12 research outputs found
Particle swarming of sensor correction filters
- Author
- Publication venue
- Bristol : Institute of Physics Publ. (IOP)
- Publication date
- 01/01/2020
- Field of study
Reducing the impact of seismic activity on the motion of suspended optics is essential for the operation of ground-based gravitational wave detectors. During periods of increased seismic activity, low-frequency ground translation and tilt cause the Advanced LIGO observatories to lose 'lock', reducing their duty cycles. This paper applies modern global-optimisation algorithms to aid in the design of the 'sensor correction' filter, used in the control of the active platforms. It is shown that a particle swarm algorithm that minimises a cost-function approximating the differential root mean squared velocity between platforms can produce control filters that perform better across most frequencies in the control bandwidth than those currently installed. These tests were conducted using training data from the LIGO Hanford Observatory seismic instruments and simulations of the Horizontal Access Module Internal Seismic Isolation platforms. These results show that new methods of producing control filters are ready for use at LIGO. The filters were implemented at LIGO's Hanford Observatory, and use the resulting data to refine the cost function. © 2020 IOP Publishing Ltd Printed in the U
Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer\u27s Disease-Relevant Phenotypes in Mice.
- Author
- Baker Deborah
- Bedwell Amanda A
- Carter Gregory W
- Eldridge Kierra
- Figueiredo Lucas L
- Howell Gareth R
- Ingraham Cynthia
- Kotredes Kevin P
- Lamb Bruce T
- Lin Peter B
- Lloyd Christopher
- Meyer Jill A
- Oblak Adrian L
- Pandey Ravi S
- Perkins Bridget
- Persohn Scott A
- Peters Johnathan S
- Reagan Alaina M
- Sasner Michael
- Soni Disha M
- Speedy Rachael
- Sukoff Rizzo Stacey J
- Territo Paul R
- Tsai Andy P
- Publication venue
- The Mouseion at the JAXlibrary
- Publication date
- 24/06/2022
- Field of study
Obesity is recognized as a significant risk factor for Alzheimer\u27s disease (AD). Studies have supported the notion that obesity accelerates AD-related pathophysiology in mouse models of AD. The majority of studies, to date, have focused on the use of early-onset AD models. Here, we evaluate the impact of genetic risk factors on late-onset AD (LOAD) in mice fed with a high fat/high sugar diet (HFD). We focused on three mouse models created through the IU/JAX/PITT MODEL-AD Center. These included a combined risk model wit
A biomimetic receptor for glucose
- Author
- A Basu
- Anthony P. Davis
- AP Davis
- AP Davis
- B Sookcharoenpinyo
- C Ke
- D Solis
- E Klein
- E Persch
- EA Kataev
- EA Meyer
- EJ Toone
- EM Peck
- FA Quiocho
- FQ Zhao
- G Hennrich
- GV Oshovsky
- Hongyu Li
- IV Kolesnichenko
- J Shoham
- JL Asensio
- Johnathan V. Matlock
- Laurent Chabanne
- M Ambrosi
- M Mazik
- Matthew P. Crump
- Michael G. Orchard
- NP Barwell
- O Francesconi
- P Rios
- P Rios
- Q Wu
- Robert A. Tromans
- T Schrader
- TD James
- TJ Mooibroek
- Tom S. Carter
- X Ma
- XL Sun
- Y Ferrand
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
- Bonfield James
- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
- Brown Andrew
- Brown Clive
- Brown Jacqui
- Brown Margaret
- Brown Mary
- Brown Mary J.
- Brown Michael
- Brown Nancy C.
- Bruce David D.
- Bruce Robert
- Bruno William J.
- Bruskiewich Richard
- Bryant Jackie
- Bryant Jennifer E.
- Bryant Nathaniel P.
- Brüls Thomas
- Buatsi Delali
- Buck David
- Buckingham Judith M.
- Buckle Veronica
- Buczek Donald
- Budd Claire
- Buhay Christian J.
- Bulbul Kerem
- Buller Sarah
- Bunker Nathan
- Burberry Jill
- Burch Paula Ellen
- Burford Deborah
- Burgess Joanne
- Burgin Matt
- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
- Butcher Phil
- Butler Adam
- Butler Jon
- Butler Paul
- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
- Cai Zhen
- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
- Camire David
- Camm Nick
- Campbell Christopher
- Campbell Connie S.
- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
- Campo Kevin
- Canning Bruno
- Cao Ting
- Cao Yuzhu
- Caoile Chenier
- Cardenas Faviola
- Cardenas Lolo
- Cardenas Veronica
- Carder Carol
- Carder Paul
- Carpenter Kelly
- Carrano Anthony V.
- Carriere Jason
- Carter Jason
- Carter Kelvin
- Carter Nigel
- Caruso Lauren
- Casias Kristal
- Cattolico Laurence
- Cavanna Tamara
- Cavazos Iracema
- Cavazos Sandra R.
- Ceasar Heather
- Cedroni Maria
- Cepeda Mario
- Chacko Joseph
- Chain Patrick
- Chalk Shani
- Challacombe Jean F.
- Chan Ka
- Chan Sheryl N.
- Chan Yee Man
- Chang Jean L.
- Chapman Jarrod
- Chapman Joanna
- Chapple Jeffrey
- Charles Rachel
- Chasteen Leslie A.
- Chavarria Simeon
- Chazaro Bruno
- Chen Baoxian
- Chen Bin
- Chen Chira
- Chen Chong
- Chen Chong
- Chen Chun-Nan
- Chen Cong
- Chen Ellson
- Chen Hsiu-Chuan
- Chen Jianlong
- Chen Jie
- Chen Jin
- Chen Junbao
- Chen Lihong
- Chen Lixia
- Chen Ray
- Chen Shu
- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
- Chissoe Stephanie
- Chiu Sally
- Chothia Tom
- Christensen Mari
- Christopoulos Constantine
- Chu Joseph
- Chui Connie
- Chung A
- Cinkowsky Michael J.
- Citroen Mieke
- Clack Rob
- Clamp Michele
- Clark Anthea
- Clark Graham
- Clark Kevin
- Clark Lynn
- Clark Lynn M.
- Clark Richard
- Clark Sarah
- Clark Sue
- Clarke Adrian
- Clarke Betty
- Clarke Eddie
- Clarke Kay
- Clarke Laura
- Clawson Hiram
- Clee Chris
- Clegg Shelia
- Clerc Blankenburg Kerstin Petra
- Cleveland David
- Clifford Karen
- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
- Cockrell Raynard
- Coffey Alison
- Cofield Jackie
- Coggill Penelope
- Cohn Judith D.
- Colayco Rick
- Cole Lotte
- Collier Rachael
- Collings Simon
- Collins Francis S.
- Collins John
- Collins Philip
- Collymore Al
- Colman Louise
- Combs Jessie
- Comstock Robin
- Cong Bin
- Conner Richard
- Connolly Anthony
- Connolly Karen
- Conquer Jennie
- Conrad Ansgar
- Conroy Donald
- Considine Tony
- Constance Doug
- Cook April
- Cook Leanna
- Cooke Patrick
- Cooper Jonathan
- Cooper Rachel
- Cooper Robert
- Copeland Alex
- Coppola Maria
- Copsey Teresa
- Corby Nicole
- Cordes Matt
- Cordray Rebecca
- Cornell Christine
- Cornell Earl
- Cornell Linda
- Cornell Ruth
- Corum Ben
- Cottage Amanda
- Cotton Sara
- Coulson Alan
- Couronne Olivier
- Courtney Laura P.
- Coville Gez
- Cox Anthony
- Cox Caroline D.
