75 research outputs found
Community structure of litter anurans in a tropical forest, Makokou, Gabon : a preliminary analysis in the minor dry season
Quatre espèces d'anoures, Arthroleptis sulvatica, Cardioglossa leucomystax, Phrynobatrachus batesi (Rani d a e) et Bufo came runensis
(Bufonidae) sont actives pendant la journée dans la litière
de feuilles de la forêt des environs de Makokou, Gabon, pendant
la petite saison sèche. L'abondance et la diversité des anoures
de la litière sont faibles dans cette localité, comme d'ailleurs dans
les autres régions tropicales du Vieux Monde, comparativement
à la situation qui prévaut dans les tropiques humides continentaux
américains. Elles sont, par contre, voisines des valeurs observées
dans la forêt sèche saisonnière de l'île de Barro Colorado, à Panama. Toutes les espèces d'anoures de la litière forestière
de Makokou se nourrissent activement de fourmis et (B. camerunensis excepté) de termites. Le régime d'A. sylvatica, de C. leucomystax
et de P. batesi est très voisin, comme l'indique la mesure
du chevauchement de leurs niches. P. batesi, cependant, est plus
"généraliste" que les autres espèces, comme l'indiquent sa plus
grande largeur de niche (Levins, 1968) et sa plus forte variabilité
inter-individuelle de régim
Assessment of patients with head and neck cancer using the MD Anderson Dysphagia Inventory: Results of a study into its comprehensiveness, comprehensibility and relevance to clinical practice
Kate Toft - ORCID: 0000-0002-0129-9329
https://orcid.org/0000-0002-0129-9329Background
The MD Anderson Dysphagia Inventory (MDADI) is a widely used patient-reported outcome measure (PROM) which assesses dysphagia-related quality of life (QoL) in head and neck cancer (HNC). Despite its common use in HNC research and clinical practice, few of its psychometric properties have been reappraised since its inception. The aim of this study was to perform a survey-based qualitative analysis of UK HNC clinicians’ perceptions of the content validity of the MDADI, evaluating it across the parameters of relevance, comprehensiveness and comprehensibility as per the COSMIN guideline for PROM assessment.
Results
Four themes relating to the content validity of the MDADI were identified: (1) MDADI items lack clarity of definition of the terms ‘swallowing’, ‘eating’ and ‘dysphagia’; (2) the MDADI is perceived to be overly negative in tone including items that service users may find distressing or disempowering; (3) items in the tool are exclusory to specific subgroups of patients, such as those who are nil by mouth or socially isolated; and (4) modifications to the MDADI were suggested and encouraged to make it more clinically useful and patient-centred.
Conclusions
This study indicates that MDADI's content validity is ‘insufficient’ when rated by COSMIN parameters. This has significant implications for its continued use in HNC research and clinical practice. Further re-evaluation of the content validity of the MDADI is warranted, with potential future amendment of items being indicated if the results of this study are corroborated in subsequent research.https://doi.org/10.1111/1460-6984.13026aheadofprintaheadofprin
RELICS: High-Resolution Constraints on the Inner Mass Distribution of the z=0.83 Merging Cluster RXJ0152.7-1357 from strong lensing
Strong gravitational lensing (SL) is a powerful means to map the distribution
of dark matter. In this work, we perform a SL analysis of the prominent X-ray
cluster RXJ0152.7-1357 (z=0.83, also known as CL 0152.7-1357) in \textit{Hubble
Space Telescope} images, taken in the framework of the Reionization Lensing
Cluster Survey (RELICS). On top of a previously known galaxy multiply
imaged by RXJ0152.7-1357, for which we identify an additional multiple image,
guided by a light-traces-mass approach we identify seven new sets of multiply
imaged background sources lensed by this cluster, spanning the redshift range
[1.79-3.93]. A total of 25 multiple images are seen over a small area of ~0.4
, allowing us to put relatively high-resolution constraints on the
inner matter distribution. Although modestly massive, the high degree of
substructure together with its very elongated shape make RXJ0152.7-1357 a very
efficient lens for its size. This cluster also comprises the third-largest
sample of z~6-7 candidates in the RELICS survey. Finally, we present a
comparison of our resulting mass distribution and magnification estimates with
