianne
- Mudry Jean
- Muron Sophie
- Nahon Stéphane
- Nahon Stéphane
- Nalet Bernard
- Namias Alain
- Nancey Stéphane
- Napoleon Bertrand
- Neveu Dominique
- Ngo Yann
- Nieuviarts Sandrine
- Nion-Larmurier Isabelle
- Nisard Andrée
- Nouel Olivier
- Nousbaum Jean-Baptiste
- Nury Bernard
- Ollivier Stéphane
- Ollivry Jean
- Ouvry Dominique
- Palacci Alain
- Papapietro Valérie
- Pariente Alex
- Parlier David David
- Parmentier Thierry
- Patenotte Arnaud
- Paupard Thierry
- Pauwels Arnaud
- Pecriaux Olivier
- Pelatan Cécile
- Pellat Benoit
- Pellet Daniel
- Perche Jean Paul
- Pereira Adelino
- Periac Pierre
- Perot Valéry
- Person Bruno
- Petit Agnès
- Petit Richard
- Petitgars Philippe
- Peyrin-Biroulet Laurent
- Peyrin-Biroulet Laurent
- Peytier Annie
- Piche Thierry
- Picon Laurence
- Picon-Coste Magali
- Pienkowski Patrice
- Pierrugues Robert
- Pigot Francois
- Pillon Didier
- Pinault Tiphaine
- Piperaud René
- Piquet Marie-Astrid
- Plane Alain
- Plihon Genevieve
- Poilroux Bernard
- Ponsot Philippe
- Popot Jean-Michel
- Pornin Béatrice
- Potier Pascal
- Pouche Philippe
- Pouderoux Philippe
- Poupardin Cécile
- Pouteau Michele
- Prades Philippe
- Prunier Annie
- Puech Jean
- Puy-Montbrun Thierry
- Quinton André
- Rambaud Serge
- Ramond François-Jean
- Ramond-Bouhali Marie-José
- Raoux Philippe
- Rat Christel
- Raymond Jean-Michel
- Rebouissoux Laurent
- Reig Jean Jacques
- Reignier Antoine
- Reijasse Didier
- Reix Nicole
- Renard Pascal
- Renkes Pascal
- Reville Marc
- Rey Jean-François
- Rey Philippe
- Reynier Catherine
- Richecoeur Martial
- Ricotie Etienne
- Rinaldi-Dovio Michel
- Riot François
- Robin Edith
- Roblin Xavier
- Roche Hervé
- Roche Jean
- Roger Jean
- Roget Laurent
- Rogier Patrice
- Roques Jean François
- Rosa Isabelle
- Roseau Gilles
- Rosenbaum Alain
- Rossi Valérie
- Rotenberg André
- Rouch Michel
- Rouillon Jean-Michel
- Roupret Bernard
- Roussin-Bretagne Sylvie
- Roux Jean-Pol
- Rozental Gerald
- Rudelli Alain
- Sabaté Jean-Marc
- Sabaté Jean-Marc
- Sahy Daniel
- Salloum Julien
- Salmeron Marcelo
- Samama Joelle
- Sanchez Jérôme
- Saurfelt Marc Michel
- Savarieau Bernard
- Savoye Guillaume
- Schneider Stéphane
- See Antoine
- Seksik Philippe
- Seroka Jacques
- Seyrig Jacques-Arnaud
- Silvie Jean
- Siproudhis Laurent
- Slama Jean Luc
- Slaoui Maurice Hakim
- Smadja Lionel
- Sobhani Iradj
- Sondag Daniel
- Soudan Denis
- Souffran Marc-Henry
- Soulé Jean-Claude
- Soupison Alain
- Souquet Jean-Christophe
- Spyckerelle Claire
- Steinberg Michel
- Stremsdoerfer Noel
- Suzanne Jean
- Svrcek Magali
- Systchenko Remi
- Sénéjoux Agnès
- Tardy Karine Delaunay-
- Tardy Ludovic
- Targues Guy
- Tawil-Longreen Christine
- Tennenbaum Ruth
- Tensaouti Abdallah
- Terdiman-Pire Michele
- Teste Yves
- Texereau Patrick
- Texier Frederic
- Thaunat Jean Luc
- Theodore Christian
- Thevenin Alain
- Thiefin Gerard
- Thorel Jean Marie
- Tissot Bertrand
- Tordjman Gilles
- Tounian Patrick
- Travers Bruno
- Tubiana Bernard
- Tucat Gilbert
- Turner Luc
- Tusseau Frank
- Tuvignon Patrick
- Uettwiller Hervé
- Uzzan Francoise
- Vacherot Bruno
- van Nieuwenhuyse Antoine
- Vandromme Luc
- Venezia Franck
- Verdier Eric
- Vergier Jean-Francois
- Veyrac Michel
- Veyres Bruno
- Vidal Alain
- Vinante Nadia
- Vincent Edmond
- Viola Sheila
- Viron Dominique
- Vitte René-Louis
- Vove Jean-Paul
- Waldner Bruno
- Wantiez Michel
- Watrin Bernard
- Weber Francois-Xavier
- Weiss Anne Marie
- Weissman Alain
- Willemin Bernard
- Wittersheim Christian
- Wohlschies Eric
- Wolff Thierry
- Wurtz-Huckert Cécile
- Zalcberg Marc
- Zamora Christophe
- Zeitoun Jean-David
- Zerbib Frank
- Zirabe Simon
- Zrihen Elie
