La eutanasia

En la actualidad, hay un gran debate sobre si se debe o no permitir legalmente la práctica de la eutanasia. En medio de este enfrentamiento algunos Estados ya han dado el paso de incluir en su marco normativo su aprobación, y a través de estudios podemos conocer el resultado de la legalización en estos con respecto a la cantidad de muertes, a su influencia en los cuidados paliativos y al cumplimiento de la ley. Desde el campo del trabajo social, se intenta dar solución a la situación de este colectivo mediante cuidados al final de su vida. Teniendo entre sus principales actuaciones la intervención con ellos y sus familias, así como la coordinación con otros profesionales con los que forman equipos multidisciplinarios con el fin de dar una respuesta física y emocional en el usuario. Por otra parte, también tiene gran importancia en esta disciplina, la investigación, con la que se intenta buscar la mejor solución para este colectivo y mejorar la realidad que viven.Grado en Trabajo Socia

Reduction of the calcium leaching rate of cement paste by addition of silica nanoparticles

Calcium leaching is a degradation process that consists in the progressive dissolution of the cement paste as a consequence of the migration of the calcium ions to the aggressive solution. Although it is a well known phenomenon, a way of reducing it has not been found yet. The aim of this work is to prove how the addition of small amounts of silica nanoparticles to the cement paste can induce such reduction. The experimental results obtained have shown that nanosilica increases the strength of the cement paste about a 30% in cured samples and more than a 100% in the asymptotically leached ones. At the level of the structure of the C–S–H gel, silica nanoparticles increase the average length of the silicate chains and reduce their polymerization as calcium dissolves. An important decrease of the degradation in terms of porosity and amount of calcium lost has also been observed

Una metodología para la formulación de planes de ordenamiento del recurso hídrico

En el marco de la política nacional para la gestión del recurso hídrico, el Decreto3930 de 2010, reafirma la necesidad y pertinencia de formular planes de ordenamientodel recurso hídrico –PORH-; si bien ya el Decreto 1594 de 1984 había planteadoesta necesidad, poco se ha avanzado en el país al respecto. Este artículo sintetiza losresultados de un proyecto de investigación realizado por la Universidad de Antioquiapor encargo de CORANTIOQUIA, en relación con el diseño de una propuestametodológica para la formulación de los PORH. Esta metodología fue ya aplicadapara formular los PORH para cuerpos de agua en microcuencas de las DireccionesTerritoriales Tahamíes y Zenufaná de CORANTIOQUIA

Morphology, Crystallinity, and Molecular Weight of Poly(E-caprolactone)/Graphene Oxide Hybrids

