360 research outputs found
Ефективність антихелікобактерних комплексів у хворих на пептичну виразку, асоційовану з хелікобактеріозом і оцінка їх впливу на стан слизового бар’єра гастродуоденальної зони
Мета - вивчити у хворих на пептичну виразку (ПВ), асоційовану з хелікобактеріозом (HP), терапевтичну ефективність антихелікобактерних комплексів (АХБК), а також їх влив на стан метаболічних процесів у слизовому бар’єрі гастродуоденальної зони
Environment Constrains Fitness Advantages of Division of Labor in Microbial Consortia Engineered for Metabolite Push or Pull Interactions
Fitness benefits from division of labor are well documented in microbial consortia, but the dependency of the benefits on environmental context is poorly understood. Two synthetic Escherichia coli consortia were built to test the relationships between exchanged organic acid, local environment, and opportunity costs of different metabolic strategies. Opportunity costs quantify benefits not realized due to selecting one phenotype over another. The consortia catabolized glucose and exchanged either acetic or lactic acid to create producer-consumer food webs. The organic acids had different inhibitory properties and different opportunity costs associated with their positions in central metabolism. The exchanged metabolites modulated different consortial dynamics. The acetic acid-exchanging (AAE) consortium had a “push” interaction motif where acetic acid was secreted faster by the producer than the consumer imported it, while the lactic acid-exchanging (LAE) consortium had a “pull” interaction motif where the consumer imported lactic acid at a comparable rate to its production. The LAE consortium outperformed wild-type (WT) batch cultures under the environmental context of weakly buffered conditions, achieving a 55% increase in biomass titer, a 51% increase in biomass per proton yield, an 86% increase in substrate conversion, and the complete elimination of by-product accumulation all relative to the WT. However, the LAE consortium had the trade-off of a 42% lower specific growth rate. The AAE consortium did not outperform the WT in any considered performance metric. Performance advantages of the LAE consortium were sensitive to environment; increasing the medium buffering capacity negated the performance advantages compared to WT
The P_33(1232) resonance contribution into the amplitudes M_{1+}^{3/2},E_{1+}^{3/2},S_{1+}^{3/2} from an analysis of the p(e,e'p)\pi^0 data at Q^2 = 2.8, 3.2, and 4 (GeV/c)^2 within dispersion relation approach
Within the fixed-t dispersion relation approach we have analysed the TJNAF
and DESY data on the exclusive p(e,e'p)\pi^0 reaction in order to find the
P_{33}(1232) resonance contribution into the multipole amplitudes
M_{1+}^{3/2},E_{1+}^{3/2},S_{1+}^{3/2}. As an input for the resonance and
nonresonance contributions into these amplitudes the earlier obtained solutions
of the integral equations which follow from dispersion relations are used. The
obtained values of the ratio E2/M1 for the \gamma^* N \to P_{33}(1232)
transition are: 0.039\pm 0.029, 0.121\pm 0.032, 0.04\pm 0.031 for Q^2= 2.8,
3.2, and 4 (GeV/c)^2, respectively. The comparison with the data at low Q^2
shows that there is no evidence for the presence of the visible pQCD
contribution into the transition \gamma N \to P_{33}(1232) at Q^2=3-4 GeV^2.
The ratio S_{1+}^{3/2}/M_{1+}^{3/2} for the resonance parts of multipoles is:
-0.049\pm 0.029, -0.099\pm 0.041, -0.085\pm 0.021 for Q^2= 2.8, 3.2, and 4
(GeV/c)^2, respectively. Our results for the transverse form factor G_T(Q^2) of
the \gamma^* N \to P_{33}(1232) transition are lower than the values obtained
from the inclusive data. With increasing Q^2, Q^4G_T(Q^2) decreases, so there
is no evidence for the presence of the pQCD contribution here too
Differences in trauma history and psychopathology between PTSD patients with and without co-occurring dissociative disorders
Wabnitz P, Gast U, Catani C. Differences in trauma history and psychopathology between PTSD patients with and without co-occurring dissociative disorders. European Journal of Psychotraumatology. 2013;2013(4): 21452.Background: The interplay between different types of potentially traumatizing events, posttraumatic symptoms, and the pathogenesis of PTSD or major dissociative disorders (DD) has been extensively studied during the last decade. However, the phenomenology and nosological classification of posttraumatic disorders is currently under debate. The current study was conducted to investigate differences between PTSD patients with and without co-occurring major DD with regard to general psychopathology, trauma history, and trauma-specific symptoms.
Methods: Twenty-four inpatients were administered the Clinician-Administered PTSD Scale for DSM-IV (CAPS) and the Mini-Structured Clinical Interview for DSM-IV Dissociative Disorders (MINI-SKID-D) to assess DD and PTSD. Additionally, participants completed questionnaires to assess general psychopathology and health status.
Results: Symptom profiles and axis I comorbidity were similar in all patients. Traumatic experiences did not differ between the two groups, with both reporting high levels of childhood trauma. Only trauma-specific avoidance behavior and dissociative symptoms differed between groups.
