The chemistry and biosynthesis of viomycin

Ph.D.John R. Dye

Service user involvement in practitioner education: movement politics and transformative change

This paper will attempt to both celebrate key developments and best practice involving the users of health and social care services in programmes of practitioner education in a UK context, and offer a critical appraisal of the extent to which such initiatives meet some of the more transformative objectives sought by service users activists for change. The approach is largely that of a discussion paper but we illustrate some of the themes relating to movement activism with selected data. These data relate to earlier research and two specially convened focus groups within the Comensus initiative at the University of Central Lancashire; itself constituted as piece of participatory action research. We conclude that universities represent paradoxical sites for the facilitation of debate and learning relevant to key issues of social justice and change. As such, they are places that can impede or support movement aims. Particular strategic responses might be more likely to engender progressive outcomes. These ought to include the presence of critically engaged academic staff operating within a scholarly culture that fosters forms of deliberative democratic decision making

TRUST IN TECHNOLOGY: DEVELOPMENT OF A SET OF CONSTRUCTS AND MEASURES

Trust plays an important role in many Information Systems (IS)-enabled situations. Most IS research employs trust as a measure of interpersonal or interfirm relations, such as trust in a Web vendor or a virtual team member. Although trust in other people is important, this paper suggests that trust in the information technology (IT) itself may also play a role in shaping IT-related beliefs and behavior. To advance trust and technology research, this paper presents a set of trust in technology construct definitions and measures. These construct measures will be examined using tests of convergent, discriminant, and nomological validity. This study will contribute to the literature by offering a) a framework for distinguishing between trust in people and trust in technology, b) offering a theory based set of definitions necessary forminvestigating different forms of trust, and c) developing measures useful to research and practice for evaluating trust in technology

Understanding temporal social dynamics in zoo animal management: an elephant case study

Zoo animal management procedures which lead to changes to social groups can cause disruption in social hierarchies and the temporary breakdown of social relationships. Animals have different roles in social networks. Understanding individual positions in social networks is important for effective management and ensuring positive welfare for all animals. Using elephants as a case study, the aim of this research was to investigate temporal social dynamics in zoo animals. Behavioural data were collected between January 2016 and February 2017 from 10 African and 22 Asian elephants housed at seven zoos and safari parks in the UK and Ireland. Social interactions were defined as positive physical, positive non-physical, negative physical or negative non-physical. Social network analysis explored social relationships including the fluidity of networks over time and dyadic reciprocity. Social interaction networks were found to be fluid but did not follow a seasonal pattern. Positive interaction networks tended to include the entire social group whereas negative interactions were restricted to specific individuals. Unbalanced ties were observed within dyads, suggesting potential inequalities in relationships. This could impact on individual experiences and welfare. This research highlights subtle temporal dynamics in zoo elephants with the potential for species-level differences. Similar temporal dynamics may also be present in other socially housed zoo species. This research thus provides evidence for the importance of understanding the social networks of zoo animals over longer periods of time. Understanding social networks enables pro-active and evidence-based management approaches. Further research should seek to identify the minimum sampling efforts for social networks in a range of species, to enable the implementation of regular monitoring of social networks and thus improve the welfare of social species under human care

The 2nd United Kingdom Extracellular Vesicle Forum Meeting Abstracts: 15 December 2015, Hadyn Ellis Building, Cardiff University

The UK Extracellular Vesicles (UKEV) Forum meetings were born of the realization that there were a number of UK laboratories studying extracellular vesicle biology and using similar techniques but without a regular national meeting dedicated to EVs at which to share their findings. This was compounded by the fact that many of these labs were working in different fields and thus networking and sharing of ideas and best practice was sometimes difficult. The first workshop was organized in 2013 by Dr Charlotte Lawson, under the auspices of the Society for Endocrinology, led to the founding of the UKEV Forum and the organization of a British Heart Foundation sponsored 1-day conference held in London in December 2014. Although growing in size every year, the central aims of these workshops have remained the same: to provide a forum for discussion and exchange of ideas, to allow young scientists to present their data in the form of short talks and poster presentations and to discuss their work with more established scientists in the field. Here we include the presented abstracts for the 2015 1-day conference hosted by Cardiff University. This meeting was attended by approximately 130 delegates throughout the United Kingdom, but also attended by delegates from Belgium, Netherlands, France, Ireland and other nations. The day composed of plenary presentations from Prof Matthias Belting, Lund University, Sweden and Dr Guillaume van Niel, Institut Curie, Paris together with 10 short presentations from submitted abstracts. The topics covered were broad, with sessions on Mechanisms of EV production, EVs in Infection, EVs in Cancer and in Blood and Characterizing EVs in Biological fluids. This hopefully gives a reflection of the range of EV-related studies being conducted currently in the UK. There were also 33 poster presentations equally broad in subject matter. The organizers are grateful to the Life Science Research Network Wales - a Welsh government-funding scheme that part-sponsored the conference. We are also grateful to commercial sponsors, and 3 paid-presentations are included in the abstracts. The UK EV Forum is expected to become an established annual event held at different Universities across the UK and continue to attract increasing delegate numbers and abstract submissions. We look forward to the next planned conference, which will be hosted by David Carter and his colleagues at Oxford Brookes University on 13th December 2016