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2018
- Field of study
International audienceBackground & AimsLittle is known about the magnitude of the risk of anal and rectal cancer in patients with anal and/or perineal Crohn’s disease. We aimed to assess the risk of anal and rectal cancer in patients with Crohn’s perianal disease followed up in the Cancers Et Surrisque Associé aux Maladies Inflammatoires Intestinales En France (CESAME) cohort.MethodsWe collected data from 19,486 patients with inflammatory bowel disease (IBD) enrolled in the observational CESAME study in France, from May 2004 through June 2005; 14.9% of participants had past or current anal and/or perianal Crohn’s disease. Subjects were followed up for a median time of 35 months (interquartile range, 29–40 mo). To identify risk factors for anal cancer in the total CESAME population, we performed a case-control study in which participants were matched for age and sex.ResultsAmong the total IBD population, 8 patients developed anal cancer and 14 patients developed rectal cancer. In the subgroup of 2911 patients with past or current anal and/or perianal Crohn’s lesions at cohort entry, 2 developed anal squamous-cell carcinoma, 3 developed perianal fistula–related adenocarcinoma, and 6 developed rectal cancer. The corresponding incidence rates were 0.26 per 1000 patient-years for anal squamous-cell carcinoma, 0.38 per 1000 patient-years for perianal fistula–related adenocarcinoma, and 0.77 per 1000 patient-years for rectal cancer. Among the 16,575 patients with ulcerative colitis or Crohn’s disease without anal or perianal lesions, the incidence rate of anal cancer was 0.08 per 1000 patient-years and of rectal cancer was 0.21 per 1000 patient-years. Among factors tested by univariate conditional regression (IBD subtype, disease duration, exposure to immune-suppressive therapy, presence of past or current anal and/or perianal lesions), the presence of past or current anal and/or perianal lesions at cohort entry was the only factor significantly associated with development of anal cancer (odds ratio, 11.2; 95% CI, 1.18-551.51; P = .03).ConclusionsIn an analysis of data from the CESAME cohort in France, patients with anal and/or perianal Crohn’s disease have a high risk of anal cancer, including perianal fistula–related cancer, and a high risk of rectal cancer
A highly virulent variant of HIV-1 circulating in the Netherlands
- Author
- Aarsman K
- Abel Sylvie
- Abeler-Dörner Lucie
- Abgrall Sophie
- Abgueguen Pierre
- Abraham Bruno
- Ackens R P
- Adam Axel
- Adams A
- Agher Nouara
- Ahmad S
- Ainsworth J
- Aissi Emmanuelle
- Ajana Faïza
- Al Moujahid A
- Alagna Laura
- Albers M
- Albert Jan
- Alberto A
- Alcaraz Isabelle
- Allavena Clotilde
- Allegre Thierry
- Allen S
- Allienne Christophe
- Alvarez Muriel
- Alvarez-Huve Sandrine
- Amirat Naouel
- Ammerlaan H S M
- Anderson J
- Andrady U
- Andre Marie
- Ang C W
- Antoniotti Odile
- Antonucci S
- Aquilina Christian
- Arastéh Keikawus
- Arbter Peter
- Arends J E
- Arumainayyagam J
- Arvieux Cédric
- Aslan Alexandre
- Assi Assi
- Atoui Nadine
- Aubert V
- Audebert Franz
- Aumaitre Hugues
- Autar R S
- Avettand Fenoel Véronique
- Baas S
- Babiker Abdel
- Back N K T
- Baclet Véronique
- Baillat Vincent
- Bakker M
- Bakker Margreet
- Bakker Y
- Balausine Stéphanie
- Balsarin Florence
- Bannert Norbert
- Bannert Norbert
- Bansaal D
- Bantsimba Jonas
- Barbe Frédérique
- Barbuat Claudine
- Barin Francis
- Barth R E
- Bassant N
- Bastides Frédéric
- Batala Anne-Sophie
- Batard Marie-Laure
- Batisse Dominique
- Battegay M
- Baudry Thomas
- Baumgarten Axel
- Bax H I
- Bazin Christine
- Beck Charles
