L'integrazione come "pratica sociale": un'etnografia delle seconde generazioni a Modena

Il presente lavoro di ricerca affronta il tema delle nuove generazioni nella societ\ue0 modenese, ai fini di esplorare gli orientamenti che si vanno delineando riguardo all\u2019integrazione, alla costruzione di legami sociali e alla formazione di identit\ue0 e appartenenze. L\u2019obiettivo principale \ue8 lo studio dei processi identitari messi in atto dagli adolescenti stranieri nel percorso di integrazione sociale nella citt\ue0 di Modena, mediante un\u2019analisi etnografica delle dinamiche che si sviluppano nella relazione di questi con la societ\ue0 modenese, per evidenziare i meccanismi reali di inclusione ed esclusione delle minoranze in un contesto urbano. Gli aspetti indagati hanno cos\uec riguardato varie dimensioni dell\u2019integrazione: quella istituzionale, attraverso la disamina dei percorsi di inserimento e riuscita scolastica dei giovani migranti nel contesto modenese; quella relazionale, mediante la riflessione sull\u2019influenza delle reti familiari, comunitarie, amicali e amorose nella definizione del processo integrativo; quella identitaria e culturale, tramite l\u2019analisi delle forme e degli usi dei riferimenti culturali nella vita quotidiana dei ragazzi stranieri; quella sociale, con l\u2019osservazione delle forme di pregiudizio e discriminazione, latenti e non, nella societ\ue0 di accoglienza e, infine, quella soggettiva, attraverso le dichiarazioni dei soggetti di ricerca sugli stili di vita e sui comportamenti ritenuti devianti dal mondo adulto. Il risultato \ue8 una lettura delle relazioni interculturali e della supposta apertura del cosiddetto modello emiliano, che permette di osservare le dinamiche integrative come processi complessi, multidimensionali, ma soprattutto profondamente ambivalenti.This research addresses the issue of the immigrant youth, in order to explore the guidelines that are emerging on the integration, the construction of social bonds and the formation of identity and belonging. The main objective is the study of identity processes implemented by foreign teenagers in the process of social integration in the city of Modena, through ethnographic analysis of the dynamics which are developed in their relationship with local society, to highlight the actual mechanisms of inclusion and exclusion of minorities in an urban setting. The investigated aspects concerned various dimensions of the integration: an institutional dimension, through the examination of the way to educational success of young migrants in the context of Modena; a relational dimension, through reflection on the influence of family networks, community, friendship and love in the definition of the integration process; a cultural dimension, through analysis of the nature and uses of cultural references in the daily life of foreign students; a social dimension with the observation of the forms of prejudice and discrimination, latent or otherwise, in the host society and, ultimately, an individual dimension through the declarations of research subjects on lifestyles and behaviors considered deviant from the adult world. The result is a reading of the intercultural relations and the supposed opening of the so-called \u201cmodello emiliano\u201d, which allows to observe the dynamics of integrative processes as complex, multidimensional, but also deeply ambivalent

Oncogenic microRNAs characterization in clear cell renal cell carcinoma

A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of this study was to identify specific miRNAs that are deregulated in tumor vs. normal kidney tissues and that could impact on the biology of ccRCC. To this end we selected four miRNAs (miR-21-5p, miR-210-3p, miR-185-5p and miR-221-3p) and their expression has been evaluated in a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) tissues from 20 ccRCC patients who underwent surgical nephrectomy resection. miR-21-5p and miR-210-3p resulted the most significantly up-regulated miRNAs in this patient cohort, highlighting these onco-miRNAs as possible relevant players involved in ccRCC tumorigenesis. Thus, this study reports the identification of specific oncogenic miRNAs that are altered in ccRCC tissues and suggests that they might be useful biomarkers in ccRCC management

