3,324 research outputs found
Stress-Related Growth Scale-Short Form: A Portuguese validation for cancer patients
Abstract background/objective: Cancer can be extremely disruptive, triggering high levels of distress, and at the same time transformative, promoting perceptions of positive life changes and growth. This study aims to analyze the psychometric proprieties of the Stress-Related Growth Scale Short-Form (SRGS-SF) in cancer patients.
Method: 209 Cancer patients heterogeneous in disease stage and diagnosis completed: clinical and sociodemographic information, Distress Thermometer, Positive and Negative Affect Schedule, Visual-analogue Scale of Perceived Positive Life Changes, and Stress-Related Growth Scale-Short Form.
Results: The analysis of internal structure pointed to an one-dimensional scale, with high reliability (.92) measured through the McDonald`s omega coefficient. Validity was also evidenced through significant correlations with other variables.
Conclusions: The Portuguese version of the SRGS-SF seems to present the necessary psychometric proprieties to be considered a valid and reliable short tool, to assess perceptions of growth following cancer and contribute to targeted and integrative psycho-oncological interventions.info:eu-repo/semantics/publishedVersio
Run Generation Revisited: What Goes Up May or May Not Come Down
In this paper, we revisit the classic problem of run generation. Run
generation is the first phase of external-memory sorting, where the objective
is to scan through the data, reorder elements using a small buffer of size M ,
and output runs (contiguously sorted chunks of elements) that are as long as
possible.
We develop algorithms for minimizing the total number of runs (or
equivalently, maximizing the average run length) when the runs are allowed to
be sorted or reverse sorted. We study the problem in the online setting, both
with and without resource augmentation, and in the offline setting.
(1) We analyze alternating-up-down replacement selection (runs alternate
between sorted and reverse sorted), which was studied by Knuth as far back as
1963. We show that this simple policy is asymptotically optimal. Specifically,
we show that alternating-up-down replacement selection is 2-competitive and no
deterministic online algorithm can perform better.
(2) We give online algorithms having smaller competitive ratios with resource
augmentation. Specifically, we exhibit a deterministic algorithm that, when
given a buffer of size 4M , is able to match or beat any optimal algorithm
having a buffer of size M . Furthermore, we present a randomized online
algorithm which is 7/4-competitive when given a buffer twice that of the
optimal.
(3) We demonstrate that performance can also be improved with a small amount
of foresight. We give an algorithm, which is 3/2-competitive, with
foreknowledge of the next 3M elements of the input stream. For the extreme case
where all future elements are known, we design a PTAS for computing the optimal
strategy a run generation algorithm must follow.
(4) Finally, we present algorithms tailored for nearly sorted inputs which
are guaranteed to have optimal solutions with sufficiently long runs
Mutational mechanism for DAB1 (ATTTC) n insertion in SCA37: ATTTT repeat lengthening and nucleotide substitution
Dynamic mutations by microsatellite instability are the molecular basis of a growing number of neuromuscular and neurodegenerative diseases. Repetitive stretches in the human genome may drive pathogenicity, either by expansion above a given threshold, or by insertion of abnormal tracts in nonpathogenic polymorphic repetitive regions, as is the case in spinocerebellar ataxia type 37 (SCA37). We have recently established that this neurodegenerative disease is caused by an (ATTTC)n insertion within an (ATTTT)n in a noncoding region of DAB1. We now investigated the mutational mechanism that originated the (ATTTC)n insertion within an ancestral (ATTTT)n . Approximately 3% of nonpathogenic (ATTTT)n alleles are interspersed by AT-rich motifs, contrarily to mutant alleles that are composed of pure (ATTTT)n and (ATTTC)n stretches. Haplotype studies in unaffected chromosomes suggested that the primary mutational mechanism, leading to the (ATTTC)n insertion, was likely one or more T>C substitutions in an (ATTTT)n pure allele of approximately 200 repeats. Then, the (ATTTC)n expanded in size, originating a deleterious allele in DAB1 that leads to SCA37. This is likely the mutational mechanism in three similar (TTTCA)n insertions responsible for familial myoclonic epilepsy. Because (ATTTT)n tracts are frequent in the human genome, many loci could be at risk for this mutational process.We are grateful to the families and individuals who participated in this work. We
thank Patricia Ribeiro for technical assistance. This study was financed by Fundo
Europeu de Desenvolvimento Regional (FEDER), through the COMPETE 2020
Operational Pro- gram for Competitiveness and Internationalization (POCI) of Portugal
2020, and by the Fundacão para a Ciência e a Tecnologia (FCT) and Ministério
da Ciência, Tecnologia e Ensino Superior (Portugal), in the framework of the project
POCI-01-0145-FEDER-029255; (PTDC/MED-GEN/29255/2017) to I.S. J.R.L. and
C.L.O. were sup- ported by scholarships from PEst-C/SAU/LA0002/2013. S.M. is
funded by the project IF/00930/2013/ CP1184/CT0002 from FCT. This work was
also funded by the Porto Neurosciences and Neurologic Disease Research Initiative
at the Instituto de Investigação e Inovação em Saúde (Norte-01-0145-FEDER-
000008), supported by Norte Portugal Regional Operational Programme (NORTE
2020), under the PORTU- GAL 2020 Partnership Agreement with FEDER
Transport Spectroscopy of Symmetry-Broken Insulating States in Bilayer Graphene
The flat bands in bilayer graphene(BLG) are sensitive to electric fields
E\bot directed between the layers, and magnify the electron-electron
interaction effects, thus making BLG an attractive platform for new
two-dimensional (2D) electron physics[1-5]. Theories[6-16] have suggested the
possibility of a variety of interesting broken symmetry states, some
characterized by spontaneous mass gaps, when the electron-density is at the
carrier neutrality point (CNP). The theoretically proposed gaps[6,7,10] in
bilayer graphene are analogous[17,18] to the masses generated by broken
symmetries in particle physics and give rise to large momentum-space Berry
curvatures[8,19] accompanied by spontaneous quantum Hall effects[7-9]. Though
recent experiments[20-23] have provided convincing evidence of strong
electronic correlations near the CNP in BLG, the presence of gaps is difficult
to establish because of the lack of direct spectroscopic measurements. Here we
present transport measurements in ultra-clean double-gated BLG, using
source-drain bias as a spectroscopic tool to resolve a gap of ~2 meV at the
CNP. The gap can be closed by an electric field E\bot \sim13 mV/nm but
increases monotonically with a magnetic field B, with an apparent particle-hole
asymmetry above the gap, thus providing the first mapping of the ground states
in BLG.Comment: 4 figure
Single valley Dirac fermions in zero-gap HgTe quantum wells
Dirac fermions have been studied intensively in condensed matter physics in
recent years. Many theoretical predictions critically depend on the number of
valleys where the Dirac fermions are realized. In this work, we report the
discovery of a two dimensional system with a single valley Dirac cone. We study
the transport properties of HgTe quantum wells grown at the critical thickness
separating between the topologically trivial and the quantum spin Hall phases.