[EN] A study was carried out to determine the effects of graphene oxide (GO) filler on the properties of poly(epsilon-caprolactone) (PCL) films. A series of nanocomposites were prepared, incorporating different graphene oxide filler contents (0.1, 0.2, and 0.5 wt%) by the solution mixing method, and an in-depth study was made of the morphological changes, crystallization, infrared absorbance, molecular weight, thermal properties, and biocompatibility as a function of GO content to determine their suitability for use in biomedical applications. The infrared absorbance showed the existence of intermolecular hydrogen bonds between the PCL's carbonyl groups and the GO's hydrogen-donating groups, which is in line with the apparent reduction in molecular weight at higher GO contents, indicated by the results of the gel permeation chromatography (GPC), and the thermal property analysis. Polarized optical microscopy (POM) showed that GO acts as a nucleating point for PCL crystals, increasing crystallinity and crystallization temperature. The biological properties of the composites studied indicate that adding only 0.1 wt% of GO can improve cellular viability and that the composite shows promise for use in biomedical applications.This work was supported by Projects GV/2016/067 of the Generalitat Valenciana and MAT2016-76039-C4-3-R of the Spanish Ministry of Economy and Competitiveness (MINECO). The authors are grateful to M. Monleon-Pradas for his helpful comments and G. Vilarino-Feltrer for his valuable advice on the cell culture experiments. A. Vidaurre would also like to express her gratitude for the support received from CIBER-BBN, an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. SEM, TEM and AFM were conducted by the authors at the Microscopy Service of the Universitat Politecnica de Valencia, whose advice is greatly appreciated.Castilla Cortázar, MIC.; Vidaurre, A.; Marí, B.; Campillo Fernandez, AJ. (2019). Morphology, Crystallinity, and Molecular Weight of Poly(E-caprolactone)/Graphene Oxide Hybrids. Polymers. 11(7):1-19. https://doi.org/10.3390/polym11071099S119117Hummers, W. S., & Offeman, R. E. (1958). Preparation of Graphitic Oxide. Journal of the American Chemical Society, 80(6), 1339-1339. doi:10.1021/ja01539a017Stankovich, S., Piner, R. D., Nguyen, S. T., & Ruoff, R. S. (2006). Synthesis and exfoliation of isocyanate-treated graphene oxide nanoplatelets. Carbon, 44(15), 3342-3347. doi:10.1016/j.carbon.2006.06.004Dreyer, D. R., Park, S., Bielawski, C. W., & Ruoff, R. S. (2010). The chemistry of graphene oxide. Chem. Soc. Rev., 39(1), 228-240. doi:10.1039/b917103gKonios, D., Stylianakis, M. M., Stratakis, E., & Kymakis, E. (2014). Dispersion behaviour of graphene oxide and reduced graphene oxide. Journal of Colloid and Interface Science, 430, 108-112. doi:10.1016/j.jcis.2014.05.033Kuilla, T., Bhadra, S., Yao, D., Kim, N. H., Bose, S., & Lee, J. H. (2010). Recent advances in graphene based polymer composites. Progress in Polymer Science, 35(11), 1350-1375. doi:10.1016/j.progpolymsci.2010.07.005Potts, J. R., Dreyer, D. R., Bielawski, C. W., & Ruoff, R. S. (2011). Graphene-based polymer nanocomposites. Polymer, 52(1), 5-25. doi:10.1016/j.polymer.2010.11.042Liang, J., Huang, Y., Zhang, L., Wang, Y., Ma, Y., Guo, T., & Chen, Y. (2009). Molecular-Level Dispersion of Graphene into Poly(vinyl alcohol) and Effective Reinforcement of their Nanocomposites. Advanced Functional Materials, 19(14), 2297-2302. doi:10.1002/adfm.200801776Han, D., Yan, L., Chen, W., & Li, W. (2011). Preparation of chitosan/graphene oxide composite film with enhanced mechanical strength in the wet state. Carbohydrate Polymers, 83(2), 653-658. doi:10.1016/j.carbpol.2010.08.038Luong, N. D., Hippi, U., Korhonen, J. T., Soininen, A. J., Ruokolainen, J., Johansson, L.