mHealth: providing a mindfulness app for women with chronic pelvic pain in gynaecology outpatient clinics: qualitative data analysis of user experience and lessons learnt

OBJECTIVES: To determine whether a pre-existing smartphone app to teach mindfulness meditation is acceptable to women with chronic pelvic pain (CPP) and can be integrated into clinical practice within the National Health Service (NHS) CPP pathways, and to inform the design of a potential randomised clinical trial. DESIGN: A prestudy patient and public involvement (PPI) group to collect feedback on the acceptability of the existing app and study design was followed by a three-arm randomised feasibility trial. In addition, we undertook interviews and focus groups with patients and staff to explore app usability and acceptability. We also obtained participant comments on the research process, such as acceptability of the study questionnaires. SETTING: Two gynaecology clinics within Barts Health NHS, London, UK. PARTICIPANTS: Patients with CPP lasting ≥6 months with access to smartphone or personal computer and understanding of basic English. INTERVENTION: The intervention was mindfulness meditation content plus additional pain module delivered by a smartphone app. Active controls received muscle relaxation content from the same app. Passive (waiting list) controls received usual care. MAIN OUTCOME MEASURES: Themes on user feedback, app usability and integration, and reasons for using/not using the app. RESULTS: The use of the app was low in both active groups. Patients in the prestudy PPI group, all volunteers, were enthusiastic about the app (convenience, content, portability, flexibility, ease of use). Women contributing to the interview or focus group data (n=14), from a 'real world' clinic (some not regular app users), were less positive, citing as barriers lack of opportunities/motivation to use the app and lack of familiarity and capabilities with technology. Staff (n=7) were concerned about the potential need for extra support for them and for the patients, and considered the app needed organisational backing and peer acceptance. CONCLUSION: The opinions of prestudy PPI volunteers meeting in their private time may not represent those of patients recruited at a routine clinic appointment. It may be more successful to codesign/codevelop an app with typical users than to adapt existing apps for use in real-world clinical populations. TRIAL REGISTRATION NUMBER: ISRCTN10925965

Minimal model for calcium alternans due to SR release refractoriness

In the heart, rapid pacing rates may induce alternations in the strength of cardiac contraction, termed pulsus alternans. Often, this is due to an instability in the dynamics of the intracellular calcium concentration, whose transients become larger and smaller at consecutive beats. This alternation has been linked experimentally and theoretically to two different mechanisms: an instability due to (1) a strong dependence of calcium release on sarcoplasmic reticulum (SR) load, together with a slow calcium reuptake into the SR or (2) to SR release refractoriness, due to a slow recovery of the ryanodine receptors (RyR2) from inactivation. The relationship between calcium alternans and refractoriness of the RyR2 has been more elusive than the corresponding SR Ca load mechanism. To study the former, we reduce a general calcium model, which mimics the deterministic evolution of a calcium release unit, to its most basic elements. We show that calcium alternans can be understood using a simple nonlinear equation for calcium concentration at the dyadic space, coupled to a relaxation equation for the number of recovered RyR2s. Depending on the number of RyR2s that are recovered at the beginning of a stimulation, the increase in calcium concentration may pass, or not, over an excitability threshold that limits the occurrence of a large calcium transient. When the recovery of the RyR2 is slow, this produces naturally a period doubling bifurcation, resulting in calcium alternans. We then study the effects of inactivation, calcium diffusion, and release conductance for the onset of alternans. We find that the development of alternans requires a well-defined value of diffusion while it is less sensitive to the values of inactivation or release conductance.Postprint (author's final draft

Influencia de la densidad animal en la respuesta productiva de conejos en una explotación industrial

publishedTomo I . Sección: Sistemas Ganaderos-Economía y Gestión. Sesión: Conejos, abejas, peces y cerdos. Ponencia nº 2

Pollen spectrum and physico-chemical attributes of heather (Erica sp.) honeys of north Portugal

