Diseño e implementación del kernel de xDEVS, versión distribuida

Para entender nuestro proyecto, debemos comprender DEVS. Dentro de los formalismos más populares de representación de sistemas de eventos discretos se encuentra DES. En la década de los 70, el matemático Bernard Zeigler propuso un formalismo general para la representación de dichos sistemas. Este formalismo denominado DEVS (Discrete EVent System Specification) es el formalismo más general para el tratamiento de DES. DEVS permite representar todos aquellos sistemas cuyo comportamiento pueda describirse mediante una secuencia de eventos discretos. Estos eventos se caracterizan por un tiempo base en el que solo un número de eventos finitos puede ocurrir. DEVS Modelado y Simulación tiene múltiples implementaciones en varios lenguajes de programación como por ejemplo en Java, C# o C++. Pero surge la necesidad de implementar una plataforma distribuida estable para proporcionar la mecánica de interoperabilidad e integrar modelos DEVS diversificados. En este proyecto, se nos dará como código base el core de xDEVS en java, aplicado de forma secuencial y paralelizada. Nuestro trabajo será implementar el core de manera distribuida de tal forma que se pueda dividir un sistema DEVS en diversas máquinas. Para esto hemos utilizado sockets de java para hacer la transmisión de datos lo más eficiente posible. En un principio deberemos especificar el número de máquinas que se conectarán al servidor. Una vez estas se hayan conectado se les enviará el trabajo específico que deberán simular. Cabe destacar que hay dos formas de dividir un sistema DEVS las cuales están implementadas en nuestro proyecto. La primera es dividirlo en módulos atómicos los cuales son subsistemas indivisibles en un sistema DEVS. Y la segunda es dividir las funciones de todos los subsistemas en grupos y repartirlos entre las máquinas. En resumen el funcionamiento de nuestro sistema distribuido será comenzar ejecutando el trabajo asignado al primer cliente, una vez finalizado actualizará la información del servidor y este mandara la orden al siguiente y así sucesivamente

Respuesta funcional en ancianos con gonartrosis con el empleo del producto natural folrex

Se realizó un ensayo clínico fase tres con pacientes ancianos afectos de artropatía de rodillas atendidos en consultas del Hospital Clínico Quirúrgico Docente “Dr. Salvador Allende” de Ciudad de la Habana, a los que se les aplicó el producto natural Folrex, para valorar la respuesta de la capacidad funcional en ancianos con Gonartrosis con el empleo del producto natural Folrex (oral y crema), de los Laboratorios Catalysis de España. Se realizó un ensayo clínico fase III en pacientes mayores de 60 años de las consultas de Geriatría y Ortopedia con diagnóstico de Gonartrosis, el universo fue de 159 enfermos de osteoartrosis, la muestra 64 divididos en 32 controles con tratamiento convencional (AINES) y 32 casos que usaron Folrex oral y crema. Del total de casos atendidos, se comprobó mejoría del dolor, rigidez, inflamación e impotencia funcional en mayor proporción de los casos que los controles, la capacidad funcional se desplazó más hacia la mejoría evidente en los casos que en los controles, las reacciones adversas fueron mínimas en los casos comparadas con los controles. Se demostraron las bondades del producto natural Folrex como modalidad terapéutica en pacientes con Gonartrosis

La migración de jornaleros agrícolas tlaxcaltecas a Canadá: un sistema complejo

In this article, system theory or a systemic approach is used inorder to explain interrelations in the complex and multi-factorialmigratory process that hundreds of people from Tlaxcala gothrough every year, especially during the season when Canadarequires labor for its agricultural work, which spans fromgreenhouse preparation to harvesting and packing fruits andvegetables; migration is legal under the implementation of theSeasonal Agricultural Workers Program México – Canada(PTAT, for its initials in Spanish), which is managed in Méxicoby the Ministry of Labor and Social Prevision, in each of theparticipating entities in the country. This is a historical processwhich, due to its complexity, requires a holistic approach inorder to tackle not only the economic, demographic or culturalaspects of the process, but also the political, environmental andeven the visible and invisible of subjective aspects that the processand actors involved present: domestic violence, psychologicaldisorders, and emotional, moral and even existential crises. Thus,a new perspective is used for the analysis of the migratory processfrom the state of Tlaxcala.En este trabajo se retoma la teoría de sistemas o enfoque sistémico,para explicar las interrelaciones del proceso migratorio complejoy multifactorial que cientos de tlaxcaltecas viven cada año, especialmenteen la temporada en que Canadá requiere de mano deobra para su trabajo agrícola, que va desde la preparación delinvernadero, hasta la cosecha y empacado de frutas y verduras;migración que es legal bajo la operación del Programa de TrabajadoresAgrícolas Temporales Mexicanos a Canadá (PTAT), manejadoen México por la Secretaria del Trabajo y Previsión Social,en cada una de las entidades federativas participantes del país. Setrata de un proceso histórico que, debido a su complejidad, precisade un enfoque holístico para abordar no sólo lo económico,demográfico, o cultural del proceso, sino también lo político, loambiental, y aun lo visible e invisible de lo subjetivo que presentanel proceso y actores involucrados: violencia intrafamiliar, trastornospsicológicos, crisis emocionales, morales y hasta existenciales.De esta manera se utiliza una nueva perspectiva para el análisisdel proceso migratorio del estado de Tlaxcala

Experiences with workflows for automating data-intensive bioinformatics

High-throughput technologies, such as next-generation sequencing, have turned molecular biology into a data-intensive discipline, requiring bioinformaticians to use high-performance computing resources and carry out data management and analysis tasks on large scale. Workflow systems can be useful to simplify construction of analysis pipelines that automate tasks, support reproducibility and provide measures for fault-tolerance. However, workflow systems can incur significant development and administration overhead so bioinformatics pipelines are often still built without them. We present the experiences with workflows and workflow systems within the bioinformatics community participating in a series of hackathons and workshops of the EU COST action SeqAhead. The organizations are working on similar problems, but we have addressed them with different strategies and solutions. This fragmentation of efforts is inefficient and leads to redundant and incompatible solutions. Based on our experiences we define a set of recommendations for future systems to enable efficient yet simple bioinformatics workflow construction and execution.Pubblicat

Physicochemical Parameters, Mineral Composition, and Nutraceutical Properties of Ready-to-Drink Flavored-Colored Commercial Teas

The physicochemical parameters, mineral composition, and nutraceutical properties of ready-to-drink flavored-colored commercial teas were analyzed in the present study. The pH of samples was slightly acidic (3.72 to 4.11), titratable acidity was low (0.092 to 0.174%), and color parameters were wide variable (pink, yellow, brown, and red). Citrus-flavored tea obtained the highest content of manganese (0.281mg·L−1), zinc (0.069mg·L−1), magnesium (2.92mg·L−1), potassium (62.65mg·L−1), and sodium (271.74mg·L−1), while lemon-, peach-, and blueberry-flavored teas obtained the highest levels of copper (0.035mg·L−1), iron (0.246mg·L−1), and calcium (18.21mg·L−1), respectively. Citrus, lemon-, sangria-, and rose petal-flavored teas obtained the highest content in total phenols (211.56mg·L−1), total flavonoids (65.46mg·L−1), total catechins (640.79mg·L−1), and total anthocyanins (640.79mg·L−1), respectively. Lemon- and rose petal-flavored teas showed the highest and lowest antioxidant capacity levels in DPPH (1096.00 to 118.77μmolTE·L−1), ABTS (1048.84 to 232.00μmolTE·L−1), and FRAP (1269.20 to 147.70μmolTE·L−1) assays. The levels of sodium reported in labels of all samples were lower than data obtained in our analysis. Alsothelevelsobservedfortotalphenolsinblueberry-,citrus-,androsepetal-flavoredteaswerelowerthanouranalysis,buttotal phenolsoflemon-,peach-,andsangria-flavoredteaswerehigherthanthecontentreportedintheirlabels.Theresultsobtainedin thepresentworkgiveinformationtoconsumersforchoosingflavored-coloredready-to-drinkteabasedonthephysicochemical, nutritional, and nutraceutical properties