- Beck-Wirth Geneviève
- Belan Alix Greder
- Belarbi Linda
- Bellenger Katharine
- Ben Abdallah Saadia
- Benomar Meryem
- Berger Jean-Luc
- Bergsma D
- Berkhout B
- Berkhout Ben
- Bermon N
- Bernard Louis
- Bernard Noëlle
- Bernard-Henry Claudine
- Bernasconi E
- Berrebi Valérie
- Berrevoets M A H
- Berthe Huguette
- Berzow Dirk
- Besnier Michel
- Bevan M
- Bevan Margaret-Ann
- Bezemer D O
- Bezemer Daniela
- Bezemer M
- Biekre Raphael
- Bieniek Bernhard
- Bierman W F W
- Biezunski Noemie
- Billaud Eric
- Blaauw H
- Blackman H
- Blackman Helen
- Blanc Arnaud
- Blanquart François
- Bloch Martine
- Blok W L
- Bodard Loïc
- Bogner Johannes
- Bollens Diane
- Bolliot Claudine
- Bomers M
- Bonmarchand Manuela
- Bonnet Bénédicte
- Bonnet Fabrice
- Bonsall David
- Bont L J
- Boonstra A
- Bor P C J
- Bornarel Dominique
- Bottero Julie
- Bouchaud Olivier
- Boucher C A B
- Bouchez Sabelline
- Boue François
- Bourgeois Christine
- Boussard Jean-Luc
- Boutoille David
- Bouwhuis J W
- Bowman C
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- Vernazza P
- Viallard Jean-François
- Viard Jean-Paul
- Viget Nathalie
- Visser E
- Visser K M
- Vittecoq Daniel
- Voigt R
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- Vrouenraets S M E
- Wagenvoort G H J
- Waldner Anne
- Wandolo Emily
- Wartel Guillaume
- Waters A
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- Wegdam M C A
- Weijenberg-Maes B
- Weijsenfeld A M
- Weinberck Pierre
- Weiss Laurence
- Weitner Lutwin
- Wemmert Charlotte
- Wensing A M J
- Wesselmann Hans
- Wessels E
- White C
- White D
- Wicke Thomas
- Wiemer Dorothea
- Wiersinga W J
- Wijnands S
- Wildenbeest G S
- Wilding H
- Wilkins E
- Williams O
- Winter A
- Wintermans B
- Wirth Gaétane
- Wit F W M N
- Wither J
- Witte E C
- Wolfs T F W
- Wolthers K C
- Woodward R
- Woudstra T
- Wouthuyzen-Bakker M
- Wttewaal E
- Wymant Chris
- Yazdanpanah Yazdan
- Yerly S
- Young Carmel
- Young F
- Young S
- Youssef Elaney
- Zaaijer H L
- Zadeh Mahsa Mohseni
- Zaheri S
- Zak Dit Zbar Olivier
- Zeng Ai-Feng
- Zhao Lele
- Zucchetti Antonella
- Zucman David
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 04/02/2022
- Field of study
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence
A highly virulent variant of HIV-1 circulating in the Netherlands.
- Author
- Aarsman K.
- Abel S.
- Abeler-Dörner L.
- Abgrall S.
- Abgueguen P.
- Abraham B.
- Ackens R.P.
- Adam A.
- Adams A.
- Agher N.
- Ahmad S.
- Ainsworth J.
- Aissi E.
- Ajana F.
- Al Moujahid A.
- Alagna L.
- Albers M.
- Albert J.
- Alberto A.
- Alcaraz I.
- Allavena C.
- Allegre T.
- Allen S.
- Allienne C.
- Alvarez M.
- Alvarez-Huve S.
- Amirat N.
- Ammerlaan HSM
- Anderson J.
- Andrady U.
- Andre M.
- Ang C.W.
- Antoniotti O.
- Antonucci S.
- Aquilina C.
- Arastéh K.
- Arbter P.
- Arends J.E.
- Arumainayyagam J.
- Arvieux C.
- Aslan A.
- Assi A.
- Atoui N.
- Aubert V.
- Audebert F.
- Aumaitre H.
- Autar R.S.
- Avettand Fenoel V.
- Baas S.
- Babiker A.
- Back NKT
- Baclet V.
- Baillat V.
- Bakker M.
- Bakker M.
- Bakker Y.
- Balausine S.
- Balsarin F.
- Bannert N.
- Bannert N.
- Bansaal D.
- Bantsimba J.
- Barbe F.
- Barbuat C.
- Barin F.
- Barth R.E.
- Bassant N.
- Bastides F.
- Batala A.S.
- Batard M.L.
- Batisse D.
- Battegay M.
- Baudry T.
- Baumgarten A.
- Bax H.I.
- Bazin C.
- Beck C.
- Beck-Wirth G.
- Belan A.G.
- Belarbi L.
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- Zhao L.
- Zucchetti A.
- Zucman D.
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 04/02/2022
- Field of study
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log <sub>10</sub> increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence