1,222 research outputs found
Unraveling business model innovation in firm internationalization: A systematic literature review and future research agenda
The international business literature has witnessed a rapid growth of studies examining business model innovation (BMI) in firm internationalization, particularly over the last decade. Despite this increased line of inquiry, the body of knowledge on BMI and firm internationalization remains largely fragmented and unsynthesized, thus compromising theoretical and empirical advancements in the field. Although past reviews have multiplied on BMI in the mainstream business literature, none have been conducted in the context of international business. The primary goal of this review is to synthesize and evaluate the research on BMI in international business and to propose a future research agenda. Accordingly, we take stock of the literature and critically assess and examine 70 peer-reviewed articles published between 1996 and 2021. This study contributes to the extant literature by capturing the current body of knowledge on this topic and further advances and cultivates the dialogue between BMI and international business. We provide greater clarification of the BMI construct by proposing more fine-grained BMI constructs to be used to advance theory and empirical testing in future IB research. We finally contribute to the literature by mapping out a future research agenda supported by an integrative framework to advance research at the interface of BMI and firm internationalization.© 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).fi=vertaisarvioitu|en=peerReviewed
Transthyretin is not necessary for thyroid hormone metabolism in conditions of increased hormone demand
Thyroid hormones circulate in blood mainly bound to plasma proteins. Transthyretin is the major thyroxine plasma carrier in mice. Studies in transthyretin-null mice revealed that the absence of transthyretin results in euthyroid hypothyroxinemia and normal thyroid hormone tissue distribution, with the exception of the choroid plexus in the brain. Therefore, transthyretin does not influence normal thyroid hormone homeostasis under standard laboratory conditions. To investigate if transthyretin has a buffer/storage role we challenged transthyretin-null and wild-type mice with conditions of increased hormone demand: (i) exposure to cold, which elicits thermogenesis, a process that requires thyroid hormones; and (ii) thyroidectomy, which abolishes thyroid hormone synthesis and secretion and induces severe hypothyroidism. Transthyretin-null mice responded as the wild-type both to changes induced by stressful events, namely in body weight, food intake and thyroid hormone tissue content, and in the mRNA levels of genes whose expression is altered in such conditions. These results clearly exclude a role for transthyretin in thyroid hormone homeostasis even under conditions of increased hormone demand.POCTI/NSE/37315/2001, from Fundação para a Ciência e Tecnologia
(Portugal) and FEDER; J C S is a recipient of a PhD
fellowship from Fundação para a Ciência e Tecnologia
(Portugal
Environmental monitoring platform based on a heterogeneous wireless sensor network
Abstract – In museums, to conserve the existing artwork is a
vital issue. To achieve this purpose, it is fundamental to monitor
its environment, either in storage or exhibition rooms. The
deployment of a Wireless Sensor Network (WSN) can help to
implement these measurements continuously, in a real-time basis,
and in a much easier and cheaper way than when using
traditional measuring equipments and procedures. This is the
main objective of the WISE-MUSE project, which uses WSNs for
monitoring and automatically controlling museums’ environment
and structural health. In this paper, the implementation and the
final results of the WISE-MUSE project, which was carried out
in two particular museums located in Madeira Island, the
Museum of Contemporary Art of Funchal and the Madeira
Whale Museum, are described. Among other important
contributions, we emphasize the development of new
environmental monitoring and controlling devices, an emergency
doors’ controlling device, as well as the development of three new
tools for monitoring, visualizing and managing WSNs, which
bring some considerable advantages when compared with other
commercially available solutions.info:eu-repo/semantics/publishedVersio
Estudo preliminar da actividade antimicrobiana das folhas de cydonia oblonga miller
O marmelo é reconhecido como uma importante fonte de compostos promotores da saúde sendo que a actividade
antimicrobiana dos extractos da sua polpa, casca e sementes foi já avaliada. Não existem porém estudos da actividade
antimicrobiana das folhas de marmeleiro. Este estudo preliminar teve como objectivo determinar a actividade dos
seus extractos metanólicos. Concluiu-se que os extractos testados não apresentam actividade em E. coli, S. aureus,
C. albicans, C. glabrata, A. niger, A. fumigatus, Mucor spp e Absídia spp pelo que novos extractos devem ser preparados
sendo posteriormente avaliados.
Quince fruit is recognized an important source of health promoting compounds being the antimicrobial activities of
the quince pulp, peel grape and seed extracts already evaluated.
No results are known for quince leaves antimicrobial activity. This preliminary work intended to determine the activity
of quince leaves methanolic extracts. These had no antimicrobial activity either against E. coli, S. aureus, C. albicans, C.
glabrata, A. niger, A. fumigatus, Mucor spp e Absídia spp and new extracts must be prepared and evaluated
Export experience counts: exploring its effect on product design change
In this paper, we explore how managers' export experience can affect the change in product design following changes in perceived past performance. Using data from 519 Portuguese exporters, we find that performance improvement will encourage safe decision making in which firms either will not change the product design or will change it in a way that makes it more similar across the product range. However, when managers' export experience is greater, they encourage change in ways that could support product differentiation. The abilities of experienced managers to read the market, i.e. to interpret changes in performance and translate them into product specifications, help explain these findings. We contribute to the literature in two ways. First, we explore the relationship among past export performance change, product design, and managers' export experience. Second, we identify specific kinds of design changes that firms adopt in response to changes in different dimensions of organizational performance. Based on our findings, we would recommend to new product development managers to consider both managers' export experience and the dimension used to measure performance when evaluating calls for standardizing the design by export managers. Our findings suggest that such calls could be driven by short-term gains in export performance. Furthermore, we would also emphasize the need to routinely capture information from experienced export managers to ensure that it is considered in future decisions about design changes
Visible and NIR hyperspectral imaging and chemometrics for prediction of microbial quality of beef Longissimus dorsi muscle under simulated normal and abuse storage conditions
[EN] There is a need to develop a rapid technique to provide real time information on the microbial load of meat along the supply chain. Hyperspectral imaging (HSI) is a rapid, non-destructive technique well suited to food analysis applications. In this study, HSI in both the visible and near infrared spectral ranges, and chemometrics were studied for prediction of the bacterial growth on beef Longissimus dorsi muscle (LD) under simulated normal (4 °C) and abuse (10 °C) storage conditions. Total viable count (TVC) prediction models were developed using partial least squares regression (PLS-R), spectral pre-treatments, band selection and data fusion methods. The best TVC prediction models developed for storage at 4 (RMSEp 0.58 log CFU/g, RPDp 4.13, R2 p 0.96), 10 °C (RMSEp 0.97 log CFU/g, RPDp 3.28, R2 p 0.94) or at either 4 or 10 °C (RMSEp 0.89 log CFU/g, RPDp 2.27, R2 p 0.86) were developed using high-level data fusion of both spectral regions. The use of appropriate spectral pre-treatments and band selection methods was key for robust model development. This study demonstrated the potential of HSI and chemometrics for real time monitoring to predict microbial growth on LD along the meat supply chainSIThe authors acknowledge funding for this project from FIRM (13/ FM/508) as administered by the Irish Department of Agriculture, Food & the Marin
The compound event that triggered the destructive fires of October 2017 in Portugal
Portugal is regularly affected by destructive wildfires that have severe social, economic, and ecological impacts. The total burnt area in 2017 (∼540,000 ha) marked the all-time record value since 1980 with a tragic toll of 114 fatalities that occurred in June and October events. The local insurance sector declared it was the costliest natural disaster in Portugal with payouts exceeding USD295 million. Here, the 2017 October event, responsible for more than 200,000 ha of burnt area and 50 fatalities is analyzed from a compound perspective. A prolonged drought led to preconditioned cumulative hydric stress of vegetation in October 2017. In addition, on 15 October 2017, two other major drivers played a critical role: 1) the passage of hurricane Ophelia off the Coast of Portugal, responsible for exceptional meteorological conditions and 2) the human agent, responsible for an extremely elevated number of negligent ignitions. This disastrous combination of natural and anthropogenic drivers led to the uncontrolled wildfires observed on 15 October
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