1,313 research outputs found
A sandpile model with tokamak-like enhanced confinement phenomenology
Confinement phenomenology characteristic of magnetically confined plasmas
emerges naturally from a simple sandpile algorithm when the parameter
controlling redistribution scalelength is varied. Close analogues are found for
enhanced confinement, edge pedestals, and edge localised modes (ELMs), and for
the qualitative correlations between them. These results suggest that tokamak
observations of avalanching transport are deeply linked to the existence of
enhanced confinement and ELMs.Comment: Manuscript is revtex (latex) 1 file, 7 postscript figures Revised
version is final version accepted for publication in PRL Revisions are mino
Continuous Time Random Walks in periodic systems: fluid limit and fractional differential equations on the circle
In this article, the continuous time random walk on the circle is studied. We
derive the corresponding generalized master equation and discuss the effects of
topology, especially important when Levy flights are allowed. Then, we work out
the fluid limit equation, formulated in terms of the periodic version of the
fractional Riemann-Liouville operators, for which we provide explicit
expressions. Finally, we compute the propagator in some simple cases. The
analysis presented herein should be relevant when investigating anomalous
transport phenomena in systems with periodic dimensions.Comment: 14 pages, 1 figure. References added. Published versio
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Developing a serocorrelate of protection against invasive group B streptococcus disease in pregnant women: a feasibility study.
BACKGROUND: Group B streptococcus is the leading cause of infection in infants. Currently, intrapartum antibiotic prophylaxis is the major strategy to prevent invasive group B streptococcus disease. However, intrapartum antibiotic prophylaxis does not prevent maternal sepsis, premature births, stillbirths or late-onset disease. Maternal vaccination may offer an alternative strategy. Multivalent polysaccharide protein conjugate vaccine development is under way and a serocorrelate of protection is needed to expedite vaccine licensure. OBJECTIVES: The ultimate aim of this work is to determine the correlate of protection against the major group B streptococcus disease-causing serotypes in infants in the UK. The aim of this feasibility study is to test key operational aspects of the study design. DESIGN: Prospective cohort study of pregnant women and their infants in a 6-month period (1 July to 31 December 2018). SETTING: Five secondary and tertiary hospitals from London and South England. National iGBS disease surveillance was conducted in all trusts in England and Wales. PARTICIPANTS: Pregnant women aged ≥ 18 years who were delivering at one of the selected hospitals and who provided consent during the study period. There were no exclusion criteria. INTERVENTIONS: No interventions were performed. MAIN OUTCOME MEASURES: (1) To test the feasibility of collecting serum at delivery from a large cohort of pregnant women. (2) To test the key operational aspects for a proposed large serocorrelates study. (3) To test the feasibility of collecting samples from those with invasive group B streptococcus. RESULTS: A total of 1823 women were recruited during the study period. Overall, 85% of serum samples were collected at three sites collecting only cord blood. At the two sites collecting maternal, cord and infant blood samples, the collection rate was 60%. A total of 614 women were screened for group B streptococcus with a colonisation rate of 22% (serotype distribution: 30% III, 25% Ia, 16% II, 14% Ib, 14% V and 1% IV). A blood sample was collected from 34 infants who were born to colonised women. Maternal and infant blood and the bacterial isolates for 15 newborns who developed invasive group B streptococcal disease during the study period were collected (serotype distribution: 29% III, 29% II, 21% Ia, 7% Ib, 7% IV and 7% V). LIMITATIONS: Recruitment and sample collection were dependent on the presence of research midwives rather than the whole clinical team. In addition, individualised consent limited the number of women who could be approached each day, and site set-up for the national surveillance study and the limited time period of this feasibility study limited recruitment of all eligible participants. CONCLUSIONS: We have verified the feasibility of collecting and processing rectovaginal swabs and blood samples in pregnant women, as well as samples from those with invasive group B streptococcal disease. We have made recommendations for the recruitment of cases within the proposed GBS3 study and for controls both within GBS3 and as an extension of this feasibility study. FUTURE WORK: A large case-control study comparing specific immunoglobulin G levels in mothers whose infants develop invasive group B streptococcal disease with those in colonised mothers whose infants do not develop invasive group B streptococcal disease is recommended. TRIAL REGISTRATION: Current Controlled Trials ISRCTN49326091; IRAS project identification number 246149/REC reference number 18/WM/0147. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 23, No. 67. See the NIHR Journals Library website for further project information
Robustness of the European power grids under intentional attack
The power grid defines one of the most important technological networks of
our times and sustains our complex society. It has evolved for more than a
century into an extremely huge and seemingly robust and well understood system.
