ECLAMPSIA: PERSPECTIVE ON THE POSSIBLE REPERCUSSIONS ON THE CHILD'S HEALTH

Eclampsia is a serious complication of pre-eclampsia, which is characterized by high blood pressure, proteinuria and edema during pregnancy. Eclampsia can cause seizures, coma and maternal and fetal death, being one of the main causes of perinatal morbidity and mortality in the world. Furthermore, eclampsia can have repercussions on the child's health, such as prematurity, low birth weight, perinatal asphyxia, intracranial hemorrhage, cerebral palsy, delayed neuropsychomotor development and increased risk of cardiovascular and kidney diseases in adulthood. Despite the importance of the topic, there are few studies that address the consequences of eclampsia on child health in a comprehensive and up-to-date manner. Objective: was to identify and analyze scientific articles that investigated the effects of eclampsia on children's health, from birth to school age, considering clinical, neurological, cognitive, behavioral and social aspects. Methodology: A search was carried out in the PubMed, Scielo and Web of Science databases, using the following descriptors: eclampsia, child health, child development, child outcome and child morbidity. Articles published in the last 10 years, in Portuguese, English or Spanish, that evaluated children born to mothers with eclampsia, whether or not compared with children born to mothers without eclampsia or with pre-eclampsia, were included. Articles that did not address the outcomes of interest, that had insufficient samples, that presented selection bias or confusion, that were reviews, case reports or letters to the editor were excluded. The selection of articles was made according to the PRISMA checklist, following the steps of identification, screening, eligibility and inclusion. The data extracted from the articles were: authors, year, country, study design, sample size, children's age, evaluated outcomes and main results. Results: 16 studies were selected. The outcomes evaluated were: mortality, morbidity, growth, neuropsychomotor development, cognition, behavior, quality of life and risk factors for chronic diseases. The main results were: higher perinatal and neonatal mortality in children born to mothers with eclampsia; higher incidence of neonatal complications, such as asphyxia, hypoglycemia, jaundice, infection, hemorrhage and convulsions; higher frequency of prematurity, low birth weight, intrauterine growth restriction and small for gestational age; greater risk of delay in neuropsychomotor development, cognitive deficit, behavior problems, low quality of life and lower school performance; higher prevalence of hypertension, obesity, dyslipidemia and insulin resistance in childhood. Conclusion: Eclampsia is a condition that negatively affects a child's health, from the perinatal period to school age, compromising their growth and development potential. It is necessary to expand research on this topic, as well as implement prevention measures, early diagnosis and adequate treatment of pre-eclampsia and eclampsia, aiming to reduce their impacts on maternal and child health.Eclampsia is a serious complication of pre-eclampsia, which is characterized by high blood pressure, proteinuria and edema during pregnancy. Eclampsia can cause seizures, coma and maternal and fetal death, being one of the main causes of perinatal morbidity and mortality in the world. Furthermore, eclampsia can have repercussions on the child's health, such as prematurity, low birth weight, perinatal asphyxia, intracranial hemorrhage, cerebral palsy, delayed neuropsychomotor development and increased risk of cardiovascular and kidney diseases in adulthood. Despite the importance of the topic, there are few studies that address the consequences of eclampsia on child health in a comprehensive and up-to-date manner. Objective: was to identify and analyze scientific articles that investigated the effects of eclampsia on children's health, from birth to school age, considering clinical, neurological, cognitive, behavioral and social aspects. Methodology: A search was carried out in the PubMed, Scielo and Web of Science databases, using the following descriptors: eclampsia, child health, child development, child outcome and child morbidity. Articles published in the last 10 years, in Portuguese, English or Spanish, that evaluated children born to mothers with eclampsia, whether or not compared with children born to mothers without eclampsia or with pre-eclampsia, were included. Articles that did not address the outcomes of interest, that had insufficient samples, that presented selection bias or confusion, that were reviews, case reports or letters to the editor were excluded. The selection of articles was made according to the PRISMA checklist, following the steps of identification, screening, eligibility and inclusion. The data extracted from the articles were: authors, year, country, study design, sample size, children's age, evaluated outcomes and main results. Results: 16 studies were selected. The outcomes evaluated were: mortality, morbidity, growth, neuropsychomotor development, cognition, behavior, quality of life and risk factors for chronic diseases. The main results were: higher perinatal and neonatal mortality in children born to mothers with eclampsia; higher incidence of neonatal complications, such as asphyxia, hypoglycemia, jaundice, infection, hemorrhage and convulsions; higher frequency of prematurity, low birth weight, intrauterine growth restriction and small for gestational age; greater risk of delay in neuropsychomotor development, cognitive deficit, behavior problems, low quality of life and lower school performance; higher prevalence of hypertension, obesity, dyslipidemia and insulin resistance in childhood. Conclusion: Eclampsia is a condition that negatively affects a child's health, from the perinatal period to school age, compromising their growth and development potential. It is necessary to expand research on this topic, as well as implement prevention measures, early diagnosis and adequate treatment of pre-eclampsia and eclampsia, aiming to reduce their impacts on maternal and child health

