An economic evaluation of salt reduction policies to reduce coronary heart disease in England: a policy modeling study

AbstractObjectivesDietary salt intake has been causally linked to high blood pressure and increased risk of cardiovascular events. Cardiovascular disease causes approximately 35% of total UK deaths, at an estimated annual cost of £30 billion. The World Health Organization and the National Institute for Health and Care Excellence have recommended a reduction in the intake of salt in people's diets. This study evaluated the cost-effectiveness of four population health policies to reduce dietary salt intake on an English population to prevent coronary heart disease (CHD).MethodsThe validated IMPACT CHD model was used to quantify and compare four policies: 1) Change4Life health promotion campaign, 2) front-of-pack traffic light labeling to display salt content, 3) Food Standards Agency working with the food industry to reduce salt (voluntary), and 4) mandatory reformulation to reduce salt in processed foods. The effectiveness of these policies in reducing salt intake, and hence blood pressure, was determined by systematic literature review. The model calculated the reduction in mortality associated with each policy, quantified as life-years gained over 10 years. Policy costs were calculated using evidence from published sources. Health care costs for specific CHD patient groups were estimated. Costs were compared against a “do nothing” baseline.ResultsAll policies resulted in a life-year gain over the baseline. Change4life and labeling each gained approximately 1960 life-years, voluntary reformulation 14,560 life-years, and mandatory reformulation 19,320 life-years. Each policy appeared cost saving, with mandatory reformulation offering the largest cost saving, more than £660 million.ConclusionsAll policies to reduce dietary salt intake could gain life-years and reduce health care expenditure on coronary heart disease

Resilience and performance of wine cooperatives in Castilla La-Mancha (Spain) during a period of financial crisis

The economic crisis has had an asymmetric effect on Spanish and regional/local economies. This study aims to analyze the strategies developed by cooperative wineries in Castilla-La Mancha (CLM) and their impact on performance measurements. The paper opted for an exploratory study based on a compilation of financial statements consisting of the traditional economic-financial profitability ratios (ROA, ROI, ROS) plus a specific analysis, Return of Owner Cooperative (ROC). We have also used two financial measurements: Liquidity and Leverage. Trade dynamism is the hallmark of wine cooperatives in CLM in terms of strategic action in the face of a crisis. Their resilience is patent in the conquest of foreign markets via low unit costs, which have been transferred to sales prices. The paper has implications for the understanding of the resilience of the agricultural cooperatives during the crisis period in question. The consistency of the results provides a context to promote the cooperative model as an essential factor in the social economy. This paper fulfils an identified need to show the cooperative model as a resilient one in the agricultural field and in the context of rural development. Highlights: Cooperative wineries contribute to economic and social development in Castilla La Mancha (Spain). Social economy companies withstood the crisis better due to their objective function (maximizing cooperative owners’ income) and thanks to their flexibility in terms of grape payment policies. The Return of Owner Cooperative (ROC) measures the transfer of income to farmers and is higher than the payment they would receive from other agents. The cooperative wineries have reacted to the crisis with good financial indicators: liquidity and leverage. The cooperative wineries have adopted a strategy based on exports that has allowed them to overcome the economic crisis.The economic crisis has had an asymmetric effect on Spanish and regional/local economies. This study aims to analyze the strategies developed by cooperative wineries in Castilla-La Mancha (CLM) and their impact on performance measurements. The paper opted for an exploratory study based on a compilation of financial statements consisting of the traditional economic-financial profitability ratios (ROA, ROI, ROS) plus a specific analysis, Return of Owner Cooperative (ROC). We have also used two financial measurements: Liquidity and Leverage. Trade dynamism is the hallmark of wine cooperatives in CLM in terms of strategic action in the face of a crisis. Their resilience is patent in the conquest of foreign markets via low unit costs, which have been transferred to sales prices. The paper has implications for the understanding of the resilience of the agricultural cooperatives during the crisis period in question. The consistency of the results provides a context to promote the cooperative model as an essential factor in the social economy. This paper fulfils an identified need to show the cooperative model as a resilient one in the agricultural field and in the context of rural development. Highlights: Cooperative wineries contribute to economic and social development in Castilla La Mancha (Spain). Social economy companies withstood the crisis better due to their objective function (maximizing cooperative owners’ income) and thanks to their flexibility in terms of grape payment policies. The Return of Owner Cooperative (ROC) measures the transfer of income to farmers and is higher than the payment they would receive from other agents. The cooperative wineries have reacted to the crisis with good financial indicators: liquidity and leverage. The cooperative wineries have adopted a strategy based on exports that has allowed them to overcome the economic crisis

Tuning the distance to the equipartition by controlling the collision rate in a driven granular gas experiment

In a granular gas experiment of magnetized particles confined in a thin layer, the rate of dissipative collisions is tuned by adjusting the amplitude of an external magnetic field. The velocity statistics are analyzed using the dynamic and static structure factors of transverse velocity modes. Using the fluctuating hydrodynamics theory we measure the deviation from kinetic energy equipartition in this out-of-equilibrium system as a function of the dissipative collision rate. When the collision rate is decreased, the distance to equipartition becomes smaller meaning that the dynamical properties of this granular gas approach by analogy those of a molecular gas in thermal equilibrium.Comment: 9 pages, 4 figures Accepted to Physical Review

Optimizing a magnetic resonance care pathway : a strategy for radiography managers

This study reports the optimization of a local MR care pathway. A search of the literature did not result in any studies regarding the optimization of MRI care pathways through a formal research process. Discussions with international MR radiographers indicated that such development is often carried out using informal methods that are highly dependent on local conditions, that are rarely reported in the public domain and the validities of which are therefore not open to scrutiny; in addition, care pathways need to be specific to local healthcare needs and culture. In this study, the authors propose a formal documented methodology for developing a local MRI care pathway based on the well-established nominal group technique.peer-reviewe

Practical recommendations for hyperspectral and thermal proximal disease sensing in potato and leek fields

Thermal and hyperspectral proximal disease sensing are valuable tools towards increasing pesticide use efficiency. However, some practical aspects of the implementation of these sensors remain poorly understood. We studied an optimal measurement setup combining both sensors for disease detection in leek and potato. This was achieved by optimising the signal-to-noise ratio (SNR) based on the height of measurement above the crop canopy, off-zenith camera angle and exposure time (ET) of the sensor. Our results indicated a clear increase in SNR with increasing ET for potato. Taking into account practical constraints, the suggested setup for a hyperspectral sensor in our experiment involves (for both leek and potato) an off-zenith angle of 17 degrees, height of 30 cm above crop canopy and ET of 1 ms, which differs from the optimal setup of the same sensor for wheat. Artificial light proved important to counteract the effect of cloud cover on hyperspectral measurements. The interference of these lamps with thermal measurements was minimal for a young leek crop but increased in older leek and after long exposure. These results indicate the importance of optimising the setup before measurements, for each type of crop

The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host

African horse sickness (AHS) is a lethal equine disease transmitted by Culicoides biting midges and caused by African horse sickness virus (AHSV). AHS is endemic to sub-Saharan Africa, but devastating outbreaks have been recorded periodically outside this region. The perceived risk of an AHS outbreak occurring in Europe has increased following the frequent epidemics caused in ruminants by bluetongue virus, closely related to AHSV. Attenuated vaccines for AHS are considered unsuitable for use in non-endemic countries due bio-safety concerns. Further, attenuated and inactivated vaccines are not compatible with DIVA (differentiate infected from vaccinated animals) strategies. All these factors stimulated the development of novel AHS vaccines that are safer, more efficacious and DIVA compatible. We showed previously that recombinant modified Vaccinia Ankara virus (MVA) vaccines encoding the outer capsid protein of AHSV (AHSV-VP2) induced virus neutralising antibodies (VNAb) and protection against AHSV in a mouse model and also in the horse. Passive immunisation studies demonstrated that immunity induced by MVA-VP2 was associated with pre-challenge VNAb titres in the vaccinates. Analyses of the inoculum of these MVA-VP2 experimental vaccines showed that they contained pre-formed AHSV-VP2. We continued studying the influence of pre-formed AHSV-VP2, present in the inoculum of MVA-VP2 vaccines, in the immunogenicity of MVA-VP2 vaccines. Thus, we compared correlates of immunity in challenged mice that were previously vaccinated with: a) MVA-VP2 (live); b) MVA-VP2 (live and sucrose gradient purified); c) MVA-VP2 (UV light inactivated); d) MVA-VP2 (UV light inactivated and diluted); e) MVA-VP2 (heat inactivated); f) MVA-VP2 (UV inactivated) + MVA-VP2 (purified); g) MVA-VP2 (heat inactivated) + MVA-VP2 (purified); and h) wild type-MVA (no insert). The results of these experiments showed that protection was maximal using MVA-VP2 (live) vaccine and that the protection conferred by all other vaccines correlated strongly with the levels of pre-formed AHSV-VP2 in the vaccine inoculum

Quantum refrigeration powered by noise in a superconducting circuit

While dephasing noise frequently presents obstacles for quantum devices, it can become an asset in the context of a Brownian-type quantum refrigerator. Here we demonstrate a novel quantum thermal machine that leverages noise-assisted quantum transport to fuel a cooling engine in steady state. The device exploits symmetry-selective couplings between a superconducting artificial molecule and two microwave waveguides. These waveguides act as thermal reservoirs of different temperatures, which we regulate by employing synthesized thermal fields. We inject dephasing noise through a third channel that is longitudinally coupled to an artificial atom of the molecule. By varying the relative temperatures of the reservoirs, and measuring heat currents with a resolution below 1 aW, we demonstrate that the device can be operated as a quantum heat engine, thermal accelerator, and refrigerator. Our findings open new avenues for investigating quantum thermodynamics using superconducting quantum machines coupled to thermal microwave waveguides