A Practical Introduction to Regression Discontinuity Designs: Extensions

This monograph, together with its accompanying first part Cattaneo, Idrobo and Titiunik (2020), collects and expands the instructional materials we prepared for more than $40$ short courses and workshops on Regression Discontinuity (RD) methodology that we taught between 2014 and 2022. In this second monograph, we discuss several topics in RD methodology that build on and extend the analysis of RD designs introduced in Cattaneo, Idrobo and Titiunik (2020). Our first goal is to present an alternative RD conceptual framework based on local randomization ideas. This methodological approach can be useful in RD designs with discretely-valued scores, and can also be used more broadly as a complement to the continuity-based approach in other settings. Then, employing both continuity-based and local randomization approaches, we extend the canonical Sharp RD design in multiple directions: fuzzy RD designs, RD designs with discrete scores, and multi-dimensional RD designs. The goal of our two-part monograph is purposely practical and hence we focus on the empirical analysis of RD designs

An Exotic Theory of Massless Spin-Two Fields in Three Dimensions

It is a general belief that the only possible way to consistently deform the Pauli-Fierz action, changing also the gauge algebra, is general relativity. Here we show that a different type of deformation exists in three dimensions if one allows for PT non-invariant terms. The new gauge algebra is different from that of diffeomorphisms. Furthermore, this deformation can be generalized to the case of a collection of massless spin-two fields. In this case it describes a consistent interaction among them.Comment: 21+1 pages. Minor corrections and reference adde

Analytical theory of forced rotating sheared turbulence: The perpendicular case

Rotation and shear flows are ubiquitous features of many astrophysical and geophysical bodies. To understand their origin and effect on turbulent transport in these systems, we consider a forced turbulence and investigate the combined effect of rotation and shear flow on the turbulence properties. Specifically, we study how rotation and flow shear influence the generation of shear flow (e.g., the direction of energy cascade), turbulence level, transport of particles and momentum, and the anisotropy in these quantities. In all the cases considered, turbulence amplitude is always quenched due to strong shear (ξ=νky2/A⪡1, where A is the shearing rate, ν is the molecular viscosity, and ky is a characteristic wave number of small-scale turbulence), with stronger reduction in the direction of the shear than those in the perpendicular directions. Specifically, in the large rotation limit (Ω⪢A), they scale as A−1 and A−1|ln ξ|, respectively, while in the weak rotation limit (Ω⪡A), they scale as A−1 and A−2/3, respectively. Thus, flow shear always leads to weak turbulence with an effectively stronger turbulence in the plane perpendicular to shear than in the shear direction, regardless of rotation rate. The anisotropy in turbulence amplitude is, however, weaker by a factor of ξ1/3|ln ξ| (∝A−1/3|ln ξ|) in the rapid rotation limit (Ω⪢A) than that in the weak rotation limit (Ω⪡A) since rotation favors almost-isotropic turbulence. Compared to turbulence amplitude, particle transport is found to crucially depend on whether rotation is stronger or weaker than flow shear. When rotation is stronger than flow shear (Ω⪢A), the transport is inhibited by inertial waves, being quenched inversely proportional to the rotation rate (i.e., ∝Ω−1) while in the opposite case, it is reduced by shearing as A−1. Furthermore, the anisotropy is found to be very weak in the strong rotation limit (by a factor of 2) while significant in the strong shear limit. The turbulent viscosity is found to be negative with inverse cascade of energy as long as rotation is sufficiently strong compared to flow shear (Ω⪢A) while positive in the opposite limit of weak rotation (Ω⪡A). Even if the eddy viscosity is negative for strong rotation (Ω⪢A), flow shear, which transfers energy to small scales, has an interesting effect by slowing down the rate of inverse cascade with the value of negative eddy viscosity decreasing as |νT|∝A−2 for strong shear. Furthermore, the interaction between the shear and the rotation is shown to give rise to a nondiffusive flux of angular momentum (Λ effect), even in the absence of external sources of anisotropy. This effect provides a mechanism for the existence of shearing structures in astrophysical and geophysical systems

