The dissemination of medical knowledge throught vernacular languages in late medieval England: a diectological approacha

El presente trabajo es una aproximación a la posible difusión de los conocimientos médicos en la Inglaterra medieval en los siglos xiv y xv. El estudio se basa en la localización geográfica de la lengua de los escribas que llevaron a cabo la labor de copia de distintos textos médicos en inglés medio. Los textos localizados se han clasificado por su temática. A través de los mapas de distribución, se persigue el objetivo de identificar áreas que pudieran haber sido significativas por su producción de literatura médica.This work is an approach to the possible dissemination of medical knowledge in Medieval England during the 14th and 15th centuries. The study is based on the localisation of the scribal language of Middle English medical texts. The localised texts have been classified according to the topic they deal with. In mapping their distributions, we aim to identify areas which might have been salient for the production of medica

The Effects of Parenteral K1 Administration in Pseudoxanthoma Elasticum Patients Versus Controls. A Pilot Study

Introduction: Pseudoxanthoma elasticum (PXE) is a rare disease caused by mutations in the ABCC6 gene. Vitamin K1 is involved in the posttranslational carboxylation of some proteins related to inhibition of the calcification process. Our aim was to investigate, in patients affected by PXE, baseline levels of vitamin K1-dependent proteins and -metabolites and whether parenteral administration of phytomenadione was effective in modulating their levels. Methods: We included eight PXE patients with typical clinical symptoms (skin, retina, and vascular calcification) and two ABCC6 causative mutations; 13 clinically unaffected first-degree patients' relatives (9 carrying one ABCC6 mutation and 4 non-carriers). We assessed urinary vitamin K1 metabolites and serum Glu- and Gla-OC, Gas6 and undercaboxylated prothrombin (PIVKA-II), at baseline and after 1 and 6\u2009weeks after a single intramuscular injection of 10\u2009mg vitamin K1. Results: Comparison of PXE patients, heterozygous, and non-carriers revealed differences in baseline levels of serum MK-4 and of urinary vitamin K metabolites. The response to phytomenadione administration on vitamin K-dependent proteins was similar in all groups. Conclusion: The physiological axis between vitamin K1 and vitamin K-dependent proteins is preserved; however, differences in the concentration of vitamin K metabolites and of MK-4 suggest that vitamin K1 metabolism/catabolism could be altered in PXE patients

Enfoques de aprendizaje en estudiantes universitarios: comparación de resultados con los cuestionarios ASSIST y R-SPQ-2F

This study compared the approaches to learning and studying of a sample of 350 Psychology students. Approaches were measured with two of the most widely used questionnaires, namely the ASSIST and the R-SPQ-2F, which were translated into Spanish. Internal validity and reliability were analysed. A correlation pattern was identified in two dimensions: superficial and deep-strategic. No sex or year differences were found in the approaches to learning measured with the ASSIST, yet differences were found in the deep approach measured with the R-SPQ-2F. It may be argued that students in upper levels have more learning experience and achieve higher scorings in constructive and deep approach. Results are discussed in the light of current theories of approaches to learning and studying.Se comparan empíricamente los enfoques de aprendizaje y estudio en una misma muestra de estudiantes universitarios a través de los dos cuestionarios más utilizados, el ASSIST y el R-SPQ-2F. Participaron 350 alumnos de todos los cursos de la titulación de Psicología. Se adaptaron ambos cuestionarios al castellano y se estudió su validez interna y su fiabilidad. Se observa un patrón de correlaciones que implica la existencia de dos grandes dimensiones diferentes entre sí: superficial y profundo-estratégico. No se aprecian diferencias por género y curso en los enfoques de aprendizaje mediante el ASSIST, aunque  sí aparecen a través del R-SPQ-2F en el enfoque profundo, de tal modo que conforme avanzan los cursos y con ello la experiencia de aprendizaje y estudio, los estudiantes mejoran sus puntuaciones en enfoques profundos y constructivos. Se discuten estos resultados en función de las actuales teorías sobre enfoques de aprendizaje y estudio

Safety and Efficacy of a Beverage Containing Lupine Protein Hydrolysates on the Immune, Oxidative and Lipid Status in Healthy Subjects: An Intervention Study (the Lupine-1 Trial)

