Novel delayed‐cure, durable press, shrink‐resist treatment of wool fabrics and garments

The relatively high heat stability of commercial easy‐care chemicals for cotton allows for greater flexibility in garment manufacturing, in particular the delayed curing of durable press, wrinkle‐resistant, shrink‐resist (SR) finishes on garments. Typically, the technology involves application of the wet chemical finish to the open width fabric, drying, storage, garment manufacture, heat pressing of the creases/pleats, and lastly garment baking to fully cure the durable press/crease‐resistant/SR finish. By contrast, for the wool industry, there is no comparable technology, and this presents an obvious commercial weakness. The reason for this technical deficiency is that the prepolymers used for imparting machine washability and potentially durable press to wool apparel polymerise on the fabric at room temperature in storage, thereby losing their reactivity. Subsequent manufacturing into the final garment still allows the fabric to offer stability to laundering, but the loss of prepolymer reactivity precludes any potential for introducing durable creases/pleats into the garment as an integrated late‐stage garment process. In this study, we present a simple solution to this technical deficiency through the use of cyclodextrin‐based technology and deliver a delayed‐cure, durable press, machine‐washable wool technology ready for market. In any commercial textile process, the effect of chemical finishing on the final fabric colour is important. It is demonstrated in this study that the addition of HP‐β‐cyclodextrin into the Synthappret BAP and EC 1354 formulations has an instrumentally detectable effect on the colour of the dyed wool fabric, but that this difference is less than one colour difference (ΔECMC) unit

Changes in strength, power, and speed across a season in English county cricketers

PURPOSE: Previous research has investigated changes in athletes' strength, power, and speed performances across the competitive season of many sports, although this has not been explored in cricketers. The aim of this study was to investigate changes in lower-body strength and jump and sprint performances across an English county cricket season. METHODS: Male cricketers (N = 12; age 24.4 ± 2.3 y, body mass 84.3 ± 9.9 kg, height 184.1 ± 8.1 cm) performed countermovement jumps (CMJs) and 20-m sprints on 4 separate occasions and back-squat strength testing on 3 separate occasions across a competitive season. RESULTS: Both absolute (12.9%, P = .005, effect size [ES] = 0.53) and relative lower-body strength (15.8%, P = .004, ES = 0.69) and CMJ height (5.3%, P = .037, ES = 0.42) improved significantly over the preseason training period, although no significant change (1.7%, P > .05) in sprint performance was observed. In contrast, absolute (14.3%, P = .001, ES = 0.72) and relative strength (15.0%, P = .001, ES = 0.77), CMJ height (4.2%, P = .023, ES = 0.40), and sprint performance (3.8%, P = .012, ES = 0.94) declined significantly across the season. CONCLUSIONS: The results of this study show that neither the demands of the competitive cricket season nor current in-season training practices provide a sufficient stimulus to maintain strength, jump, and sprint performances in these cricketers. Therefore, coaches should implement a more-frequent, higher-load strength-training program across the competitive cricket season

Preparation and physical properties of regenerated cellulose fibres from cotton waste garments

The aim of this research was to investigate the recycling of cotton waste garments by fibre regeneration. Easy care finished cotton fabrics and indigo dyed waste denim garments were successfully purified, dissolved in a suitable solvent and spun into fibres. The physical properties of the resultant fibres were compared with standard lyocell fibres spun from wood pulp and the fibres regenerated from the cotton waste garments exhibited improved mechanical and molecular properties relative to the typical fibres regenerated from wood pulp. Furthermore the results have indicated that a suitable blend of wood pulp and pulp reclaimed form cotton based waste garments can produce fibres with properties that are intermediate to cotton and lyocell fibres. The results suggest an alternative approach to fibre resource management by converting cotton based waste garment through regeneration processing into second lifetime cellulosic fibre. The approach will contribute to the reduction of both economic and environmental impact of waste garments and better management of resources required for production of cotton and synthetic fibres

Clinical findings and genetic screening for copy number variation mutations in a cohort of South African patients with Parkinson’s disease

