Gestión del manejo integral de los desechos sólidos en el hospital Alemán Nicaragüense de Managua

Key words: hospital solid waste, managementDOI: 10.5377/nexo.v23i2.238Nexo: Revista Científica Vol. 23, No. 02, pp.53-61/Nov 2010La gestión de los desechos sólidos hospitalarios (DSH) del Hospital Alemán Nicaragüense (HAN) fue estudiada. El objetivo general propuesto fue un sistema de gestión de los desechos sólidos hospitalarios (comunes y peligrosos sin incluir los radiactivos), generados en el HAN. Se efectuó la cuantificación de los DSH durante el periodo de muestreo, elaboración de un listado de los DSH, se identificaron problemas existentes en el manejo actual de éstos desechos, y se elaboró una propuesta de plan de manejo seguro de los mismos, la que contempla: Plan integral de manejo de DSH que incluye todos los desechos (comunes y peligrosos, sin incluir los radiactivos), una propuesta de equipo adecuado para recolección y transporte interno y externo de DSH; propuesta de construcción de depósito para almacenamiento temporal interno de los DSH; y una propuesta de sistema de tratamiento y disposición final alternativo para los DSH/P generados en el HAN.Palabras Clave: desechos sólidos hospitalarios; gestión; manejoDOI: http://dx.doi.org/10.5377/nexo.v23i2.238Nexo: Revista Científica Vol. 23, No. 02, pp.53-61/Nov 2010

Tensión de chispa con impulsos atmosféricos de polaridad positiva para distancias de aislamiento cortas, utilizando electrodos punta-punta y punta-placa

Se presenta el resultado de un estudio para determinar expresiones analíticas que relacionan latensión de chispa (V 50y) del aislamiento bajo el aire con la distancia de separación interelectródica(hasta 85 cm). utilizando impulsos atmosféricos normalizados. Estas expresiones podrán serempleadas en el sistema eléctrico colombiano a las condiciones atmosféricas del sitio de ubicaciónde los equipos y aplicables a distancias cortas. Se uülizó la metodología IIUp and down" paradeterminar la V 5O% y el método de la máxJma verosimilitud para su tratamiento estadístico. Elestudio se efectuó utilizando las configuraciones punta-punta y punta placa normalizadas.  We present the results of a study to determine analytical expressions that relate the spark voltage (V50%) of the insulation under the air to the inter electronic separation distance (up to 85 cm). Using standard atmospheric pulses. These expressions may be used in the Colombian electrical system to the atmospheric conditions of the location of the equipment and applicable to short distances. The "Up and down" methodology was used to determine the VJO% and the maximum likelihood method for its statistical treatment. The study was carried out using the tip-tip and tip-standard configurations

Mechanical properties of freely suspended semiconducting graphene-like layers based on MoS2

We fabricate freely suspended nanosheets of molybdenum disulphide (MoS2) which are characterized by quantitative optical microscopy and high-resolution friction force microscopy. We study the elastic deformation of freely suspended nanosheets of MoS2 using an atomic force microscope. The Young's modulus and the initial pre-tension of the nanosheets are determined by performing a nanoscopic version of a bending test experiment. MoS2 sheets show high elasticity and an extremely high Young's modulus (0.30 TPa, 50% larger than steel). These results make them a potential alternative to graphene in applications requiring flexible semiconductor materials

Vortex states in 2D superconductor at high magnetic field in a periodic pinning potential

The effect of a periodic pinning array on the vortex state in a 2D superconductor at low temperatures is studied within the framework of the Ginzburg-Landau approach. It is shown that attractive interaction of vortex cores to a commensurate pin lattice stabilizes vortex solid phases with long range positional order against violent shear fluctuations. Exploiting a simple analytical method, based on the Landau orbitals description, we derive a rather detailed picture of the low temperatures vortex state phase diagram. It is predicted that for sufficiently clean samples application of an artificial periodic pinning array would enable one to directly detect the intrinsic shear stiffness anisotropy characterizing the ideal vortex lattice.Comment: 8 pages, 5 figure

Noiseless nonreciprocity in a parametric active device

Nonreciprocal devices such as circulators and isolators belong to an important class of microwave components employed in applications like the measurement of mesoscopic circuits at cryogenic temperatures. The measurement protocols usually involve an amplification chain which relies on circulators to separate input and output channels and to suppress backaction from different stages on the sample under test. In these devices the usual reciprocal symmetry of circuits is broken by the phenomenon of Faraday rotation based on magnetic materials and fields. However, magnets are averse to on-chip integration, and magnetic fields are deleterious to delicate superconducting devices. Here we present a new proposal combining two stages of parametric modulation emulating the action of a circulator. It is devoid of magnetic components and suitable for on-chip integration. As the design is free of any dissipative elements and based on reversible operation, the device operates noiselessly, giving it an important advantage over other nonreciprocal active devices for quantum information processing applications.Comment: 17 pages, 4 figures + 12 pages Supplementary Informatio