Scope: We have previously demonstrated the anti-inflammatory and antioxidant properties of in vitro administered Lupinus angustifolius protein hydrolysates (LPHs) on human peripheral blood mononuclear cells (PBMCs). This study aims to evaluate the safety and efficacy of a beverage containing LPHs (LPHb) on the immune, oxidative and metabolic status of healthy subjects. Methods and Results: In this open-label intervention, 33 participants daily ingest a LPHb containing 1 g LPHs for 28 days. Biochemical parameters are assayed in fasting peripheral blood and urine samples before, during (14 days) and after LPHb ingestion. Participants’ health status and the immune and antioxidant responses of PBMCs are also evaluated throughout the trial. The LPHb ingestion is safe and effective in both increasing the anti-/pro-inflammatory response of PBMCs and improving the cellular anti-oxidant capacity. LPHb also reduces the low-density lipoprotein-cholesterol (LDL-C)/high-density lipoprotein-cholesterol (HDL-C) atherogenic index. LPHb effect is particularly beneficial on decreasing not only the LDL-C/HDL-C index but also serum total cholesterol levels in the male cohort that shows the highest baseline levels of well-known cardiovascular risk factors. Conclusion: This is the first study to show the pleiotropic actions of a lupine bioactive peptides-based functional food on key steps of atherosclerosis including inflammation, oxidative stress, and cholesterol metabolism.Ministerio de Economía y Competitividad AGL2012-40247-C02-01, AGL2012-40247- C02-02Junta de Andalucía PC-0111-2016- 0111, CTS160Ministerio de Ciencia e Innovación RD06/0013/0001, RD12/0043/001

Lansoprazole Increases Inorganic Pyrophosphate in Patients with Pseudoxanthoma Elasticum: A Double-Blind, Randomized, Placebo-Controlled Crossover Trial

Pseudoxanthoma elasticum (PXE) is characterized by low levels of inorganic pyrophosphate (PPi) and a high activity of tissue-nonspecific alkaline phosphatase (TNAP). Lansoprazole is a partial inhibitor of TNAP. The aim was to investigate whether lansoprazole increases plasma PPi levels in subjects with PXE. We conducted a 2 × 2 randomized, double-blind, placebo-controlled crossover trial in patients with PXE. Patients were allocated 30 mg/day of lansoprazole or a placebo in two sequences of 8 weeks. The primary outcome was the differences in plasma PPi levels between the placebo and lansoprazole phases. 29 patients were included in the study. There were eight drop-outs due to the pandemic lockdown after the first visit and one due to gastric intolerance, so twenty patients completed the trial. A generalized linear mixed model was used to evaluate the effect of lansoprazole. Overall, lansoprazole increased plasma PPi levels from 0.34 ± 0.10 µM to 0.41 ± 0.16 µM (p = 0.0302), with no statistically significant changes in TNAP activity. There were no important adverse events. 30 mg/day of lansoprazole was able to significantly increase plasma PPi in patients with PXE; despite this, the study should be replicated with a large number of participants in a multicenter trial, with a clinical end point as the primary outcome.Funding for open access charge: Universidad de Málag

Current clinical spectrum of common variable immunodeficiency in Spain: The multicentric nationwide GTEM-SEMI-CVID registry

Common variable immunodeficiency (CVID) constitutes a heterogenic group of primary immunodeficiency disorders with a wide-ranging clinical spectrum. CVID-associated non-infectious morbidity constitutes a major challenge requiring a full understanding of its pathophysiology and its clinical importance and global variability, especially considering the broad clinical, genetic, and regional heterogeneity of CVID disorders. This work aimed to develop a nationwide, multicenter, retrospective study over a 3-year period describing epidemiological, clinical, laboratory, therapeutic, and prognostic features of 250 CVID patients in Spain. The mean diagnostic delay was around 10 years and most patients initially presented with infectious complications followed by non-infectious immune disorders. However, infectious diseases were not the main cause of morbimortality. Non-infectious lung disease was extraordinarily frequent in our registry affecting approximately 60% of the patients. More than one-third of the patients in our cohort showed lymphadenopathies and splenomegaly in their follow-up, and more than 33% presented immune cytopenias, especially Evans' syndrome. Gastrointestinal disease was observed in more than 40% of the patients. Among biopsied organs in our cohort, benign lymphoproliferation was the principal histopathological alteration. Reaching 15.26%, the global prevalence of cancer in our registry was one of the highest reported to date, with non-Hodgkin B lymphoma being the most frequent. These data emphasize the importance of basic and translational research delving into the pathophysiological pathways involved in immune dysregulation and diffuse lymphocytic infiltration. This would reveal new tailored strategies to reduce immune complications, and the associated healthcare burden, and ensure a better quality of life for CVID patients

Caracterización en la dinámica temporal de los macrohábitats acuáticos en la región de La Mojana

Con el fin de consolidar el levantamiento y análisis de la información sobre ecología de hábitats acuáticos en La Mojana, este documento describe la biodiversidad asociada a las zonas de transición entre los principales macrohábitats naturales y agroecosistemas identificados en esta región, su relación con la variabilidad en cuatro periodos hídricos desde la estacionalidad seca a la más húmeda e identificando la ocupación en el territorio por los distintos grupos biológicos.Bogotá, ColombiaPrograma Gestión Territorial de la Biodiversida

Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA

The screening of the BCR::ABL1 kinase domain (KD) mutation has become a routine analysis in case of warning/failure for chronic myeloid leukemia (CML) and B-cell precursor acute lymphoblastic leukemia (ALL) Philadelphia (Ph)-positive patients. In this study, we present a novel DNA-based next-generation sequencing (NGS) methodology for KD ABL1 mutation detection and monitoring with a 1.0E-4 sensitivity. This approach was validated with a well-stablished RNA-based nested NGS method. The correlation of both techniques for the quantification of ABL1 mutations was high (Pearson r = 0.858, p < 0.001), offering DNA-DeepNGS a sensitivity of 92% and specificity of 82%. The clinical impact was studied in a cohort of 129 patients (n = 67 for CML and n = 62 for B-ALL patients). A total of 162 samples (n = 86 CML and n = 76 B-ALL) were studied. Of them, 27 out of 86 harbored mutations (6 in warning and 21 in failure) for CML, and 13 out of 76 (2 diagnostic and 11 relapse samples) did in B-ALL patients. In addition, in four cases were detected mutation despite BCR::ABL1 < 1%. In conclusion, we were able to detect KD ABL1 mutations with a 1.0E-4 sensitivity by NGS using DNA as starting material even in patients with low levels of disease

Conclusiones finales del 1er Congreso Internacional sobre Desarrollo Personal en la Formación Inicial del Docente

El estudio que presentamos forma parte del proyecto de investigación “La formación ética docente de los futuros profesionales de los grados de Educación Infantil y Educación Primaria como elemento de selección: diagnóstico y análisis, (PID2021-129018NB-I00)”, financiado por MCIN/AEI/10.13039/501100011033/FEDER Una manera de hacer Europa. El estudio también forma parte del proyecto titulado “El desarrollo personal en la formación inicial del docente: la empatía del estudiantado y del profesorado”, que ha sido financiado con cargo a la ayuda P20-00698 concedida por la Consejería de Universidad, Investigación e Innovación de la Junta de Andalucía y por FEDER, Una manera de Hacer Europa.Ser docente en el siglo XXI requiere desempeñar funciones, algunas similares y otras diferentes, a las de los siglos que nos han precedido, para las que hemos de formarnos y formar. El papel del nuevo docente ya no es únicamente ser “transmisor de conocimientos”, sino que le toca ser “una persona comprometida y transformadora”, capaz de enseñar de forma crítica, así como conseguir que su alumnado aprenda a convivir y a ser un ciudadano responsable en la sociedad. Este documento recoge las conclusiones finales en torno a cuatro interrogantes: ¿Qué perfil docente exige la sociedad del siglo XXI?; ¿Son las habilidades blandas una necesidad formativa global?; ¿Deberíamos poner el foco en la entrada o en la salida de la formación inicial?; ¿Con el diseño de los planes de estudios de los grados actuales, podemos afrontar los retos que exige la Agenda 2030?P20_00698PID2021-129018NB-100 financiado por MCIN/AEI/10.13039/501100011033/FEDE

Mis casos clínicos de especialidades odontológicas

Libro que muestra la atención de casos clínicos particulares referente a las diferentes especialidades odontológicasLibro que muestra la atención de casos clínicos particulares referente a las diferentes especialidades odontológicasUniversidad Autónoma de Campeche Universidad Autónoma del Estado de Hidalgo Universidad Autónoma del Estado de Méxic