Conclusion: Results support the view that PTSD and DD are affiliated disorders that could be classified within the same diagnostic category. Our results accord with a typological model of dissociation in which profound forms of dissociation are specific to DD and are accompanied with higher levels of trauma-specific avoidance in DD patients
Experiments to Find or Exclude a Long-Lived, Light Gluino
Gluinos in the mass range ~1 1/2 - 3 1/2 GeV are absolutely excluded. Lighter
gluinos are allowed, except for certain ranges of lifetime. Only small parts of
the mass-lifetime parameter space are excluded for larger masses unless the
lifetime is shorter than ~ 2 10^{-11} (m_{gluino}/ GeV) sec. Refined mass and
lifetime estimates for R-hadrons are given, present direct and indirect
experimental constraints are reviewed, and experiments to find or definitively
exclude these possibilities are suggested.Comment: 27 pp, latex with 1 uufiled figure, RU-94-35. New version amplifies
discussion of some points and corresponds to version for Phys. Rev.
Inflammation, insulin resistance, and diabetes-mendelian randomization using CRP haplotypes points upstream
Background
Raised C-reactive protein (CRP) is a risk factor for type 2 diabetes. According to the Mendelian randomization method, the association is likely to be causal if genetic variants that affect CRP level are associated with markers of diabetes development and diabetes. Our objective was to examine the nature of the association between CRP phenotype and diabetes development using CRP haplotypes as instrumental variables.
Methods and Findings
We genotyped three tagging SNPs (CRP + 2302G > A; CRP + 1444T > C; CRP + 4899T > G) in the CRP gene and measured serum CRP in 5,274 men and women at mean ages 49 and 61 y (Whitehall II Study). Homeostasis model assessment-insulin resistance (HOMA-IR) and hemoglobin A1c (HbA1c) were measured at age 61 y. Diabetes was ascertained by glucose tolerance test and self-report. Common major haplotypes were strongly associated with serum CRP levels, but unrelated to obesity, blood pressure, and socioeconomic position, which may confound the association between CRP and diabetes risk. Serum CRP was associated with these potential confounding factors. After adjustment for age and sex, baseline serum CRP was associated with incident diabetes (hazard ratio = 1.39 [95% confidence interval 1.29-1.51], HOMA-IR, and HbA1c, but the associations were considerably attenuated on adjustment for potential confounding factors. In contrast, CRP haplotypes were not associated with HOMA-IR or HbA1c (p=0.52-0.92). The associations of CRP with HOMA-IR and HbA1c were all null when examined using instrumental variables analysis, with genetic variants as the instrument for serum CRP. Instrumental variables estimates differed from the directly observed associations (p=0.007-0.11). Pooled analysis of CRP haplotypes and diabetes in Whitehall II and Northwick Park Heart Study II produced null findings (p=0.25-0.88). Analyses based on the Wellcome Trust Case Control Consortium (1,923 diabetes cases, 2,932 controls) using three SNPs in tight linkage disequilibrium with our tagging SNPs also demonstrated null associations.
Conclusions
Observed associations between serum CRP and insulin resistance, glycemia, and diabetes are likely to be noncausal. Inflammation may play a causal role via upstream effectors rather than the downstream marker CRP
Problems with Extraction of the Nucleon to Delta(1232) Photonic Amplitudes
We investigate the model dependence and the importance of choice of database
in extracting the {\it physical} nucleon-Delta(1232) electromagnetic transition
amplitudes, of interest to QCD and baryon structure, from the pion
photoproduction observables. The model dependence is found to be much smaller
than the range of values obtained when different datasets are fitted. In
addition, some inconsistencies in the current database are discovered, and
their affect on the extracted transition amplitudes is discussed.Comment: Revtex, 2 figs., submitted to PR
Identification of Radiopure Titanium for the LZ Dark Matter Experiment and Future Rare Event Searches
The LUX-ZEPLIN (LZ) experiment will search for dark matter particle
interactions with a detector containing a total of 10 tonnes of liquid xenon
within a double-vessel cryostat. The large mass and proximity of the cryostat
to the active detector volume demand the use of material with extremely low
intrinsic radioactivity. We report on the radioassay campaign conducted to
identify suitable metals, the determination of factors limiting radiopure
production, and the selection of titanium for construction of the LZ cryostat
and other detector components. This titanium has been measured with activities
of U~1.6~mBq/kg, U~0.09~mBq/kg,
Th~~mBq/kg, Th~~mBq/kg, K~0.54~mBq/kg, and Co~0.02~mBq/kg (68\% CL).
Such low intrinsic activities, which are some of the lowest ever reported for
titanium, enable its use for future dark matter and other rare event searches.
Monte Carlo simulations have been performed to assess the expected background
contribution from the LZ cryostat with this radioactivity. In 1,000 days of
WIMP search exposure of a 5.6-tonne fiducial mass, the cryostat will contribute
only a mean background of (stat)(sys) counts.Comment: 13 pages, 3 figures, accepted for publication in Astroparticle
Physic
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