- Cox Tony
- Coxhill Robert
- Coyle Marcus D.
- Craig Matthew
- Crane Tom
- Crawford Amanda L.
- Crawley Matt
- Cree Andrew
- Crespeau Hervé
- Crew Victor
- Critchlow Terrance
- Critz Paul
- Cruaud Corinne
- Cuff James
- Cui Hongjuan
- Cui Jinhui
- Cui Peng
- Cui Peng
- Culley Karl
- Cummings Auli
- Cummings Kirsti
- Cummings Paul
- Cummings Stephanie
- Cuomo Christina A.
- Curran Adam
- Curwen Valery
- Cutts Jeffrey
- Czubayko Martin
- D\u27Souza Lisa Marie
- Da Silva Corinne
- Dai Li
- Dalin Eillen
- Dang Michelle
- Danganan Linda
- Daniels Rachael
- Dathorne Stephanie R.
- Daum Christopher
- David Robert
- Davidson Lucy
- Davidson Stuart
- Davies Jonathon
- Davies Joy
- Davies Nicholas
- Davies Robert
- Davila Mary Louise
- Davis Candi Mon\u27et
- Davis Cheryl
- Davis Clay
- Davis Jayne
- Davis John
- Davis Matthew
- Davy-Carroll Latarsha
- Dawoe Tenzin
- Dawson Elisabeth
- De Anda Claudia
- De Latorre Andrea
- Deadman Rebecca
- Dean Peter
- Dear Simon
- Dearden Frances
- DeArellano Kurt
- Deaven Larry I.
- Deaven Larry L.
- Deere Kerry
- DeGray Stewart
- Degusta David
- Deguzman Maria
- Dehal Paramvir
- Delgado Marcos
- Delgado Oliver
- Delhaunty Kimberley
- Deloukas Panos
- Deng Yajun
- Dennis Janet
- Denson Shawn
- Denys Mirian
- Deramo Christine
- Desai Anu
- Detter John C.
- Devlin Laurie
- Dewar Ken
- Dhami Pawandeep
- Dhongsar Chemey
- Dias Jennifer
- Dias Victoria
- Dibartolo Genevieve
- Dibling Catherine
- Dickson Mark
- Diekhans Mark
- Dietz-Band Jeanne
- Digennaro Richard
- Dilts Karen
- Dimitrijevic-Bussod Mira
- Ding Hao
- Ding Keyue
- Ding Li
- Ding Yan
- Dinh Huyen H.
- Dixon Kami
- Do Long
- Dobbs Ruth
- Dobson Richard
- Dockree Catherine
- Doddington Daniel
- Dodsworth Steven
- Doggett Norman
- Doggett Norman A.
- Dong Hui
- Dong Kimberly
- Dong Wei
- Dong Wei
- Dong Xiaojia
- Donlin Jeremy E.
- Dooley Kathy
- Dooling David
- Dorje Passang
- Dorjee Kunsang
- Dorris Lester
- Dorsett Victor
- Doucette-Stamm Lynn
- Douthwaite Karen J.
- Down Thomas
- Draper Heather
- Du Feiyu
- Du Hui
- Du Yutao
- Duarte Suzanne
- Dubchak Inna
- Duffy Noah
- Dugan-Rocha Shannon
- Dunham Andrew
- Dunham Ian
- Dunn Adam M.
- Dunn Anne
- Dunn Matthew
- Dunwell Erin
- Dupes Alan
- Durbin Kenneth J.
- Durbin Richard
- Durham Jillian
- Dutta Ireena
- Dwyer Ruth
- Dyer Lauren
- Dziuda Darius
- Earnhardt Christopher D.
- Earthrowl Mark
- Eastham Emma
- Eastham Timothy
- Eaves Kristy A.
- Eckenberg Ralph
- Edgar Darren
- Edionwe Susan Omwanghe Osayanro
- Edwards Carol
- Edwards Jennifer
- Edwards Karen
- Egan Amy
- Eichler Evan
- Eichler Evan
- Ejima Fumio
- Elkin Chris
- Ellington Andrew
- Elliot David
- Elliot Glendoria
- Elliot Jeffrey
- Ellwood Matthew
- Emberson Becky
- Emelianenko Natalia
- Emery-Cohen Alexandra J.
- Endrizzi Matthew
- Engh Ger van den
- Engle David
- Erickson Jeffery
- Erler Anne Marie
- Errington Helen
- Escobar Julio
- Escotto Michael
- Eugene Craig S.
- Evans Gareth
- Evans John
- Evans Katie
- Evans Richard
- Eveleth Gerald
- Eyras Eduardo
- Fan Hongyuan
- Fan Keke
- Fang Jianqiu
- Farina Abderrahim
- Faro Susan
- Faulkner Louisa
- Fawcett Joseph J.
- Fechtel Kim
- Fellingham Charlotte
- Felming Claire
- Felsenfeld Adam
- Feltwell Theresa
- Feng Guodong
- Feng Haiyan
- Feng Jie
- Feng Xiaoli
- Fennell Stephen
- Ferguson Alicia
- Fernandez Sonia
- Fernandez-Suarez Xose
- Fernando Pushpa Ranjani
- Ferriera Pat
- Fertitta Anne
- Fey Jim
- Fidel Patrick
- Fields Elizabeth
- Fink Marie
- Finley Maria C.
- Finn Robert
- Fischer Heather
- Fischer Laurice
- Fisher Shelia
- Fitch Pat
- Fitzgerald Mike
- Flack Tina
- Flagg Nicole
- Flanagan J.
- Fleming Kerry
- Flint Jonathan
- Flint Mark
- Flowers Dave
- Floyd Yvonne
- Foley Karen
- Folta Peg
- Fong Jonathan
- Fonknechten Núrua
- Footman Simon
- Forbes Lisa D.
- Ford Amanda F.
- Foster Myre J.
- Fotopulos Dea
- Fourcade Matthew
- Fowler John
- Fox Jessica
- Frame Deborah
- Francis Matthew
- Francis Stephen
- Frankel Ken
- Frankish Adam
- Frankland John
- Fraser Audrey
- Fraser David
- Frazier Marvin
- French Lisa
- Fricker David
- Fridlyand Jane
- Fronick Catrina
- Frost Carole
- Frost Daniel
- Frost Jackie
- Frost Lorna
- Fu Gang
- Fu Gang
- Fu Gang
- Fu Qiushi
- Fujioka Michiru
- Fujiyama Asao
- Fukawa Rintaro
- Fuller Liam
- Fuller Sharin
- Fullerton Kathryn
- Fulton Lucinda A.
- Fulton Robert S.
- Furey Terrence S.
- Furuhashi Mie
- Förste Silke
- Gabisi Abdul M.
- Gage Diane
- Gaige Tony
- Galgoczy Petra
- Gallegos Celsa
- Galvez Michael
- Gammon Stuart
- Gao Anwu
- Gao Jimei
- Gao Quan
- Gao Yang
- Gao Yimei
- Garcia Carmen
- Garcia Emilio
- Garcia Marvin
- Garcia Ricardo M, III
- Garcia-Martinez Antonio
- Gardner Alison
- Gardner Alison
- Garduno Consuelo
- Gardyna Steph
- Garner Patrick
- Garner Toni T.
- Garnes Jeffrey A.
- Garnett Jane
- Garza Melissa
- Gatewood Joseph M.
- Gatland Leigh
- Gatland Lindsay
- Gattung Stacie
- Gay Laura
- Gearin Gary
- Gebreyesus Binyam
- Gelein Cynthia
- Gelpke Maartin
- Gench Stephanie L.
