Short term effects of irradiance on the growth of Pterocladiella capillacea (Gelidiales, Rhodophyta)

Pterocladiella capillacea has been economically exploited for agar extraction in the Azores for many years. Harvesting dropped to a full stop in the early 1990s due to a population collapse, but restarted in 2013. Since then it has been intensively harvested and overexploitation must be prevented, with both sustainable harvesting and effective cultivation practices. This study represents the first attempt to determine optimal conditions for P. capillacea production in the Azores, and evaluates its vegetative growth in two experiments using von Stosch’s medium designed to test entire thallus and tips portions response to different irradiances (30, 70 and 150 μmol photons m¯² s¯¹). The best relative growth rate (RGR) was recorded at 150 μmol photons m¯² s¯¹ for the entire thalli and tips after two-weeks and three-weeks, respectively, indicating that an acclimation period is necessary to assure the growth of this alga under experimental conditions. Higher RGR was obtained at higher irradiance (3.98 ± 2.10% fm day¯¹), but overall, growth rates were low or negative. Epiphytes were a serious problem towards the end of the entire thallus experiments, where Feldmannia irregularis proliferate at all irradiances. Future cultivation approaches complemented with other relevant environmental factors (e.g. pH, photoperiod, salinity), are recommended.FCT – Fundação para a Ciência e Tecnologia projects UID/BIA/00329/2013, 2015 - 2018 and UID/BIA/00329/2019, CIRN (Centro de Investigação de Recursos Naturais, University of the Azores), and CIIMAR (Interdisciplinary Centre of Marine and Environmental Research, Porto, Portugal). RFP was supported by a doctoral grant M3.1.2/F/024/2011, Fundo Regional para a Ciência e Tecnologia.info:eu-repo/semantics/publishedVersio

The interconnection between law and bioethics in the light of their theoretical, institutional, and regulatory dimensions

O presente artigo objetiva analisar a interconexão entre Direito e bioética tendo como foco as contribuições deste novo saber para os aplicadores do Direito na sua função de harmonização do convívio social. Para tanto, utilizou-se linha de pesquisa que propõe o recurso de dividir a bioética em três perspectivas: teórica, institucional e normativa. A partir de cada um desses enfoques, analisou-se os pontos de contato entre os dois saberes, bem como o modo em que a bioética concorre para o aprimoramento do Direito. Constatou-se que a bioética pode auxiliar o Poder Judiciário e o aplicador do Direito a compatibilizar a racionalidade jurídica com a reflexão ética propiciada por novos paradigmas científicos, contribuindo, assim, para a diminuição das dificuldades surgidas na busca de soluções para questões complexas relativas a conflitos nas áreas das ciências da vida, medicina e tecnologias associadas.This article aims to analyze the interconnection between Law and bioethics, focusing on the contributions of this new knowledge to the enforcers of Law in its function of social harmonization. For this purpose, we used the research line which features splitting bioethics into three perspectives: theoretical Bioethics, institutional and regulatory, and from each of these approaches, we analyzed the points of contact between the two fields of knowledge, and how bioethics contributes to the improvement of the Law. It was found that bioethics, helps the Judiciary Power and the ones who work with Law to deal with the complexity of issues related to life sciences, medicine and associated technologies.Este artículo tiene como objetivo analizar la interconexión entre el derecho y la bioética, centrándose en las contribuciones de este nuevo conocimiento para encargados de hacer cumplir la ley en su tarea de armonización de la vida social. Para este fin, se utilizó una línea de investigación que propone como recurso la división de la bioética en tres dimensiones: la bioética teórica, institucional y normativa. A partir de cada uno de estos enfoques, se analizaron los puntos de contacto entre los dos conocimientos, así como la manera que la bioética que contribuye a la mejor comprensión del Derecho. Se comprobó que la bioética puede ayudar al Poder Judiciario y al aplicador de la ley a conciliar la racionalidad legal con el pensamiento ético fomentado por nuevos paradigmas científicos, contribuyendo de esa forma para las cuestiones complejas relacionadas a conflictos en ámbito de las ciencias de la vida, médica y tecnologías adjuntas

Cognition and evaluation of architecture environments based on geometric contour references and aesthetic judgements

This paper presents the outline and the achieved results of an experimental study developed to understand the differences on how close architecture spaces with distinct geometric characteristics at contour level, including rounded, curvilinear and sharp, rectilinear elements, are perceived and evaluated. In order to do so, eighteen virtual reality architecture spaces were evaluated by thirty-two test-subjects according to like/dislike aesthetic judgments. As expected, the tested subjects showed a higher level of preference for spaces with rounded, curvilinear contour elements. On another way, when the level of space curvature was high, considering the whole space surface and not only the contour of plan transitions, the level of preference decreased significantly. These results support the idea that rounded, curvilinear elements are interpreted as being more pleasant and preferred than sharp, rectilinear ones and create new knowledge on the how the levels of such preference are more accurate for moderate rather than radical curvature rates

Travel of studies: cities of João Pessoa, Maceio, Natal and Recife: a look on the urban space and brazilian architectural production

Ponencia presentada a Session 8: Dimensiones psicosociales de la arquitectura y el urbanismo / Psycological dimensions of architecture and planningThis article aims to present the methodology and the final results of the elective course “Travel of Studies” which belongs to the new pedagogical project from the Architecture and Urbanism course at the University Federal of Pernambuco. It was offered for the first time in 2013.The discipline was organized to occur in four long weekends through visits of four capitals of the Northeast of Brazil: Recife, João Pessoa, Natal and Maceió. The purpose was to allow the students to apprehend the cities through four axis: intervention in historical center (axis 1), production of urban space (axis 2), production of coastline space (axis 3) and contemporary architecture (axis 4). After the four visits were complete, we prepared a poster with the comparison of the cities based on the identification of the similarities and differences of each axis we have studied

