55 research outputs found
Thyroid-HormoneâDisrupting Chemicals: Evidence for Dose-Dependent Additivity or Synergism
- Author
- Publication venue
- National Institute of Environmental Health Sciences
- Publication date
- 21/07/2005
- Field of study
Endocrine disruption from environmental contaminants has been linked to a broad spectrum of adverse outcomes. One concern about endocrine-disrupting xenobiotics is the potential for additive or synergistic (i.e., greater-than-additive) effects of mixtures. A short-term dosing model to examine the effects of environmental mixtures on thyroid homeostasis has been developed. Prototypic thyroid-disrupting chemicals (TDCs) such as dioxins, polychlorinated biphenyls (PCBs), and poly-brominated diphenyl ethers have been shown to alter thyroid hormone homeostasis in this model primarily by up-regulating hepatic catabolism of thyroid hormones via at least two mechanisms. Our present effort tested the hypothesis that a mixture of TDCs will affect serum total thyroxine (T(4)) concentrations in a dose-additive manner. Young female Long-Evans rats were dosed via gavage with 18 different polyyhalogenated aromatic hydrocarbons [2 dioxins, 4 dibenzofurans, and 12 PCBs, including dioxin-like and non-dioxin-like PCBs] for 4 consecutive days. Serum total T(4) was measured via radioimmunoassay in samples collected 24 hr after the last dose. Extensive doseâresponse functions (based on seven to nine doses per chemical) were determined for individual chemicals. A mixture was custom synthesized with the ratio of chemicals based on environmental concentrations. Serial dilutions of this mixture ranged from approximately background levels to 100-fold greater than background human daily intakes. Six serial dilutions of the mixture were tested in the same 4-day assay. Doses of individual chemicals that were associated with a 30% TH decrease from control (ED(30)), as well as predicted mixture outcomes were calculated using a flexible single-chemical-required method applicable to chemicals with differing dose thresholds and maximum-effect asymptotes. The single-chemical data were modeled without and with the mixture data to determine, respectively, the expected mixture response (the additivity model) and the experimentally observed mixture response (the empirical model). A likelihood-ratio test revealed statistically significant departure from dose additivity. There was no deviation from additivity at the lowest doses of the mixture, but there was a greater-than-additive effect at the three highest mixtures doses. At high doses the additivity model underpredicted the empirical effects by 2- to 3-fold. These are the first results to suggest dose-dependent additivity and synergism in TDCs that may act via different mechanisms in a complex mixture. The results imply that cumulative risk approaches be considered when assessing the risk of exposure to chemical mixtures that contain TDCs
Venous thromboembolism after inpatient surgery in administrative data vs NSQIP: a multi-institutional study
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/05/2018
- Field of study
Previous studies have documented significant differences between administrative data and registry data in the determination of postoperative venous thromboembolism (VTE). The goal of this study was to characterize the discordance between administrative and registry data in the determination of postoperative VTE.This study was performed using data from the American College of Surgeons NSQIP merged with administrative data from 8 different hospitals (5 different medical centers) between 2013 and 2015. Occurrences of postoperative vein thrombosis (VT) and pulmonary embolism (PE) as ascertained by administrative data and NSQIP data were compared. In each situation where the 2 sources disagreed (discordance), a 2-clinician chart review was performed to characterize the reasons for discordance.The cohort used for analysis included 43,336 patients, of which 53.3% were female and the mean age was 59.5 years. Concordance between administrative and NSQIP data was worse for VT (Îș 0.57; 95% CI 0.51 to 0.62) than for PE (Îș 0.83; 95% CI 0.78 to 0.89). A total of 136 cases of discordance were noted in the assessment of VT; of these, 50 (37%) were explained by differences in the criteria used by administrative vs NSQIP systems. In the assessment of postoperative PE, administrative data had a higher accuracy than NSQIP data (odds ratio for accuracy 2.86; 95% CI 1.11 to 7.14) when compared with the 2-clinician chart review.This study identifies significant problems in ability of both NSQIP and administrative data to assess postoperative VT/PE. Administrative data functioned more accurately than NSQIP data in the identification of postoperative PE. The mechanisms used to translate VTE measurement into quality improvement should be standardized and improved
Paneth cells as a site of origin for intestinal inflammation.