Sugarcane (Saccharum X officinarum): A Reference Study for the Regulation of Genetically Modified Cultivars in Brazil

Global interest in sugarcane has increased significantly in recent years due to its economic impact on sustainable energy production. Sugarcane breeding and better agronomic practices have contributed to a huge increase in sugarcane yield in the last 30 years. Additional increases in sugarcane yield are expected to result from the use of biotechnology tools in the near future. Genetically modified (GM) sugarcane that incorporates genes to increase resistance to biotic and abiotic stresses could play a major role in achieving this goal. However, to bring GM sugarcane to the market, it is necessary to follow a regulatory process that will evaluate the environmental and health impacts of this crop. The regulatory review process is usually accomplished through a comparison of the biology and composition of the GM cultivar and a non-GM counterpart. This review intends to provide information on non-GM sugarcane biology, genetics, breeding, agronomic management, processing, products and byproducts, as well as the current technologies used to develop GM sugarcane, with the aim of assisting regulators in the decision-making process regarding the commercial release of GM sugarcane cultivars

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Os aspectos semiológicos do acidente vascular encefálico: uma abordagem neurológica

O Acidente Vascular Encefálico (AVC) é um evento neurológico súbito, com um foco de isquemia ou hemorragia. Ambos, qualificados pelo déficit neurológico focal abrupto. Ressaltando, que estes déficits podem ocorrer, sendo a ocorrência espontânea, perduração de 15 minutos, autoresolutiva é denominada como Ataque Isquêmico Transitório (AIT), no entanto, toda insuficiência neural que não melhorar pós esse período deve ser manejado como AVC. O artigo objetivou descrever os principais aspectos clínicos do AVC. O AVC é uma emergência para a saúde pública, em razão de ser um potencial em gerar morbimortalidades para os portadores e prejuízos para os sistemas de saúde. O AVC do tipo isquêmico representa a maioria das ocorrências, o quadro clínico do paciente é correspondente ao tecido neural afetado, inicialmente a tomografia computadorizada sem contraste é o primeiro exame, por ser crucial para descartar a etiologia hemorrágica, a condução terapêutica se baseia em medidas neuroprotetoras através da estabilização da glicemia, temperatura e sódio, adequar os níveis pressóricos, mediante o prazo estipulado impor terapia antitrombótica. A manifestação hemorrágica, pode ocorrer por torção de aneurisma sacular originando o sangramento subaracnóideo ou por hipertensão gerando o sangramento intraparenquimatoso. A partir da análise das informações coletadas, elucida-se que o diagnóstico precoce e o período transcorrido até o manejo terapêutico são cruciais para o desfecho clínico do portador, ou seja, é possível a normalização ou ocorrer sequelas neurais e óbito

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost