506 research outputs found
The democratic engagement of Britain's ethnic minorities
Democratic engagement is a multi-faceted phenomenon that embraces citizens' involvement with electoral politics, their participation in ‘conventional’ extra-parliamentary political activity, their satisfaction with democracy and trust in state institutions, and their rejection of the use of violence for political ends. Evidence from the 2010 BES and EMBES shows that there are important variations in patterns of democratic engagement across Britain's different ethnic-minority groups and across generations. Overall, ethnic-minority engagement is at a similar level to and moved by the same general factors that influence the political dispositions of whites. However, minority democratic engagement is also strongly affected by a set of distinctive ethnic-minority perceptions and experiences, associated particularly with discrimination and patterns of minority and majority cultural engagement. Second-generation minorities who grew up in Britain are less, rather than more, likely to be engaged
Saving and reproducing the nation: Struggles around right-wing politics of social reproduction, gender and race in austerity Europe
This article suggests the analytic lens of cultural, social and national reproduction to understand the centrality of gendered and ethnic relations, in particular a focus on family life in contemporary UK. Proposing a theoretical focus on reproduction, the article then provides some contextualisation with wider European experiences to show connections between the political articulations across the far-right and mainstream right-wing. It argues that there is much overlap between the far-right and mainstream rightwing, conservative gender and family ideologies, where contradictory aspects of their gender and family ideals (simultaneously progressive and traditional) are articulated as care for the nation's future. Care is then articulated for the purpose of racist activism and constructing governmental belonging. The racialized migrant family plays a central role in these debates, marking the boundaries of the nation. The article explores these issues in depth through the example of material and symbolic constructions of the racialized migrant family as undeserving of care, exemplified through the UK policy of No Recourse to Public Funding
What lies beneath: exploring links between asylum policy and hate crime in the UK
This paper explores the link between increasing incidents of hate crime and the asylum policy of successive British governments with its central emphasis on deterrence. The constant problematisation of asylum seekers in the media and political discourse ensures that 'anti-immigrant' prejudice becomes mainstr earned as a common-sense response. The victims are not only the asylum seekers hoping for a better life but democratic society itself with its inherent values of pluralism and tolerance debased and destabilised
Zombie multiculturalism meets liberative difference:Searching for a new discourse of diversity
This paper grapples with an unresolved tension – twenty-first century Britain is indelibly multicultural and yet diversity is increasingly depicted as a threat to social cohesion. A society characterised by superdiverse cities where some suggest that ‘multiculturalism has failed’. On the basis of an analysis of three dominant theoretical and ideological discourses – community cohesion, multiculturalism and interculturalism – it will be argued that there is an urgent need to forge a new understanding of diversity that can counter the zombie discourse that characterises current debates about diversity in Britain. Difference will be framed as a potential source of mutual liberation, not a problem seeking a solution. It will be argued that a critical engagement with political theology can help us to fashion a new discourse of diversity that is characterised by a hermeneutics of liberative difference, which can help to defeat the zombies sucking the life out of diverse Britain. Publisher Statement: This is an Accepted Manuscript of an article published by Taylor & Francis in Culture and Religion on 20th February 2017, available online: http://www.tandfonline.com/10.1080/14755610.2017.128710
Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes.
Listeria monocytogenes is an important cause of maternal-fetal infections and serves as a model organism to study these important but poorly understood events. L. monocytogenes can infect non-phagocytic cells by two means: direct invasion and cell-to-cell spread. The relative contribution of each method to placental infection is controversial, as is the anatomical site of invasion. Here, we report for the first time the use of first trimester placental organ cultures to quantitatively analyze L. monocytogenes infection of the human placenta. Contrary to previous reports, we found that the syncytiotrophoblast, which constitutes most of the placental surface and is bathed in maternal blood, was highly resistant to L. monocytogenes infection by either internalin-mediated invasion or cell-to-cell spread. Instead, extravillous cytotrophoblasts-which anchor the placenta in the decidua (uterine lining) and abundantly express E-cadherin-served as the primary portal of entry for L. monocytogenes from both extracellular and intracellular compartments. Subsequent bacterial dissemination to the villous stroma, where fetal capillaries are found, was hampered by further cellular and histological barriers. Our study suggests the placenta has evolved multiple mechanisms to resist pathogen infection, especially from maternal blood. These findings provide a novel explanation why almost all placental pathogens have intracellular life cycles: they may need maternal cells to reach the decidua and infect the placenta
‘As a woman…’; ‘As a Muslim…’: Subjects, positions and counter-terrorism powers in the United Kingdom
This article presents findings from original focus group research on the importance of identity claims within public understandings of counter-terrorism across the UK. Following a review of existing literature on the terrorism/counter-terrorism/identity nexus, the article introduces four prominent subject positions inhabited within public articulations of counter-terrorism powers: the ‘Muslim’, the ‘target’, the ‘woman’ and the ‘unaffected’. Positions such as these, we argue, both enable and inhibit particular normative, political and anecdotal claims about counter-terrorism frameworks and their impact upon the body politic. This, we suggest, is demonstrative of the co-constitutive role between counter-terrorism and identity claims. Thus, on the one hand, counter-terrorism initiatives work to position individuals socially, politically, and culturally: (re)producing various religious, ethnic and other identities. Yet, at the same time, specific subject positions are integral to the articulation of people’s attitudes toward developments in counter-terrorism. The article concludes by thinking through some of the implications of this, including for resistance toward securitising moves and for citizenship more generally
Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths. We found repeat length-dependent transcriptional signatures to be prominent in the striatum, less so in cortex, and minimal in the liver. Coexpression network analyses revealed 13 striatal and 5 cortical modules that correlated highly with CAG length and age, and that were preserved in HD models and sometimes in patients. Top striatal modules implicated mHtt CAG length and age in graded impairment in the expression of identity genes for striatal medium spiny neurons and in dysregulation of cyclic AMP signaling, cell death and protocadherin genes. We used proteomics to confirm 790 genes and 5 striatal modules with CAG length-dependent dysregulation at the protein level, and validated 22 striatal module genes as modifiers of mHtt toxicities in vivo
- …
