Association between Dentin Hypersensitivity and Health/Oral Health-related Quality of Life: A Systematic Review and Meta-Analysis

Objective: To investigate the association between DH and Health (HRQoL) or Oral Health-Related Quality of Life (OHRQoL). Material and Methods: PubMed, Web of Science, Scopus, EMBASE, Cochrane, Scielo, LILACS/BBO, Biblioteca Digital de Teses e Dissertações (BDTD), Open Grey, and Google Scholar databases were screened in September 2019 (updated in October 2022). Observational studies were selected to compare HRQoL/OHRQoL(outcome) according to DH(exposure) or evaluate the association among these variables. Standardized Joanna Briggs Institute critical appraisal tool for analytical cross-sectional studies was used to analyze the risk of bias. A random-effects meta-analysis was conducted to synthesize evidence for the association between DH and OHRQoL. Results: 10 papers met inclusion criteria and were evaluated. In most studies, presenting or having a greater intensity of DH was associated with a negative impact on one\u27s quality of life. However, most of these studies showed a moderate to high risk of methodological bias. The consistent finding from studies with a low risk of bias suggests a significant association between DH and OHRQoL. Meta-analysis was feasible for three studies with substantial heterogeneity. The pooled Odds Ratio was 2.14 (95%CI 1.15-3.99; I2=57,44%).Conclusion: Many studies presented a high risk of bias; therefore, the actual effect of DH on one\u27s quality of life remains uncertain

Periodontal diseases: is it possible to prevent them? A populational and individual approach

Periodontal diseases are infectious inflammatory chronic diseases of a multifactorial nature. They are primarily caused by dysbiotic ecological changes in dental biofilm, which may be influenced by risk factors. The prevention of periodontal diseases may involve different strategies focused on reducing distal, intermediate, and proximal risk factors at both the population and individual levels. Effective prevention depends on interdisciplinary and common risk factor approaches. Also, patient-centered preventive models are more effective than professional-centered models in the management of periodontal diseases. Regular and periodic control of dental biofilm is an essential measure for the different levels of prevention of periodontal diseases. The effectiveness of periodontal disease prevention largely depends on positive modifications of behavior, knowledge, health literacy, patient empowerment, motivation, and compliance.publishedVersio

Critical appraisal of systematic reviews of intervention studies in periodontology using AMSTAR 2 and ROBIS tools

Systematic reviews of intervention studies are used to support treatment recommendations. The aim of this study was to assess the methodological quality and risk of bias of systematic reviews of intervention studies in in the field of periodontology using AMSTAR 2 and ROBIS.Systematic reviews of randomized and non-randomized clinical trials, published between 2019 and 2020, were searched at MedLine, Embase, Web of Science, Scopus, Cochrane Library, LILACS with no language restrictions between October 2019 to October 2020. Additionally, grey literature and hand search was performed. Paired independent reviewers screened studies, extracted data and assessed the methodological quality and risk of bias through the AMSTAR 2 and ROBIS tools.One hundred twenty-seven reviews were included. According to AMSTAR 2, the methodological quality was mainly critically low (64.6%) and low (24.4%), followed by moderate (0.8%) and high (10.2%). According to ROBIS, 90.6% were at high risk of bias, followed by 7.1% low, and 2.4% unclear risk of bias. The risk of bias decreased with the increased in the impact factor of the journal.Current systematic reviews of intervention studies in periodontics were classified as low or critically low methodological quality and high risk of bias. Both tools led to similar conclusions. Better adherence to established reporting guidelines and stricter research practices when conducting systematic reviews are needed

Caracterização dos carcinomas mamários de fenótipo triplo negativo em um laboratório privado da cidade de Goiânia, Goiás