-S., … Seppälä, J. (2011). Enhanced mechanical and electrical properties of polyimide film by graphene sheets via in situ polymerization. Polymer, 52(23), 5237-5242. doi:10.1016/j.polymer.2011.09.033Yang, X., Tu, Y., Li, L., Shang, S., & Tao, X. (2010). Well-Dispersed Chitosan/Graphene Oxide Nanocomposites. ACS Applied Materials & Interfaces, 2(6), 1707-1713. doi:10.1021/am100222mSalavagione, H. J., Gómez, M. A., & Martínez, G. (2009). Polymeric Modification of Graphene through Esterification of Graphite Oxide and Poly(vinyl alcohol). Macromolecules, 42(17), 6331-6334. doi:10.1021/ma900845wXu, Z., & Gao, C. (2010). In situ Polymerization Approach to Graphene-Reinforced Nylon-6 Composites. Macromolecules, 43(16), 6716-6723. doi:10.1021/ma1009337Kulkarni, D. D., Choi, I., Singamaneni, S. S., & Tsukruk, V. V. (2010). Graphene Oxide−Polyelectrolyte Nanomembranes. ACS Nano, 4(8), 4667-4676. doi:10.1021/nn101204dBao, C., Guo, Y., Song, L., & Hu, Y. (2011). Poly(vinyl alcohol) nanocomposites based on graphene and graphite oxide: a comparative investigation of property and mechanism. Journal of Materials Chemistry, 21(36), 13942. doi:10.1039/c1jm11662bTang, L.-C., Wan, Y.-J., Yan, D., Pei, Y.-B., Zhao, L., Li, Y.-B., … Lai, G.-Q. (2013). The effect of graphene dispersion on the mechanical properties of graphene/epoxy composites. Carbon, 60, 16-27. doi:10.1016/j.carbon.2013.03.050Song, Y. S., & Youn, J. R. (2005). Influence of dispersion states of carbon nanotubes on physical properties of epoxy nanocomposites. Carbon, 43(7), 1378-1385. doi:10.1016/j.carbon.2005.01.007Kim, H., Miura, Y., & Macosko, C. W. (2010). Graphene/Polyurethane Nanocomposites for Improved Gas Barrier and Electrical Conductivity. Chemistry of Materials, 22(11), 3441-3450. doi:10.1021/cm100477vAhmad, H., Fan, M., & Hui, D. (2018). Graphene oxide incorporated functional materials: A review. Composites Part B: Engineering, 145, 270-280. doi:10.1016/j.compositesb.2018.02.006Kai, W., Hirota, Y., Hua, L., & Inoue, Y. (2007). Thermal and mechanical properties of a poly(ε-caprolactone)/graphite oxide composite. Journal of Applied Polymer Science, 107(3), 1395-1400. doi:10.1002/app.27210Woodruff, M. A., & Hutmacher, D. W. (2010). The return of a forgotten polymer—Polycaprolactone in the 21st century. Progress in Polymer Science, 35(10), 1217-1256. doi:10.1016/j.progpolymsci.2010.04.002Wan, C., & Chen, B. (2011). Poly(ε-caprolactone)/graphene oxide biocomposites: mechanical properties and bioactivity. Biomedical Materials, 6(5), 055010. doi:10.1088/1748-6041/6/5/055010Song, J., Gao, H., Zhu, G., Cao, X., Shi, X., & Wang, Y. (2015). The preparation and characterization of polycaprolactone/graphene oxide biocomposite nanofiber scaffolds and their application for directing cell behaviors. Carbon, 95, 1039-1050. doi:10.1016/j.carbon.2015.09.011Hua, L., Kai, W. H., & Inoue, Y. (2007). Crystallization behavior of poly(ϵ-caprolactone)/graphite oxide composites. Journal of Applied Polymer Science, 106(6), 4225-4232. doi:10.1002/app.26976Sayyar, S., Murray, E., Thompson, B. C., Gambhir, S., Officer, D. L., & Wallace, G. G. (2013). Covalently linked biocompatible graphene/polycaprolactone composites for tissue engineering. Carbon, 52, 296-304. doi:10.1016/j.carbon.2012.09.031Murray, E., Sayyar, S., Thompson, B. C., Gorkin III, R., Officer, D. L., & Wallace, G. G. (2015). A bio-friendly, green route to processable, biocompatible graphene/polymer composites. RSC Advances, 5(56), 45284-45290. doi:10.1039/c5ra07210gHassanzadeh, S., Adolfsson, K. H., Wu, D., & Hakkarainen, M. (2015). Supramolecular Assembly of Biobased Graphene Oxide Quantum Dots Controls the Morphology of and Induces Mineralization on Poly(ε-caprolactone) Films. Biomacromolecules, 17(1), 256-261. doi:10.1021/acs.biomac.5b01339Kumar, S., Azam, D., Raj, S., Kolanthai, E., Vasu, K. S., Sood, A. K., & Chatterjee, K. (2015). 3D scaffold alters cellular response to graphene in a polymer composite for orthopedic applications. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 104(4), 732-749. doi:10.1002/jbm.b.33549Shin, S. R., Li, Y.-C., Jang, H. L., Khoshakhlagh, P., Akbari, M., Nasajpour, A., … Khademhosseini, A. (2016). Graphene-based materials for tissue engineering. Advanced Drug Delivery Reviews, 105, 255-274. doi:10.1016/j.addr.2016.03.007Bianco, A. (2013). Graphene: Safe or Toxic? The Two Faces of the Medal. Angewandte Chemie International Edition, 52(19), 4986-4997. doi:10.1002/anie.201209099Zhang, X., Yin, J., Peng, C., Hu, W., Zhu, Z., Li, W., … Huang, Q. (2011). Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration. Carbon, 49(3), 986-995. doi:10.1016/j.carbon.2010.11.005Jasim, D. A., Murphy, S., Newman, L., Mironov, A., Prestat, E., McCaffrey, J., … Kostarelos, K. (2016). The Effects of Extensive Glomerular Filtration of Thin Graphene Oxide Sheets on Kidney Physiology. ACS Nano, 10(12), 10753-10767. doi:10.1021/acsnano.6b03358Santos, C. M., Mangadlao, J., Ahmed, F., Leon, A., Advincula, R. C., & Rodrigues, D. F. (2012). Graphene nanocomposite for biomedical applications: fabrication, antimicrobial and cytotoxic investigations. Nanotechnology, 23(39), 395101. doi:10.1088/0957-4484/23/39/395101Lim, H. N., Huang, N. M., & Loo, C. H. (2012). Facile preparation of graphene-based chitosan films: Enhanced thermal, mechanical and antibacterial properties. Journal of Non-Crystalline Solids, 358(3), 525-530. doi:10.1016/j.jnoncrysol.2011.11.007Some, S., Ho, S.-M., Dua, P., Hwang, E., Shin, Y. H., Yoo, H., … Lee, H. (2012). Dual Functions of Highly Potent Graphene Derivative–Poly-l-Lysine Composites To Inhibit Bacteria and Support Human Cells. ACS Nano, 6(8), 7151-7161. doi:10.1021/nn302215ySydlik, S. A., Jhunjhunwala, S., Webber, M. J., Anderson, D. G., & Langer, R. (2015). In Vivo Compatibility of Graphene Oxide with Differing Oxidation States. ACS Nano, 9(4), 3866-3874. doi:10.1021/acsnano.5b01290Crescenzi, V., Manzini, G., Calzolari, G., & Borri, C. (1972). Thermodynamics of fusion of poly-β-propiolactone and poly-ϵ-caprolactone. comparative analysis of the melting of aliphatic polylactone and polyester chains. European Polymer Journal, 8(3), 449-463. doi:10.1016/0014-3057(72)90109-7Luo, H., Meng, X., Cheng, C., Dong, Z., Zhang, S., & Li, B. (2010). Enzymatic Degradation of Supramolecular Materials Based on Partial Inclusion Complex Formation between α-Cyclodextrin and Poly(ε-caprolactone). The Journal of Physical Chemistry B, 114(13), 4739-4745. doi:10.1021/jp1001836Vidaurre, A., Dueñas, J. M. M., Estellés, J. M., & Cortázar, I. C. (2008). Influence of Enzymatic Degradation on Physical Properties of Poly(ε-caprolactone) Films and Sponges. Macromolecular Symposia, 269(1), 38-46. doi:10.1002/masy.200850907Honma, T., Senda, T., & Inoue, Y. (2003). Thermal properties and crystallization behaviour of blends of poly(?-caprolactone) with chitin and chitosan. Polymer International, 52(12), 1839-1846. doi:10.1002/pi.1380Ramazani, S., & Karimi, M. (2015). Aligned poly(ε-caprolactone)/graphene oxide and reduced graphene oxide nanocomposite nanofibers: Morphological, mechanical and structural properties. Materials Science and Engineering: C, 56, 325-334. doi:10.1016/j.msec.2015.06.045Coleman, M. M., & Zarian, J. (1979). Fourier-transform infrared studies of polymer blends. II. Poly(ε-caprolactone)–poly(vinyl chloride) system. Journal of Polymer Science: Polymer Physics Edition, 17(5), 837-850. doi:10.1002/pol.1979.180170509Huang, Y., Xu, Z., Huang, Y., Ma, D., Yang, J., & Mays, J. W. (2003). Characterization of Poly(ε-Caprolactone) via Size Exclusion Chromatography with Online Right-Angle Laser-Light Scattering and Viscometric Detectors. International Journal of Polymer Analysis and Characterization, 8(6), 383-394. doi:10.1080/714975019Sharaf, M. A., Kloczkowski, A., Sen, T. Z., Jacob, K. I., & Mark, J. E. (2006). Filler-induced deformations of amorphous polyethylene chains. The effects of the deformations on elastomeric properties, and some comparisons with experiments. European Polymer Journal, 42(4), 796-806. doi:10.1016/j.eurpolymj.2005.10.009Nusser, K., Neueder, S., Schneider, G. J., Meyer, M., Pyckhout-Hintzen, W., Willner, L., … Richter, D. (2010). Conformations of Silica−Poly(ethylene−propylene) Nanocomposites. Macromolecules, 43(23), 9837-9847. doi:10.1021/ma101898cVacatello, M. (2002). Chain Dimensions in Filled Polymers:  An Intriguing Problem. Macromolecules, 35(21), 8191-8193. doi:10.1021/ma020416sDuan, T., Lv, Y., Xu, H., Jin, J., & Wang, Z. (2018). Structural Effects of Residual Groups of Graphene Oxide on Poly(ε-Caprolactone)/Graphene Oxide Nanocomposite. Crystals, 8(7), 270. doi:10.3390/cryst8070270Wang, G., Wei, Z., Sang, L., Chen, G., Zhang, W., Dong, X., & Qi, M. (2013). Morphology, crystallization and mechanical properties of poly(ɛ-caprolactone)/graphene oxide nanocomposites. Chinese Journal of Polymer Science, 31(8), 1148-1160. doi:10.1007/s10118-013-1278-8Balkova, R., Hermanova, S., Voberkova, S., Damborsky, P., Richtera, L., Omelkova, J., & Jancar, J. (2013). Structure and Morphology of Microbial Degraded Poly(ε-caprolactone)/Graphite Oxide Composite. Journal of Polymers and the Environment, 22(2), 190-199. doi:10.1007/s10924-013-0630-yYıldırım, S., Demirtaş, T. T., Dinçer, C. A., Yıldız, N., & Karakeçili, A. (2018). Preparation of polycaprolactone/graphene oxide scaffolds: A green route combining supercritial CO2 technology and porogen leaching. The Journal of Supercritical Fluids, 133, 156-162. doi:10.1016/j.supflu.2017.10.009Peng, H., Han, Y., Liu, T., Tjiu, W. C., & He, C. (2010). Morphology and thermal degradation behavior of highly exfoliated CoAl-layered double hydroxide/polycaprolactone nanocomposites prepared by simple solution intercalation. Thermochimica Acta, 502(1-2), 1-7. doi:10.1016/j.tca.2010.01.009Michailidis, M., Verros, G. D., Deliyanni, E. A., Andriotis, E. G., & Achilias, D. S. (2017). An experimental and theoretical study of butyl methacrylatein situradical polymerization kinetics in the presence of graphene oxide nanoadditive. Journal of Polymer Science Part A: Polymer Chemistry, 55(8), 1433-1441. doi:10.1002/pola.28512Tsagkalias, I., Manios, T., & Achilias, D. (2017). Effect of Graphene Oxide on the Reaction Kinetics of Methyl Methacrylate In Situ Radical Polymerization via the Bulk or Solution Technique. Polymers, 9(9), 432. doi:10.3390/polym9090432Geng, L.-H., Peng, X.-F., Jing, X., Li, L.-W., Huang, A., Xu, B.-P., … Mi, H.-Y. (2016). Investigation of poly(l-lactic acid)/graphene oxide composites crystallization and nanopore foaming behaviors via supercritical carbon dioxide low temperature foaming. Journal of Materials Research, 31(3), 348-359. doi:10.1557/jmr.2016.13Song, P., Cao, Z., Cai, Y., Zhao, L., Fang, Z., & Fu, S. (2011). Fabrication of exfoliated graphene-based polypropylene nanocomposites with enhanced mechanical and thermal properties. Polymer, 52(18), 4001-4010. doi:10.1016/j.polymer.2011.06.045Bao, C., Guo, Y., Song, L., Kan, Y., Qian, X., & Hu, Y. (2011). In situ preparation of functionalized graphene oxide/epoxy nanocomposites with effective reinforcements. Journal of Materials Chemistry, 21(35), 13290. doi:10.1039/c1jm11434dSánchez-Correa, F., Vidaurre-Agut, C., Serrano-Aroca, Á., & Campillo-Fernández, A. J. (2017). Poly(2-hydroxyethyl acrylate) hydrogels reinforced with graphene oxide: Remarkable improvement of water diffusion and mechanical properties. Journal of Applied Polymer Science, 135(15), 46158. doi:10.1002/app.46158Liao, K.-H., Lin, Y.-S., Macosko, C. W., & Haynes, C. L. (2011). Cytotoxicity of Graphene Oxide and Graphene in Human Erythrocytes and Skin Fibroblasts. ACS Applied Materials & Interfaces, 3(7), 2607-2615. doi:10.1021/am200428

Automated Readability Assessment for Spanish e-Government Information

This paper automatically evaluates the readability of Spanish e-government websites. Specifically, the websites collected explain e-government administrative procedures. The evaluation is carried out through the analysis of different linguistic characteristics that are presumably associated with a better understanding of these resources. To this end, texts from websites outside the government websites have been collected. These texts clarify the procedures published on the Spanish Government"s websites. These websites constitute the part of the corpus considered as the set of easy documents. The rest of the corpus has been completed with counterpart documents from government websites. The text of the documents has been processed, and the difficulty is evaluated through different classic readability metrics. At a later stage, automatic learning methods are used to apply algorithms to predict the difficulty of the text. The results of the study show that government web pages show high values for comprehension difficulty. This work proposes a new Spanish-language corpus of official e-government websites. In addition, a large number of combined linguistic attributes are applied, which improve the identification of the level of comprehensibility of a text with respect to classic metrics.Work supported by the Spanish Ministry of Economy, Industry and Competitiveness, (CSO2017-86747-R)

a systematic review and meta-analysis

Purpose: To determine the effects of maturation stage (eg, classified in the same intervention protocol as early-, and late-mature) on linear sprinting speed adaptations to plyometric jump training (PJT) in youth (aged <18 years) male team sports players. Patients and Methods: Eligibility criteria was determined based on PICOS: (P) healthy youth male team sport players classified in the same intervention protocol in ≥2 maturation-related categories, based on a recognized maturation stage-determination method, including (but not limited to) Tanner stage; peak height velocity (eg, Mirwald method); radiography-based method (eg, Fels method); (I) athletes exposed to PJT with a minimum of 4 weeks duration; (C) athletes non-exposed to PJT (non-dedicated intervention, ie, only field-based regular training) or performing a parallel intervention not-related with PJT organized by maturation levels; (O) sprinting speed (eg, time, maximal sprint speed) measured in any linear sprint test trajectories before and after the intervention; (S) only randomized controlled and/or parallel trials. Searches were conducted on December 2021 in EMBASE, PubMed, Scopus, SPORTDiscus and Web of Science, restricted to Portuguese, Spanish and English languages, with no restrictions regarding publication date, and no filters applied. The PEDro scale was used to assess the risk of bias in the included studies. Meta-analysis was computed using the inverse variance random-effects model. The significance level was set at p < 0.05. Results: The search identified 1219 titles. From those, four studies were selected for qualitative and quantitative synthesis. Four studies provided data for sprinting performance, involving 10 experimental and 8 control groups showing a small effect of trained participants on sprinting performance (ES = 0.31; p = 0.064; I2 = 41.3%) when compared to controls. No significant moderator effect was noted for somatic maturity (p = 0.473 between groups). Conclusion: PJT had no significant effect on sprinting performance, although the inclusion criteria partially may explain that.9E1A-F9DD-3EB8 | Filipe Manuel ClementeN/