Molecular modeling to study dendrimers for biomedical applications

© 2014 by the authors; licensee MDPI; Basel; Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). Date of Acceptance: 17/11/2014Molecular modeling techniques provide a powerful tool to study the properties of molecules and their interactions at the molecular level. The use of computational techniques to predict interaction patterns and molecular properties can inform the design of drug delivery systems and therapeutic agents. Dendrimers are hyperbranched macromolecular structures that comprise repetitive building blocks and have defined architecture and functionality. Their unique structural features can be exploited to design novel carriers for both therapeutic and diagnostic agents. Many studies have been performed to iteratively optimise the properties of dendrimers in solution as well as their interaction with drugs, nucleic acids, proteins and lipid membranes. Key features including dendrimer size and surface have been revealed that can be modified to increase their performance as drug carriers. Computational studies have supported experimental work by providing valuable insights about dendrimer structure and possible molecular interactions at the molecular level. The progress in computational simulation techniques and models provides a basis to improve our ability to better predict and understand the biological activities and interactions of dendrimers. This review will focus on the use of molecular modeling tools for the study and design of dendrimers, with particular emphasis on the efforts that have been made to improve the efficacy of this class of molecules in biomedical applications.Peer reviewedFinal Published versio

UNA MIRADA SOBRE LA INVESTIGACIÓN EN LA UNIVERSIDAD NACIONAL DE MAR DEL PLATA

Las expectativas de este trabajo están centradas en el conocimiento del desarrollo de la investigación en la UNMDP, los recursos disponibles para cumplir con los objetivos propuestos y su estado actual. Para ello se procedió a la recolección y el análisis de datos, fundamentalmente los correspondientes a esta última década. Una observación importante, que define el campo de análisis de la información expuesta en este trabajo, es que sólo se tienen en cuenta los aspectos de la investigación que promueve o fomenta la UNMDP, (proyectos, subsidios, becas, etc), sin considerar el aporte de otras instituciones u organizaciones que ayudan considerablemente al desarrollo de la ciencia en la Universidad, como el CONICET, o las agencias de cooperación internacional, por ejemplo. En este trabajo se han seleccionado algunos aspectos fundamentales del desarrollo de la investigación, unos por lo reveladores que resultan en la observación general, otros por ser los que reúnen una mayor confiabilidad en sus datos. Así aparecen: la evolución histórica, el sistema organizativo, los proyectos de investigación, las becas, los fondos para la investigación, la producción científica y el impacto de la investigación en la docencia. Se intenta de este modo perfilar a la UNMDP con indicadores que permitan, en breve, conformar un verdadero proceso de autoevaluación y su comparación con Instituciones similares. La investigación en la UNMDP posee historia y tiene presencia en su continuo hacer. Hoy es posible concebir a la trilogía docencia - investigación - extensión como síntesis de la finalidad que le cabe como Institución. Podrán cambiar los mecanismos de financiamiento, los objetos de la investigación, las estructuras organizativas y los planes de formación y estímulo de los recursos humanos, pero no se puede dejar de pensar en la investigación como una función primordial de la Universidad, creando conocimiento, y especialmente aquel conocimiento que tienda a resolver los problemas que el medio requiere. De lo presentado y analizado podría deducirse que esta Universidad está, en esta década tendiendo a encontrar sus propias dimensiones en el campo de la investigación: el número de proyectos se ha estabilizado, también los recursos y las cantidades de becas, existe una marcada presencia de las Facultades de Ingeniería, Humanidades, Cs. Exactas y Naturales, Cs. Agrarias y Arquitectura por sobre las demás, se tiende lentamente a incrementar la dedicación de sus docentes, se fomenta su formación a nivel cuaternario, se establecen convenios que permitan el intercambio y la cooperación y, así, tantas otras actividades que remarcan la intención de integrar la investigación al quehacer de nuestra Universidad. Queda mucho por hacer. Y, seguramente seguirán marchas y contramarchas, persistiendo el anhelo de que la institución encuentre el modo de concretar el trascendente fin para el que ha sido creada

Quality of life aspects of a low protein diet using GMP in patients with phenylketonuria

Objective: To assess some quality of life (QOL) aspects of a low protein diet, using glycomacropeptide (GMP) as a protein substitute in patients with phenylketonuria (PKU). Methods: This was a multicentre, prospective observational cohort, study. Metabolic control, nutritional parameters, and dietary adherence were assessed in patients with PKU before (T0), and six months after (T6) starting a low protein diet using GMP. Selected items from the PKUQOL questionnaire were used to assess patients’ acceptance of their modified diet. Results: 18 patients from three Italian Centres, completed the study. With the exception of LDL-cholesterol and vitamin 25OH-D concentrations, there were no differences between T0 and T6 in metabolic or nutritional parameters. Data suggested that patients have a good acceptance of protein substitutes containing GMP, probably because of their improved palatability. Conclusions: According to our patients’ responses to items related to dietary regimen, GMP based protein substitutes do not appear to significantly affect QOL

Sala de recursos multifuncional em escolas do campo: direito assegurado?

