Rôle du/de la diététicien-ne dans la prise en charge du cancer du sein: travail de Bachelor

Introduction : Les diététicien-ne-s ont plusieurs rôles dans la prise en charge nutritionnelle de femmes atteintes d’un cancer du sein. Ce dernier est un cadre particulier, avec une prise de poids fréquente dans un contexte oncologique, qui requiert une expertise spécifique. Cependant, peu de recommandations sont consacrées précisément au cancer du sein et les diététicien-ne-s y sont peu cité-e-s comme personnes de référence. Nous nous sommes donc intéressées à des études d’interventions dans le but de les comparer avec les recommandations afin de mieux pouvoir définir la place du/de la diététicien-ne dans la prise en charge de ces femmes. Méthode : Pour ce travail, nous avons mené deux recherches en parallèle. La première sur les interventions de prises en charges nutritionnelles décrites dans la littérature. La deuxième recherche a été faite dans le but de recenser les recommandations de prises en charges nutritionnelles de femmes atteintes d’un cancer du sein. Nous avons ensuite procédé à une comparaison entre les recommandations et les interventions. Résultats : Nous avons retenu 22 articles dans les descriptions d’interventions. Une large majorité d’articles (19/22) avaient pour but une perte de poids, souvent par l’introduction d’un régime hypocalorique basé sur une restriction des lipides et/ou glucides. Il ressort que les articles respectent les recommandations sur certains points, comme la restriction calorique, le régime hypolipidique ou certains conseils alimentaires. Cependant, d’autres aspects des recommandations ne sont que peu traités dans les articles, tels que le maintien et la gestion du poids. Dans l’ensemble, il était difficile de comparer les recommandations avec les interventions car ces dernières étaient peu décrites dans les articles. Conclusion : Les interventions nutritionnelles dans le cadre du cancer du sein sont peu détaillées dans la littérature. La comparaison des programmes mis en place avec les recommandations reste difficile à faire de façon précise au vu des informations manquantes lors de la description des interventions. Ce travail nous a tout de même permis d'avoir une idée plus précise de la place et des rôles du/de la diététicien-ne dans la prise en charge nutritionnelle de femmes atteintes de cancer du sein et pourrait être complété par une analyse des pratiques professionnelles des diététiciennes dans la prise en charge du cancer du sein en Suisse

Response To The Pandemic: Housing For Health In The Va Tent Community

In response to the COVID-19 pandemic, an innovative approach to providing integrated primary care services was initiated in the Veterans Administration Greater Los Angeles Healthcare System (Figure 1). The Care, Treatment and Rehabilitation Services, a unique street medicine program, was placed within an encampment that is supported by the West Los Angeles VA health care services including onsite provision of 24/7 security, stability of tent sites, 3 meals a day, unlimited water, hygiene stations, face masks, showers and housing placement services.http://deepblue.lib.umich.edu/bitstream/2027.42/170780/1/AFM-348-21_PP.pdfDescription of AFM-348-21_PP.pdf : Main ArticleSEL

Development of the Circulation Control Flow Scheme Used in the NTF Semi-Span FAST-MAC Model

The application of a circulation control system for high Reynolds numbers was experimentally validated with the Fundamental Aerodynamic Subsonic Transonic Modular Active Control semi-span model in the NASA Langley National Transonic Facility. This model utilized four independent flow paths to modify the lift and thrust performance of a representative advanced transport type of wing. The design of the internal flow paths highlights the challenges associated with high Reynolds number testing in a cryogenic pressurized wind tunnel. Weight flow boundaries for the air delivery system were identified at mildly cryogenic conditions ranging from 0.1 to 10 lbm/sec. Results from the test verified system performance and identified solutions associated with the weight-flow metering system that are linked to internal perforated plates used to achieve flow uniformity at the jet exit

Enhancements to the FAST-MAC Circulation Control Model and Recent High-Reynolds Number Testing in the National Transonic Facility

A second wind tunnel test of the FAST-MAC circulation control model was recently completed in the National Transonic Facility at the NASA Langley Research Center. The model was equipped with four onboard flow control valves allowing independent control of the circulation control plenums, which were directed over a 15% chord simple-hinged flap. The model was configured for low-speed high-lift testing with flap deflections of 30 and 60 degrees, along with the transonic cruise configuration with zero degree flap deflection. Testing was again conducted over a wide range of Mach numbers up to 0.88, and Reynolds numbers up to 30 million based on the mean chord. The first wind tunnel test had poor transonic force and moment data repeatability at mild cryogenic conditions due to inadequate thermal conditioning of the balance. The second test demonstrated that an improvement to the balance heating system significantly improved the transonic data repeatability, but also indicated further improvements are still needed. The low-speed highlift performance of the model was improved by testing various blowing slot heights, and the circulation control was again demonstrated to be effective in re-attaching the flow over the wing at off-design transonic conditions. A new tailored spanwise blowing technique was also demonstrated to be effective at transonic conditions with the benefit of reduced mass flow requirements

Development and validation of the Arizona Cognitive Test Battery for Down syndrome