- Geng Jianing
- Georgescu Anca
- Geotina Amy
- Ghori Jilur
- Ghose Sayantan
- Gibbs Ben
- Gibbs Richard A.
- Gibson Diane
- Gibson Elizabeth
- Gifford Mary
- Gil Isaias
- Gilbert James
- Gilby Lisa
- Gill Rachel
- Gillet Will
- Gillson Christopher
- Gilna Paul
- Gimmel Verena
- Gingrich Jeff
- Giovanelli Kira
- Glavina Tijana
- Glithero Rebecca
- Glöckner Gernot
- Gnerre Sante
- Gnirke Andreas
- Gold Darren
- Golinveaux Kristen
- Gomez Maria
- Gong Guanghui
- Gong Jinying
- Gonzales Eidelyn
- Gonzalez Guillermo B.
- Gooderham April
- Goodstadt Leo
- Goodstein David
- Goodwin Lynne A.
- Gordon Catherine
- Gordon Laurie A.
- Gordon Seth
- Gorton Matthew
- Gorvad Ann
- Gould Christine
- Goyea Ernest
- Goyette Audra
- Grady Deborah I.
- Grady Michelle L.
- Grafham Darren
- Graham Joe
- Grandbois Edward
- Grant Jennifer
- Grant Michael
- Grant Susan
- Graves Tina A.
- Gray Bruce
- Gray Emma
- Gray Lain
- Green Lisa
- Greenhalgh James
- Greenhill Joe
- Gregg Philippa
- Gregory Simon
- Grewal Nennu
- Gribble Susan
- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
- Griffiths Mark
- Griffiths-Jones Sam
- Grigoriev Igor
- Grimwood Jane
- Grocock Russell
- Groza Matthew
- Gu Jingli
- Gu Jun
- Gu Jun
- Gu Wenyi
- Gu Wenyi
- Gu Xiaochang
- Guan Qiaoning
- Guarin Hannibal
- Guel Metzalli
- Guerra William
- Guevara Whitney V.
- Gui Qi
- Gunaratne Preethi
- Gunning Kate
- Guo Daorong
- Guo Jane
- Guo Lili
- Gustafson Erik
- Guthrie Ian
- Guyer Mark
- Gwilliam Rhian
- Gyaltsen Kunsang
- Gyapay Gábor
- Görlich Yvonne
- Ha Chi
- Hafez Nabil
- Haglund Krista
- Hagopian Daniel
- Hagos Birhane
- Haim Allen
- Hajek Patrick
- Hall Brett Lynn
- Hall Brittany
- Hall Jennifer
- Hall Rebekah
- Hall-Tamly Gretta
- Halls Karen
- Hallsworth-Pepin Kym
- Hamada Junko
- Hamilton Cerissa
- Hamilton Keelan A.
- Hamilton Matt
- Hamlett John
- Hamlett John
- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
- Han Shunsheng
- Han Xurong
- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
- Harley Joanne
- Harper David
- Harper Georgina
- Harper Patrik
- Harradence Grant
- Harris Anthony
- Harrison Charlene-Lou
- Harrison Elliot
- Harrison Ruth
- Hart Elizabeth
- Hasegawa Tomoko
- Hashimoto Etsuko
- Hashimoto Wakako
- Hassan Daniel
- Hatcher Beath
- Hattori Masahira
- Haugen Eric
- Haussler David
- Havlak Paul
- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
- Hawkins Trevor
- Hawley Kellie
- Haydu Lauren
- Hayes Kerry
- He Fengying
- He Jiaying
- He Lin
- Heaford Andrew
- Heath Paul
- Heathcott Rosemary
- Heilig Roland
- Heiner Cheryl
- Heinze Ivonne
- Heitmann Katja
- Helfenbein Keven
- Heller Andrew
- Hellsten Uffe
- Hembry Cathy
- Henderson Carl
- Henderson Nicholas
- Henderson Nina
- Hendrix David
- Hennig Steffen
- Henning Karla
- Hepa Victor
- Herd Tim
- Herman Charles
- Hernandez Judith
- Hernandez Omar
- Herseim Allyson
- Hewitt Stephen
- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
- Holden Jane
- Holdgate Janet
- Hollaway Mara
- Hollins Barbara
- Holloway Ele
- Holmes Andrea
- Holmes Ian
- Holmes Sarah
- Holroyd Simon
- Holtz Ann
- Holtzer Caleb
- Homsi Deana K.
- Homsi Farah J.
- Honan Tracy
- Hood Leroy
- Hooper Alison
- Hopewell Lucy
- Hopkins Ben
- Horne Jennifer
- Hornett Gary
- Hornischer Klaus
- Hornsby Amber
- Hornsby Geoff
- Hornsby Tony
- Horsley Sharon
- Horton Roger
- Hosage-Norman Catherine
- Hosoda Kei
- Hosono Katsuhiro
- Hosseini Roya
- Hou Shunfang
- Hou Xiaodi
- Houde Nathan
- Howard Philip
- Howard Stephanie R.
- Howden Philip
- Howe Kevin
- Howell Gareth
- Howell Latoya Lynette
- Howells Sally Lucinda
- Hsu Fan
- Hu George
- Hu Jie
- Hu Songnian
- Huang Fang
- Huang Guyang
- Huang Katherine
- Huang Mei
- Huang Wayne
- Huang Wei
- Huang Wei
- Huang Wei
- Huang Zhengping
- Hubbard Timothy
- Huber James W.
- Huckle Elizabeth
- Hue Heather
- Hughes Jaime
- Hughes Jennifer
- Hughes Lee
- Hughes-Hull Hillary
- Hull Louisa
- Hulme Bill
- Hulyk Steven
- Hume Jennifer
- Hummeric Holger
- Humphray Sean
- Humphries David
- Humphries Matthew
- Hunt Adrienne
- Hunt Michael
- Hunt Paul
- Hunt Sarah
- Hunter Giselle
- Hunter Rov, II
- Hupman Matt
- Huynh Sandy
- Hyde David
- Hynds Christopher
- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
- Inagaki Naomi
- Ince Michael
- Ingram Drew
- Inoue Shuuji
- Isak Amber
- Isherwood Judith
- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
- Isozaki Emi
- Israni Sanjay
- Ito Fumiaki
- Ito Noriko
- Itoh Takehiko
- Iwakawa Shinobu
- Iwatate Mariko
- Iwatsu Mikiko
- Iyer Vivek
- Izatt Janet
- Izmajlowicz Monica
- Izumiyama Tomohiro
- Jacintho Mark
- Jackson Laronda R.
- Jackson Terri
- Jacob Leni Susan
- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
- James Kent W.
- Jareborg Niclas
- Jarek Michael
- Jassal Bijay
- Jeffery Grant
- Jeffery Kim
- Jeffrey Colin
- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
- Jia Xingchang
- Jiang Lu
- Jiang Yanrui
- Jiang Ziyou
- Jimenez Alberto
- Jin Jian
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- Jones Myrna D.
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- Keenan Stephen
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- Kegg Lisa
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- Kettleborough Ross
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- Khan Umer F.
- Khan Ziad Mohid
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- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
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- Kruchowski Scott S.
- Kube Michael
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- Lorensuhewa Lorna M.
- Lou Yunian
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- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
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- Lucas Robert
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- Lucier Raymond L.
- Ludeman Thom
- Lui Annie
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- Luo Chunqing
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- Lv Gang
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- Machrus Migdad
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- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
- Maglott Donna
- Maheshwari Manjula
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- Maltbie Mary I.
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- Manning Jonathan
- Manohar Chitra
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- Mareth David
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- Marquis-Homeyer Catherine
- Marr Thomas G.