those from a Lenstool model. These models are made publicly available through
the MAST archive.Comment: 15 Pages, 7 Figures, 4 Tables Accepted for publication in Ap
Genome-wide determinants of mortality and motor progression in Parkinson’s disease
There are 90 independent genome-wide significant genetic risk variants for Parkinson’s disease (PD) but currently only five nominated loci for PD progression. The biology of PD progression is likely to be of central importance in defining mechanisms that can be used to develop new treatments. We studied 6766 PD patients, over 15,340 visits with a mean follow-up of between 4.2 and 15.7 years and carried out genome-wide survival studies for time to a motor progression endpoint, defined by reaching Hoehn and Yahr stage 3 or greater, and death (mortality). There was a robust effect of the APOE ε4 allele on mortality in PD. We also identified a locus within the TBXAS1 gene encoding thromboxane A synthase 1 associated with mortality in PD. We also report 4 independent loci associated with motor progression in or near MORN1, ASNS, PDE5A, and XPO1. Only the non-Gaucher disease causing GBA1 PD risk variant E326K, of the known PD risk variants, was associated with mortality in PD. Further work is needed to understand the links between these genomic variants and the underlying disease biology. However, these may represent new candidates for disease modification in PD
RELICS: A Very Large () Cluster Lens -- RXC J0032.1+1808
Extensive surveys with the \textit{Hubble Space Telescope} (HST) over the
past decade, targeting some of the most massive clusters in the sky, have
uncovered dozens of galaxy-cluster strong lenses. The massive cluster
strong-lens scale is typically \theta_{E}\sim10\arcsec to \sim30-35\arcsec,
with only a handful of clusters known with Einstein radii
\theta_{E}\sim40\arcsec or above (for , nominally). Here we
report another very large cluster lens, RXC J0032.1+1808 (), the
second richest cluster in the redMapper cluster catalog and the 85th most
massive cluster in the Planck Sunyaev-Zel'dovich catalog. With our
Light-Traces-Mass and fully parametric (dPIEeNFW) approaches, we construct
strong lensing models based on 18 multiple images of 5 background galaxies
newly identified in the \textit{Hubble} data mainly from the
\textit{Reionization Lensing Cluster Survey} (RELICS), in addition to a known
sextuply imaged system in this cluster. Furthermore, we compare these models to
Lenstool and GLAFIC models that were produced independently as part of the
RELICS program. All models reveal a large effective Einstein radius of
\theta_{E}\simeq40\arcsec (), owing to the obvious
concentration of substructures near the cluster center. Although RXC
J0032.1+1808 has a very large critical area and high lensing strength, only
three magnified high-redshift candidates are found within the field targeted by
RELICS. Nevertheless, we expect many more high-redshift candidates will be seen
in wider and deeper observations with \textit{Hubble} or \emph{JWST}. Finally,
the comparison between several algorithms demonstrates that the total error
budget is largely dominated by systematic uncertainties.Comment: 23 pages, accepted for publication in Ap
RELICS: Strong Lensing analysis of the galaxy clusters Abell S295, Abell 697, MACS J0025.4-1222, and MACS J0159.8-0849
We present a strong-lensing analysis of four massive galaxy clusters imaged
with the Hubble Space Telescope in the Reionization Lensing Cluster Survey. We
use a Light-Traces-Mass technique to uncover sets of multiply images and
constrain the mass distribution of the clusters. These mass models are the
first published for Abell S295 and MACS J0159.8-0849, and are improvements over
previous models for Abell 697 and MACS J0025.4-1222. Our analysis for MACS
J0025.4-1222 and Abell S295 shows a bimodal mass distribution supporting the
merger scenarios proposed for these clusters. The updated model for MACS
J0025.4-1222 suggests a substantially smaller critical area than previously
estimated. For MACS J0159.8-0849 and Abell 697 we find a single peak and
relatively regular morphology, revealing fairly relaxed clusters. Despite being
less prominent lenses, three of these clusters seem to have lensing strengths,
i.e. cumulative area above certain magnification, similar to the Hubble
Frontier Fields clusters (e.g., A() arcmin, A()
arcmin), which in part can be attributed to their merging
configurations. We make our lens models publicly available through the Mikulski
Archive for Space Telescopes. Finally, using Gemini-N/GMOS spectroscopic
observations we detect a single emission line from a high-redshift
galaxy candidate lensed by Abell 697. While we cannot rule
out a lower-redshift solution, we interpret the line as Ly at
, in agreement with its photometric redshift and dropout
nature. Within this scenario we measure a Ly rest-frame equivalent
width of \AA, and an observed Gaussian width of km/s.Comment: 23 pages, 16 figures; V2, accepted for publication in Ap
RELICS: Reionization Lensing Cluster Survey
Large surveys of galaxy clusters with the Hubble and Spitzer Space
Telescopes, including CLASH and the Frontier Fields, have demonstrated the
power of strong gravitational lensing to efficiently deliver large samples of
high-redshift galaxies. We extend this strategy through a wider, shallower
survey named RELICS, the Reionization Lensing Cluster Survey. This survey,
described here, was designed primarily to deliver the best and brightest
high-redshift candidates from the first billion years after the Big Bang.
RELICS observed 41 massive galaxy clusters with Hubble and Spitzer at 0.4-1.7um
and 3.0-5.0um, respectively. We selected 21 clusters based on Planck PSZ2 mass
estimates and the other 20 based on observed or inferred lensing strength. Our
188-orbit Hubble Treasury Program obtained the first high-resolution
near-infrared images of these clusters to efficiently search for lensed
high-redshift galaxies. We observed 46 WFC3/IR pointings (~200 arcmin^2) with
two orbits divided among four filters (F105W, F125W, F140W, and F160W) and ACS
imaging as needed to achieve single-orbit depth in each of three filters
(F435W, F606W, and F814W). As previously reported by Salmon et al., we
discovered 322 z ~ 6 - 10 candidates, including the brightest known at z ~ 6,
and the most distant spatially-resolved lensed arc known at z ~ 10. Spitzer
IRAC imaging (945 hours awarded, plus 100 archival) has crucially enabled us to
distinguish z ~ 10 candidates from z ~ 2 interlopers. For each cluster, two HST
observing epochs were staggered by about a month, enabling us to discover 11
supernovae, including 3 lensed supernovae, which we followed up with 20 orbits
from our program. We delivered reduced HST images and catalogs of all clusters
to the public via MAST and reduced Spitzer images via IRSA. We have also begun
delivering lens models of all clusters, to be completed before the JWST GO call
for proposals.Comment: 29 pages, 6 figures, submitted to ApJ. For reduced images, catalogs,
lens models, and more, see relics.stsci.ed
Evolution of Interstellar Medium, Star Formation, and Accretion at High Redshift
ALMA observations of the long wavelength dust continuum are used to estimate
the interstellar medium (ISM) masses in a sample of 708 galaxies at z = 0.3 to
4.5 in the COSMOS field. The galaxy sample has known far-infrared luminosities
and, hence, star formation rates (SFRs), and stellar masses (M) from
the optical-infrared spectrum fitting. The galaxies sample SFRs from the main
sequence (MS) to 50 times above the MS. The derived ISM masses are used to
determine the dependence of gas mass on redshift, M, and specific SFR
(sSFR) relative to the MS. The ISM masses increase approximately 0.63 power of
the rate of increase in SFRs with redshift and the 0.32 power of the
sSFR/sSFR. The SF efficiencies also increase as the 0.36 power of the SFR
redshift evolutionary and the 0.7 power of the elevation above the MS; thus the
increased activities at early epochs are driven by both increased ISM masses
and SF efficiency. Using the derived ISM mass function we estimate the
accretion rates of gas required to maintain continuity of the MS evolution
( \msun yr at z 2.5). Simple power-law dependences are
similarly derived for the gas accretion rates. We argue that the overall
evolution of galaxies is driven by the rates of gas accretion. The cosmic
evolution of total ISM mass is estimated and linked to the evolution of SF and
AGN activity at early epochs
Parrots Eat Nutritious Foods despite Toxins
