MobileBrick: building LEGO for 3D reconstruction on mobile devices

High-quality 3D ground-truth shapes are critical for 3D object reconstruction evaluation. However, it is difficult to create a replica of an object in reality, and even 3D reconstructions generated by 3D scanners have artefacts that cause biases in evaluation. To address this issue, we introduce a novel multi-view RGBD dataset captured using a mobile device, which includes highly precise 3D ground-truth annotations for 153 object models featuring a diverse set of 3D structures. We obtain precise 3D ground-truth shape without relying on high-end 3D scanners by utilising LEGO models with known geometry as the 3D structures for image capture. The distinct data modality offered by high-resolution RGB images and low-resolution depth maps captured on a mobile device, when combined with precise 3D geometry annotations, presents a unique opportunity for future research on high-fidelity 3D reconstruction. Furthermore, we evaluate a range of 3D reconstruction algorithms on the proposed dataset

Effect of cough technique and cryogen gas on temperatures achieved during simulated cryotherapy

<p>Abstract</p> <p>Background</p> <p>Cryotherapy is often used to treat cervical precancer in developing countries. There are different methods and cryogen gases used for cryotherapy, including the freeze-flush-freeze (cough) technique employed to minimize gas blockage. However, there is limited information to compare their effectiveness.</p> <p>Methods</p> <p>Using a tissue model, we compared temperature-time curves for four cryotherapy methods: uninterrupted freezing with nitrous oxide (N₂O) and carbon dioxide (CO₂), and two methods using a standard and extended version of the cough technique with CO₂.</p> <p>Results</p> <p>Uninterrupted freezing with both N₂O and CO₂produced tissue temperatures less than -20°C (-40°C and -30°C respectively). CO₂cryotherapy procedures using the two cough techniques produced temperatures greater than -20°C in the model tissue.</p> <p>Conclusion</p> <p>CO₂cryotherapy using the cough technique may not achieve sufficiently low temperatures to produce the desired therapeutic effect. Other alternatives to the prevention of gas blockage should be developed.</p

Evolutionarily conserved and diverged alternative splicing events show different expression and functional profiles

To better decipher the functional impact of alternative splicing, we classified alternative splicing events in 10 818 pairs of human and mouse genes based on conservation at genome and transcript levels. Expression levels of conserved alternative splices in human and mouse expressed sequence tag databases show strong correlation, indicating that alternative splicing is similarly regulated in both species. A total of 43% (8921) of mouse alternative splices could be found in the human genome but not in human transcripts. Five of eleven tested mouse predictions were observed in human tissues, demonstrating that mouse transcripts provide a valuable resource for identifying alternative splicing events in human genes. Combining gene-specific measures of conserved and diverged alternative splicing with both gene classification based on Gene Ontology (GO) and microarray-determined gene expression in 52 diverse human tissues and cell lines, we found conserved alternative splicing most enriched in brain-expressed signaling pathways. Diverged alternative splicing is more prevalent in testis and cancerous cell line up-regulated processes, including protein biosynthesis, responses to stress and responses to endogenous stimuli. Using conservation as a surrogate for functional significance, these results suggest that alternative splicing plays an important role in enhancing the functional capacity of central nervous systems, while non-functional splicing more frequently occurs in testis and cell lines, possibly as a result of cellular stress and rapid proliferation

Long term improvements in activities of daily living in patients with hemispatial neglect

No abstract available

Demand-side factors related to the registration of births, marriages, and deaths : a literature review

This report considers civil registration throughout life, and includes evidence from interventions aimed at improving registration at multiple levels. Strategies include greater integration of birth registration within existing health services, such as immunization and the use of multimedia campaigns. Demand-side barriers are defined as those that influence demand, operating at individual, household, and community levels. Less than 50 percent of all births are registered in Africa (UNICEF 2019), and evidence suggests that disparities in registration in the region are linked to social inequalities. The scope and implications of under-registration are wide ranging.Global Affairs Canad

Facteurs de demande liés à l’enregistrement des naissances, des mariages et des décès : revue de la littérature

Affaires mondiales Canad

Development of a single-board computer high-resolution microendoscope (PiHRME) to increase access to cervical cancer screening in underserved areas