Background. Parkinson’s disease (PD), with a prevalence of up to 4% in Western countries, appears to be less common in Africa, possibly in part because of genetic factors. African studies investigating the genetic causation of PD are limited.Objective. To describe the clinical and genetic findings in a group of black South African patients with PD.Methods. All black African patients with PD from a tertiary hospital neurology clinic were examined. Symptoms were scored according to the Unified Parkinson’s Disease Rating Scale (UPDRS), and patients were classified according to motor features. Genomic DNA was extracted and multiplex ligation-dependent probe amplification was used for detection of copy number variation (CNV) mutations in the known PD-causing genes.Results. Sixteen patients were identified (ages 56 - 82 years). Three had a family history of PD. Classification into motor subtypes showed 44% mixed, 31% akinetic-rigid, and 25% tremor-dominant subtypes. UPDRS scores ranged from 7 to 88, with dementia in 20%. No patient had G2019S LRRK2 and A30P SNCA mutations, and all except one had no CNV mutations in the known PD-causing genes. A female patient (age of onset 50 years, no family history) had a parkin gene heterozygous deletion of exon 4. She had hyperreflexia, bilateral Hoffmann’s reflexes, normal plantar responses and no dystonia.Conclusion. This group of black African patients showed similar characteristics to patients in Western studies, possibly with a higher proportion having tremor dominant disease. Genetic analysis showed one parkin gene mutation. The limited knowledge on PD-causing genes and mutations in black populations warrants further studies involving next-generation sequencing approaches

Dedifferentiation of neurons precedes tumor gormation in lola mutants

The ability to reprogram differentiated cells into a pluripotent state has revealed that the differentiated state is plastic and reversible. It is evident, therefore, that mechanisms must be in place to maintain cells in a differentiated state. Transcription factors that specify neuronal characteristics have been well studied, but less is known about the mechanisms that prevent neurons from dedifferentiating to a multipotent, stem cell-like state. Here, we identify Lola as a transcription factor that is required to maintain neurons in a differentiated state. We show that Lola represses neural stem cell genes and cell-cycle genes in postmitotic neurons. In lola mutants, neurons dedifferentiate, turn on neural stem cell genes, and begin to divide, forming tumors. Thus, neurons rather than stem cells or intermediate progenitors are the tumor-initiating cells in lola mutants

A critical review on recent advancements of the removal of reactive dyes from dyehouse effluent by ion-exchange adsorbents

The effluent discharged by the textile dyehouses has a seriously detrimental effect on the aquatic environment. Some dyestuffs produce toxic decomposition products and the metal complex dyes release toxic heavy metals to watercourses. Of the dyes used in the textile industry, effluents containing reactive dyes are the most difficult to treat because of their high water-solubility and poor absorption into the fibers. A range of treatments has been investigated for the decolorization of textile effluent and the adsorption seems to be one of the cheapest, effective and convenient treatments. In this review, the adsorbents investigated in the last decade for the treatment of textile effluent containing reactive dyes including modified clays, biomasses, chitin and its derivatives, and magnetic ion-exchanging particles have been critically reviewed and their reactive dye binding capacities have been compiled and compared. Moreover, the dye binding mechanism, dye sorption isotherm models and also the merits/demerits of various adsorbents are discussed. This review also includes the current challenges and the future directions for the development of adsorbents that meet these challenges. The adsorption capacities of adsorbents depend on various factors, such as the chemical structures of dyes, the ionic property, surface area, porosity of the adsorbents, and the operating conditions. It is evident from the literature survey that decolorization by the adsorption shows a great promise for the removal of color from dyehouse effluent. If biomasses want to compete with the established ion-exchange resins and activated carbon, their dye binding capacity will need to be substantially improved

Deep subcutaneous application of poly-L-lactic acid as a filler for facial lipoatrophy in HIV-infected patients

Introduction: Facial lipoatrophy is a crucial problem of HIV-infected patients undergoing highly active antiretroviral therapy (HAART). Poly-L-lactic acid (PLA), provided as New-Fill(R)/Sculptra(TM), is known as one possible treatment option. In 2004 PLA was approved by the FDA as Sculptra(TM) for the treatment of lipoatrophy of the face in HIV-infected patients. While the first trials demonstrated relevant efficacy, this was to some extent linked to unwanted effects. As the depth of injection was considered relevant in this context, the application modalities of the preparation were changed. The preparation was to be injected more deeply into subcutaneous tissue, after increased dilution. Material and Methods: To test this approach we performed a pilot study following the new recommendations in 14 patients. Results: While the efficacy turned out to be about the same, tolerability was markedly improved. The increase in facial dermal thickness was particularly obvious in those patients who had suffered from lipoatrophy for a comparatively small period of time. Conclusion: With the new recommendations to dilute PLA powder and to inject it into the deeper subcutaneous tissue nodule formation is a minor problem. However, good treatment results can only be achieved if lipoatrophy is not too intense; treatment intervals should be about 2 - 3 weeks. Copyright (C) 2005 S. Karger AG, Basel