- Author
- A Bertolotti
- A Kaser
- A Kaser
- B Levine
- BB Madison
- DR Shimshek
- E Tashiro
- EH Carchman
- EM Garabedian
- F Urano
- F Zhao
- G Rogler
- I Novoa
- J Hampe
- J Wehkamp
- JC Barrett
- JD Rioux
- JW Pierce
- K Cadwell
- K Cadwell
- K Vidal
- KJ Maloy
- KM Rouschop
- KS Kobayashi
- L Baert
- L Bry
- L Jostins
- L Yang
- M Boyce
- M Kaneko
- M Komatsu
- M Parkes
- N Fujita
- N Fujita
- N Mizushima
- N Mizushima
- P Hu
- P Kuballa
- S Sarkar
- S Srinivas
- S Vaishnava
- SL Hempel
- SS Cao
- T Iwawaki
- T Sato
- X Tréton
- Y Satoh
- Y Wei
- Publication venue
- Nature
- Publication date
- 02/10/2013
- Field of study
The recognition of autophagy related 16-like 1 (ATG16L1) as a genetic risk factor has exposed the critical role of autophagy in Crohn's disease. Homozygosity for the highly prevalent ATG16L1 risk allele, or murine hypomorphic (HM) activity, causes Paneth cell dysfunction. As Atg16l1(HM) mice do not develop spontaneous intestinal inflammation, the mechanism(s) by which ATG16L1 contributes to disease remains obscure. Deletion of the unfolded protein response (UPR) transcription factor X-box binding protein-1 (Xbp1) in intestinal epithelial cells, the human orthologue of which harbours rare inflammatory bowel disease risk variants, results in endoplasmic reticulum (ER) stress, Paneth cell impairment and spontaneous enteritis. Unresolved ER stress is a common feature of inflammatory bowel disease epithelium, and several genetic risk factors of Crohn's disease affect Paneth cells. Here we show that impairment in either UPR (Xbp1(ÎIEC)) or autophagy function (Atg16l1(ÎIEC) or Atg7(ÎIEC)) in intestinal epithelial cells results in each other's compensatory engagement, and severe spontaneous Crohn's-disease-like transmural ileitis if both mechanisms are compromised. Xbp1(ÎIEC) mice show autophagosome formation in hypomorphic Paneth cells, which is linked to ER stress via protein kinase RNA-like endoplasmic reticulum kinase (PERK), elongation initiation factor 2α (eIF2α) and activating transcription factor 4 (ATF4). Ileitis is dependent on commensal microbiota and derives from increased intestinal epithelial cell death, inositol requiring enzyme 1α (IRE1α)-regulated NF-ÎșB activation and tumour-necrosis factor signalling, which are synergistically increased when autophagy is deficient. ATG16L1 restrains IRE1α activity, and augmentation of autophagy in intestinal epithelial cells ameliorates ER stress-induced intestinal inflammation and eases NF-ÎșB overactivation and intestinal epithelial cell death. ER stress, autophagy induction and spontaneous ileitis emerge from Paneth-cell-specific deletion of Xbp1. Genetically and environmentally controlled UPR function within Paneth cells may therefore set the threshold for the development of intestinal inflammation upon hypomorphic ATG16L1 function and implicate ileal Crohn's disease as a specific disorder of Paneth cells
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
- Abudu Y. P.
- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
- Adolph T. E.
- Adornetto A.
- Aflaki E.
- Agam G.
- Agarwal A.
- Aggarwal B. B.
- Agnello M.
- Agostinis P.
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- Ahmad S. T.
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- Ahumada-Castro U.
- Aits S.
- Aizawa S.
- Akkoc Y.
- Akoumianaki T.
- Akpinar H. A.
- Al-Abd A. M.
- Al-Akra L.
- Al-Gharaibeh A.
- Alaoui-Jamali M. A.
- Alberti S.
- Alcocer-Gomez E.
- Alessandri C.
- Ali M.
- Alim Al-Bari M. A.
- Aliwaini S.
- Alizadeh J.
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- Zwerschke W.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-GĂłmez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
- AntĂłn Z
- Anwar T
- Apetoh L
- Apostolova N
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- Araki Y
- Arasaki K
- Araya J
- AraĂșjo WL
- Arden C
- Arguelles S
- Arias E
- Arikkath J
- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
- Aroca A
- Arroyo DS
- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
- Au AK
- Auberger P
- Auner HW
- Aurelian L
- Autelli R
- Avagliano L
- Aveic S
- Aveleira CA
- Avin-Wittenberg T
- Aydin Y
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- Ayyadevara S
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- Backer JM
- Backues SK
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- Baehrecke EH
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- Baldari CT
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- Chen Y-J
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- Chen Z-H
- Chen ZJ
- Chen ZS
- Cheng H
- Cheng J
- Cheng S-Y
- Cheng W
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- Cheng X-T
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- Der CJ
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- Dobrovinskaya O
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- Zorzano A
- Zou W
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- Zou Z
- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
WSES guidelines for management of Clostridium difficile infection in surgical patients
- Author
- A Bhangu
- A Gupta
- A Olson
- A Sundriyal
- AA Samie
- AC Cheng
- AC Clements
- AC Clements
- AD Olivas
- AdriĂĄn Camacho-Ortiz
- AE PĂ©rez-Cobas
- AL Vecchio
- Aleksandar Karamarkovic
- AN Ananthakrishnan
- Aneel Bhangu
- Angela Vassallo
- Arda Isik
- Ari Leppaniemi
- Arnab Ray
- AS Walker
- B Geric
- B Skovrlj
- Basant K. Puri
- BK Puri
- BL Herpers
- Boris E. Sakakushev
- C Eckert
- C Eckmann
- C Landelle
- C Mittal
- C Seretis
- CA Huber
- CA Muto
- CA Vargo
- Carl Erik Nord
- Carlos A. Ordoñez
- Carlos Augusto Gomes
- Catherine Eckert
- CF Haines
- CH Yeom
- Charles H. Cook
- Christian Eckmann
- CiarĂĄn P. Kelly
- CM Surawicz
- CM Surawicz
- CM Theriot
- CN Abou Chakra
- CR Kelly
- Cristian TranĂ
- CS Kwok
- CW Seder
- D Jodorkovsky
- David B. Stewart
- DB Downey
- DB Stewart
- DG Teasley
- DM Lyerly
- DM Musher
- DN Gerding
- DN Gerding
- DS Merine
- DW Eyre
- DW Eyre
- DW Eyre
- DY Lee
- DY Lee
- DZ Bliss
- E Brown
- E Gough
- E Nood van
- E Tsironi
- EA Sailhamer
- EC Iv
- Edward H. Eiland
- EH Carchman
- EH Eiland 3rd
- EK Fishman
- EM Clayton
- Emanuele Caproli
- ER Dubberke
- Ernest E. Moore
- Ewen A. Griffiths
- F Barbut
- F Barbut
- F Lamontagne
- FA Zar
- Fausto Catena
- FC Lessa
- FD LaBarbera
- Federico Coccolini
- Felicia Humphrey
- FG Rosa De
- Fikri M. Abu-Zidan
- FJ Piacenti
- FM Abu-Zidan
- Francis D. LaBarbera
- Francisco Portela
- Frederick Alan Moore
- Frédéric Barbut
- G Cammarota
- G Guyatt
- G Privitera
- Gabriele Sganga
- George C. Velmahos
- Gerson Alves Pereira JĂșnior
- GM Wilden van der
- Gokhan Metan
- Goran Augustin
- GP Carter
- Gustavo P. Fraga
- GW Boland
- H Barth
- H Huang
- H Westh
- H Yanai
- H Yasunaga
- Harry van Goor
- HL Koo
- I Absah
- I Castagliuolo
- I Lowy
- I Ramachandran
- I Youngster
- Ian Eltringham
- ID Kirkpatrick
- Irina Magdalena Dumitru
- Isidoro Di Carlo
- J Clanton
- J Clanton
- J Lawrence
- J PĂ©pin
- J Yee
- Jacek Czepiel
- Jae Gil Lee
- Jae Il Kim
- JB Albright
- JC OâHoro
- Jean Francois Timsit
- Jean Louis Frossard
- Jean Ralph Zahar
- Jesse Clanton
- JF Hall
- JF Rodemann
- JG Bartlett
- JG Bartlett
- JG Bartlett
- Jill R. Cherry-Bukowiec
- JL Brozek
- John E. Mazuski
- Joseph Derek Forrester
- JP Kelly
- JS Bakken
- JS Garner
- K Lumpkins
- KA Osman
- Kathleen B. To
- KB To
- KC Carroll
- KC Kent
- KJ Walker
- Koray Das
- KW Garey
- KW Garey
- L Furuya-Kanamori
- L Kyne
- L Kyne
- Laura A. Canterbury
- Layan Alrahmani
- LC McDonald
- Libor UrbĂĄnek
- LM Feazel
- LN Diebel
- Luca Ansaloni
- Luis Furuya-Kanamori
- LV McFarland
- LV McFarland
- LV McFarland
- LV McFarland
- LV McFarland
- LV McFarland
- LV McFarland
- Lynne V. McFarland
- M Gerber
- M Girotra
- M Goudarzi
- M Issa
- M Kazanowski
- M Warny
- M Willt
- M Zerey
- MA Miller
- MA Rodrigues
- Mansoor Raza
- Maria Elena Cocuz
- Mario Faro
- Mark A. Malangoni
- Massimo Sartelli
- MD Neal
- MD Zilberberg
- ME McCusker
- ME OâMalley
- MF Wang
- MH Samore
- Miguel A. CaĂnzos
- Miklosh Bala
- Miran Rems
- MJ Kim
- MK Shaughnessy
- ML Schmidt
- Mohamed Hassan Ahmed
- MP Bauer
- MP Bauer
- MP Hensgens
- MR Jaber
- MR Welfare
- MS Abourgergi
- Mushira Abdulaziz Enani
- MY Hu
- MY Hu
- N Bagdasarian
- N Kamada
- N Kamada
- Nicola Petrosillo
- NL Sanders
- NN Egorova
- O Marufu
- OA Cornely
- OA Cornely
- OA Cornely
- Offir Ben-Ishay
- P Davey
- P Ferrada
- P Hookman
- P Hookman
- Patrizia Spigaglia
- Paul Juang
- Paula Ferrada
- PB Sullivan
- Peter K Kim
- Pierluigi Viale
- Pierre Tattevin
- PJ Collini
- PK Kim
- PR Ros
- R Campbell
- R Cunningham
- R Fekety
- R Fekety
- R Kariv
- R Razzaq
- R Viscidi
- R Voelker
- Rao Ivatury
- Raul Coimbra
- RC Owens
- RC Owens
- RI El-Herte
- Rita Galeiras
- RL Nelson
- RM Dallal
- RN Damle
- RN Pruitt
- RP Vonberg
- S Bacci
- S Bella Di
- S Ben-Horin
- S Chan
- S Dial
- S Johnson
- S Johnson
- S Khanna
- S Khanna
- S Khanna
- S Khanna
- S Kundrapu
- S Magalini
- S Schneeweiss
- S Shah
- SA Kuehne
- SA Kuehne
- Sahil Khanna
- Salomone Di Saverio
- Sanjay Marwah
- SB Debast
- SD Adams
- SD Malnick
- SH Cohen
- Shirley Chan
- SJ OâKeefe
- SJ OâKeefe
- SM Brecher
- SM Wren
- SO Ali
- SS Johal
- Stefano Di Bella
- Stephen M. Brecher
- SV Kazakova
- T Chopra
- T Jank
- T Planche
- TD Planche
- TJ Louie
- Torsten Herzog
- U Navaneethan
- Varut Lohsiriwat
- Venkata Gorrepati
- VG Loo
- VG Loo
- Vishal G. Shelat
- VT Chang
- W Flegel
- Wagih Ghnnam
- Waldemar Uhl
- Walter L. Biffl
- Wen Chien Ko
- WJ Halabi
- WN Al-Nassir
- Y Li
- Y Zhu
- Yeong Yeh Lee
- Yoram Kluger
- YP Tabak
- Yunfeng Cui
- Z Kassam
- Zaid M. Abdelsattar
- Zaza Demetrashvili
- ZM Abdelsattar
- Publication venue
- Publication date
- 01/01/2015
- Field of study
In the last two decades there have been dramatic changes in the epidemiology of Clostridium difficile infection (CDI), with increases in incidence and severity of disease in many countries worldwide. The incidence of CDI has also increased in surgical patients. Optimization of management of C difficile, has therefore become increasingly urgent. An international multidisciplinary panel of experts prepared evidenced-based World Society of Emergency Surgery (WSES) guidelines for management of CDI in surgical patients.Peer reviewe
WSES guidelines for management of Clostridium difficile infection in surgical patients
- Author
- A Bhangu
- A Gupta
- A Olson
- A Sundriyal
- AA Samie
- AC Cheng
- AC Clements
- AC Clements
- AD Olivas
- AdriĂĄn Camacho-Ortiz
- AE PĂ©rez-Cobas
- AL Vecchio
- Aleksandar Karamarkovic
- AN Ananthakrishnan
- Aneel Bhangu
- Angela Vassallo
- Arda Isik
- Ari Leppaniemi
- Arnab Ray
- AS Walker
- B Geric
- B Skovrlj
- Basant K. Puri
- BK Puri
- BL Herpers
- Boris E. Sakakushev
- C Eckert
- C Eckmann
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- Carl Erik Nord
- Carlos A. Ordoñez
- Carlos Augusto Gomes
- Catherine Eckert
- CF Haines
- CH Yeom
- Charles H. Cook
- Christian Eckmann
- CiarĂĄn P. Kelly
- CM Surawicz
- CM Surawicz
- CM Theriot
- CN Abou Chakra
- CR Kelly
- Cristian TranĂ
- CS Kwok
- CW Seder
- D Jodorkovsky
- David B. Stewart
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- DB Stewart
- DG Teasley
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- DW Eyre
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- DY Lee
- DY Lee
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- E Brown
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- Edward H. Eiland
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- EK Fishman