A minimal BV action for Vasiliev's four-dimensional higher spin gravity

The action principle for Vasiliev's four-dimensional higher-spin gravity proposed recently by two of the authors, is converted into a minimal BV master action using the AKSZ procedure, which amounts to replacing the classical differential forms by vectorial superfields of fixed total degree given by the sum of form degree and ghost number. The nilpotency of the BRST operator is achieved by imposing boundary conditions and choosing appropriate gauge transitions between charts leading to a globally-defined formulation based on a principal bundle.Comment: 39 pages, 1 figure. Additional comments in the conclusion

Longitudinal Changes in Health-Related Quality of Life in Patients With Atrial Fibrillation.

Background Optimizing health-related quality of life (HRQoL) is an important aim of atrial fibrillation (AF) treatment. Little is known about patients' long-term HRQoL trajectories and the impact of patient and disease characteristics. The aim of this study was to describe HRQoL trajectories in an observational AF study population and in clusters of patients with similar patient and disease characteristics. Methods and Results We used 5-year follow-up data from the Swiss-Atrial Fibrillation prospective cohort, which enrolled 2415 patients with prevalent AF from 2014 to 2017. HRQoL data, collected yearly, comprised EuroQoL-5 dimension utilities and EuroQoL visual analog scale scores. Patient clusters with similar characteristics at enrollment were identified using hierarchical clustering. HRQoL trajectories were analyzed descriptively and with inverse probability-weighted regressions. Effects of postbaseline clinical events were additionally assessed using time-shifted event variables. Among 2412 (99.9%) patients with available baseline HRQoL, 3 clusters of patients with AF were identified, which we characterized as follows: "cardiovascular dominated," "isolated symptomatic," and "severely morbid without cardiovascular disease." Utilities and EuroQoL visual analog scale scores remained stable over time for the full population and the clusters; isolated symptomatic patients showed higher levels of HRQoL. Utilities were reduced after occurrences of stroke, hospitalization for heart failure, and bleeding, by -0.12 (95% CI, -0.18 to -0.06), -0.10 (95% CI, -0.13 to -0.08), and -0.06 (95% CI, -0.08 to -0.04), respectively, on a 0 to 1 utility scale. Utility of surviving patients returned to preevent levels 4 years after heart failure hospitalization; 3 years after bleeding; and 1 year after stroke. Conclusions In patients with prevalent AF, HRQoL was stable over time, irrespective of baseline patient characteristics. Clinical events of hospitalization for heart failure, stroke, and bleeding had only a temporary effect on HRQoL

Longitudinal Changes in Health-Related Quality of Life in Patients With Atrial Fibrillation

Background: Optimizing health-related quality of life (HRQoL) is an important aim of atrial fibrillation (AF) treatment. Little is known about patients' long-term HRQoL trajectories and the impact of patient and disease characteristics. The aim of this study was to describe HRQoL trajectories in an observational AF study population and in clusters of patients with similar patient and disease characteristics. Methods and Results: We used 5-year follow-up data from the Swiss-Atrial Fibrillation prospective cohort, which enrolled 2415 patients with prevalent AF from 2014 to 2017. HRQoL data, collected yearly, comprised EuroQoL-5 dimension utilities and EuroQoL visual analog scale scores. Patient clusters with similar characteristics at enrollment were identified using hierarchical clustering. HRQoL trajectories were analyzed descriptively and with inverse probability-weighted regressions. Effects of postbaseline clinical events were additionally assessed using time-shifted event variables. Among 2412 (99.9%) patients with available baseline HRQoL, 3 clusters of patients with AF were identified, which we characterized as follows: "cardiovascular dominated," "isolated symptomatic," and "severely morbid without cardiovascular disease." Utilities and EuroQoL visual analog scale scores remained stable over time for the full population and the clusters; isolated symptomatic patients showed higher levels of HRQoL. Utilities were reduced after occurrences of stroke, hospitalization for heart failure, and bleeding, by -0.12 (95% CI, -0.18 to -0.06), -0.10 (95% CI, -0.13 to -0.08), and -0.06 (95% CI, -0.08 to -0.04), respectively, on a 0 to 1 utility scale. Utility of surviving patients returned to preevent levels 4 years after heart failure hospitalization; 3 years after bleeding; and 1 year after stroke. Conclusions: In patients with prevalent AF, HRQoL was stable over time, irrespective of baseline patient characteristics. Clinical events of hospitalization for heart failure, stroke, and bleeding had only a temporary effect on HRQoL

