Legal rights of the gifted

Law Briefs on Litigation and the Rights of Exceptional Children, Youth, and Adults, by Ernest E. Singletary, Gary D. Collings, and H. Floyd Denni

Concert recording 2013-04-13

[Track 01]. In Ireland / Hamilton Harty -- [Track 02]. Winter spirits for solo flute / Katherine Hoover -- [Track 03]. L\u27Aube enchantee The enchanted dawn / Ravi Shankar -- [Track 04]. Kassouga Spring day / Makoto Shinohara -- [Track 05]. Sonata Latino. I. Salsa Montunate ; [Track 06] II. Rumbango ; [Track 07] III. Bossa Merengova / Mike Mower

Transcriptional regulation and chromatin remodeling mechanisms at PHO5

Regulation of gene expression is vital for proper growth and prevention of disease states. In eukaryotes this regulation occurs in the context of chromatin which creates an inherent barrier for the binding of trans-acting factors, such as transcription factors and RNA polymerase. This dissertation focuses on the role of transcriptional activators and chromatin remodeling coactivators in the regulation of the repressible acid phosphatase gene PHO5. Our studies show that histone methylation at lysine 4 of histone H3 is required for the full repression of PHO5and GAL1-10. We show that bromodomains, a domain conserved in chromatin remodeling coactivators, may function to stabilize binding. Finally, we present a strategy using DNA methyltransferases as in vivo probes to detect DNA-protein interactions and examine chromatin structure. We extend this strategy to zinc-finger proteins which can be engineered to bind to any desired DNA sequence as a means of targeting methylation with potential use in epigenetic silencing

Analysing flux decline in dead-end filtration

Can we rely on the analysis of flux decline to evaluate the risks of a filter media to be clogged during filtration of a given particle suspension? This important issue can be dealt with a macroscopic approach described in this paper. We seek to identify and quantify the successive prevailing mechanisms which occur during a filtration run, directly and solely from experimental flux data. This is achieved from the collection of experimental data (filtrate volume V vs. time t) and the use of the differential equation (d2t/dV2) = k(dt/dV)n. A methodology is then proposed to define and validate experimental procedures with the purpose of quantifying occurring fouling mechanism. For the purpose of illustrating its valuable impact for a bench marking procedure, the methodology has been applied on a model system composed of a bentonite suspension and a series of microfiltration membranes of different structures

The United States and the politics of the laws of war since 1945.

The critique of the laws of war (and international law in general) coming out of America as the war on terror began seemed to have emerged as a response to the horror of 9/11 and the belief that the US was now engaged in a 'new paradigm' of warfare. However, the Bush administration's argument needs to be situated in a wider historical context. The source of the arguments against the post-Vietnam US military legal regime emerged well before 9/11 and can be traced to the end of the Cold War. These doctrines emerged out of the work of the 'new sovereigntists' and out of the frustrations guided by coalition warfare. The implications of the Bush administration's arguments are very significant for America's relationship with the laws of war, challenging the traditional division between jus ad bellum and jus in bello associated with the rise of the Westphalian system. As the world's most powerful army, and the most active army in the West, America's stance will have important implications as to how the laws of war are applied to future conflicts. Additionally, as the war on terror has generated new ethical dilemmas for the American military, the rebalancing of the priority between international law and the need for security has proved very problematic. Legal uncertainties and inconsistent policies have arguably resulted in several scandals, most notably the abuse at Abu Ghraib prison in Iraq. The thesis will trace US thinking on the laws of war since 1945, noting in particular the impact of Vietnam, the 1991 Gulf War, Kosovo, Afghanistan and Iraq