Kairos study protocol: a multidisciplinary approach to the study of school timing and its effects on health, well-being and students’ performance

Recent evidence from chronobiology, chssronomedicine and chronopsychology shows that the organisation of social time (e.g., school schedules) generally does not respect biological time. This raises concerns about the impact of the constant mismatch between students’ social and internal body clocks on their health, well-being and academic performance. The present paper describes a protocol used to investigate the problem of (de) synchronisation of biological times (chronotypes) in childhood and youth in relation to school times. It studies the effects of student chronotype vs. school schedule matches/mismatches on health behaviours (e.g., how many hours students sleep, when they sleep, eat, do physical activity, spend time outdoors in daylight) and learning (verbal expression, spatial structuring, operations) and whether alert-fatigue levels mediate this effect alignments/misalignments on learning (verbal expression, spatial structuring, operations) and their mediation by alert-fatigue levels. The novelty of our protocol lies in its multidisciplinary and mixed methodology approach to a relevant and complex issue. It draws on up-to-date knowledge from the areas of biology, medicine, psychology, pedagogy and sociology. The methods employed include a varied repertoire of techniques from hormonal analysis (cortisol and melatonin), continuous activity and light monitoring, self-registration of food intake, sleep timings, exercise and exposure to screens, alongside with systematic application of cognitive performance tests (e.g., memory, reasoning, calculation, attention) and self-reported well-being. This comprehensive and interdisciplinary protocol should support evidence-based education policy measures related to school time organisation. Appropriate and healthier school timetables will contribute to social change, healthier students and with more efficient learning. The results of studies using a similar methodology in other countries would ensure replication and comparability of results and contribute to knowledge to support policy making

Salud de los trabajadores

Actividad física y su relación con los factores de riesgo cardiovascular de carteros chilenosAnálisis de resultados: riesgos psicosociales en el trabajo Suceso-Istas 21 en Cesfam QuellónAusentismo laboral por enfermedades oftalmológicas, Chile 2009Brote de diarreas por norovirus, posterremoto-tsunami, Constitución, Región del MauleCalidad de vida en profesionales de la salud pública chilenaCaracterización del reposo laboral en personal del SSMN durante el primer semestre de 2010Concentración de nicotina en pelo en trabajadores no fumadores expuestos a humo de tabaco ambientalCondiciones de trabajo y bienestar/malestar docente en profesores de enseñanza media de SantiagoDisfunción auditiva inducida por exposición a xilenoErgonomía aplicada al estudio del síndrome de dolor lumbar en el trabajoEstimación de la frecuencia de factores de riesgo cardiovascular en trabajadores de una empresa mineraExposición a plaguicidas inhibidores de la acetilcolinesterasa en Colombia, 2006-2009Factores de riesgo y daños de salud en conductores de una empresa peruana de transporte terrestre, 2009Las consecuencias de la cultura en salud y seguridad ocupacional en una empresa mineraPercepción de cambios en la práctica médica y estrategias de afrontamientoPercepción de la calidad de vida en la Universidad del BiobíoPesos máximos aceptables para tareas de levantamiento manual de carga en población laboral femeninaRiesgo coronario en trabajadores mineros según la función de Framingham adaptada para la población chilenaTrastornos emocionales y riesgo cardiovascular en trabajadores de la salu

Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry

Aim To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Methods Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality

Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when = 50 years and symptomatic for <= 7days were included. The intervention consisted of 200-300mL of CP with a predefined minimum level of antibodies. Primary endpoints were a 5-point disease severity scale and a composite of hospitalization or death by 28 days. Amongst the 797 patients included, 390 received CP and 392 placebo; they had a median age of 58 years, 1 comorbidity, 5 days symptoms and 93% had negative IgG antibody-test. Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of CP for improved disease severity scale was 0.936 (credible interval (CI) 0.667-1.311); OR for hospitalization or death was 0.919 (CI 0.592-1.416). CP effect on hospital admission or death was largest in patients with <= 5 days of symptoms (OR 0.658, 95%CI 0.394-1.085). CP did not decrease the time to full symptom resolution