But it becomes extremely fragile as well, when unexpected, usually minimal,
failures turn into unknown dynamical behaviours leading, for example, to sudden
and massive blackouts. Here we explore the fragility of the European power grid
under the effect of selective node removal. A mean field analysis of fragility
against attacks is presented together with the observed patterns. Deviations
from the theoretical conditions for network percolation (and fragmentation)
under attacks are analysed and correlated with non topological reliability
measures.Comment: 7 pages, 4 figure
How big is too big? Critical Shocks for Systemic Failure Cascades
External or internal shocks may lead to the collapse of a system consisting
of many agents. If the shock hits only one agent initially and causes it to
fail, this can induce a cascade of failures among neighoring agents. Several
critical constellations determine whether this cascade remains finite or
reaches the size of the system, i.e. leads to systemic risk. We investigate the
critical parameters for such cascades in a simple model, where agents are
characterized by an individual threshold \theta_i determining their capacity to
handle a load \alpha\theta_i with 1-\alpha being their safety margin. If agents
fail, they redistribute their load equally to K neighboring agents in a regular
network. For three different threshold distributions P(\theta), we derive
analytical results for the size of the cascade, X(t), which is regarded as a
measure of systemic risk, and the time when it stops. We focus on two different
regimes, (i) EEE, an external extreme event where the size of the shock is of
the order of the total capacity of the network, and (ii) RIE, a random internal
event where the size of the shock is of the order of the capacity of an agent.
We find that even for large extreme events that exceed the capacity of the
network finite cascades are still possible, if a power-law threshold
distribution is assumed. On the other hand, even small random fluctuations may
lead to full cascades if critical conditions are met. Most importantly, we
demonstrate that the size of the "big" shock is not the problem, as the
systemic risk only varies slightly for changes of 10 to 50 percent of the
external shock. Systemic risk depends much more on ingredients such as the
network topology, the safety margin and the threshold distribution, which gives
hints on how to reduce systemic risk.Comment: 23 pages, 7 Figure
Characterising anomalous transport in accretion disks from X-ray observations
Whilst direct observations of internal transport in accretion disks are not yet possible, measurement of the energy emitted from accreting astrophysical systems can provide useful information on the physical mechanisms at work. Here we examine the unbroken multi-year time variation of the total X-ray flux from three sources: Cygnus X-1 , the microquasar GRS 1915+105 , and for comparison the nonaccreting Crab nebula. To complement previous analyses, we demonstrate that the application of advanced statistical methods to these observational time-series reveals important contrasts in the nature and scaling properties of the transport processes operating within these sources. We find the Crab signal resembles Gaussian noise; the Cygnus X-1 signal is a leptokurtic random walk whose self-similar properties persist on timescales up to three years; and the GRS 1915+105 signal is similar to that from Cygnus X-1, but with self-similarity extending possibly to only a few days. This evidence of self-similarity provides a robust quantitative characterisation of anomalous transport occuring within the systems
Statistics of extremal intensities for Gaussian interfaces
The extremal Fourier intensities are studied for stationary
Edwards-Wilkinson-type, Gaussian, interfaces with power-law dispersion. We
calculate the probability distribution of the maximal intensity and find that,
generically, it does not coincide with the distribution of the integrated power
spectrum (i.e. roughness of the surface), nor does it obey any of the known
extreme statistics limit distributions. The Fisher-Tippett-Gumbel limit
distribution is, however, recovered in three cases: (i) in the non-dispersive
(white noise) limit, (ii) for high dimensions, and (iii) when only
short-wavelength modes are kept. In the last two cases the limit distribution
emerges in novel scenarios.Comment: 15 pages, including 7 ps figure
Role of Network Topology in the Synchronization of Power Systems
We study synchronization dynamics in networks of coupled oscillators with
bimodal distribution of natural frequencies. This setup can be interpreted as a
simple model of frequency synchronization dynamics among generators and loads
working in a power network. We derive the minimum coupling strength required to
ensure global frequency synchronization. This threshold value can be
efficiently found by solving a binary optimization problem, even for large
networks. In order to validate our procedure, we compare its results with
numerical simulations on a realistic network describing the European
interconnected high-voltage electricity system, finding a very good agreement.
Our synchronization threshold can be used to test the stability of frequency
synchronization to link removals. As the threshold value changes only in very
few cases when aplied to the European realistic network, we conclude that
network is resilient in this regard. Since the threshold calculation depends on
the local connectivity, it can also be used to identify critical network
partitions acting as synchronization bottlenecks. In our stability experiments
we observe that when a link removal triggers a change in the critical
partition, its limits tend to converge to national borders. This phenomenon,
which can have important consequences to synchronization dynamics in case of
cascading failure, signals the influence of the uncomplete topological
integration of national power grids at the European scale.Comment: The final publication is available at http://www.epj.org (see
http://www.springerlink.com/content/l22k574x25u6q61m/
Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma in Asia Frequently Shows SETD2 Alterations.
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare primary T-cell lymphoma of the digestive tract derived from intraepithelial lymphocytes and characterized by an aggressive clinical course. In this study, nine cases of Japanese MEITL were analyzed by targeted Next Generation Sequencing (NGS) and immunohistochemistry and were integrated with previously reported whole-genome copy number microarray-based assay data. The highlight of our findings is that all cases showed alterations of the tumor suppressor gene SETD2 by mutations and/or loss of the corresponding 3p21 locus. We also demonstrated that all cases showed mutations in one or more genes of JAK/STAT pathway. Therefore, the combination of epigenetic deregulation and cell signaling activation represent major oncogenic events in the pathogenesis of MEITL in Asian MEITL, similar to Western MEITL
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