Elongated theropod tracks from the Cretaceous Apenninic Carbonate Platform of southern Latium (central Italy)

New dinosaur footprints were recently discovered in southern Latium (Italy). The tracks all appear slightly differently preserved and are characterized by elongated metatarsal impressions, recording the complex locomotor behaviour of a medium-sized theropod. The spatial distribution and the features of the footprints indicate that the trackmaker adopted a “crouched” position as part of an activity as well as a resting phase suggested by sub-parallel, calcigrade tracks. These new data once again highlight the great potential of ichnological evidence in the study of the biology and behaviour of extinct tetrapods

The application of cast SiC/Al to rotary engine components

A silicon carbide reinforced aluminum (SiC/Al) material fabricated by Dural Aluminum Composites Corporation was tested for various components of rotary engines. Properties investigated included hardness, high temperature strength, wear resistance, fatigue resistance, thermal conductivity, and expansion. SiC/Al appears to be a viable candidate for cast rotors, and may be applicable to other components, primarily housings

Association between a single measurement of progesterone and cortisol blood concentrations at two to one week before parturition, and number of fetuses in the Teramana goat

The Teramana goat is an at-risk breed, needing population protection and programs to increase their numbers. The first step for a population increase is the best management of reproduction, leading to an as high as possible number of healthy and viable kids born. To this purpose, beside the optimization of mating, the best possible management of pregnancy and parturition is mandatory. The goat is a prolific farm animal in which single, double, or triple ovulations can occur, leading to singleton, twin or triple pregnancies, and the birth of multiple kids. Twins and triplets are associated to increased risk for perinatal mortality and need a special surveillance and possible assistance at birth. Knowledge of the number of fetuses that have to be delivered from each goat could be a practical tool for a better management of parturition. Among the methods to define the number of fetuses in the goat, the measurement of blood progesterone (P4) concentrations have provided inconsistent results. Therefore, the present study was aimed to assess the possible association between the maternal concentrations of plasma P4 and cortisol (C), two hormones possibly associated to the number of fetuses, measured only once at about two to one week before parturition in Teramana goats, and the number of fetuses. The results, obtained from 23 does, showed that both plasma P4 and C are higher in does bearing multiple fetuses than does with singleton pregnancies. However, the single measurement of plasma C, but not P4, two to one week before the expected parturition in the Teramana goat is useful to distinguish between does bearing singleton and triplet pregnancies for a better surveillance and assistance at delivery. Therefore, it could represent a tool for the best management of reproduction in a breed population at risk for extinctio

After Treatment Decrease of Bone Marrow Tregs and Outcome in Younger Patients with Newly Diagnosed Acute Myeloid Leukemia

An emerging body of evidence demonstrates that defects in antileukemic effector cells in patients with acute myeloid leukemia (AML) can contribute to the development and/or persistence of the disease. In particular, immune suppressive regulatory T cells (Tregs) may contribute to this defective antileukemic immune response, being recruited by bone marrow leukemic cells to evade immune surveillance. We evaluated Tregs (CD4+/CD45RA-/CD25high/CD127low), performing multiparametric flow cytometry on freshly collected bone marrow aspirate (BMA), in addition to the usual molecular and cytogenetic work-up in newly diagnosed AML patients to look for any correlation between Tregs and the overall response rate (ORR). We studied 39 AML younger patients (<65 years), all treated with standard induction chemotherapy. ORR (complete remission (CR)+CR with incomplete hematologic recovery (CRi)) was documented in 21 out of 39 patients (54%); two partial responder patients were also recorded. Apart from the expected impact of the molecular-cytogenetic group (p=0.03) and the NPM mutation (p=0.05), diagnostic BMA Tregs did not show any correlation with ORR. However, although BMA Tregs did not differ in the study population after treatment, their counts significantly decreased in responder patients (p=0.039), while no difference was documented in nonresponder ones. This suggested that the removal of Treg cells is able to evoke and enhance anti-AML immune response. However, the role of BMA Tregs in mediating immune system-AML interactions in the diagnostic and posttreatment phase should be confirmed in a greater number of patients

Cryotolerance of equine spermatozoa correlates with specific fatty acid pattern: A pilot study

Sperm cryopreservation represents a powerful tool for horse breeding. To improve the efficiency of artificial insemination in the horse using cryopreserved spermatozoa, an adequate understanding of the underlying biophysical properties that affect sperm cryosurvival needs to be reached yet. In this pilot study, we described isolation and analysis of the main fatty acids from sperms of stallions classified as good and poor freezers (7 GF and 5 PF, according to sperm motility and viability, before and after cryopreservation). Fatty acid profiles were only assessed in pre-thaw sperms. Eight main fatty acids were identified, using gas chromatography, and their contents were expressed as percentage of the total lipid content. We found that lauric, myristic and oleic acid (C12:0, C14:0 and C18:1n9c) turned out to be about 2-fold more abundant in the sperm cells of the GFs compared with PFs. Moreover, we described for the first time the presence of a very high amount of a trans geometrical isomer of linoleic acid, linolelaidic acid (C18:2n6t), in pre-thaw PF spermatozoa. Notably, we found in fresh sperms of PF stallions a ratio of unsaturated fatty acids to saturated fatty acids which was twice that of those of GF group, suggesting a positive effect of a high saturated-to-unsaturated fatty acid ratio for the “freezability” of equine spermatozoa. Finally, principal component analysis (PCA) confirmed the relationships between specific fatty acids and cryotolerance of equine spermatozoa, also providing a graphical classification and additional information about the dominant variables governing the classification process

Revealing the coral habitat effect on benthopelagic fauna diversity in the Santa Maria di Leuca cold-water coral province using different devices and Bayesian hierarchical modelling

Data from two experimental longline surveys and two video inspections carried out in Santa Maria di Leuca cold-water coral province (Mediterranean Sea) during spring-autumn 2010 were used in order to compare the benthopelagic abundance and diversity between coral and non-coral habitats and between different devices. The sampling was carried out in two types of habitat: a coral habitat with carbonate mounds and a non-coral habitat characterized by intermound sea floor. A Bayesian hierarchical modelling approach to accommodate factors influencing community assemblages was used considering the number of species, the Shannon-Wiener diversity index and the two most abundant species represented by the European conger (Conger conger) and blackbelly rosefish (Helicolenus dactylopterus). A relevant effect of the habitat factor was observed for both the number of species and the diversity index, showing a higher species number and diversity index in the coral habitat than in the non-coral habitat. Concerning the relevance of fixed effects from the model on the probability of observing non-zero (positive) abundances, the devices considered, longline and baited lander, did not show different influence for either C. conger or H. dactylopterus. In the case of positive abundance, a relevant device effect was only observed for H. dactylopterus, showing higher abundances for longline than for baited lander. A habitat effect was detected, with positive abundances for both species in the coral habitat. This study proves that structurally complex habitats generated by cold-water corals influence the distribution and diversity of the benthopelagic fauna, and that the use of different devices can provide complementary useful results. Increased knowledge about the role of cold-water corals in the associated benthopelagic fauna could lead to better conservation of one of the most important hot spots of biodiversity in the Mediterranean Sea

The Impact of a Very Weak and Thin Upper Asthenosphere on Subduction Motions

Recent geophysical observations report the presence of a very weak and thin upperasthenosphere underneath subducting oceanic plates at convergent margins. Along these margins, trenchmigrations are significantly slower than plate convergence rates. We use numerical models to assess therole of a weak upper asthenospheric layer on plate and trench motions. We show that the presence of thislayer alone can enhance an advancing trend for the motion of the plate and hamper trench retreat. Thismechanism provides a novel and alternative explanation for the slow rates of trench migration andfast-moving plates observed globally at natural subduction zones

Imaging the structural style of an active normal fault through multidisciplinary geophysical investigation: a case study from the Mw 6.1, 2009 L'Aquila earthquake region (central Italy)

The normal fault-system responsible of the 2009 Mw 6.1 L'Aquila earthquake (Paganica-San Demetrio fault-system) comprises several narrow, fault-parallel valleys of controversial origin. We investigated a key section of the southeastern portion of this fault network along the small Verupola Valley. In order to characterize its nature and possible tectonic activity, we applied multiple-geosciences techniques able to image at depth the structure associated to this peculiar landform. We integrated magnetometry, 2-D P wave and resistivity tomography, surface waves and seismic noise analysis coupled with field mapping, shallow boreholes and trenching. According to our results, the Verupola Valley is a ∼30–40-m-deep graben controlled by a SW-dipping master fault and synthetic splays paired with an antithetic NE-dipping fault. The SW-dipping splays are active and cut very shallow (<2 m deep) Late Pleistocene sediments. The small amount of cumulated vertical offset (∼15 m) across the conjugated system may indicate a young fault inception or very low Quaternary slip-rates. Due to its structural continuity with the adjacent mapped strands of the Paganica–San Demetrio fault network, we relate the Verupola Valley to the recent activity of the southeastern segment of this fault system. We also suggest that other fault-parallel valleys can have the same tectonic origin and setting of the Verupola Valley. This latter represents a scale-independent analogue from metric scale (exposed in the palaeoseismological trenches) to the Middle Aterno Basin scale (seen from seismic profiles and fault mapping). Overall, the imaged structural style is coherent with the regional tectonic setting due to Quaternary crustal extension