The 2nd United Kingdom Extracellular Vesicle Forum Meeting Abstracts

The UK Extracellular Vesicles (UKEV) Forum meetings were born of the realization that there were a number of UK laboratories studying extracellular vesicle biology and using similar techniques but without a regular national meeting dedicated to EVs at which to share their findings. This was compounded by the fact that many of these labs were working in different fields and thus networking and sharing of ideas and best practice was sometimes difficult. The first workshop was organized in 2013 by Dr Charlotte Lawson, under the auspices of the Society for Endocrinology, led to the founding of the UKEV Forum and the organization of a British Heart Foundation sponsored 1-day conference held in London in December 2014. Although growing in size every year, the central aims of these workshops have remained the same: to provide a forum for discussion and exchange of ideas, to allow young scientists to present their data in the form of short talks and poster presentations and to discuss their work with more established scientists in the field. Here we include the presented abstracts for the 2015 1-day conference hosted by Cardiff University. This meeting was attended by approximately 130 delegates throughout the United Kingdom, but also attended by delegates from Belgium, Netherlands, France, Ireland and other nations. The day composed of plenary presentations from Prof Matthias Belting, Lund University, Sweden and Dr Guillaume van Niel, Institut Curie, Paris together with 10 short presentations from submitted abstracts. The topics covered were broad, with sessions on Mechanisms of EV production, EVs in Infection, EVs in Cancer and in Blood and Characterizing EVs in Biological fluids. This hopefully gives a reflection of the range of EV-related studies being conducted currently in the UK. There were also 33 poster presentations equally broad in subject matter. The organizers are grateful to the Life Science Research Network Wales – a Welsh government-funding scheme that part-sponsored the conference. We are also grateful to commercial sponsors, and 3 paid-presentations are included in the abstracts. The UK EV Forum is expected to become an established annual event held at different Universities across the UK and continue to attract increasing delegate numbers and abstract submissions. We look forward to the next planned conference, which will be hosted by David Carter and his colleagues at Oxford Brookes University on 13th December 2016

Small Sample Calorimetry, and Specific Heat of Gadolinium(1)barium(2-X)strontium(x)copper(3)oxygen(7).

The development of an automated small sample (0.5 to 50mg) calorimeter is discussed and evaluated. With this calorimeter, measurements of the specific heat of Gd\sb1Ba\sb{\rm 2-x}Sr\sb{\rm x}Cu\sb3O\sb7 for x = 0, 0.25, and 0.5 in the temperature range 0.6 to 3 K are reported. Measurements on the x = 0 sample agree with data collected by other groups. In addition, measurements in magnetic fields from 0 to 3 T for the x = 0 sample are reported. In each case a peak in the specific heat at the antiferromagnetic ordering temperature (the Neel temperature) is recorded and analyzed. Strontium doping does not appreciably change the Neel temperature, but drastically changes the shape of the specific heat curve below the ordering temperature. The Neel temperature is reduced proportional to the square of the applied magnetic field, becoming no longer observable for fields greater than 3.0 T. Mean field theory is applied to the Neel temperature shift in order to gain a qualitative description for this behavior. The model calculation of the spin wave contribution to the low temperature specific heat discussed in the paper indicates that strong couplings along the c axis and weak dipolar couplings in the a-b plane are responsible for the antiferromagnetic order. The strontium doping further substantiates this argument by showing that the removal of the barium ions weakens the gadolinium coupling in the c direction by removing the super-exchange path

Are exoplanetesimals differentiated?

Metals observed in the atmospheres of white dwarfs suggest that many have recently accreted planetary bodies. In some cases, the compositions observed suggest the accretion of material dominantly from the core (or the mantle) of a differentiated planetary body. Collisions between differentiated exoplanetesimals produce such fragments. In this work, we take advantage of the large numbers of white dwarfs where at least one siderophile (core-loving) and one lithophile (rock-loving) species have been detected to assess how commonly exoplanetesimals differentiate. We utilise N-body simulations that track the fate of core and mantle material during the collisional evolution of planetary systems to show that most remnants of differentiated planetesimals retain core fractions similar to their parents, whilst some are extremely core-rich or mantle-rich. Comparison with the white dwarf data for calcium and iron indicates that the data are consistent with a model in which $66^{+4}_{-6}\%$ have accreted the remnants of differentiated planetesimals, whilst $31^{+5}_{-5}\%$ have Ca/Fe abundances altered by the effects of heating (although the former can be as high as $100\%$, if heating is ignored). These conclusions assume pollution by a single body and that collisional evolution retains similar features across diverse planetary systems. These results imply that both collisions and differentiation are key processes in exoplanetary systems. We highlight the need for a larger sample of polluted white dwarfs with precisely determined metal abundances to better understand the process of differentiation in exoplanetary systems

Students’ Perspective of Self-Guided Simulation Training on Process in the Initial Phase of Private Pilot Flight Training: A Preliminary Review

As the demand for flight training increases, self-guided training methods for students can be explored to determine their effect on environment for learning. A series of self-guided simulation training scenarios, aimed at assisting initial private pilot students, were created to be used on Advanced Aviation Training Devices (AATD). A pilot study was conducted where participants, using an AATD, followed a lesson plan with detailed instructions and then were evaluated by an instructor. In addition to evaluation scores, participants were given surveys on their perceptions of the experience overall and how prepared they felt for each evaluation. This preliminary study was conducted to determine student perception of self-guided training, the effectiveness of this type of training, and if there is any impact on the number of flight hours required prior to passing their private pilot pre-solo stage check