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- Emanuele Caproli
- ER Dubberke
- Ernest E. Moore
- Ewen A. Griffiths
- F Barbut
- F Barbut
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- FA Zar
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- FD LaBarbera
- Federico Coccolini
- Felicia Humphrey
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- Fikri M. Abu-Zidan
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- FM Abu-Zidan
- Francis D. LaBarbera
- Francisco Portela
- Frederick Alan Moore
- Frédéric Barbut
- G Cammarota
- G Guyatt
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- Gabriele Sganga
- George C. Velmahos
- Gerson Alves Pereira JĂșnior
- GM Wilden van der
- Gokhan Metan
- Goran Augustin
- GP Carter
- Gustavo P. Fraga
- GW Boland
- H Barth
- H Huang
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- Harry van Goor
- HL Koo
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- Irina Magdalena Dumitru
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- J Clanton
- J Clanton
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- Jean Francois Timsit
- Jean Louis Frossard
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- Jesse Clanton
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- JG Bartlett
- JG Bartlett
- Jill R. Cherry-Bukowiec
- JL Brozek
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- Joseph Derek Forrester
- JP Kelly
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- K Lumpkins
- KA Osman
- Kathleen B. To
- KB To
- KC Carroll
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- Koray Das
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- L Furuya-Kanamori
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- L Kyne
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- LV McFarland
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- LV McFarland
- Lynne V. McFarland
- M Gerber
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- M Warny
- M Willt
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- MA Miller
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- Mansoor Raza
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- Mario Faro
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- N Bagdasarian
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- O Marufu
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- RN Damle
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- RP Vonberg
- S Bacci
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- S Ben-Horin
- S Chan
- S Dial
- S Johnson
- S Johnson
- S Khanna
- S Khanna
- S Khanna
- S Khanna
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- S Magalini
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- SA Kuehne
- SA Kuehne
- Sahil Khanna
- Salomone Di Saverio
- Sanjay Marwah
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- SD Malnick
- SH Cohen
- Shirley Chan
- SJ OâKeefe
- SJ OâKeefe
- SM Brecher
- SM Wren
- SO Ali
- SS Johal
- Stefano Di Bella
- Stephen M. Brecher
- SV Kazakova
- T Chopra
- T Jank
- T Planche
- TD Planche
- TJ Louie
- Torsten Herzog
- U Navaneethan
- Varut Lohsiriwat
- Venkata Gorrepati
- VG Loo
- VG Loo
- Vishal G. Shelat
- VT Chang
- W Flegel
- Wagih Ghnnam
- Waldemar Uhl
- Walter L. Biffl
- Wen Chien Ko
- WJ Halabi
- WN Al-Nassir
- Y Li
- Y Zhu
- Yeong Yeh Lee
- Yoram Kluger
- YP Tabak
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- Z Kassam
- Zaid M. Abdelsattar
- Zaza Demetrashvili
- ZM Abdelsattar
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Growth and phagocytosis characteristics of p388d1 cells in tissue culture. Abstr.
- Publication venue
- The Mouseion at the JAXlibrary
- Publication date
- 01/01/1976
- Field of study
Effects of inhibitors of nucleic acid and protein synthesis on growth and aggregation of the cellular slime mold Dictyostelium discoideum.
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- Field of study
The inhibition of dna synthesis by cannabinoids.
- Publication venue
- The Mouseion at the JAXlibrary
- Publication date
- 01/01/1976
- Field of study
- âŠ