A neoplasia de mama é o tipo de câncer mais frequente entre as mulheres, com uma estimativa de cerca de 66 mil novos casos para cada ano entre 2020-2022. A incidência deste carcinoma, por si só, justifica a necessidade de estudos aprofundados acerca desta temática. Trata-se de um estudo descritivo transversal, que é um estudo utilizado para traçar perfil epidemiológico da doença em questão, podendo-se levantar dados em um ponto no tempo pré-definido. Foram avaliados 6.379 casos de carcinoma mamário invasor, dos quais 817 foram classificados com fenótipo triplo negativo (TN). O ano de 2020 apresentou o maior número de casos TN. A idade das pacientes variou de 23 a 95 anos, com uma média de 51,8 anos. Nesta pesquisa, apenas 12,8% dos casos de carcinoma mamário invasor foram classificados como Triplo-negativo. Este padrão se repete em estudos internacionais, confirmando que este subtipo é ligeiramente mais raro do que os outros. Pesquisas apontaram que apenas 16% das mulheres que tiveram diagnóstico de neoplasia mamária dentre os anos de 2006-2011 no país receberam a classificação Triplo-negativa. Entre os anos de 2015 e 2021, observamos um aumento de cerca de 73% de diagnósticos de carcinoma triplo negativos no laboratório INGOH. Os casos de câncer de mama são caracterizados pelo tipo Ductal não especial, com predomínio do grau 3, mais prevalentes na mama esquerda e provenientes de Core Biopsy e de pacientes com idade acima de 50 anos