Honey legislation has been addressed to establish the minimum marketing level of the product and the need for consumer protection through correct denominations. Research oriented toward assessment of floral origin and physicochemical properties may increase the commercial value of these products. The characteristics of 23 unifloral honeys of Erica sp., from Portugal, were studied. Pollen features and some physicochemical parameters (moisture, ash, pH, free acidity, electrical conductivity, hydroxymethylfurfural content, apparent sucrose, reducing sugars and diastase activity) were determined. RESULTS: All honey samples can be classified as monofloral Erica sp., they gave a mean value of 56% of Erica pollen type. The families Fabaceae and Rosaceae provided the greatest number of pollen types with 8 and 4 pollen types each respectively. The second most important pollen type is Eucalyptus, present in 69.6% of the samples. All honey samples met the international physicochemical quality standards. The present study found a linear correlation (R = 0.996) between the ash content of honeys and their specific conductivity. CONCLUSION: All honey samples can be classified as monofloral Erica sp. Unifloral honeys are increasingly requested and appreciated, despite their higher prices. The samples were found to meet allmajor international honey specifications

Estudio del crecimiento de terneros con alimentador automático en la raza Holstein Frisia en la región de entre Douro y Minho de Portugal

publishedTomo I . Sección: Sistemas Ganaderos-Economía y Gestión. Sesión: Producción de leche. Ponencia nº 3

Indicadores del alimentador automático en terneros de la raza Holstein Frisian en la región de entre Douro y Minho de Portugal

publishedTomo I . Sección: Sistemas Ganaderos-Economía y Gestión. Sesión: Producción de leche. Ponencia nº 3

Minhota breed cattle: Carcass characterisation and meat quality affected by sex and slaughter age

7 páginas, 2 tablasThis work focuses on the effect of slaughter age (6 and 9 months) and sex on carcass characteristics and meat quality of the Minhota cattle breed. In this study, data from 52 cattle (34 entire males and 18 females) were used for the carcass and meat characterisation. Regarding carcass characteristics, entire male carcasses (158 kg and 223 kg for animals of 6 and 9 months, respectively), were heavier than female carcasses (130 kg and 161 kg for animals of 6 and 9 months, respectively), with better dressing percentages, increased lengths, thicknesses and depths and compactness indexes. The quality of meat from carcasses of both entire males and females had strong luminosity (L*), a pale pink tone (lower a*-value) and high yellowness. Mean tenderness of Longissimus thoracis, expressed as shear force, was below 5.5 kg/cm2, without significant differences (P > 0.05) between either the slaughter age or sexPeer reviewe

Behavioral valuation of welfare in the milking parlor for dairy cows

Oral session 2[EN] Milking cows is one of the most important tasks on dairy farms. Poorly performed milking can lead to animal welfare problems manifested by increased aversive behaviour. Kicking is defined as the cow's behaviour as she shifts her weight from one leg to the other (Rousing et al., 2006). Several factors are associated with stepping behaviour during milking, such as the quality of the human-animal relationship, lameness, teat injuries, milk production, and number of parturitions, among others

Mirandesa breed calves: growth performance and carcass characterization affected by sex and livestock production system

12 páginas, 8 tablas, 2 figuras.-- Under License of Creative Commons Attribution 3.0 LicenseThe effect of sex and livestock production system (LPS) on growth performance and carcass characteristics of Mirandesa breed calves was studied. A total of 2,263 and 60 animals for growth performance and carcass characteristics, respectively were used. Initially, the suitability of several equations to describe the growth of cattle from the Mirandesa variety was studied. In all situations, mathematical models were formulated with parameters of clear biological meaning. Bertalanffy and Gompertz equations were the most satisfactory equations to model the growth of males and females, respectively. Calves from traditional system were 68.61 kg heavier than animals from extensive system. On the other hand, calves from traditional systems showed (P<0.01) higher dressing percentage compared to animals from extensive system. There were significant differences for all morphometric parameters by LPS effect with the exception of internal depth pf chest, whereas sex effect had less importance. The LPS had statistically significant effect in all individual joints in the front quarter and hind quarter with the exception of sirloin and eye of round for front quarter and shoulder and the sum of chuck plus neck in the hind quarter. Finally, the LPS had statistically significant effect in all components of fifth quarter, with the exception of intestines, liver, tail and spleen, whereas sex effect only affected heart proportionPeer reviewe