367 research outputs found
Imaging Findings in Patients with Immune Checkpoint Inhibitor-Induced Arthritis
Immune checkpoint inhibitor (ICI)-induced arthritis is an increasingly recognized adverse event in patients with oncologic disease during immunotherapy. Four patterns are well described, including rheumatoid arthritis (RA)-like, polymyalgia rheumatica (PMR)-like, psoriatic arthritis (PsA)-like, and oligo-monoarthritis, among others. Despite better clinical recognition of these syndromes, information about the main imaging findings is limited. Methods: We conducted a retrospective observational study including all adult patients referred to the Rheumatology Department of a single-center due to ICI-induced arthritis who underwent imaging studies [ultrasound (US), magnetic resonance imaging (MRI), and (18)F-FDG PET/CT)] between January 2017 and January 2022. Results: Nineteen patients with ICI-induced arthritis with at least one diagnostic imaging assessment were identified (15 US, 4 MRI, 2 (18)F-FDG PET/CT). Most patients were male (84.2%), with a median age at inclusion of 73 years. The main underlying diagnoses for ICI treatment were melanoma in five cases. The distribution of ICI-induced arthritis was as follows: PMR-like (5, 26.2%), RA-like (4, 21.1%), PsA-like (4, 21.1%), and others (6, 31.6%). All RA-like patients had US findings indistinguishable from conventional RA patients. In addition, 3/5 (60%) of PMR-like patients had significant involvement of the hands and wrists. Abnormal findings on MRI or PET-CT were reported by clinical symptoms. No erosions or myofascitis were seen. Conclusions: ICI-induced arthritis patients present inflammatory patterns on imaging studies similar to conventional inflammatory arthropathies, and therefore these syndromes should be followed carefully and treated according to these findings
Control and soft sensing strategies for a wastewater treatment plant using a neuro-genetic approach
During the last years, machine learning-based control and optimization systems are playing an important role in the operation of wastewater treatment plants in terms of reduced operational costs and improved effluent quality. In this paper, a machine learning-based control strategy is proposed for optimizing both the consumption and the number of regulation violations of a biological wastewater treatment plant. The methodology proposed in this study uses neural networks as a soft-sensor for on-line prediction of the effluent quality and as an identification model of the plant dynamics, all under a neuro-genetic optimum model-based control approach. The complete scheme was tested on a simulation model of the activated sludge process of a large-scale municipal wastewater treatment plant running under the GPS-X simulation frame and validated with operational gathered data, showing optimal control performance by minimizing operational costs while satisfying the effluent requirements, thus reducing the investment in expensive sensor devices.info:eu-repo/semantics/publishedVersio
Precision mass measurements on neutron-rich rare-earth isotopes at JYFLTRAP - reduced neutron pairing and implications for the -process calculations
The rare-earth peak in the -process abundance pattern depends sensitively
on both the astrophysical conditions and subtle changes in nuclear structure in
the region. This work takes an important step elucidating the nuclear structure
and reducing the uncertainties in -process calculations via precise atomic
mass measurements at the JYFLTRAP double Penning trap. Nd, Pm,
Sm, and Gd have been measured for the first time and the
precisions for Nd, Pm, Eu, Gd, and
Tb have been improved considerably. Nuclear structure has been probed
via two-neutron separation energies and neutron pairing energy metrics
. The data do not support the existence of a subshell closure at .
Neutron pairing has been found to be weaker than predicted by theoretical mass
models. The impact on the calculated -process abundances has been studied.
Substantial changes resulting in a smoother abundance distribution and a better
agreement with the solar -process abundances are observed.Comment: 8 pages, 4 figures, accepted for publication in Physical Review
Letter
Measuring and modelling the energy cost of reconfiguration in sensor networks [forthcoming]
As Wireless Sensor Networks (WSN) must operate for long periods on a limited power budget, estimating the energy cost of software operations is critical. Contemporary reconfiguration approaches for WSN allow for software evolution at various granularities; from reflashing of a complete software image, through replacement of complete applications, to the reconfiguration of individual software components. This paper contributes a generic model for measuring and modelling the energy cost of reconfiguration in WSN. We validate that this model is accurate in the face of different hardware platforms, software stacks and software encapsulation approaches. We have embedded this model in the LooCI middleware, resulting in the first energy aware reconfigurable component model for sensor networks. We evaluate our approach using two real-world WSN applications and demonstrate that our model predicts the energy cost of reconfiguration with 93% accuracy. Using this model we demonstrate that selecting the most appropriate software modularisation approach is key to minimising energy consumption
Levels and patterns of objectively assessed physical activity and compliance with different public health guidelines in university students
ArticleBackground
Physical activity (PA) is associated with health enhancement. The aim of this study was to assess: 1) levels and patterns of PA in university students by using accelerometers; and 2) the percentage of fulfilment of PA recommendations for adults, according to different public health guidelines.
Methods
Observational cross-sectional study (Cuenca’s Adults Study) involving 296 (206 women) healthy Spanish university students aged 18–25 years old. Participants wore the ActiGraph GT1M accelerometer for seven consecutive days. Total PA, steps and time spent in sedentary time, light, moderate, vigorous, and moderate to vigorous PA (MVPA) was assessed, and the prevalence of sufficient PA was calculated according to various public health guidelines.
Results
No sex differences in total PA were found. University students were more sedentary during weekend days than weekdays (p<0.05). Only 30.3% of participants accumulated 30 min/day at least five days a week of MVPA. A total of 5.4% of students met the recommendation of 150 min/week of MVPA or 75 min/week of vigorous PA, in PA bouts of at least 10 min. using the same definition, but on five or more days a week, only 0.5% students were found to meet the recommendation. In addition, only 0.5% of students met the recommendation of 30 min/day of MVPA, at least five days a week and in bouts of at least 10 min. Finally, 28.1% of the students met the recommendation of 10,000 steps/day.
Conclusions
Our study shows a high incidence of sedentary time in university students. The number of students meeting PA recommendations significantly differed depending on the recommendation proposed. Specific strategies to promote PA in this population are necessary as well as an agreement as to which PA guidelines should be used.Fundación para la Investigación SanitariaMinistry of Health and Consumer AffairsInstituto de Salud Carlos IIIRed de Investigación en Actividades Preventivas y de Promoción de Salu
The Advanced LIGO Photon Calibrators
The two interferometers of the Laser Interferometry Gravitaional-wave
Observatory (LIGO) recently detected gravitational waves from the mergers of
binary black hole systems. Accurate calibration of the output of these
detectors was crucial for the observation of these events, and the extraction
of parameters of the sources. The principal tools used to calibrate the
responses of the second-generation (Advanced) LIGO detectors to gravitational
waves are systems based on radiation pressure and referred to as Photon
Calibrators. These systems, which were completely redesigned for Advanced LIGO,
include several significant upgrades that enable them to meet the calibration
requirements of second-generation gravitational wave detectors in the new era
of gravitational-wave astronomy. We report on the design, implementation, and
operation of these Advanced LIGO Photon Calibrators that are currently
providing fiducial displacements on the order of
m/ with accuracy and precision of better than 1 %.Comment: 14 pages, 19 figure
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