At high magnetic fields, the quantized Hall plateaus demonstrate the presence
of a single valley Dirac point in this system. In addition, we clearly observe
the linear dispersion of the zero mode spin levels. Also the conductivity at
the Dirac point and its temperature dependence can be understood from single
valley Dirac fermion physics.Comment: version 2: supplementary material adde
Preliminary report of a gas conditioner to improve operational reliability of cryotherapy in developing countries
BACKGROUND: Cryotherapy is a safe, affordable, and effective method of treatment for cervical intraepithelial neoplasia. In some low-resource settings, environmental conditions or qualities of the refrigerant gas can lead to blockage of cryotherapy equipment, terminating treatment. A prototype of a gas conditioner to prevent operational failure was designed, built, and field tested. METHODS: The prototype conditioner device consists of an expansion chamber that filters and dries the refrigerant gas. Users in Peru and Kenya reported on their experience with the prototype conditioner. In Ghana, simulated cryotherapy procedures were used to test the effects of the prototype conditioner, as well as the commonly used "cough technique." RESULTS: Anecdotal reports from field use of the device were favorable. During simulated cryotherapy, the prevalence of blockage during freezing were 0% (0/25) with the device alone, 23.3% (7/30) with the cough technique alone, 5.9% (1/17) with both, and 55.2% (16/29) with neither (Pearson's Chi square = 26.6, df = 3, p < 0.001 (comparison amongst all groups)). CONCLUSION: This prototype design of a cryotherapy gas conditioner is a potential solution for low-resource settings that are experiencing cryotherapy device malfunction
Gate-tuned normal and superconducting transport at the surface of a topological insulator
Three-dimensional topological insulators are characterized by the presence of
a bandgap in their bulk and gapless Dirac fermions at their surfaces. New
physical phenomena originating from the presence of the Dirac fermions are
predicted to occur, and to be experimentally accessible via transport
measurements in suitably designed electronic devices. Here we study transport
through superconducting junctions fabricated on thin Bi2Se3 single crystals,
equipped with a gate electrode. In the presence of perpendicular magnetic field
B, sweeping the gate voltage enables us to observe the filling of the Dirac
fermion Landau levels, whose character evolves continuously from electron- to
hole-like. When B=0, a supercurrent appears, whose magnitude can be gate tuned,
and is minimum at the charge neutrality point determined from the Landau level
filling. Our results demonstrate how gated nano-electronic devices give control
over normal and superconducting transport of Dirac fermions at an individual
surface of a three-dimensional topological insulator.Comment: 28 pages, 5 figure
Reforming EIA systems : a critical review of proposals in Brazil.
Environmental Impact Assessment (EIA) systems are under pressure in many countries, driven by a call for efficiency
and streamlining. Such a phenomenon is particularly clear in Brazil,where, in the past fewyears, a number
of influential associations put forward documents proposing significant changes to environmental licensing and
impact assessment regulations. So far, there is no publicly available information about any initiative towards
scrutinizing those proposals. The objective of this study was to critically review the merits and drawbacks of
the changes proposed in those documents. The analysis triangulated content analysis, focus group and online survey
data. The focus group included ten seasoned Brazilian EIA specialists; the survey, based on Likert-scale and
open-ended questions, resulted in 322 valid responses from EIA professionals. Results show that the proposals
generally agree that the current EIA system, while playing a key role in mitigating impacts and enhancing project
design, needs many changes.Nonetheless, the proposals neither offered solutions to overcomepolitical, technical
and budget barriers, nor established a sense of priority of the most urgent issues. Findings from the focus group
and the survey signaled that a number of proposed actions might face public outcry, and that those changes that
do not depend on legislative action are more likely to be implementable. Previous studies about EIA reform focused
mostly on the context of developed countries after changes had taken place. This study, while addressing
the perspective of a large developing country in a ?before-reform? stage, shows that capacity-building is a key requirement
in EIA reform
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