Association between periodontitis and metabolic syndrome: a case-control study

Submitted by Rafael Paula ([email protected]) on 2019-10-11T17:59:05Z No. of bitstreams: 1 Mets_periodontitis-Julya_biblioteca.pdf: 2108815 bytes, checksum: 2e105e2fba2520aa6ff36a9df13df53f (MD5)Approved for entry into archive by Eliane Andrade ([email protected]) on 2019-10-14T14:59:07Z (GMT) No. of bitstreams: 1 Mets_periodontitis-Julya_biblioteca.pdf: 2108815 bytes, checksum: 2e105e2fba2520aa6ff36a9df13df53f (MD5)Made available in DSpace on 2019-12-10T21:57:32Z (GMT). No. of bitstreams: 1 Mets_periodontitis-Julya_biblioteca.pdf: 2108815 bytes, checksum: 2e105e2fba2520aa6ff36a9df13df53f (MD5) Previous issue date: 2019-06-24Nos últimos anos, a associação entre distúrbios metabólicos e periodontite foi amplamente estudada e reconhecida. No entanto, a relação entre síndrome metabólica (SMet) e periodontite permanece conflitante, particularmente a associação da gravidade da SMet e da periodontite. O presente estudo caso-controle (1:3) teve como objetivo avaliar a associação entre SMet e periodontite, bem como a influência dos diferentes fatores de risco nesta associação. O trabalho foi aprovado pelo Comitê de Ética em Pesquisa da Universidade Federal de Minas Gerais. A amostra foi composta por 488 indivíduos (122 casos e 366 controles), de ambos os sexos e idade entre 35-55 anos, examinados entre junho/2009 e abril/2017. Foram coletados dados sociodemográficos e médicos de interesse. Diagnóstico de SMet (casos) foi definido como a combinação de elevados níveis plasmáticos de glicose, hipertensão, dislipidemia e/ou circunferência abdominal aumentada. Exame periodontal completo foi realizado por três examinadores experientes (kappa = 0,89 e índice de correlação intraclasse = 0,87). O estudo incluiu indivíduos com periodontite moderada, grave ou avançada, ou seja, estágio II, III e IV, respectivamente, sendo a) estágio II - nível de inserção clínico (NIC) interdental 3 a 4mm, Profundidade de sondagem (PS) máxima ≤ 5mm, perda óssea radiográfica no terço coronal entre 15% a 33% e ausência de perda dentária devido à periodontite; b) estágio III - NIC interdental ≥ 5mm, perda óssea radiográfica que se estende até o terço médio da raiz; e perda dentária devido a periodontite; c) estágio IV – NIC interdental ≥ 5mm e presença de lesões periodontais profundas que se estendem à porção apical da raiz e/ou história de perda dentária múltipla. Quanto à extensão da periodontite, as formas localizadas foram classificadas como 5 mm. No modelo logístico final, foram associados a periodontite após ajuste para as variáveis de confusão gênero, uso de álcool, idade e tabagismo: SMet (OR = 1,98 95%IC 1.31-32.86), presença de até 14 dentes (OR = 1,61 95%IC 1.02-2.04), índice de massa corporal >25kg/m² (OR = 1,81 95%IC 1.26-2.21) e tabagismo (OR = 2.13 95%IC 1.16-3.62). Presença de dentes até 14 (p = 0,027) e tabagismo (p = 0,001) foram associados com ao NIC, considerando circunferência abdominal elevada, hipertensão e dislipidemia como componentes da SMet. Quando o diabetes foi tomado como um componente SMet, a idade (p = 0,015) também foi associada ao NIC. Os resultados demonstraram que há uma importante associação entre SMet e periodontite. No entanto, são necessários estudos futuros com desenhos prospectivos e de intervenção, em diferentes populações, para confirmar esses achados.In recent years, the association between metabolic disorders and periodontitis has been widely studied and recognized. However, the relationship between metabolic syndrome (MetS) and periodontitis remains controversial. The present case-control study (1:3) aimed to evaluate the association between MetS and periodontitis, as well as the influence of potentialt risk factors in this association. Study sample comprised 488 individuals, of which 122 were cases and 366 were controls, both genders and aged between 35-55 years, that were examined from June/2009 and April/2017. Sociodemographic and medical data of interest were collected. Diagnosis of MetS (cases) was defined as the combination of the following parameters: high plasma glucose levels, hypertension, dyslipidemia and/or increased abdominal circumference. Complete periodontal examination was performed by three experienced examiners (kappa = 0.89 and intraclass correlation index = 0.87). The study included individuals with moderate, severe or advanced periodontitis, that is, stage II, III and IV, respectively, being a) stage II – clinical attachment level (CAL) 3 to 4mm, maximum probing depth (PD) ≤ 5mm, radiographic bone loss at the coronal third between 15% to 33%, and no tooth loss due to periodontitis); b) stage III – at least interdental CAL ≥ 5mm, radiographic bone loss extending to mild-third of the root; and tooth loss due to periodontitis; c) stage IV – interdental CAL ≥ 5mm and presence of deep periodontal lesions that extend to the apical portion of the root, and/or history of multiple tooth loss. In relation to the extension of periodontitis, localized forms were classified as 5 mm. In the final logistic model, after adjusting for gender, alcohol use, age and smoking, the following variables were associated with periodontitis: MetS (OR = 1.98 95% CI 1.31-32.86), presence of up to 14 teeth (OR = 1 , 61 95% CI 1.02-2.04), body mass index >25kg / m² (OR = 1.81 95% CI 1.26-2.21) and smoking (OR = 2.13 95% CI 1.16-3.62). Presence of teeth up to 14 (p = 0.027) and smoking (p = 0.001) were associated with CAL, when considering elevated abdominal circumference, hypertension and dyslipidemia as components of MetS diagnosis. When diabetes was also taken as MetS component, age (p = 0.015) was also associated with CAL. These findings demonstrated that there is an important association between MetS and periodontitis. However, future studies with prospective and interventional designs in different populations are needed to confirm these results

Periodontal diseases: is it possible to prevent them? A populational and individual approach

Periodontal diseases are infectious inflammatory chronic diseases of a multifactorial nature. They are primarily caused by dysbiotic ecological changes in dental biofilm, which may be influenced by risk factors. The prevention of periodontal diseases may involve different strategies focused on reducing distal, intermediate, and proximal risk factors at both the population and individual levels. Effective prevention depends on interdisciplinary and common risk factor approaches. Also, patient-centered preventive models are more effective than professional-centered models in the management of periodontal diseases. Regular and periodic control of dental biofilm is an essential measure for the different levels of prevention of periodontal diseases. The effectiveness of periodontal disease prevention largely depends on positive modifications of behavior, knowledge, health literacy, patient empowerment, motivation, and compliance

Additional file 1 of Association between shortened dental configurations and health outcomes: a scoping review

Additional file 1. Definitions of shortened dental configurations evaluated by the review