69 research outputs found

    Plasmon scattering approach to energy exchange and high frequency noise in nu=2 quantum Hall edge channels

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    Inter-edge channel interactions in the quantum Hall regime at filling factor nu= 2 are analyzed within a plasmon scattering formalism. We derive analytical expressions for energy redistribution amongst edge channels and for high frequency noise, which are shown to fully characterize the low energy plasmon scattering. In the strong interaction limit, the predictions for energy redistribution are compared with recent experimental data and found to reproduce most of the observed features. Quantitative agreement can be achieved by assuming 25 % of the injected energy is lost towards other degrees of freedom, possibly the additional gapless excitations predicted for smooth edge potentials.Comment: 4 pages, 4 figure

    L’élaboration scripturale du francoprovençal au Moyen Âge

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    Francoprovençal has generally been viewed as an oral dialect group with a highly varied character (due to the mountainous regions of the Alps, the Jura and the Massif Central), and with no elaborated written textual tradition. The virtual absence of such a tradition may indeed be observed for the modern period (i.e. the second half of the second millennium). However, this is not the case for the medieval period, during which Francoprovençal underwent a process of elaboration similar to that of the neighbouring Romance languages, at first fragmentary and embedded in Latin. From these beginnings emerged a pure Romance scripta which remained in existence until the end of the 15th century, when it was replaced by French. This process remained incomplete, characterised by the continuous copresence of either Latin or French and essentially limited to legal and administrative documents. Nonetheless, the first half of the second millennium yields a complex written vernacular which displays both diatopic and diachronic variation, and which has never before undergone systematic analysis. The present contribution is based on a corpus of medieval documents from the Francoprovençal regions of France and Switzerland (approx. 700.000 words), digitised as part of the project Documents linguistiques galloromans and presented for the first time here. Taking one of the most salient and frequent phenomena as an example – the outcome of lat. /a/ in tonic free syllables (ˈpratu> Frpr. pra vs Fr. pré) – the authors assess the nature and extent of the presence of Francoprovençal in medieval scripturality, examining a total of 60.000 occurrences. The results thus obtained allow an interpretation of the historical development of Francoprovençal on the basis of entirely new evidence

    The evolutionary history of Neanderthal and Denisovan Y chromosomes

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    Ancient DNA has provided new insights into many aspects of human history. However, we lack comprehensive studies of the Y chromosomes of Denisovans and Neanderthals because the majority of specimens that have been sequenced to sufficient coverage are female. Sequencing Y chromosomes from two Denisovans and three Neanderthals shows that the Y chromosomes of Denisovans split around 700 thousand years ago from a lineage shared by Neanderthals and modern human Y chromosomes, which diverged from each other around 370 thousand years ago. The phylogenetic relationships of archaic and modern human Y chromosomes differ from the population relationships inferred from the autosomal genomes and mirror mitochondrial DNA phylogenies, indicating replacement of both the mitochondrial and Y chromosomal gene pools in late Neanderthals. This replacement is plausible if the low effective population size of Neanderthals resulted in an increased genetic load in Neanderthals relative to modern humans.Q.F. was supported by funding from the Chinese Academy of Sciences (XDB26000000) and the National Natural Science Foundation of China (91731303, 41925009, 41630102). A.R. was funded by Spanish government (MICINN/ FEDER) (grant number CGL2016-75109-P). The reassessment of the Spy collection by H.R., I.C., and P.S. was supported by the Belgian Science Policy Office (BELSPO 2004-2007, MO/36/0112). M.V.S., M.B.K., and A.P.D. were supported by the Russian Foundation for Basic Research (RFBR 17-29-04206). This study was funded by the Max Planck Society and the European Research Council (grant agreement number 694707)

    The evolutionary history of Neandertal and Denisovan Y chromosomes

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    Ancient DNA has allowed the study of various aspects of human history in unprecedented detail. However, because the majority of archaic human specimens preserved well enough for genome sequencing have been female, comprehensive studies of Y chromosomes of Denisovans and Neandertals have not yet been possible. Here we present sequences of the first Denisovan Y chromosomes (Denisova 4 and Denisova 8), as well as the Y chromosomes of three late Neandertals (Spy 94a, Mezmaiskaya 2 and El Sidrón 1253). We find that the Denisovan Y chromosomes split around 700 thousand years ago (kya) from a lineage shared by Neandertal and modern human Y chromosomes, which diverged from each other around 370 kya. The phylogenetic relationships of archaic and modern human Y chromosomes therefore differ from population relationships inferred from their autosomal genomes, and mirror the relationships observed on the level of mitochondrial DNA. This provides strong evidence that gene flow from an early lineage related to modern humans resulted in the replacement of both the mitochondrial and Y chromosomal gene pools in late Neandertals. Although unlikely under neutrality, we show that this replacement is plausible if the low effective population size of Neandertals resulted in an increased genetic load in their Y chromosomes and mitochondrial DNA relative to modern humans.Q.F. was supported by funding from the Chinese Academy of Sciences (XDB26000000), and the National Natural Science Foundation of China (91731303, 41925009,41630102). A.R. was funded by Spanish government (MICINN/FEDER), grant number CGL2016-75109-P. The reassessment of the Spy collection by H.R., I.C. and P.S. was supported by the Belgian Science Policy Office (BELSPO 2004-2007, MO/36/0112). M.S., M.K. and A.D. were supported by the Russian Foundation for Basic Research (RFBR 17-29-04206). This study was funded by the Max Planck Society and the European Research Council (grant agreement number 694707).N

    Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

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    Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

    Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

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    RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

    L’innovation lexicale chez Chrétien de Troyes

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    Carles Hélène. L’innovation lexicale chez Chrétien de Troyes. In: Romania, tome 131 n°523-524, 2013. pp. 281-337

    Les écrits des Poilus. Miroir du français au début du XXe siècle

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    Les écrits des Poilus

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    This book offers a thorough and detailed analysis of the exemplary dictionary of the Mots des Poilus (The language of the "Poilus") by Pierre Rézeau (2018). On the basis of some 15,000 citations which illustrate the extensive nomenclature of the dictionary, the fourteen authors emphasise the linguistic diversity of a country which was still entirely plurilingual, shedding light on the variation displayed by French dialects, regional varieties, argot and literary writing. The book details the impact of the Great War on the history of written French through an analysis of the daily correspondence between soldiers and their families, which amounts to almost ten billion letters written over a period of four years. A new and sometimes unexpected portrait of the French diasystem at the beginning of the twentieth century emerges, revealing numerous lexical, grapho-phonetic and morphosyntactic particularities. The linguistic choices which frequently diverge from those found in contemporary correspondence written in Italian or German are described in a complementary section. The appendix contains texts which supplement the chronological description of the Mots des Poilus, and a detailed analysis of the letters written by the wife of a Breton soldier provides an overview of the grapho-phonetic and morphosyntactic characteristics typically found in the letters
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