HUBUNGAN ANTARA KELEMBAPAN DAN CURAH HUJAN TERHADAP ANGKA KEJADIAN DEMAM BERDARAH DENGUE (DBD) DI WILAYAH KOTA MANADO TAHUN 2014-2018

Latar Belakang: Berdasarkan Data Dinas Kesehatan (Dinkes) Kota Manado kasus DBD pada tahun 2015 tercatat sebanyak 446 kasus dan 6 kasus diantaranya meninggal dunia, tahun 2016 tercatat 567 kasus dan 6 kasus diantaranya meninggal dunia, tahun 2017 tercatat 139 kasus dan tidak ada yang meninggal dunia dan pada tahun 2018 tercatat 294 kasus (Dinkes Kota Manado, 2019). Metode :Penelitian ini menggunakan metode survei analitik dengan rancangan penelitian cross sectional study.Sampel penelitian ini Kejadian DBD 1.969 kasus kejadian DBD tahun 2014-2018 (Dinas Kesehatan Kota Manado) dan jumlah kelembaban, dan curah hujan yang diambil dari tahun 2014-2018 (BMKG Kota Manado) Hasil :hasil uji korelasi (r) dengan p-value yang diperoleh nilai korelasir= -0.0341 tentang hubungan antara kejadian Demam berdarah dengue dengan kelembaban di kota manado tahun 2014-2018 dan hubungan yang cukup antara kejadian demam berdarah dengue dengan curah hujan di Kota Manado tahun 2014-2018 r= -0.0482. Kesimpulan:Dalam penelitian ini tidak terdapat hubungan antara kejadian Demam berdarah dengue dengan kelembaban di kota manado tahun 2014-2018 dan tidak terdapat hubungan yang cukup antara kejadian demam berdarah dengue dengan curah hujan di Kota Manado tahun 2014-2018.. Saran : Disarankan kepada Dinas Kesehatan baik kota maupun provinsi agar dapat mengontrol wilayah-wilayah yang rentan kejadian DBD yang tinggi dan dapat memantau kesehatan lingkungan pada masyarakat secara berkala serta mengadakan pembinaan kepada masyarakat sebagai upaya pencegahan penyakit DBD. Kata kunci : DBD, Curah Hujan dan Kelembaban ABSTRACTBackground: Based on Data of the Ministry of Health (Dinkes) Manado City DBD case in 2015 recorded as many as 446 cases and 6 cases were passed away, the year 2016 recorded 567 cases and 6 cases of which died, 2017 recorded in 139 Case and no one died and in 2018 recorded 294 cases (Dinkes Kota Manado, 2019). Method: This study uses analytical survey methods with cross sectional study draft research. Sample of this research event DBD 1,969 cases of DBD year 2014-2018 (Dinas Health Office of Manado) and the amount of humidity, and rainfall taken from the year 2014-2018 (BMKG of Manado City). Result: Correlation test result (R) with P-value obtained the correlation value R =-0.0341 about the relationship between the incidence of dengue fever with the humidity in the city of Manado in 2014-2018 and sufficient relationship between dengue fever incidence with The rainfall in Manado city in 2014-2018 r =-0.0482 Conclusion: In this research there is no connection between the incidence of dengue fever with the humidity in the city of Manado in 2014-2018 and there is no adequate relationship between dengue fever occurrence with rainfall in Manado city in 2014-2018. Advice: It is recommended to the health Department of both cities and provinces in order to control areas vulnerable to high DBD events and can monitor environmental health in the community periodically and to conduct coaching to the community As an effort to prevent DBD disease. Keywords: DBD, rainfall and humidit

Witness: The Modern Writer as Witness

Editor\u27s Note [Excerpt] The United States, as a society, is on the brink of profound and positive change. Demographically and culturally, things are improving, and the reason is obvious to people who study history: Conflict pushes us to be better, to strive for principled goals. Consider the inspired eco-advocacy of Greta Thunberg. Or the swearing in of most diverse class of lawmakers in history into the 116th Congress. Or billionaire Robert F. Smith’s pledge to pay off every Morehouse College (in Atlanta, Georgia) student’s debt. Indeed, there are many good people helping and great moments happening in spite of a bleak 24-hour news cycle designed to ruin happiness and to limit our understanding of our human potential. We at Witness see this yearning for transformation in the works we selected. The doorway must be crossed, and the voices and characters we featured in our Winter 2019 issue stand at the vestibule, ready for the light to warm them, primed to fight for that necessary illumination.https://digitalscholarship.unlv.edu/witness/1000/thumbnail.jp

