Biblioteca América, presente y futuro del sueño de un visionario emigrante gallego

Coloquio internacional “Setenta años de Cuadernos Americanos: migración y exilio español republicano (1942-2012)

La biblioteca universitaria de Santiago de Compostela

[ES] En este artículo se describe el origen de la Biblioteca de la Universidad de Santiago de Compostela, una de las universidades más antiguas de España. Su origen se remonta al siglo XVI, en la Librería de la Universidad y continúa con algunos avatares en el siglo XVII, con el esplendor de la biblioteca en el siglo XVIII, con el engrosamiento de fondos en el XIX, y con tres hitos importantes en el XX. También se describen los fondos que contiene y qué se está haciendo en la actualidad con miras al futuro

Minerva, o Repositorio Institucional da USC : xornadas formativas

Presentación empregada nas diversas sesións de difusión do repositorio institucional da USC, Minerva que tiveron lugar en 201

DIA INTERNACIONAL DAS MULLERES 2019 Acto de recoñecemento á BUSC pola súa traxectoria en prol da igualdade de xénero

Discurso pronunciado o 7 de marzo de 2019 no Acto de recoñecemento á Biblioteca Universitaria da USC pola súa traxectoria en prol da igualdade de xénero

Relation between habitual sleep duration and depressed mood state: somatic versus cognitive symptoms

The present ex post facto prospective investigation analyses the association between habitual sleep duration and depressed mood state in college students. The sample was composed of 141 healthy students of both sexes, 19 with short sleep pattern (sleeping 6 hours or less per night), 64 with intermediate sleep pattern (sleeping 7-8 hours per night) and 58 with long sleep pattern (sleeping more than 9 hours per night). Depressed mood was evaluated with the Beck´s Depression Inventory (BDI) and the depression subscale of the General Health Questionnaire (GHQ-28). The scores for depressed mood state were higher for individuals with short and long sleep pattern than for those with intermediate sleep pattern. The item analysis of specific depression symptoms indicated that short sleepers differ from intermediate sleepers in the somatic symptoms of depressed mood, whereas the differences between long and intermediate sleepers are observed in cognitive aspects. Some explicative hypothesis about the mechanisms that could be mediating relations between sleep duration and depressed mood are discussed. The development of educational initiatives destined to optimise students’ sleep habits may be useful to prevent future depression.La presente investigación ex post facto analiza la relación entre la duración habitual de sueño y el estado de ánimo deprimido. La muestra estuvo compuesta por 141 estudiantes sanos de ambos sexos, 19 con patrón de sueño corto (6 horas de sueño diario o menos), 64 con patrón de sueño intermedio (7-8 horas de sueño diario) y 58 con patrón de sueño largo (más de 9 horas de sueño diario). El ánimo deprimido se evaluó con el Inventario de Depresión de Beck (BDI) y la subescala de depresión del Cuestionario de Salud General (GHQ-28). Los sujetos con patrón de sueño corto y largo mostraban puntuaciones superiores en ánimo deprimido que aquellos con patrón de sueño intermedio. El análisis de cada uno de los ítems de depresión específicos mostró que los sujetos con patrón de sueño corto diferían de los patrones de sueño intermedio en los síntomas somáticos de la depresión, mientras las diferencias entre los sujetos con patrón de sueño largo e intermedio se producían en aspectos cognitivos. Se presentan algunas hipótesis explicativas sobre los mecanismos que pueden estar mediando las relaciones entre duración de sueño y estado de ánimo deprimido. El desarrollo de iniciativas educacionales destinadas a optimizar los hábitos de sueño de los estudiantes puede ser útil para prevenir depresiones futuras.A presente investigação ex post facto analisa a relação entre a duração habitual do sono e o estado de humor deprimido. A amostra foi constituída por 141 estudantes saudáveis de ambos os sexos, 19 com padrão de sono breve (pelo menos 6 horas de sono diário), 64 com padrão de sono intermédio (7-8 horas de sono diário) e 58 com padrão de sono longo (mais de 9 horas de sono diário). O humor deprimido foi avaliado com o inventário de depressão de Beck (BDI) e a subescala de depressão do questionário de saúde geral (GHQ-28). Os sujeitos com padrão de sono breve e longo mostraram pontuações superiores no humor deprimido às daqueles com um padrão de sono intermédio. A análise de cada um dos itens de depressão específicos mostrou que os sujeitos com padrão de sono breve diferiam dos que tinham um padrão de sono intermédio nos sintomas sintomáticos da depressão, enquanto que as diferenças entre os sujeitos com padrão de sono longo e intermédio se produziam em aspectos cognitivos. Apresentam-se algumas hipóteses explicativas sobre os mecanismos que podem estar a mediar as relações entre duração do sono e o humor deprimido. O desenvolvimento de iniciativas educacionais destinadas a optimizar os hábitos de sono dos estudantes pode ser útil para prevenir depressões futuras

Aproximación ao Open Access

Sesión organizada polo CITIUS e a BUSC sobre os conceptos básicos e a historia do Open Access, as distintas vías do acceso aberto e as políticas editoriais en relación ao copyright e autoarquiv

Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance

Contact lenses (CLs) are prone to biofilm formation, which may cause severe ocular infections. Since the use of antibiotics is associated with resistance concerns, here, two alternative strategies were evaluated to endow CLs with antibiofilm features: copolymerization with the antifouling monomer 2-methacryloyloxyethyl phosphorylcholine (MPC) and loading of the antioxidant resveratrol with known antibacterial activity. MPC has, so far, been used to increase water retention on the CL surface (Proclear® 1 day CLs). Both poly(hydroxyethyl methacrylate) (HEMA) and silicone hydrogels were prepared with MPC covering a wide range of concentrations (from 0 to 101 mM). All hydrogels showed physical properties adequate for CLs and successfully passed the hen’s egg-chorioallantoic membrane (HET-CAM) test. Silicone hydrogels had stronger affinity for resveratrol, with higher loading and a slower release rate. Ex vivo cornea and sclera permeability tests revealed that resveratrol released from the hydrogels readily accumulated in both tissues but did not cross through. The antibiofilm tests against Pseudomonas aeruginosa and Staphylococcus aureus evidenced that, in general, resveratrol decreased biofilm formation, which correlated with its concentration-dependent antibacterial capability. Preferential adsorption of lysozyme, compared to albumin, might also contribute to the antimicrobial activity. In addition, importantly, the loading of resveratrol in the hydrogels preserved the antioxidant activity, even against photodegradation. Overall, the designed hydrogels can host therapeutically relevant amounts of resveratrol to be sustainedly released on the eye, providing antibiofilm and antioxidant performanceThis research was funded by MINECO (SAF2017-83118-R), Agencia Estatal de Investigación (AEI) Spain, Xunta de Galicia (ED431C 2020/17), FEDER, and Fundação para a Ciência e Tecnologia (FCT) Portugal (UIDB/00100/2020 and UIDB/04585/2020). M. Vivero-Lopez acknowledges Xunta de Galicia (Consellería de Cultura, Educación e Ordenación Universitaria) for a predoctoral research fellowship (ED481A-2019/120)S

Occurrence of mycotoxins and mycotoxigenic fungi in silage from the north of Portugal at feed-out

Maize and grass silages are important dietary components for ruminant livestock that influence the quality of animal products for human consumption, such as milk, in many parts of the world. Infection of plants by fungi able to produce mycotoxins, either in the field or post-harvest, can result in a decrease of silage nutritional quality and, consequently, in milk quality. In this study, 45 maize and grass silage samples were collected from 25 dairy farms located in the north of Portugal. The occurrence of fungi was evaluated in samples, the most frequently isolated species being Aspergillus fumigatus, Dipodascus geotrichum, Mucor circinelloides, Penicillium paneum, and Aspergillus flavus. The mycotoxigenic profile of the fungal species was studied using the ultra-high-performance liquid chromatography coupled to mass spectrometry–ion trap–time-of-flight (UHPLC–MS–IT–TOF) detection. In addition, a new method based on a QuEChERS extraction followed by the UHPLC- tandem mass spectrometry (UHPLC-MS/MS) detection was developed for simultaneous analysis of 39 mycotoxins in silage. A high co-occurrence of Fusarium mycotoxins was found, although at low levels of contamination. Deoxynivalenol and beauvericin were found in more than 82% of maize silage samples. It can be highlighted the low occurrence of Penicillium and Aspergillus toxins in the maize and grass silages studied despite the frequent detection of species of both generaThe research leading to these results has received funding from the following FEDER cofunded-grants. From Conselleria de Cultura, Educacion e Ordenación Universitaria, Xunta de Galicia, GRC (ED431C 2021/01). From Ministerio de Ciencia e Innovación IISCIII/PI19/001248 and PID 2020-11262RB-C21. From European Union Interreg AlertoxNet EAPA-317-2016, Interreg Agritox EAPA-998-2018, and H2020 778069-EMERTOXS

Perimeter and carvacrol-loading regulate angiogenesis and biofilm growth in 3D printed PLA scaffolds

rvacrol is a natural low-cost compound derived from oregano which presents anti-bacterial properties against both Gram-positive and Gram-negative bacteria. In this work, carvacrol-loaded PLA scaffolds were fabricated by 3D printing as platforms to support bone tissue regeneration while preventing biofilm development. Scaffolds were printed with or without a perimeter (lateral wall) mimicking the cortical structure of bone tissue to further evaluate if the lateral interconnectivity could affect the biological or antimicrobial properties of the scaffolds. Carvacrol incorporation was performed by loading either the PLA filament prior to 3D printing or the already printed PLA scaffold. The loading method determined carvacrol localization in the scaffolds and its release profile. Biphasic profiles were recorded in all cases, but scaffolds loaded post-printed released carvacrol much faster, with 50–80% released in the first day, compared to those containing carvacrol in PLA filament before printing which sustained the release for several weeks. The presence or absence of the perimeter did not affect the release rate, but total amount released. Tissue integration and vascularization of carvacrol-loaded scaffolds were evaluated in a chorioallantoic membrane model (CAM) using a novel quantitative micro-computed tomography (micro-CT) analysis approach. The obtained results confirmed the CAM tissue ingrowth and new vessel formation within the porous structure of the scaffolds after 7 days of incubation, without leading to hemorrhagic or cytotoxic effects. The absence of lateral wall facilitated lateral integration of the scaffolds in the host tissue, although increased the anisotropy of the mechanical properties. Scaffolds loaded with carvacrol post-printing showed antibiofilm activity against Staphylococcus aureus and Pseudomonas aeruginosa as observed in a decrease in CFU counting after biofilm detachment, changes in metabolic heat measured by calorimetry, and increased contact killing efficiency. In summary, this work demonstrated the feasibility of tuning carvacrol release rate and the amount released from PLA scaffolds to achieve antibiofilm protection without altering angiogenesis, which was mostly dependent on the perimeter density of the scaffoldsThis work was supported by MCIN/AEI/http://dx.doi.org/10.13039/501100011033 [PID2020-113881RB-I00], FEDER, and Xunta de Galicia [ED431C 2020/17, ED481D-2021-014]. Xián Farto-Vaamonde acknowledges Xunta de Galicia for a predoctoral research fellowship [ED481A-2018/073]S