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- Marrone Anne
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- Newes Christian
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- Nguyen Ngoc Bich
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- Ning Zemin
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- Nivens Amber
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- Nordsiek Gabriele
- Norris Sarah Louise
- Novik Karen
- Nowlin Larry
- Nusbaum Chad
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- Nwokenkwo Stanley
- O\u27Donnell Paula
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- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
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- Ohta Nao
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- Okoawo Ose
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- Omotosho Bamidele
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- Oragunye Njideka
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- Palazzolo Michael
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- Prathalingham Radhika
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- Qiao Zhenyong
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- Solovyev Victor
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- Sonaike Titilola
- Song Liping
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- Sonnhammer Erik
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- Sorelle Richard P.
- Sotheran Elizabeth
- Sougnez Carrie
- Spainhower Corey
- Sparks Anastasia L.
- Spencer Brian
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- Spraggon Lee
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- Stabenau Arne
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- Stallings Raymond I.
- Stalvey Malinda
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- Standring Lisa
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- Stege Justin T.
- Steingruber Helen
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- Su Xiaohu
- Subramanian Sandhya
- Subramanian Sandhya
- Sudbrak Ralf
- Sugnet Charles W.
- Sulston John
- Summers Leslie J.
- Sun Hui
- Sun Jiajia
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- Sun Jiu Qin
- Sun Min
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- Sun Yu
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- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
- Svetz Jessica
- Svetz Leah Anne
- Swainson Chris
- Swann Mark
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- Sycamore Neil
- Ségurens Béatrice
- Tabor Paul E.
- Tacey Kristina
- Tagett Beckie
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- Takaoka Tori
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- Tatsuyama Miho
- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
- Taylor Christina C.
- Taylor Gillian
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- Taylor Ruth
- Taylor Sam
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- Wickremasinghe Manosha I.
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- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
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- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
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Laser/matter interactions by laser-launched plates and direct laser shocks
- Author
- Publication venue
- Los Alamos National Laboratory
- Publication date
- Field of study
Explosives, gas guns, laser-launched flyer plates, and direct laser-irradiation can be used to generate shocks and high-stress in materials. Each method has a unique diameter and thickness of shock that can be generated. In past years, small laboratory lasers have been used to launch flyer plates 2 - 200-pm thick to terminal velocities 0.1 to 5 k d s . Over the past few years we have been using our TRIDENT laser facility (1kJ in 0.2 to 2ps) to accelerate larger diameter (8 mm) and thicker (0.1 - 1.5 mm) flyer plates. These larger diameters and thicker one-dimensional plates more closely compliment traditional experimental methods such as gas guns. The 8-mm diameter and 1-mm thick flyer plates can impart shocks in metals for constitutive dynamic property measurements. The versatility of laser-driven plates permits spatial and temporal profiles of the flyer plate impact on sample targets. LASNEX models and parameters of the laser drive can be used to optimize optical coupling efficiency. The flyer plate launch, acceleration, terminal velocity, and, depending on the experiment, flyer plate impact on to target materials are recorded using point-interferometry (VISAR), and line-imaging interferometry. These high speed optical and laser experimental methods will be described along with ancillary methods, and material data. Constitutive properties of bulk materials, rate effects, and grain size and/or orientation have been studied for several metals including copper, beryllium, gold, and some alloys
An in vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-clinical Animal Models.
- Author
- Adhikari Anna
- Anderson Johnathan D
- Beitnere Ulrika
- Buchanan Fiona KB
- Cameron David
- Carter Jasmine
- Copping Nycole
- Deng Peter
- Fierro Fernando A
- Fink Kyle D
- Gonzalez Casiana E
- Halmai Julian ANM
- Lee Charles C
- Lee Ruth D
- Lock Samantha
- Martinez Michele L
- Nolta Jan A
- O'Geen Henriette
- Palomares Miranda
- Petkova Stela P
- Segal David J
- Silverman Jill L
- Tarantal Alice F
- Thongphanh Krista
- Waldo Jennifer J
- Publication venue
- eScholarship, University of California
- Publication date
- 01/01/2021
- Field of study