O Atendimento Educacional Especializado é a base para o desenvolvimento de uma escola inclusiva, no tocante às pessoas com algum tipo de deficiência. O presente artigo tem como objetivo descrever e analisar a organização de três Salas de Recursos Multifuncional em Escolas do Campo de um município do interior paulista. Para tanto, seguiu-se uma abordagem quanti-qualitativa de pesquisa que teve como procedimento metodológico o Estudo de Caso. Para coleta dos dados foram utilizados questionários, observações, registro fotográfico e análise de documentos escolares. Será apresentado um recorte das observações, fotos e do questionário respondido por 31 professores. Os resultados apontam que as três unidades escolares não apresentam espaço próprio para funcionamento da Sala de Recursos Multifuncional, inclusive esta situação continua a mesma dois anos após a realização da pesquisa. Assim sendo, cabe a reflexão se os direitos assegurados nas políticas públicas sobre Educação Especial na perspectiva Inclusiva são validados nas escolas do campo

Sala de recursos multifuncional em escolas do campo: direito assegurado?

O Atendimento Educacional Especializado é a base para o desenvolvimento de uma escola inclusiva, no tocante às pessoas com algum tipo de deficiência. O presente artigo tem como objetivo descrever e analisar a organização de três Salas de Recursos Multifuncional em Escolas do Campo de um município do interior paulista. Para tanto, seguiu-se uma abordagem quanti-qualitativa de pesquisa que teve como procedimento metodológico o Estudo de Caso. Para coleta dos dados foram utilizados questionários, observações, registro fotográfico e análise de documentos escolares. Será apresentado um recorte das observações, fotos e do questionário respondido por 31 professores. Os resultados apontam que as três unidades escolares não apresentam espaço próprio para funcionamento da Sala de Recursos Multifuncional, inclusive esta situação continua a mesma dois anos após a realização da pesquisa. Assim sendo, cabe a reflexão se os direitos assegurados nas políticas públicas sobre Educação Especial na perspectiva Inclusiva são validados nas escolas do campo

Understanding the Biological Significance of Anti-DFS70 Antibodies: Effect of Biologic Therapies on Their Occurrence in Inflammatory Arthritis

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Essential oils: pharmaceutical applications and encapsulation strategies into lipid-based delivery systems

Essential oils are being studied for more than 60 years, but a growing interest has emerged in the recent decades due to a desire for a rediscovery of natural remedies. Essential oils are known for millennia and, already in prehistoric times, they were used for medicinal and ritual purposes due to their therapeutic properties. Using a variety of methods refined over the centuries, essential oils are extracted from plant raw materials: the choice of the extraction method is decisive, since it determines the type, quantity, and stereochemical structure of the essential oil molecules. To these components belong all properties that make essential oils so interesting for pharmaceutical uses; the most investigated ones are antioxidant, anti-inflammatory, antimicrobial, wound-healing, and anxiolytic activities. However, the main limitations to their use are their hydrophobicity, instability, high volatility, and risk of toxicity. A successful strategy to overcome these limitations is the encapsulation within delivery systems, which enable the increase of essential oils bioavailability and improve their chemical stability, while reducing their volatility and toxicity. Among all the suitable platforms, our review focused on the lipid-based ones, in particular micro- and nanoemulsions, liposomes, solid lipid nanoparticles, and nanostructured lipid carriers.This work was supported by a grant from the Italian Ministry of Research [Grant PRIN2017 #20173ZECCM Tracking biological barriers to antigen delivery by nanotechnological vaccines(NanoTechVax)] and by Research Funding for University of Catania (Piano per la Ricerca 2016–2018—Linea Di Intervento 2 “Dotazione Ordinaria” cod. 57722172106). Cinzia Cimino was supported bythe PhD program in Biotechnology, XXXVI cycle, University of Cataniainfo:eu-repo/semantics/publishedVersio