Generalist herbivores are challenged not only by the low nitrogen and high indigestibility of their plant foods, but also by physical and chemical defenses of plants. This study investigated the foods of wild parrots in the Peruvian Amazon and asked whether these foods contain dietary components that are limiting for generalist herbivores (protein, lipids, minerals) and in what quantity; whether parrots chose foods based on nutrient content; and whether parrots avoid plants that are chemically defended.We made 224 field observations of free-ranging parrots of 17 species in 8 genera foraging on 102 species of trees in an undisturbed tropical rainforest, in two dry seasons (July-August 1992-1993) and one wet season (January-February1994). We performed laboratory analyses of parts of plants eaten and not eaten by parrots and brine shrimp assays of toxicity as a proxy for vertebrates. Parrots ate seeds, fruits, flowers, leaves, bark, and insect larvae, but up to 70% of their diet comprised seeds of many species of tropical trees, in various stages of ripeness. Plant parts eaten by parrots were rich in protein, lipid, and essential minerals, as well as potentially toxic chemicals. Seeds were higher than other plant materials in protein and lipid and lower in fiber. Large macaws of three species ate foods higher in protein and lipids and lower in fiber compared to plant parts available but not eaten. Macaws ate foods that were lower in phenolic compounds than foods they avoided. Nevertheless, foods eaten by macaws contained measurable levels of toxicity. Macaws did not appear to make dietary selections based on mineral content.Parrots represent a remarkable example of a generalist herbivore that consumes seeds destructively despite plant chemical defenses. With the ability to eat toxic foods, rainforest-dwelling parrots exploited a diversity of nutritious foods, even in the dry season when food was scarce for other frugivores and granivores
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Background Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade. We aimed to use the largest aggregate of GWAS data to identify novel risk loci and gain further insight into the causes of Parkinson's disease. Methods We did a meta-analysis of 17 datasets from Parkinson's disease GWAS available from European ancestry samples to nominate novel loci for disease risk. These datasets incorporated all available data. We then used these data to estimate heritable risk and develop predictive models of this heritability. We also used large gene expression and methylation resources to examine possible functional consequences as well as tissue, cell type, and biological pathway enrichments for the identified risk factors. Additionally, we examined shared genetic risk between Parkinson's disease and other phenotypes of interest via genetic correlations followed by Mendelian randomisation. Findings Between Oct 1, 2017, and Aug 9, 2018, we analysed 7·8 million single nucleotide polymorphisms in 37 688 cases, 18 618 UK Biobank proxy-cases (ie, individuals who do not have Parkinson's disease but have a first degree relative that does), and 1·4 million controls. We identified 90 independent genome-wide significant risk signals across 78 genomic regions, including 38 novel independent risk signals in 37 loci. These 90 variants explained 16–36% of the heritable risk of Parkinson's disease depending on prevalence. Integrating methylation and expression data within a Mendelian randomisation framework identified putatively associated genes at 70 risk signals underlying GWAS loci for follow-up functional studies. Tissue-specific expression enrichment analyses suggested Parkinson's disease loci were heavily brain-enriched, with specific neuronal cell types being implicated from single cell data. We found significant genetic correlations with brain volumes (false discovery rate-adjusted p=0·0035 for intracranial volume, p=0·024 for putamen volume), smoking status (p=0·024), and educational attainment (p=0·038). Mendelian randomisation between cognitive performance and Parkinson's disease risk showed a robust association (p=8·00 × 10−7). Interpretation These data provide the most comprehensive survey of genetic risk within Parkinson's disease to date, to the best of our knowledge, by revealing many additional Parkinson's disease risk loci, providing a biological context for these risk factors, and showing that a considerable genetic component of this disease remains unidentified. These associations derived from European ancestry datasets will need to be followed-up with more diverse data. Funding The National Institute on Aging at the National Institutes of Health (USA), The Michael J Fox Foundation, and The Parkinson's Foundation (see appendix for full list of funding sources)
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