Zinc finger (ZF), transcription activator-like effectors (TALE), and CRISPR/Cas9 therapies to regulate gene expression are becoming viable strategies to treat genetic disorders, although effective in vivo delivery systems for these proteins remain a major translational hurdle. We describe the use of a mesenchymal stem/stromal cell (MSC)-based delivery system for the secretion of a ZF protein (ZF-MSC) in transgenic mouse models and young rhesus monkeys. Secreted ZF protein from mouse ZF-MSC was detectable within the hippocampus 1 week following intracranial or cisterna magna (CM) injection. Secreted ZF activated the imprinted paternal Ube3a in a transgenic reporter mouse and ameliorated motor deficits in a Ube3a deletion Angelman Syndrome (AS) mouse. Intrathecally administered autologous rhesus MSCs were well-tolerated for 3 weeks following administration and secreted ZF protein was detectable within the cerebrospinal fluid (CSF), midbrain, and spinal cord. This approach is less invasive when compared to direct intracranial injection which requires a surgical procedure
Combined MRI-targeted Plus Systematic Confirmatory Biopsy Improves Risk Stratification for Patients Enrolling on Active Surveillance for Prostate Cancer
- Author
- Ahdoot
- Ahmed
- Alex Z. Wang
- Amir H. Lebastchi
- Barentsz
- Baris Turkbey
- Bloom
- Bradford J. Wood
- Carlsson
- Carlsson
- Carter
- Dell'Oglio
- Filson
- Gold
- Greer
- Howard L. Parnes
- Jayadevan
- Johnathan Zeng
- Kasabwala
- Kasivisvanathan
- Klotz
- Klotz
- Klotz
- Lange
- Leyh-Bannurah
- Loeb
- Luke P. O'Connor
- Maria J. Merino
- Marzouk
- Michael Ahdoot
- Neal
- Nitin K. Yerram
- Peter A. Pinto
- Peter L. Choyke
- Pilatz
- Richard
- Sandeep Gurram
- Sato
- Schoots
- Sharma
- Sherif Mehralivand
- Siddiqui
- Stephanie Harmon
- Tosoian
- Turkbey
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
A biomimetic receptor for glucose
- Author
- A Basu
- Anthony P. Davis
- AP Davis
- AP Davis
- B Sookcharoenpinyo
- C Ke
- D Solis
- E Klein
- E Persch
- EA Kataev
- EA Meyer
- EJ Toone
- EM Peck
- FA Quiocho
- FQ Zhao
- G Hennrich
- GV Oshovsky
- Hongyu Li
- IV Kolesnichenko
- J Shoham
- JL Asensio
- Johnathan V. Matlock
- Laurent Chabanne
- M Ambrosi
- M Mazik
- Matthew P. Crump
- Michael G. Orchard
- NP Barwell
- O Francesconi
- P Rios
- P Rios
- Q Wu
- Robert A. Tromans
- T Schrader
- TD James
- TJ Mooibroek
- Tom S. Carter
- X Ma
- XL Sun
- Y Ferrand
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
\u3ci\u3eDrosophila\u3c/i\u3e Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution
- Author
- Abdelnabi Mai
- Abrams Marita K
- Abusheikh Tariq
- Ackerman Cheri M
- Adams Andrew
- Adams Stephanie J
- Agarwalla Anant
- Agbley Kwabea
- Aldrup Megan E
- Alldredge Justin
- Allen Alicia B
- Alvarez Consuelo J
- Alvendia Erica L
- Ament Caitlin
- Anderson John E
- Archambault Alexi
- Armistead Isaac O
- Armstrong Andrew R
- Armstrong William
- Aronhalt Todd
- Ashrawi Yara
- Asinof Sam
- Aso Soham
- Augustine LaJerald
- Baatenberg Lara
- Bahr Thomas J
- Bailey Robert J
- Baker Atlee
- Baker Morgan
- Baldassari Shane M
- Banker Roxanne
- Barberi Chelsea R
- Barnett Jason M
- Bartling Justina R
- Baumgardner Jordan S
- Beck Christopher
- Beck Lauren R
- Beckett Alissa
- Bedard James E J
- Bednarski April E
- Beken Levent H
- Belella Carissa
- Bellush James M
- Benitez Pedro
- Benson Jonathon M
- Bertolet Anne
- Bhalla Satish C
- Bhatiya Chinmoy I
- Blaker Amanda L
- Blunden Christopher E
- Bodenberg Jessica M
- Boham Sampson K
- Bor Matthew J
- Botsford Bobbi
- Boudoures Anna L
- Boudreaux Lauren R
- Bourland Megan
- Brand Jordan P
- Braverman John M
- Brinkley Briana
- Brock Ethan J
- Brooks Dana W
- Broomfield Daniel
- Brouwer Lindsay K
- Brown Adam D
- Brown Ashley S
- Brown Carter
- Brown Marie
- Bryant Ashley
- Bryant Julie
- Burg Martin G
- Burke Christa
- Burkhart Brandon J
- Bushhouse Kelsey T
- Butzler Sarah C
- Caesar Nicole M
- Campana Christopher
- Carney Jordan E
- Caronna Jason
- Carranza David
- Cassidy Daniel W
- Cesko Lejla
- Chamma Norma
- Chandrasekaran Vidya
- Chapman Julia
- Chapman Kayla
- Chase Ian O
- Chau Kim M
- Chavez Miranda
- Chavez Ramiro A
- Chen Maida
- Chiang Scott
- Chlebina Ben
- Choeying Tenzin
- Choi Tiffany Y Y
- Chong Insun
- Christgen Shelbi L
- Christiansen Lena
- Christie Jordan S
- Cifelli Alyssa
- Clark Eric M
- Clark Nicole B
- Clarke-Medley Nicole
- Clary Andrea N
- Cognetti Peter A
- Cohen Heather
- Cole Mara G
- Collins Ashley A
- Conn Michael A
- Conrad Turner
- Conturso Alaina C
- Cooper Kristen M
- Corrielus Maureen
- Cotteleer Rebecca J
- Coulson Kevin
- Cristostomo Michael C
- Cromwell Avery B
- Crowley Matt J
- Crowley Samuel T
- Cruz Samantha
- Cullimore Peterson R
- Custer Ashley F
- Cyranowski Olivia
- Damsteegt Amanda M
- Danner Benjamin L
- Darusz Jess M
- DaSilva Paolo A
- Dauphin Cory M
- Davis Kristen C
- Davis Yelena P
- Davis-Reyes Brionna
- Dawson Seth G
- Debow Calise
- DeFazio Steve
- DeJong Randall J
- Delacruz Noelle
- DeMichele Gabriella A
- Deranek Kelly M
- DeShetler Megan
- Deuschle Frederic J
- DiAngelo Justin R
- Diekema Emily J
- DiLorenzo Lauren A
- Dirkes William
- DiTommaso Tia M
- Dobbe Ali
- Dobbe Ian
- Docking Carter T
- Does Benjamin R
- Dorsett Sasha L
- dos Santos Vieira Carolina Marques
- Dothager Matthew
- Doty Jennifer S
- Dougherty Grace A
- Dow Brian A
- Dowd Rose M
- Downey Kaitlyn A
- Drake Andrew P
- Drewry Melissa
- Drumm Kelly
- Du Chunguang
- Dunbar David A
- Dunham Carrie A
- Earl Erica K
- Echendu Vivienne
- Eckardt Alexandra K
- Eckdahl Todd T
- Edwards Curtis R
- Ehret Sharon C
- Eisen Michelle E M
- Eisler Heather L
- El-Adaimi Jad
- Elder Darcie D
- Elliott GiNell
- Emerson Charlene
- Emerson Julia A
- Emiah Shadie
- English Johnathan D
- Enoch Erica
- Faber Hayley M
- Faber Katherine J
- Fadus Matthew C
- Falk I N
- Fanning John P
- Farek Jesse R
- Farrar Cassandra
- Fearnow Adam
- Feenstra Elizabeth
- Fefelova Nadezhda
- Felzer-Kim Isabella T
- Fese Jessica
- Fick Cameron N
- Fitzgibbons John D
- Flohr Sarah
- Flores Amanda H
- Floyd Trevor G
- Foret Don
- Forsyth Joshua D
- Fosselman Daniel S
- Foust Jonathan D
- Franchi Spencer L
- Freda Philip J
- Freeburg Trip
- French Kristin M
- Friedman Harrison
- Friedrichs Chelsey
- Fusco Zach
- Garibay Edgar
- Garrett Amanda D
- Gaur Shailly
- Geary James F
- Gier Chad
- Gill Ishwar S
- Gilman Hannah
- Glenn Omolara
- Goeller Katie L
- Gomez Carolina
- Gonzales Justin A
- Gooch John
- Goodman Anya L
- Goodwin Zane
- Goscinski Nora C
- Gosser Yuying