Van Allen Probes, THEMIS, GOES, and Cluster Observations of EMIC waves, ULF pulsations, and an electron flux dropout

We examined an electron flux dropout during the 12-14 November 2012 geomagnetic storm using observations from seven spacecraft: the two Van Allen Probes, Time History of Events and Macroscale Interactions during Substorms (THEMIS)-A (P5), Cluster 2, and Geostationary Operational Environmental Satellites (GOES) 13, 14, and 15. The electron fluxes for energies greater than 2.0 MeV observed by GOES 13, 14, and 15 at geosynchronous orbit and by the Van Allen Probes remained at or near instrumental background levels for more than 24 h from 12 to 14 November. For energies of 0.8 MeV, the GOES satellites observed two shorter intervals of reduced electron fluxes. The first interval of reduced 0.8 MeV electron fluxes on 12-13 November was associated with an interplanetary shock and a sudden impulse. Cluster, THEMIS, and GOES observed intense He+ electromagnetic ion cyclotron (EMIC) waves from just inside geosynchronous orbit out to the magnetopause across the dayside to the dusk flank. The second interval of reduced 0.8 MeV electron fluxes on 13-14 November was associated with a solar sector boundary crossing and development of a geomagnetic storm with Dst<100 nT. At the start of the recovery phase, both the 0.8 and 2.0 MeV electron fluxes finally returned to near prestorm values, possibly in response to strong ultralow frequency (ULF) waves observed by the Van Allen Probes near dawn. A combination of adiabatic effects, losses to the magnetopause, scattering by EMIC waves, and acceleration by ULF waves can explain the observed electron behavior

GeneTIER: prioritization of candidate disease genes using tissue-specific gene expression profiles.

Motivation In attempts to determine the genetic causes of human disease, researchers are often faced with a large number of candidate genes. Linkage studies can point to a genomic region containing hundreds of genes, while the high-throughput sequencing approach will often identify a great number of non-synonymous genetic variants. Since systematic experimental verification of each such candidate gene is not feasible, a method is needed to decide which genes are worth investigating further. Computational gene prioritization presents itself as a solution to this problem, systematically analyzing and sorting each gene from the most to least likely to be the disease-causing gene, in a fraction of the time it would take a researcher to perform such queries manually. Results Here we present GeneTIER (Gene TIssue Expression Ranker), a new web-based application for candidate gene prioritization. GeneTIER replaces knowledge-based inference traditionally used in candidate disease gene prioritization applications with experimental data from tissue-specific gene expression datasets and thus largely overcomes the bias towards the better characterized genes/diseases that commonly afflict other methods. We show that our approach is capable of accurate candidate gene prioritization and illustrate its strengths and weaknesses using case study examples. Availability and Implementation Freely available on the web at http://dna.leeds.ac.uk/GeneTIER/ Contact: [email protected]

Proactive Collaborative Conservation: Museums and companies working towards sustainability

Purpose: This paper describes a system of collaboration between cultural institutions, conservation scientists and companies focussed on achieving global sustainability in museum and heritage sites through proactive conservation. The purpose of this paper is to propose the Proactive Collaborative Conservation (ProCoCo) as a viable tool to accomplish this objective. Design/methodology/approach: The lack of degradation studies on contemporary materials, such as composites, was identified as an issue for the future of cultural heritage. Developing new approaches to heritage and conservation becomes vital and it is in this landscape that ProCoCo is inserted. A concise review of the literature is reported and the process that led to the development of ProCoCo is explained. Backcasting and forecasting were used to develop different parts of the approach. Findings: ProCoCo consists in studying parameters of the new materials, manufactured by the commercial partner, then simulating the ageing and, finally, re-studying the same parameters in order to predict lifetime changes. During the case study, it was confirmed that such an approach helps in identifying weaknesses in the material, which can then become useful for conservators and manufacturers. Practical implications: The approach allows conservation scientists and conservators to measure the conservation state of materials and to detect degradation at an early stage. Originality/value: ProCoCo offers a different vision of the long-term issue of funding accessibility faced by museums and suggests a way of improving heritage global sustainability. It proposes a pragmatic and lasting solution to the insufficient public economic support in the arts which runs parallel to government aid