Over 85% of cervical cancer deaths occur in developing countries.1 Even though the early detection and treatment of cervical precancerous lesions has been shown to prevent invasive cervical cancer, limited resources make it difficult to implement standard cervical cancer screening methods, such as the Pap Smear, in low-resource areas. Instead, many developing countries rely on the visual inspection of the cervix with acetic acid (VIA) to help identify precancerous and cancerous lesions. While VIA has a high sensitivity (82.14%), it has a poor specificity (50.00%), resulting in the overtreatment of women and misallocation of limited resources.2 Recent studies have shown that combining VIA with high-resolution microendoscope (HRME) imaging increases the specificity of cervical cancer screening.3-4 The HRME is a low-cost imaging system (~$2,100) that allows the user to image epithelial tissue in vivo at sub-cellular resolutions at the point-of-care. The current HRME imaging system is also accompanied with automatic image analysis software to distinguish normal and low-grade lesions from high-grade precancerous and cancerous lesions of the cervix. Please click Additional Files below to see the full abstract

Treatment of cervical intraepithelial lesions

Precancerous cervical lesions precede the development of invasive cervical cancer by 10–20 years, making cervical cancer preventable if these lesions are detected and effectively treated. Treatment has evolved in the last few decades and now includes ablative options that can be performed in lower‐resource settings where surgical excision is not feasible or routinely available. Gas‐based cryotherapy, which freezes cervical tissue to induce localized necrosis, is the most commonly used ablative treatment. However, its implementation in low‐resource settings is difficult because the refrigerant gas can be difficult to procure and transport, and is expensive. New cryotherapy devices that do not require an external supply of gas appear promising. Thermal coagulation, which burns cervical tissue to induce necrosis, has become more widely available in the last few years owing to its portability and the feasibility of using battery‐powered devices. These two ablative treatments successfully eradicate 75%–85% of high‐grade cervical lesions and have minor adverse effects

The evolving definition of carcinogenic human papillomavirus

Thirteen human papillomavirus (HPV) genotypes have been judged to be carcinogenic or probably carcinogenic, and the cause of virtually all cervical cancer worldwide. Other HPV genotypes could possibly be involved. Although the inclusion of possibly carcinogenic HPV genotypes may hurt test specificity, it may indirectly increase the reassurance following a negative HPV test (i.e. the negative predictive value of an HPV test for cervical precancer and cancer). The future of cervical cancer screening in low-resource setting, however, may include once-in-a-lifetime, low-cost and rapid HPV testing. However, the tradeoff of more false positives for greater reassurance may not be acceptable if the local infrastructure cannot manage the screen positives. Now is the time for the community of scientists, doctors, and public health advocates to use the data presented at the 100th International Agency for Research on Cancer monograph meeting to rationally decide the target HPV genotypes for the next generation of HPV tests for use in high-resource and low-resource settings. The implications of including possibly HPV genotypes on HPV test performance, also for guidance on the use of these tests for cervical cancer prevention programs, are discussed

Real-world data on cervical cancer risk stratification by cytology and HPV genotype to inform the management of HPV-positive women in routine cervical screening

Background HPV16/18 detection may improve cervical cancer risk stratification and better guide which HPV-positive women warrant immediate colposcopy/biopsy. We estimated risks of cervical precancer and cancer by HPV genotype and cytology during the implementation phase of primary HPV testing in Norway. Methods A total of 3111 women, aged 34–69 years, testing HPV-positive at baseline and undergoing cytology testing from February 2015 to April 2018 had data available for analysis. Risk estimates with 95% confidence intervals (95%CIs) of cervical intraepithelial neoplasia grade 3 or more severe (CIN3+) were estimated for cytology results and HPV genotypes (HPV16, HPV18, and other high-risk HPV). Results CIN3+ risks were higher for HPV16/18 than other high-risk HPV genotypes. Among women with any cytologic abnormality [atypical squamous cells of undetermined significance or worse], immediate risks were 57.8% (95%CI = 53.0–62.6%) for HPV16, 40.2% (95%CI = 32.3–49.2%) for HPV18, and 31.4% (95%CI = 28.7–34.3%) for other high-risk HPV. Among those with normal cytology, CIN3+ risks were 19.9% (95%CI = 15.0–26.1%) for HPV16 positives, 10.8% (95%CI = 5.6–20.5%) for HPV18 positives, and 5.5% (95%CI = 4.2–7.1%) for other high-risk HPV. Conclusions The benefits and harms of managing women based on HPV positivity and cytology results can be better balanced by inclusion of HPV genotyping in screening and choosing more conservative management for other high-risk HPV compared to HPV16/18.publishedVersio