Reacção ao Glutamato Monossódico – Avaliação por Prova de Provocação em Ocultação Simples

Em 1968 foram descritos sintomas autolimitados que surgiam até 30 minutos após refeição em restaurante chinês. Esta síndrome tem sido atribuída ao consumo de glutamato monossódico (GMS), sendo designada por “complexo de sintomas associado ao GMS”. Foi objectivo deste estudo avaliar a resposta ao GMS em dois adultos com história sugestiva de reacção adversa a este aditivo alimentar. Em ocultação simples, foram administrados oralmente, em jejum e em dias diferentes, placebo ou doses crescentes de GMS, até à dose cumulativa de 5 gramas, sendo a prova considerada positiva caso surgissem pelo menos dois sintomas de vinte descritos na literatura. Apenas a prova com GMS foi positiva num doente, que referiu mal-estar geral, astenia e hipersudorese, na dose máxima. À semelhança de outros estudos, os resultados sugerem que doses elevadas de GMS, administradas sem alimentos, podem provocar sintomas em indivíduos com história suspeita de “complexo de sintomas associado a GMS”

Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity

Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry. Isatin, due to its unique reactivity, can undergo different MCRs, affording multiple interesting scaffolds, namely oxindole-derivatives (including spirooxindoles, bis-oxindoles and 3,3-disubstituted oxindoles) and even, under certain conditions, ring-opening reactions occur that leads to other heterocyclic compounds. Over the past few years, new methodologies have been described for the application of this important and easily available starting material in MCRs. In this review, we explore these novelties, displaying them according to the structure of the final products obtained

Drug Provocation Tests to Betalactam Antibiotics: Experience in a Paediatric Setting

Background: Few studies have been performed in children withs uspected betalactam allergy.We aimed to assess the role of the drug provocation test(DPT)with betalactams in a paediatric setting and to study the association between allergy to betalactam antibiotics and other allergic diseases. Methods:We included all the patients under 15 years old who were consecutively referred to the Immunoallergy Department, Dona Estefânia Hospital,Portugal(January 2002 to April 2008)for a compatible history of allergic reaction to betalactam. All were submitted to a DPT.Children were proposed to performs kintests(ST)to betalactam antibiotics followed by DPT. If they decline ST,a DPT with the culprit drug was performed. Results: We studied 161 children,60%were boys,with a median age of 5years old at the time of the DPT.Thirty-three patients(20.5%)had an immediate reaction and 33(20.5%)a non-immediate reaction. These verity of there porte dreactions was low in most cases. Skin tests to betalactams were performed in 47 children and were positive in 8.DPT was positive inonlyone(3.4%)of the patients skin tested and in 11(13.4%)of those not skin tested. These verity of the DPT reaction was low.Asthma and food allergy were associated with a positive DPT in the later group. Conclusions: DPT seems a safe procedure even in the absence of ST in non-severe cases. This could be a practical optionin infants and pre-school children,where ST are painful and difficult to perform.Additional caution should be taken in children with asthma and food allergy

Admission for Imported Malaria in Children, in Two Hospitals of Lisbon Urban Area

Introdução: Apesar de em Portugal não haver malária endógena,a crescente mobilidade das populações e os laços históricos com África possibilitam a importação de casos para o nosso país. O presente estudo pretende contribuir para melhorar o conhecimento epidemiológico e clínico da malária importada na região de Lisboa. Métodos: Realizou-se um estudo descritivo das crianças com malária, internadas em dois hospitais da Grande Lisboa, durante um período de seis anos (1999-2004). Resultados: Foram identificados 134 casos, sendo a mediana das idades de sete anos. A maioria (93,3%) era de origem africana e referia estadia em região endémica (90%). O Plasmodium falciparum foi o agente etiológico mais frequente (73%). A febre foi a manifestação clínica mais frequente, seguida de manifestações gastrointestinais e cefaleias. Ocorreram complicações em 42% dos doentes, sendo a trombocitopenia (19,4%) e a anemia grave (9%) as mais frequentes. A halofantrina e o quinino foram os anti-maláricos mais usados. Conclusões: A malária importada é uma patologia relativamente comum na Grande Lisboa e, dada a inespecificidade do quadro clínico, todas as crianças febris ou doentes com estadia recente num país endémico devem ser rastreadas para esta entidade

A clinical argument or an access constraint?

Funding Information: In the preparation of this article, the authors received collaboration from the medical writer Duarte Oliveira (W4Research) financially supported by Sanofi. Sanofi had no role in the preparation of the manuscript or in the decision to submit the manuscript for publication. All authors declare collaborating and receiving fees from Sanofi and other pharmaceutical companies either through participation in advisory boards or consultancy, congress symposia, conducting clinical trials, investigator-initiated trials or grants. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.proofpublishe

Immunodeficiency and Autoimmunity Coming Together: a Nearly Missed Diagnosis

The coexistence of human immunodeficiency virus (HIV) and systemic lupus erythematosus (SLE) appears to be unusual and the prevalence of patients who carry the dual diagnosis is currently unknown. We hereby present a case of a C4 deficient HIV-1 positive Caucasian female under highly active antiretroviral therapy for the past eight years, admitted to hospital with an aggressive and potentially fatal clinical presentation of SLE. There was a favorable outcome despite a significant diagnostic delay. Despite its rarity, the case highlights that this association is remarkable and may be overlooked by clinicians familiar with either condition.info:eu-repo/semantics/publishedVersio