Analysis of the 'Endoworm' prototype's ability to grip the bowel in in vitro and ex vivo models

[EN] Access to the small bowel by means of an enteroscope is difficult, even using current devices such as single-balloon or double-balloon enteroscopes. Exploration time and patient discomfort are the main drawbacks. The prototype 'Endoworm' analysed in this paper is based on a pneumatic translation system that, gripping the bowel, enables the endoscope to move forward while the bowel slides back over its most proximal part. The grip capacity is related to the pressure inside the balloon, which depends on the insufflate volume of air. Different materials were used as in vitro and ex vivo models: rigid polymethyl methacrylate, flexible silicone, polyester urethane and ex vivo pig small bowel. On measuring the pressure-volume relationship, we found that it depended on the elastic properties of the lumen and that the frictional force depended on the air pressure inside the balloons and the lumen's elastic properties. In the presence of a lubricant, the grip on the simulated intestinal lumens was drastically reduced, as was the influence of the lumen's properties. This paper focuses on the Endoworm's ability to grip the bowel, which is crucial to achieving effective endoscope forward advance and bowel foldingThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The study was funded by the Spanish Ministry of Economy and Competitiveness through Project (PI18/01365) and by the UPV/IIS LA Fe through the (Endoworm 3.0) Project. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with the assistance of the European Regional Development FundTobella, J.; Pons-Beltrán, V.; Santonja, A.; Sánchez-Diaz, C.; Campillo Fernandez, AJ.; Vidaurre, A. (2020). Analysis of the 'Endoworm' prototype's ability to grip the bowel in in vitro and ex vivo models. Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine. 234(5):1-10. https://doi.org/10.1177/09544119209014141102345Iddan, G., Meron, G., Glukhovsky, A., & Swain, P. (2000). Wireless capsule endoscopy. Nature, 405(6785), 417-417. doi:10.1038/35013140Yamamoto, H., Sekine, Y., Sato, Y., Higashizawa, T., Miyata, T., Iino, S., … Sugano, K. (2001). Total enteroscopy with a nonsurgical steerable double-balloon method. Gastrointestinal Endoscopy, 53(2), 216-220. doi:10.1067/mge.2001.112181Arnott, I. D. R., & Lo, S. K. (2004). REVIEW: The Clinical Utility of Wireless Capsule Endoscopy. Digestive Diseases and Sciences, 49(6), 893-901. doi:10.1023/b:ddas.0000034545.58486.e6Hosoe, N., Takabayashi, K., Ogata, H., & Kanai, T. (2019). Capsule endoscopy for small‐intestinal disorders: Current status. 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QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson's Disease