Des livres et des idées - Biennale des sciences humaines et sociales 2012

"L\u27édition de sciences humaines et sociales : le cœur en danger", ainsi Sophie Barluet intitulait-elle son rapport commandé par le ministère de la Culture et de la Communication, remis en 2004. Si la question du devenir des sciences humaines et sociales n\u27est pas réductible à sa seule présence sur les tables des libraires, la vitalité du secteur est sans cesse questionnée, depuis la mort des Pères : Sartre, Foucault, Barthes, Bourdieu, Derrida…, depuis la chute du mur de Berlin, et la prégnance – comme allant de soi - du capitalisme (financier), et l\u27effacement du politique, depuis le 11 septembre 2001, entrée fracassante dans le XXIe siècle, comme il y eut Sarajevo un siècle plus tôt, depuis le bouleversement des techniques de lecture et de publication (numérique). Pour autant, la pensée est toujours féconde. De jeunes chercheurs interrogent l\u27histoire et le colonialisme pour comprendre les révolutions du Moyen-Orient, sondent l\u27économie et la finance, analysent nos sociétés. Pour autant, l\u27édition critique traduit, découvre, parfois survit, les chercheurs publient ; voir, à ce propos, l\u27ouvrage de Sophie Noël : L\u27édition indépendante critique : engagements politiques et intellectuels (Presses de l\u27enssib, novembre 2012), ainsi que les trois volumes Faire les sciences sociales aujourd\u27hui publiés par les éditions de l\u27EHESS (octobre 2012). C\u27est pour donner la parole à ceux et celles qui nous aident à comprendre le monde que l\u27enssib, avec la librairie Passages, l\u27école des hautes études en sciences sociales (EHESS) et la bibliothèque municipale de Lyon, en collaboration avec la Fondation de la Maison des sciences de l\u27homme (FMSH), ont organisé cette première biennale des sciences humaines et sociales, dont le thème (générique) est "penser la crise"

Application of vertex and mass constraints in track-based alignment

The software alignment of planar tracking detectors using samples of charged particle trajectories may lead to global detector distortions that affect vertex and momentum resolution. We present an alignment procedure that constrains such distortions by making use of samples of decay vertices reconstructed from two or more trajectories and putting constraints on their invariant mass. We illustrate the method by using a sample of invariant-mass constrained vertices from D^0 --> K^- pi^+ decays to remove a curvature bias in the LHCb spectrometer.Comment: 18 pages, 6 figure

Expert consensus document: A 'diamond' approach to personalized treatment of angina.

In clinical guidelines, drugs for symptomatic angina are classified as being first choice (β-blockers, calcium-channel blockers, short-acting nitrates) or second choice (ivabradine, nicorandil, ranolazine, trimetazidine), with the recommendation to reserve second-choice medications for patients who have contraindications to first-choice agents, do not tolerate them, or remain symptomatic. No direct comparisons between first-choice and second-choice treatments have demonstrated the superiority of one group of drugs over the other. Meta-analyses show that all antianginal drugs have similar efficacy in reducing symptoms, but provide no evidence for improvement in survival. The newer, second-choice drugs have more evidence-based clinical data that are more contemporary than is available for traditional first-choice drugs. Considering some drugs, but not others, to be first choice is, therefore, difficult. Moreover, double or triple therapy is often needed to control angina. Patients with angina can have several comorbidities, and symptoms can result from various underlying pathophysiologies. Some agents, in addition to having antianginal effects, have properties that could be useful depending on the comorbidities present and the mechanisms of angina, but the guidelines do not provide recommendations on the optimal combinations of drugs. In this Consensus Statement, we propose an individualized approach to angina treatment, which takes into consideration the patient, their comorbidities, and the underlying mechanism of disease