- Govind Shubha
- Grantham Alaina J
- Greenwell Alyson
- Grove Ryan A
- Guadron Leslie
- Gutierrez Nestor
- Haberman Adam
- Hales Jasmine
- Hammett Deborah
- Hammond Brandy L
- Hammond Maureen S
- Hanson Cynthia K
- Harding Taylor S
- Hare Amber N
- Hark Amy T
- Harker Katherine S
- Harnoto Raechel S
- Harrington William
- Harris Cameron B
- Hatfield Kristen R
- Hauke Jeanette
- Hauser Charles R
- Havill Jessen T
- Heckman Jonathan M
- Hedeen Heather
- Helmreich Eric
- Hendricksma Jesse
- Hennessy Bryan M
- Henry Tyneshia C P
- Herbstsomer Robert A
- Herrick Douglas A
- Herrold Milton R
- Heslop Michelle
- Hilbrands Julia A
- Hirsch Sarah
- Hockenberger Kelsey
- Holderness Heather L
- Hong Emily L
- Hoogenboom Lindsay
- Hoogewerf Arlene J
- Hoopes Laura L M
- Hoover Betsy
- Hopkins Barbara L
- Howell Emily J
- Howey Nicole A
- Huerta Vilma F
- Ibarra Sharon
- Ibrahem Marwan
- Ighile Osagie
- Intriago Stephanie
- Jacobs Dontae A
- Janssen Bridget M
- Jarrell Jenifer N
- Jelgerhuis Sarah A
- Jelsema Timothy R
- Jewell Elizabeth S
- Jimenez Luis A
- Jipp Jacob
- Johnson Ashlee G
- Johnson Benjamin K
- Johnson Cristen
- Johnson Diana E
- Johnson Jaelyn L
- Johnson Lauriaun
- Johnson Todd D
- Jones Christopher J
- Jones Jennifer K
- Jones Kelly K
- Jones Melissa
- Kabaso Rita
- Kaehler Marian M
- Kaisler Maria
- Kammrath Anna
- Kandahari Adrese
- Kappes Michelle L
- Karaska Elizabeth A
- Katz Brandon M
- Kaur Sukhjit
- Kehoe James L
- Kelley Colleen V
- Kelly Elisabeth A
- Kennedy Andre
- Kennedy William R
- Keny Lauren J
- Kerber John M
- Keysock Nicholas
- Khan Ambreen
- Khayrullina Guzal
- Khoshabian Colin
- Khoury Christopher B
- Kiernan Elizabeth
- Kiley John
- Kim Andrew J
- Kim Anna
- Kim Van
- King Jessica E
- Klett Bethany M
- Knepper John Mark
- Knob Christopher R
- Knouse Kristin A
- Knudsen Nelson H
- Koaches Hannah C
- Koehler Jessica
- Koenig Dana
- Kokan Nighat P
- Kolibas Kimberly S
- Kooienga Ross D
- Koplinsky Chad A
- Kraftmann Karen J
- Kubricky Cassandra
- Kufel Christina N
- Kujawski Alexander J
- Kuleck Gary A
- Kulich Danielle
- Kung Faith
- Kus Jordan E
- Kuschner Cyrus E
- Kusner Matt
- Kwan Wa Shum Yuki
- Ladzekpo Danielle
- LaForge Kristin M
- Lamb Travis
- Lambright Anthony K
- Lammers Jennifer A
- Lane Curtiss E
- Langner Christine
- Lau Dawn
- Lea Charlotte
- Leads Rachel R
- Leatherman Emily C
- LeBlanc Mark T
- Lee Cassidy T
- Lee Paul
- Lemmon Eric
- Leung Wilson
- Lewis Benjamin M
- Li Linghui
- Light Morgan R
- Limle Austin B
- Lin Devry
- Lindbeck Peter
- Lippert Rachel N
- Lopez Lenin
- Lopilato Jane E
- Louie Christopher A
- Lowell Shannon M
- Lu Alvin
- Lucas Gabi
- Luippold Erin K
- Lupey Lena N
- Lydon Anniken M
- Macchi Christopher R
- Machone Joshua F
- Macias Elizabeth
- Macias Jason S
- Maffa Amanda
- Mageeney Catherine M
- Malkowitz Lorraine
- Mammo Danny
- Maniaci Brian J
- Marra Jonathan
- Martinez Megan
- Martiniuc Daniela
- Martinov Tijana
- Mason Portia
- Matthews Jordan E
- May Francis J
- Mayorga Lissett
- Mazur Tammy
- Mazzeo Cheryl
- McCabe Nikie L
- McCartha Shannon R
- McCracken Marly R
- McDonald Mitchell
- McDonough Alexa M
- McFarland Darryl
- McLaughlin Christopher
- Mecoli Jonathan P
- Medina Joseph
- Meghdari Mariam
- Meier Anne C
- Melton Amy D
- Membreno Nelson
- Mendoza Carlos
- Menillo Daniella
- Menyes Erika E
- Mercer Amanda
- Merry Callie R
- Messenger Gregory S
- Messiah Shady
- Messler James
- Meyer Lauren R
- Miller Emily G
- Minnick Phillip J
- Minniti Carl J
- Minton Thomas F
- Misch Jonathan
- Mitchell Ryan D
- Monsma Nicholaus
- Moran Joseph V
- Morgan Abbie
- Morlock Elaine V
- Morris William M
- Morrow Adam T
- Mudumbi Krishna
- Mullen Gregory J
- Muller Sarah E
- Musick Adam E
- Musokotwane Sepo
- Myirski Kevin
- Naik Monal
- Naik Priyanka
- Neufeld Lacey
- Neutzling William
- Newcomb Victoria
- Newhart William H
- Newman Alyssa M
- Ng Chun Leung
- Ng Simon
- Nguyen San Francisco
- Nguyen Trung T
- Nichols Zachary
- Nicolas Daniel S
- Nietmann Jana
- Nikam Vinyak S
- Nollet Eric A
- Nordman Elizabeth C
- Norton Diana
- Noynaert Joseph W
- Nyabeta Onsarigo Eric
- O\u27Rouke Allison
- Obiorah Ifeanyi
- Ochoa Andrea
- Odisho George
- Ogden Bradley J
- Olson Nicole C
- Ortiz Carlos
- Ostby Kristine
- Osterloh Jeanette M
- Overvoorde Paul J
- Ovu Steven
- Paetkau Don W
- Palozola Katherine C
- Paluskievicz Christina
- Pamnani Brad
- Parrish Susan
- Parry Kesley
- Pasierb Brittany D
- Patao Melissa D
- Patao Shane M
- Patterson Seantay D
- Pattison Claire
- Penn Jessica
- Peoples Emily
- Perella Mallory
- Perez Marcos A
- Peterson Daymon
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- Poet Jeffrey L
- Polk Jessica W
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- Powers Michelle K
- Pozmanter Caitlin
- Prasad Shreya
- Presley Jonathan D
- Price Amber L
- Primus Shekerah
- Puetz William J
- Quach Michael
- Ragland Nicolas
- Raimey England
- Ramic Alen
- Ramirez Roman E, Jr.
- Ramsey Kimberley
- Ramthun Jennifer R
- Randazzo Matt J
- Rankin Helen
- Rathore Sunil
- Ratliff Camille D
- Rauf Sabya A
- Reed Emily
- Reem Rachel M
- Regan Melanie K
- Regisford E Gloria C
- Reilly Mary T
- Rekai Jade Lea
- Rempe Ryan Michael
- Rennhack Jonathan P
- Revie Dennis
- Reynolds Katherine R
- Reynolds Lyndsey A
- Reynolds Thomas J
- Reza Evangelina
- Rhee Dong K
- Rigby Nichole
- Rios Lindsay
- Rivard Allyson B
- Robertson Gregory M
- Robic Srebenka
- Robinett Deirdre
- Robinson Lauren M
- Rodela Laura
- Rodriguez Priscilla
- Rodriguez Vanessa
- Roecklein-Canfield Jennifer A
- Ronk Adam J
- Rooney Meghan B
- Rose Jenny L
- Rose Thomas J
- Rosenwald Anne G
- Rossi Franca G
- Rossi Nadine L
- Rubin Lainey S
- Ruiz Jorge
- Rupley Bryan J
- Sable Joseph E
- Sadovsky Griffin
- Safa Nadia
- Salbert Luke R
- Salgado Michael S
- Saluja Rasleen K
- Salzman Garrett
- Sandusky Michael W
- Sanusi Fareed
- Sassu Eric D
- Saville Kenneth
- Scala Victoria
- Schauder Taylor
- Schepers Allison J
- Schibler Jeanine
- Schiedermeyer Holly
- Schmidt Lasse
- Schmuecker Samantha M
- Schneiter Allison R
- Schottler Jennifer