Relationships between tumour response and primary tumour location, and predictors of long-term survival, in patients with RAS wild-type metastatic colorectal cancer receiving first-line panitumumab therapy: retrospective analyses of the PRIME and PEAK clinical trials

Background: Data from two trials of panitumumab in metastatic colorectal cancer (mCRC) were retrospectively analysed to investigate the effects of primary tumour location on early-tumour shrinkage (ETS) and depth of response (DpR), and identify factors predicting long-term survival. Methods: Patients with RAS wild-type mCRC from PRIME (NCT00364013) and PEAK (NCT00819780) were included. ETS was defined as a 6530% reduction in the sum-of-the-longest-diameters of measurable target lesions at eight weeks. DpR was the maximum percentage change from baseline to nadir in patients with shrinkage. Univariate and multivariate logistic analyses of short- versus long-term survivor data were performed. Results: A total of 435/559 (78%) patients had left-sided disease. Of these, a higher proportion of patients treated with panitumumab versus comparator achieved ETS (PRIME: 62% vs. 36%; PEAK: 58% vs. 41%); median DpR was also higher with panitumumab (PRIME: 59% vs. 49%; PEAK: 70% vs. 48%). In pooled analyses of the studies, more patients with right-sided disease achieved ETS if treated with panitumumab than comparator (39% vs. 29%). Panitumumab treatment consistently predicted long-term survival. Conclusions: First-line panitumumab was associated with improved ETS and DpR vs. comparator in patients with left-sided mCRC. ETS may identify a subgroup of patients with right-sided disease who might respond to panitumumab

Are we on the same page? Knowledge boundaries and transactive memory system development in cross-functional teams

One of the key challenges that organizations face when trying to integrate knowledge across different functions is the need to overcome knowledge boundaries between team members. In cross-functional teams, these boundaries, associated with different knowledge backgrounds of people from various disciplines, create communication problems, necessitating team members to engage in complex cognitive processes when integrating knowledge toward a joint outcome. This research investigates the impact of syntactic, semantic, and pragmatic knowledge boundaries on a team’s ability to develop a transactive memory system (TMS)—a collective memory system for knowledge coordination in groups. Results from our survey show that syntactic and pragmatic knowledge boundaries negatively affect TMS development. These findings extend TMS theory beyond the information-processing view, which treats knowledge as an object that can be stored and retrieved, to the interpretive and practice-based views of knowledge, which recognize that knowledge (in particular specialized knowledge) is localized, situated, and embedded in practice

Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE

In this minireview, we briefly revisit the Drosophila Notch and epidermal growth factor receptor pathways, and relate to the relationship between them. We then mainly focus on the involvement of Groucho (Gro)/TLE, a global developmental corepressor, in these pathways. In particular, we discuss Gro/TLE's role at the junction between these two signal transduction cascades

Relationship between the Sensory-Determined Astringency and the Flavanolic Composition of Red Wines

[EN] The relationship between the proanthocyanidin profile and the perceived astringency was assessed in 13 commercial Tempranillo red wines. The concentration and compositional information were obtained by liquid chromatography with diode array detection coupled to electrospray ionization mass spectrometry after acid-catalyzed depolymerization of wine proanthocyanidins in the presence of excess phloroglucinol. Statistical analysis of the results showed significant correlations between sensory and chemical determinations. Astringency was more affected by the subunit composition than by the total concentration or the average degree of polymerization of wine proanthocyanidins. Higher proportions of epicatechin (EC) subunits in extension positions and gallocatechin (GC) subunits in terminal positions were shown to increase astringency. On the contrary, the amount of epigallocatechin (EGC) in both extension and terminal positions was negatively correlated with the perceived astringency

Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression

Colorectal cancer (CRC) is the most common gastrointestinal malignancy in the U.S.A. and approximately 50% of patients develop metastatic disease (mCRC). Despite our understanding of long non-coding RNAs (lncRNAs) in primary colon cancer, their role in mCRC and treatment resistance remains poorly characterized. Therefore, through transcriptome sequencing of normal, primary, and distant mCRC tissues we find 148 differentially expressed RNAs Associated with Metastasis (RAMS). We prioritize RAMS11 due to its association with poor disease-free survival and promotion of aggressive phenotypes in vitro and in vivo. A FDA-approved drug high-throughput viability assay shows that elevated RAMS11 expression increases resistance to topoisomerase inhibitors. Subsequent experiments demonstrate RAMS11-dependent recruitment of Chromobox protein 4 (CBX4) transcriptionally activates Topoisomerase II alpha (TOP2α). Overall, recent clinical trials using topoisomerase inhibitors coupled with our findings of RAMS11-dependent regulation of TOP2α supports the potential use of RAMS11 as a biomarker and therapeutic target for mCRC