Two-dimensional materials for improved resolution in total internal reflection fluorescence microscopy

We propose and theoretically demonstrate that two-dimensional materials at the interface between glass and water layers in a total internal reflection fluorescence microscopy (TIRFM) technique can decrease the detection volume of a target sample, and hence improve the resolution of the obtained image. In particular, we calculate the change in fluorescence characteristics of the fluorophore labels on a target sample when monolayer black phosphorus, hexagonal boron nitride, and graphene are added at the glass-water interface of a TIRFM structure. We also calculate the change in the detection volume due to the presence of two-dimensional materials, and when the polarization, wavelength, and angle of the incident light vary. We find $\gtrsim$ 10% and $\gtrsim$ 5% decrease in the detection volume when monolayer black phosphorus and hexagonal boron nitride are used, respectively, and up to  ~50% decrease when monolayer graphene is used. The proposed use of the two-dimensional material will significantly improve the resolution of TIRFM technique, and hence facilitate the study of nanoscale biological features

Strongly anisotropic spin relaxation in graphene/transition metal dichalcogenide heterostructures at room temperature

Graphene has emerged as the foremost material for future two-dimensional spintronics due to its tuneable electronic properties. In graphene, spin information can be transported over long distances and, in principle, be manipulated by using magnetic correlations or large spin-orbit coupling (SOC) induced by proximity effects. In particular, a dramatic SOC enhancement has been predicted when interfacing graphene with a semiconducting transition metal dechalcogenide, such as tungsten disulphide (WS$_2$). Signatures of such an enhancement have recently been reported but the nature of the spin relaxation in these systems remains unknown. Here, we unambiguously demonstrate anisotropic spin dynamics in bilayer heterostructures comprising graphene and WS$_2$. By using out-of-plane spin precession, we show that the spin lifetime is largest when the spins point out of the graphene plane. Moreover, we observe that the spin lifetime varies over one order of magnitude depending on the spin orientation, indicating that the strong spin-valley coupling in WS$_2$ is imprinted in the bilayer and felt by the propagating spins. These findings provide a rich platform to explore coupled spin-valley phenomena and offer novel spin manipulation strategies based on spin relaxation anisotropy in two-dimensional materials

CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes

CD69 is a transmembrane lectin that can be expressed on most hematopoietic cells. In monocytes, it has been functionally linked to the 5-lipoxygenase pathway in which the leukotrienes, a class of highly potent inflammatory mediators, are produced. However, regarding CD69 gene expression and its regulatory mechanisms in monocytes, only scarce data are available. Here, we report that CD69 mRNA expression, analogous to that of 5-lipoxygenase, is induced by the physiologic stimuli transforming growth factor-β (TGF-β) and 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) in monocytic cells. Comparison with T- and B-cell lines showed that the effect was specific for monocytes. CD69 expression levels were increased in a concentration-dependent manner, and kinetic analysis revealed a rapid onset of mRNA expression, indicating that CD69 is a primary TGF-β/1α,25(OH)2D3 target gene. PCR analysis of different regions of the CD69 mRNA revealed that de novo transcription was initiated and proximal and distal parts were induced concomitantly. In common with 5-lipoxygenase, no activation of 0.7 kb or ~2.3 kb promoter fragments by TGF-β and 1α,25(OH)2D3 could be observed in transient reporter assays for CD69. Analysis of mRNA stability using a transcription inhibitor and a 3′UTR reporter construct showed that TGF-β and 1α,25(OH)2D3 do not influence CD69 mRNA stability. Functional knockdown of Smad3 clearly demonstrated that upregulation of CD69 mRNA, in contrast to 5-LO, depends on Smad3. Comparative studies with different inhibitors for mitogen activated protein kinases (MAPKs) revealed that MAPK signalling is involved in CD69 gene regulation, whereas 5-lipoxygenase gene expression was only partly affected. Mechanistically, we found evidence that CD69 gene upregulation depends on TAK1-mediated p38 activation. In summary, our data indicate that CD69 gene expression, conforming with 5-lipoxygenase, is regulated monocyte-specifically by the physiologic stimuli TGF-β and 1α,25(OH)2D3 on mRNA level, although different mechanisms account for the upregulation of each gene

Anisotropic vortex pinning in superconductors with a square array of rectangular submicron holes

We investigate vortex pinning in thin superconducting films with a square array of rectangular submicron holes ("antidots"). Two types of antidots are considered: antidots fully perforating the superconducting film, and "blind antidots", holes that perforate the film only up to a certain depth. In both systems, we observe a distinct anisotropy in the pinning properties, reflected in the critical current Ic, depending on the direction of the applied electrical current: parallel to the long side of the antidots or perpendicular to it. Although the mechanism responsible for the effect is very different in the two systems, they both show a higher critical current and a sharper IV-transition when the current is applied along the long side of the rectangular antidots