- Schueler Mary Grace
- Schultz Darrin
- Schulz Robert W
- Schwartz Nicholas U
- Scoma Alexandra H
- Scott Geoff
- Scott Zachary W
- Sessions Bridget J
- Seydoux Marie-Isabelle B
- Shallman Devon
- Shantzer Lindsey
- Sharif Karim A
- Shaw Mary E
- Shelton Micah
- Sherrill Will
- Shevin Yakov
- Shipman Anna L
- Shoemaker Emma
- Shoop Elizabeth
- Shuen Jessica A
- Shuford Rebecca
- Silva Valeria
- Silver Key S Catherine
- Simon Matthew
- Simone Bisogno Laura
- Smith Anna L
- Smith Christopher D
- Smith Jonathan E
- Smith Joshua R
- Smith Karl E
- Smith Mary A
- Smith Melanie A
- Smith Samuel I
- Smith-Gee Maxwell T
- Snavely Michael
- Soliterman Eugenia A
- Song Roy
- Soos Mahdi
- Spaeder Lindsay A
- Spana Eric P
- Sparks Ciani J
- Sparks Jeri
- Spencer Eric
- Spencer Sarah
- Sreenivasan Aparna
- Stagaard Erica
- Starcher Justin R
- Starkey Kristin M
- Statton Geeta
- Sterling Allison M
- Svoronos Petros
- Swanson Bryant R
- Sweeney Edward P
- Tache Melissa A
- Tare Archana
- Tenney Jenna C
- Tewilliager Ashley A
- Thistle Katrina
- Thomas Jessica G
- Thompson Jeffrey S
- Thomsen Kristen M
- Tilot Amanda K
- Timko Ashley S
- Tirasawasdichai Tiara
- Tomkins Trisha
- Torchon Karvyn
- Townsend Ashley
- Tran Danny L
- Trieu Melissa
- Tuberty Sarah
- Tucci Jessica M
- Tumminello Richard A
- Turner Bryce A
- Tynon Marykathryn
- Uitvlugt Chris
- Undem Blair
- Unruh Anna K
- Unzicker Matthew R
- Urick Damian
- Valdez Isabel
- VanderVennen Marielle
- VanDyken Rachel E
- VanEck Eve
- Velasquez Vicente
- Verbofsky Evan M
- Vernon William B
- Vetor Ashley
- Villerot Matthew M
- Vondy Kayla
- Vrable Abby
- Vue Samantha
- Vuong Tam
- Vylonis Megan B
- Waggoner Andrew W
- Walji Tezin A
- Walker Chelsea A
- Wan Tiffany
- Wande Lucia
- Ward Alyssa
- Waters Mary
- Watson David T
- Wawersik Matthew
- Weaver Jennifer A
- Welker Anne A
- Wellinghoff Jules
- Wendland Pete
- Westphal Kyle
- White Jackie X
- Williams Charlotte
- Winkler Stacey
- Winn Wesley W
- Winters Jenifer
- Woehlke Sarah
- Wolski Matthew W
- Wolyniak Michael J
- Wong Jeanette
- Wong Jeremy N
- Woyski Dustin S
- Wurzler Juliana A
- Wylie Anna
- Wysocki Lauren M
- Xiong David
- Xu Amy
- Xu Thomas Q
- Yalamanchili Monica
- Yang Bib
- Yarrington Bryan
- Yemelyanova Anastasia K
- Youngblom Jim
- Yu Nicole S
- Yuan Han
- Zaborowicz Matthew A
- Zarrasola Stephanie
- Zhang Yi
- Zhu Xiao
- Zidan Ameer
- Zumkehr Joannee
- Publication venue
- ScholarWorks@GVSU
- Publication date
- 01/05/2015
- Field of study
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25–50%) than euchromatic reference regions (3–11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11–27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4–3.6 vs. 8.4–8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu
CAGI, the critical assessment of genome interpretation, establishes progress and prospects for computational genetic variant interpretation methods
- Author
- Adamson Scott I.
- Adato Orit
- Adebali Ogün
- Adhikari Aashish
- Adzhubey Ivan
- Ahituv Nadav
- Alontaga Aileen Y.
- Altman Russ B.
- Andreoletti Gaia
- Arkin Adam P.
- Aspromonte Maria C.
- Avsec Ziga
- Azaria Johnathan R.
- Babbi Giulia
- Bachman Benjamin
- Bakolitsa Constantina
- Ball Mad P.
- Barsky Daniel
- Batzoglou Serafim
- Beer Michael A.
- Bellazzi Riccardo
- Bellini Mariagrazia
- Benedicenti Francesco
- Bergquist Timothy R.
- Bernard Brady M.
- Berry Michael
- Bettella Elisa
- Bhat Rajendra R.
- Bhattacharya Rohit
- Bigoni Stefania
- Bobe Jason R.
- Bonache Sandra
- Bonvini Paolo
- Bovo Samuele
- Bowdin Sarah
- Boyle Alan P.
- Breese Marcus R.
- Brenner Steven E.
- Brodie Aharon
- Bromberg Yana
- Buckley Bethany A.
- Burke Wylie
- Butte Atul J.
- Cai Binghuang
- Campagna Joan
- Cao Chen
- Cao Yue
- Capriotti Emidio
- Carmel Liran
- Carr Lawrence R.
- Carraro Marco
- Carter Hannah
- Casadio Rita
- Cesca Federica
- Chandonia John Marc
- Chang Billy
- Chang Ray
- Chellapan Ajithavalli
- Chen Flavia
- Chen Haoran
- Chen Jingqi
- Chen Ken
- Chen Rui
- Chen Yun Ching
- Chhibber Aparna
- Chiaraluce Roberta
- Chong Ka Chun
- Chu Hoyin
- Church George M.
- Clark Wyatt T.
- Cline Melissa S.
- Cohen Noa E.
- Cong Qian
- Consalvi Valerio
- Cooper David N.
- Corbi-Verge Carles
- Cote Atina G.
- Cutting Garry R.
- Cygan Kamil J.
- Dabbiru Navya
- Dahary Dvir
- Daneshjou Roxana
- De Baets Greet
- De la Cruz Xavier
- Di Lena Pietro
- Diekhans Mark
- Dimster-Denk Dago F.
- Dong Shengcheng
- Douville Christopher
- Dunbrack Roland L.
- DÃez Orland
- Edwards Matthew D.
- Elefanti Lisa
- Elnitski Laura
- Eraslan Gökcen
- Fairbrother William G.
- Fan Jean
- Fariselli Piero
- Favorov Alexander V.
- Fenesh Tzila
- Fenton Aron W.
- Fernández Alejandro
- Fishilevich Simon
- Folkman Lukas
- Ford Colby T.
- Forman Julia R.
- Fornasari Maria S.
- Fowler Douglas M.
- Franke Andre
- Frankish Adam
- Fredericks Alger M.
- Friedberg Iddo
- Fullerton Stephanie M.
- Furutsuki Mabel
- Gagneur Julien
- Garg Aditi
- Getz Gad A.
- Gianni Stefano
- Gifford David K.
- Giollo Manuel
- Glidden David T.
- Gonzaludo Nina
- Gotea Valer
- Gough Julian
- Graveley Brenton R.
- Gray Joe W.
- Greenblatt Marc S.
- Grishin Nick V.
- Grubb Soren
- Guerrero Rafael F.
- Guo Yuchun
- Guthrie Violeta Beleva
- Gutiérrez-EnrÃquez Sara
- Göke Jonathan
- Han James J.
- Harris-Wai Julie
- Harrow Jennifer
- Hart Reece K.
- Hasenahuer Marcia
- Hawkins-Hooker Alex
- Hernandez Ryan
- Holtzer Tamar
- Hoskins Roger A.
- Hosur Raghavendra
- Hu Inchi
- Hu Zhiqiang
- Huang Cheng Lai V.
- Hubbard Tim J.P.
- Huff Chad D.
- Hunter Jesse M.
- Huwe Peter J.
- Imanishi Tadashi
- Inoue Fumitaka
- Ioannidis Nilah M.
- Jacobsen Julius O.B.
- Jain Shantanu
- Jeong Chan Seok
- Jiang Yuxiang
- Jones David T.
- Jordan Daniel M.
- Joseph Thomas
- Juven-Gershon Tamar
- Kahn Scott
- Kane John P.
- Kann Maricel G.
- Karchin Rachel
- Karimi Mostafa
- Kasak Laura
- Katsanis Nicholas
- Katsonis Panagiotis
- Keles Sunduz
- Kellis Manolis
- Kenlay Henry
- Kiga Nikki
- Kim Dewey
- Kim Dongsup
- Kim Philip M.
- Kim Serra
- Kinch Lisa N.
- Kircher Martin
- Kirsch Jack F.
- Klein Teri E.