Parkinson's disease is one of the most common neurodegenerative illnesses in older persons and the leucine-rich repeat kinase 2 (LRRK2) is an auspicious target for its pharmacological treatment. In this work, quantitative structure-activity relationship (QSAR) models for identification of putative inhibitors of LRRK2 protein are developed by using an in-house chemical library and several machine learning techniques. The methodology applied in this paper has two steps: first, alternative subsets of molecular descriptors useful for characterizing LRRK2 inhibitors are chosen by a multi-objective feature selection method; secondly, QSAR models are learned by using these subsets and three different strategies for supervised learning. The qualities of all these QSAR models are compared by classical metrics and the best models are discussed in statistical and physicochemical terms.Fil: Sebastián Pérez, Víctor. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; EspañaFil: Martínez, María Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias e Ingeniería de la Computación. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación. Instituto de Ciencias e Ingeniería de la Computación; ArgentinaFil: Gil, Carmen. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; EspañaFil: Campillo Martín, Nuria Eugenia. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; EspañaFil: Martínez, Ana. Consejo Superior de Investigaciones Científicas. Centro de Investigaciones Biológicas; EspañaFil: Ponzoni, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias e Ingeniería de la Computación. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación. Instituto de Ciencias e Ingeniería de la Computación; Argentin

A comparative study on Poly(ε-caprolactone) film degradation at extreme pH values

The present paper studies the effect of pH on hydrolytic degradation of Poly(&#949;-aprolactone) (PCL) Degradation of the films was performed at 37 C in 2.5 M NaOH solution (pH 13) and 2.5 M HCl solution (pH 1). Weight loss, degree of swelling, molecular weight, and calorimetric and mechanical properties were obtained as a function of degradation time. Morphological changes in the samples were carefully studied through electron microscopy. At the start of the process the degradation rate of PCL films at pH 13 was faster than at pH 1. In the latter case, there was an induction period of around 300 h with no changes in weight loss or swelling rate, but there were drastic changes in molecular weight and crystallinity. The changes in some properties throughout the degradation period, such as crystallinity, molecular weight and Young s modulus were lower in degradations at higher pH, highlighting differences in the degradation mechanism of alkaline and acid hydrolysis. Along with visual inspection of the degraded samples, this suggests a surface degradation at pH 13, whereas bulk degradation may occur at pH 1.The authors would like to acknowledge the support of the Spanish Ministry of Science and Education through the MAT2013-46467-C4-1-R Project. A. Vidaurre would also like to acknowledge the support from CIBER-BBN, an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund.Sailema-Palate, GP.; Vidaurre Garayo, AJ.; Campillo Fernández, AJ.; Castilla Cortázar, MIC. (2016). A comparative study on Poly(ε-caprolactone) film degradation at extreme pH values. Polymer Degradation and Stability. 130:118-125. https://doi.org/10.1016/j.polymdegradstab.2016.06.005S11812513

Sustainable technologies for older adults

: The exponential evolution of technology and the growth of the elderly population are two phenomena that will inevitably interact with increasing frequency in the future. This paper analyses scientific literature as a means of furthering progress in sustainable technology for senior living. We carried out a bibliometric analysis of papers published in this area and compiled by the Web of Science (WOS) and Scopus, examining the main participants and advances in the field from 2000 to the first quarter of 2021. The study describes some interesting research projects addressing three different aspects of older adults’ daily lives—health, daily activities and wellbeing—and policies to promote healthy aging and improve the sustainability of the healthcare system. It also looks at lines of research into transversal characteristics of technology. Our analysis showed that publications mentioning sustainability technologies for older adults have been growing progressively since the 2000s, but that the big increase in the number of research works in this area took place during the period 2016–2021. These more recent works show a tendency to study those factors that improve healthy aging, ensure the social inclusion of the elderly through technology and prolong the time in which they can live independent lives thanks to smart environments. Current research gaps in the literature are also discussed.: This work was funded by the Spanish Ministry of Economy, Industry and Competitiveness, (CSO2017-86747-R) and supported in part by the FEDER/Ministerio de Ciencia, Innovación y Universidades-Agencia Estatal de Investigación, through the Smartlet and H2O Learn Projects under Grants TIN2017-85179-C3-1-R and PID2020-112584RB-C31, and in part by the Madrid Regional Government through the e-Madrid-CM Project under Grant S2018/TCS-4307