Neurocognitive assessment in individuals with intellectual disabilities requires a well-validated test battery. To meet this need, the Arizona Cognitive Test Battery (ACTB) has been developed specifically to assess the cognitive phenotype in Down syndrome (DS). The ACTB includes neuropsychological assessments chosen to 1) assess a range of skills, 2) be non-verbal so as to not confound the neuropsychological assessment with language demands, 3) have distributional properties appropriate for research studies to identify genetic modifiers of variation, 4) show sensitivity to within and between sample differences, 5) have specific correlates with brain function, and 6) be applicable to a wide age range and across contexts. The ACTB includes tests of general cognitive ability and prefrontal, hippocampal and cerebellar function. These tasks were drawn from the Cambridge Neuropsychological Testing Automated Battery (CANTAB) and other established paradigms. Alongside the cognitive testing battery we administered benchmark and parent-report assessments of cognition and behavior. Individuals with DS (n = 74, ages 7–38 years) and mental age (MA) matched controls (n = 50, ages 3–8 years) were tested across 3 sites. A subsample of these groups were used for between-group comparisons, including 55 individuals with DS and 36 mental age matched controls. The ACTB allows for low floor performance levels and participant loss. Floor effects were greater in younger children. Individuals with DS were impaired on a number ACTB tests in comparison to a MA-matched sample, with some areas of spared ability, particularly on tests requiring extensive motor coordination. Battery measures correlated with parent report of behavior and development. The ACTB provided consistent results across contexts, including home vs. lab visits, cross-site, and among individuals with a wide range of socio-economic backgrounds and differences in ethnicity. The ACTB will be useful in a range of outcome studies, including clinical trials and the identification of important genetic components of cognitive disability

Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study

With improved healthcare, the Down syndrome (DS) population is both growing and aging rapidly. However, with longevity comes a very high risk of Alzheimer's disease (AD). The LIFE-DSR study (NCT04149197) is a longitudinal natural history study recruiting 270 adults with DS over the age of 25. The study is designed to characterize trajectories of change in DS-associated AD (DS-AD). The current study reports its cross-sectional analysis of the first 90 subjects enrolled. Plasma biomarkers phosphorylated tau protein (p-tau), neurofilament light chain (NfL), amyloid β peptides (Aβ1-40, Aβ1-42), and glial fibrillary acidic protein (GFAP) were undertaken with previously published methods. The clinical data from the baseline visit include demographics as well as the cognitive measures under the Severe Impairment Battery (SIB) and Down Syndrome Mental Status Examination (DS-MSE). Biomarker distributions are described with strong statistical associations observed with participant age. The biomarker data contributes to understanding DS-AD across the spectrum of disease. Collectively, the biomarker data show evidence of DS-AD progression beginning at approximately 40 years of age. Exploring these data across the full LIFE-DSR longitudinal study population will be an important resource in understanding the onset, progression, and clinical profiles of DS-AD pathophysiology

Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo

Meeting Abstracts: Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo Clearwater Beach, FL, USA. 9-11 June 201

Evaluation of Selenite Effects on Selenoproteins and Cytokinome in Human Hepatoma Cell Lines

The need to explore new alternative therapeutic strategies and chemoprevention methods for hepatocellular carcinoma is growing significantly. Selenium is a trace element that plays a critical role in physiological processes, and is used in cancer chemoprevention. The aim of this work was to test in vitro the effect of sodium selenite on the human hepatoma cell lines, HepG2 and Huh7, to assess its effect on the expression of GPX1, SELK and SELENBP1 and also to evaluate its action on inflammation determinants such as cytokines. Our results show that: (i) the increase observed for the GPX1 and SELK expression is correlated with an increase in the sodium selenite concentration, also evidencing an inverse association between the levels of these two proteins and SELENBP1; (ii) the selenium concentrations evaluated in protein extracts increase in proportional way with the selenite concentrations used in the treatment, suggesting that other selenoproteins can also be modulated and should be evaluated in further studies, and (iii) some cytokines, VEGF and three pro-inflammatory cytokines, i.e., IL-6, IL-8, and IL-17, decreased with an increasing selenite concentration. Finally, interactomic studies show that GPX1 and SELK, and the four pro-inflammatory cytokines are functionally correlated evidencing a putative anti-inflammatory role for the selenite

Evaluation of Selenite Effects on Selenoproteins and Cytokinome in Human Hepatoma Cell Lines

The need to explore new alternative therapeutic strategies and chemoprevention methods for hepatocellular carcinoma is growing significantly. Selenium is a trace element that plays a critical role in physiological processes, and is used in cancer chemoprevention. The aim of this work was to test in vitro the effect of sodium selenite on the human hepatoma cell lines, HepG2 and Huh7, to assess its effect on the expression of GPX1, SELK and SELENBP1 and also to evaluate its action on inflammation determinants such as cytokines. Our results show that: (i) the increase observed for the GPX1 and SELK expression is correlated with an increase in the sodium selenite concentration, also evidencing an inverse association between the levels of these two proteins and SELENBP1; (ii) the selenium concentrations evaluated in protein extracts increase in proportional way with the selenite concentrations used in the treatment, suggesting that other selenoproteins can also be modulated and should be evaluated in further studies, and (iii) some cytokines, VEGF and three pro-inflammatory cytokines, i.e., IL-6, IL-8, and IL-17, decreased with an increasing selenite concentration. Finally, interactomic studies show that GPX1 and SELK, and the four pro-inflammatory cytokines are functionally correlated evidencing a putative anti-inflammatory role for the selenite