Mixtures of independent component analyzers for EEG prediction

This paper presents a new application of independent component analysis mixture modeling (ICAMM) for prediction of electroencephalographic (EEG) signals. Demonstrations in prediction of missing EEG data in a working memory task using classic methods and an ICAMM-based algorithm are included. The performance of the methods is measured by using four error indicators: signal-to-interference (SIR) ratio, Kullback-Leibler divergence, correlation at lag zero and mean structural similarity index. The results show that the ICAMM-based algorithm outperforms the classical spherical splines method which is commonly used in EEG signal processing. Hence, the potential of using mixtures of independent component analyzers (ICAs) to improve prediction, as opposed on estimating only one ICA is demonstrated.This work has been supported by Generalitat Valenciana under grants PROMETEO/2010/040 and ISIC/2012/006Safont Armero, G.; Salazar Afanador, A.; Vergara Domínguez, L.; Gonzalez, A.; Vidal Maciá, AM. (2012). Mixtures of independent component analyzers for EEG prediction. En Green and smart technology with sensor applications. Springer Verlag (Germany). 338:328-335. doi:10.1007/978-3-642-35251-5_46S328335338Common, P., Jutten, C.: Handbook of Blind Source Separation: Independent Component Analysis and Applications. Academic Press, USA (2010)Salazar, A., Vergara, L., Serrano, A., Igual, J.: A general procedure for learning mixtures of independent component analyzers. Pattern Recognition 43(1), 69–85 (2010)Lee, T.W., Lewicki, M.S., Sejnowski, T.J.: ICA mixture models for unsupervised classification of non-gaussian classes and automatic context switching in blind signal separation. IEEE Transactions on Pattern Analysis and Machine Intelligence 22(10), 1078–1089 (2000)Salazar, A., Vergara, L.: ICA mixtures applied to ultrasonic nondestructive classification of archaeological ceramics. Eurasip Journal on Advances in Signal Processing 2010, article ID 125201, 11 pages (2010), doi:10.1155/2010/125201Klein, C., Feige, B.: An independent component analysis (ICA) approach to the study of developmental differences in the saccadic contingent negative variation. Biological Psychology 70, 105–114 (2005)Makeig, S., Westerfield, M., Jung, T.P., Covington, J., Townsend, J., Sejnowski, T.J., Courchesne, E.: Functionally Independent Components of the Late Positive Event-Related Potential during Visual Spatial Attention. Journal of Neuroscience 19(7), 2665–2680 (1999)Wibral, M., Turi, G., Linden, D.E.J., Kaiser, J., Bledowski, C.: Decomposition of working memory-related scalp ERPs: Crossvalidation of fMRI-constrained source analysis and ICA. Internt J. of Psychol. 67, 200–211 (2008)Castellanos, N.P., Makarov, V.A.: Recovering EEG brain signals: Artifact suppression with wavelet enhanced independent component analysis. Journal of Neuroscience Methods 158, 300–312 (2006)Salazar, A., Vergara, L., Miralles, R.: On including sequential dependence in ICA mixture models. Signal Processing 90, 2314–2318 (2010)Dayan, P., Abbot, L.F.: Theoretical neuroscience: computational and mathematical modeling of neural systems. The MIT Press (2001)Sternberg, S.: High-speed scanning in human memory. Science 153(3736), 652–654 (1966)Raghavachari, S., Lisman, J.E., Tully, M., Madsen, J.R., Bromfield, E.B., Kahana, M.J.: Theta oscillations in human cortex during a working-memory task: evidence for local generators. J. of Neurophys. 95, 1630–1638 (2006)Gorriz, J.M., Puntonet, C.G., Salmeron, G., Lang, E.W.: Time series prediction using ICA algorithms. In: Proc. of 2nd IEEE Internat. W. on Intellig Data Acquisition and Advanc. Comp. Systems: Tech. and App., pp. 226–230 (2003)Lin, C.-T., Cheng, W.-C., Liang, S.-F.: An On-line ICA-Mixture-Model-Based Self-Constructing Fuzzy Neural Network. IEEE Transactions on Circuits and Systems I: Regular Papers 52(1), 207–221 (2005)Lee, T.W., Girolami, M., Sejnowski, T.J.: Independent component analysis using an extended InfoMax algorithm for mixed sub-gaussian and super-gaussian sources. Neural Computation 11(2), 417–441 (1999)Perrin, F., Pernier, J., Bertrand, D., Echallier, J.F.: Spherical splines for scalp potential and current density matching. Electroencep. and Clin. Neurophys. 72, 184–187 (1989)Wang, Z., Bovik, A., Sheikh, H., Simoncelli, E.: Image quality assessment: from error visibility to structural similarity. IEEE Transactions on Image Processing 13(4), 600–612 (2004