- Kleyman Michael
- Koenig Barbara A.
- Kollipara Naveen K.
- Kotte Sujatha
- Kousi Maria
- Kreimer Anat
- Krämer Andreas
- Kulakovskiy Ivan V.
- Kundaje Anshul
- Kundu Kunal
- Kwok Pui Yan
- Lai Carmen
- Lam Hugo Y.K.
- Lancet Doron
- Lathrop Richard H.
- LeBowitz Jonathan H.
- Lee Gyu Rie
- Lee Insuk
- Leonardi Emanuela
- Li Biao
- Li Mulin Jun
- Li Yue
- Lichtarge Olivier
- Limongelli Ivan
- Lin Chiao Feng
- Liu Xiaoming
- Lovisa Federica
- Lu Yutong
- Lua Rhonald C.
- Ly Melissa
- Löscher Britt Sabina
- Mak Angel C.Y.
- Mak Angel C.Y.
- Makeev Vsevolod J.
- Malloy Mary J.
- Mammi Isabella
- Mantuano Elide
- Margolin Gennady
- Marino-Buslje Cristina
- Marshall Christian
- Martelli Pier Luigi
- Martinez Selena
- Masica David
- Matreyek Kenneth A.
- McCombie W. Richard
- McInnes Gregory
- Menin Chiara
- Meyn M. Stephen
- Mezlini Aziz M.
- Milani Donatella
- Miller Maximilian
- Minervini Giovanni
- Minicozzi Velia
- Mishne Gilad
- Mohan Rahul
- Montalban Gemma
- Monzon Alexander M.
- Mooney Sean D.
- Morgan Alexander A.
- Moronfoye Oluwaseyi
- Mort Matthew
- Moult John
- Mount Stephen M.
- Mucaki Eliseos J.
- Mudge Jonathan M.
- Mueller Nikola S.
- Mungall Christopher J.
- Murakami Katsuhiko
- Murgia Alessandra
- Nadeau Kari C.Y.
- Nagai Yoko
- Naito Tatsuhiko
- Neil Christopher
- Neuhausen Susan L.
- Neumann Andrew J.
- Ng Pauline C.
- Nguyen Thi Yen Duong
- Nicora Giovanna
- Niknafs Noushin
- Niroula Abhishek
- Nodzak Conor
- Novak Leonore
- Nussbaum Robert L.
- Odell Eric
- Ofran Yanay
- Olatubosun Ayodeji
- Ootes Lars
- Ozturk Kivilcim
- O’Connor Robert
- O’Donnell-Luria Anne
- Padilla Natà lia
- Pagel Kymberleigh A.
- Paik Jodi
- Pal Debnath
- Pal Lipika R.
- Pandey Gaurav
- Parisi Gustavo
- Pasquo Alessandra
- Pastore Annalisa
- Patra Ayoti
- Pejaver Vikas
- Peng Jian
- Penzar Dmitry D.
- Peron Angela
- Peters-Petrulewicz Robin C.
- Petrosino Maria
- Pirooznia Mehdi
- Polli Roberta
- Potash James B.
- Puglisi Rita
- Radivojac Predrag
- Rana Sadhna
- Rao Aditya
- Rao Aliz R.
- Refaat Marwan M.
- Reid John
- Repo Susanna
- Rhine Christy L.
- Riera Casandra
- Rine Jasper D.
- Ritchie Graham R.S.
- Rizzo Ettore
- Rogan Peter K.
- Roth Frederick P.
- Rousseau Frederic
- Sabeti Pardis C.
- Saipradeep V. G.
- Sanford Jeremy R.
- Sartori Stefano
- Savojardo Castrense
- Scaini Maria Chiara
- Schmitt Nicole
- Schubach Max
- Schwarz Jana M.
- Schymkowitz Joost
- Searls David B.
- Sengupta Sohini
- Seok Chaok
- Shah Sohela
- Shatsky Maxim
- Shen Yang
- Shendure Jay
- Sheridan Molly B.
- Shi Fang Yuan
- Shi Xinghua
- Shigaki Dustin
- Shigeta Ron
- Shin Sunyoung
- Shon John
- Sinnott-Armstrong Nicholas A.
- Sivadasan Naveen
- Snyder Michael
- Sokolov Artem
- Spurdle Amanda B.
- Srinivasan Rajgopal
- Stackpole Mary
- Stamboulian Moses H.
- Stanke Mario
- Stanzial Franco
- Starita Lea M.
- Stavropoulos Dimitri J.
- Strokach Alexey V.
- Stuart Joshua M.
- Su Andrew
- Sun Rui
- Sun Song
- Sun Yuanfei
- Sundaram Laksshman
- Sunderam Uma
- Sunyaev Shamil
- Tang Paul L.F.
- Tavtigian Sean V.
- Teerakulkittipong Nuttinee
- Tewhey Ryan
- Thusberg Janita
- Tian Kevin
- Tokheim Collin
- Toldo Irene
- Topper Scott
- Tosatto Silvio C.E.
- Toto Angelo
- Tran Elizabeth
- Turina Paola
- Turner Tychele N.
- Turolla Licia
- Udani Rupa
- Unger Ron
- Uppal Aneeta
- van den Akker Jeroen
- Van Durme Joost
- Veltman Joris
- Veneziano Liana
- Verby Marta W.
- Vihinen Mauno
- Viswanath Vivek
- Vorontsov Ilya E.
- Voskanian Alin
- Väliaho Jouni
- Wahl Mary E.
- Wainberg Michael
- Walton Nephi A.
- Wang Maggie H.
- Wang Meng
- Wang Robert
- Wang Yanran
- Wang Yaqiong
- Wei Qiong
- Wei Zhipeng
- Weile Jochen
- Welch Rene
- Wilson Stephen J.
- Wojciak Julianne
- Wu Chunlei
- Wu William Ka Kei
- Xia Xiaoxuan
- Xu Qifang
- Yan Zhongxia
- Yang Yang
- Yang Yuedong
- Yao Zhaomin
- Yarborough Mark
- Yates Christopher M.
- Yee Stephen F.
- Yeleswarapu Sri Jyothsna
- Yeo Hui Ting Grace
- Yin Yizhou
- Yosef Nir
- Young Erin L.
- Yu Changhua
- Yu Chen Hsin
- Yu Guoying K.
- Yu Yao
- Zandi Peter P.
- Zaucha Jan
- Zee Benny C.
- Zeng Haoyang
- Zhang Jing
- Zhao Huying
- Zhou Alicia Y.
- Zhou Fengfeng
- Zhou Yaoqi
- Zimmer Anjali D.
- Ziv Elad
- Zook Justin M.
- Zuhl Maya
- Çelik Muhammed H.
- Özkan Selen
- Publication venue
- BioMed Central
- Publication date
- 01/02/2024
- Field of study
Background: The Critical Assessment of Genome Interpretation (CAGI) aims to advance the state-of-the-art for computational prediction of genetic variant impact, particularly where relevant to disease. The five complete editions of the CAGI community experiment comprised 50 challenges, in which participants made blind predictions of phenotypes from genetic data, and these were evaluated by independent assessors. Results: Performance was particularly strong for clinical pathogenic variants, including some difficult-to-diagnose cases, and extends to interpretation of cancer-related variants. Missense variant interpretation methods were able to estimate biochemical effects with increasing accuracy. Assessment of methods for regulatory variants and complex trait disease risk was less definitive and indicates performance potentially suitable for auxiliary use in the clinic. Conclusions: Results show that while current methods are imperfect, they have major utility for research and clinical applications. Emerging methods and increasingly large, robust datasets for training and assessment promise further progress ahead