Universal Kinetic Model to Simulate Two-Step Biodiesel Production from Vegetable Oil

To date, to simulate biodiesel production, kinetic models from different authors have been provided, each one usually applied to the use of a specific vegetable oil and experimental conditions. Models, which may include esterification, besides transesterification simulation, were validated with their own experimental conditions and raw material. Moreover, information about the intermediate reaction steps, besides catalyst concentration variation, is either rare or nonexistent. Here, in this work, a universal mathematical model comprising the chemical kinetics of a two-step (esterification and transesterification) vegetable oil-based biodiesel reaction is proposed. The proposed model is universal, as it may simulate any vegetable oil biodiesel reaction from the literature. For this purpose, a mathematical model using the software MATLAB has been designed. Using the mathematical model, the estimation of mass variation with time, of both reactants and products, as well as glyceride conversion and homogeneous catalyst concentration variation (instead of only alcohol/catalyst solution) are allowed. Moreover, analysis of the influence of some important variables affecting the reaction kinetics of biodiesel production (e.g., catalyst concentration), along with comparison and model validation with data from different authors may be carried out. In addition, Supplementary material with a collection of 290 rate constants, derived from 55 different experiments using different vegetable oils and conditions is provided

Quality Evaluation of Parmigiano Reggiano Cheese by a Novel Nanowire Device S3 and Evaluation of the VOCs Profile

Abstract A novel nanowire-based sensor device is presented for the quality evaluation of the Italian Parmigiano Reggiano (PR) cheese. As a Protected Designation of Origin (PDO) trademark product, the cheese should follow stringent manufacturing guidelines and must exhibit the representative aromatic volatile organic compounds (VOCs) biomarkers and sensory profile. Any alteration in these features indicates an adulteration of the product as many low quality and substandard PR cheeses are widely available in the market. Different types of grated cheese samples were analyzed and the VOCs were characterized by evaluating the samples with the portable sensor device S3 and Gas Chromatography–Mass Spectrometry technique. The ability of S3 device to distinguish the cheese quality demonstrates its suitability for monitoring the quality control and authenticity of PR cheese

Compatibility studies between an indirect injection diesel injector and biodiesel with different composition: Stationary tests

Compatibility between automotive materials and biodiesel is key for engine manufacturers, since failures occur in the medium term and may significantly reduce engine useful life. There are only few studies about compatibility between biodiesel and pure materials, but all agree there is biodiesel degradation and material corrosion beyond desirable values. This manuscript shows results about the compatibility behavior of an indirect injection diesel engine injector, with different types of biodiesel (from rapeseed, soybean, coconut and palm oil). Tests were carried out by static immersion of actual injector parts inside biodiesel, at room temperature, during 1100 h. To analyze elemental composition of each injector part and potential compatibility problems, scanning electron microscope (SEM) and energy-dispersive X-ray spectroscopy (EDS) were used. Visual variations were detected in both biodiesel and metals, showing the need of a further quantification of both piece mass loss and biodiesel acid value increase. Metallic oxides on the surface were detected by X-ray photoelectron spectroscopy (XPS). After immersion tests, mass variation in alloying elements of each piece (behaving differently depending on their composition), besides biodiesel acid value differences, were found. In this sense, pieces with aluminum alloys showed the highest corrosion (mass loss) compared to those without aluminum in their structure, no matter the unsaturation degree and chain length of biodiesel. In sum, there were not conclusive results about the influence of biodiesel composition over injector materials. However, it was found that European biodiesel standard EN 14214 should include other parameters than just copper band corrosion, to determine material deterioration, provided that aluminum alloys and other metals react with biodiesel

Scalar field in the Bianchi I: Non commutative classical and Quantum Cosmology

Using the ADM formalism in the minisuperspace, we obtain the commutative and noncommutative exact classical solutions and exact wave function to the Wheeler-DeWitt equation with an arbitrary factor ordering, for the anisotropic Bianchi type I cosmological model, coupled to a scalar field, cosmological term and barotropic perfect fluid. We introduce noncommutative scale factors, considering that all minisuperspace variables $\rm q^i$ do not commute, so the symplectic structure was modified. In the classical regime, it is shown that the anisotropic parameter $\rm \beta_{\pm nc}$ and the field $\phi$, for some value in the $\lambda_{eff}$ cosmological term and noncommutative $\theta$ parameter, present a dynamical isotropization up to a critical cosmic time $t_{c}$; after this time, the effects of isotropization in the noncommutative minisuperspace seems to disappear. In the quantum regimen, the probability density presents a new structure that corresponds to the value of the noncommutativity parameter.Comment: 17 pages, 6 figures, Acepted in IJT

(Non)commutative isotropization in Bianchi I with Barotropic perfect fluid and Λ\Lambda Cosmological

We present the classical solutions to the Einstein field equations derived using the WKB-like and Hamilton procedures. The investigation is carried out in the commutative and noncommutative scenario for the Bianchi type I cosmological model coupled to barotropic perfect fluid and $\lambda$ Cosmological for two different gauges. Noncommutativity is achieved by modifying the symplectic structure considering that all minisuperspace variables $\rm q^i$ does not commute and by a deformation between all the minisuperspace variables. In the gauge N=1, it is possible to obtain that the anisotropic parameter $\rm \beta_{\pm nc}$ tend to a constant curvature for large period of time considering different values in the noncommutative parameters $\theta$ and cosmological term. However, this behavior give the idea that is necessary introduce other class of matter in the models, for to have a real isotropization in the model, such as dark energy or dark matter.Comment: 15 pages, 1 figur

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

Altres ajuts: This work has also been supported by a "Marató TV3" grant (20141210 to J.F. and 044412 to R.B.).Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by ill-defined mechanisms. Here we report a large metabolomics study of plasma and cerebrospinal fluid, showing in independent cohorts that people with DS produce elevated levels of kynurenine and quinolinic acid, two tryptophan catabolites with potent immunosuppressive and neurotoxic properties, respectively. Immune cells of people with DS overexpress IDO1, the rate-limiting enzyme in the kynurenine pathway (KP) and a known interferon (IFN)-stimulated gene. Furthermore, the levels of IFN-inducible cytokines positively correlate with KP dysregulation. Using metabolic tracing assays, we show that overexpression of IFN receptors encoded on chromosome 21 contribute to enhanced IFN stimulation, thereby causing IDO1 overexpression and kynurenine overproduction in cells with T21. Finally, a mouse model of DS carrying triplication of IFN receptors exhibits KP dysregulation. Together, our results reveal a mechanism by which T21 could drive immunosuppression and neurotoxicity in DS

Fast-timing measurements in neutron-rich odd-mass zirconium isotopes using LaBr3:Ce detectors coupled with Gammasphere

A fast-timing experiment was performed at the Argonne National Laboratory to measure the lifetimes of the lowest lying states of nuclei belonging to the deformed regions around mass number A 110 and A 150. These regions were populated via spontaneous fission of 252 Cf and the gamma radiation following the decay of excited states in the fission fragments was measured using 51 Gammasphere detectors coupled with 25 LaBr 3 :Ce detectors. A brief description of the acquisition system and some preliminary results from the fast-timing analysis of the fission fragment 100Zr are presented. The lifetime value of \u3c4 = 840(65) ps was found for the 2 + state in 100 Zr consistent within one standard deviation of the adopted value with 791 +26 -35 ps. This is associated with a quadrupole deformation parameter of 0.36(2) which is within one standard deviation of the literature value of 0.3556 +82 -57

Trends and outcome of neoadjuvant treatment for rectal cancer: A retrospective analysis and critical assessment of a 10-year prospective national registry on behalf of the Spanish Rectal Cancer Project

Introduction: Preoperative treatment and adequate surgery increase local control in rectal cancer. However, modalities and indications for neoadjuvant treatment may be controversial. Aim of this study was to assess the trends of preoperative treatment and outcomes in patients with rectal cancer included in the Rectal Cancer Registry of the Spanish Associations of Surgeons. Method: This is a STROBE-compliant retrospective analysis of a prospective database. All patients operated on with curative intention included in the Rectal Cancer Registry were included. Analyses were performed to compare the use of neoadjuvant/adjuvant treatment in three timeframes: I)2006–2009; II)2010–2013; III)2014–2017. Survival analyses were run for 3-year survival in timeframes I-II. Results: Out of 14, 391 patients, 8871 (61.6%) received neoadjuvant treatment. Long-course chemo/radiotherapy was the most used approach (79.9%), followed by short-course radiotherapy ± chemotherapy (7.6%). The use of neoadjuvant treatment for cancer of the upper third (15-11 cm) increased over time (31.5%vs 34.5%vs 38.6%, p = 0.0018). The complete regression rate slightly increased over time (15.6% vs 16% vs 18.5%; p = 0.0093); the proportion of patients with involved circumferential resection margins (CRM) went down from 8.2% to 7.3%and 5.5% (p = 0.0004). Neoadjuvant treatment significantly decreased positive CRM in lower third tumors (OR 0.71, 0.59–0.87, Cochrane-Mantel-Haenszel P = 0.0008). Most ypN0 patients also received adjuvant therapy. In MR-defined stage III patients, preoperative treatment was associated with significantly longer local-recurrence-free survival (p < 0.0001), and cancer-specific survival (p < 0.0001). The survival benefit was smaller in upper third cancers. Conclusion: There was an increasing trend and a potential overuse of neoadjuvant treatment in cancer of the upper rectum. Most ypN0 patients received postoperative treatment. Involvement of CRM in lower third tumors was reduced after neoadjuvant treatment. Stage III and MRcN + benefited the most

Evolution of the use of corticosteroids for the treatment of hospitalised COVID-19 patients in Spain between March and November 2020: SEMI-COVID national registry

Objectives: Since the results of the RECOVERY trial, WHO recommendations about the use of corticosteroids (CTs) in COVID-19 have changed. The aim of the study is to analyse the evolutive use of CTs in Spain during the pandemic to assess the potential influence of new recommendations. Material and methods: A retrospective, descriptive, and observational study was conducted on adults hospitalised due to COVID-19 in Spain who were included in the SEMI-COVID- 19 Registry from March to November 2020. Results: CTs were used in 6053 (36.21%) of the included patients. The patients were older (mean (SD)) (69.6 (14.6) vs. 66.0 (16.8) years; p < 0.001), with hypertension (57.0% vs. 47.7%; p < 0.001), obesity (26.4% vs. 19.3%; p < 0.0001), and multimorbidity prevalence (20.6% vs. 16.1%; p < 0.001). These patients had higher values (mean (95% CI)) of C-reactive protein (CRP) (86 (32.7-160) vs. 49.3 (16-109) mg/dL; p < 0.001), ferritin (791 (393-1534) vs. 470 (236- 996) µg/dL; p < 0.001), D dimer (750 (430-1400) vs. 617 (345-1180) µg/dL; p < 0.001), and lower Sp02/Fi02 (266 (91.1) vs. 301 (101); p < 0.001). Since June 2020, there was an increment in the use of CTs (March vs. September; p < 0.001). Overall, 20% did not receive steroids, and 40% received less than 200 mg accumulated prednisone equivalent dose (APED). Severe patients are treated with higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%. Conclusions: Patients with greater comorbidity, severity, and inflammatory markers were those treated with CTs. In severe patients, there is a trend towards the use of higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%

Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019

Altres ajuts: Spanish AIDS Research Network; European Funding for Regional Development (FEDER).Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. Methods: The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results: The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions: In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population