Broadband and low loss high refractive index metamaterials in the microwave regime

Copyright © 2013 American Institute of PhysicsA broadband, low-loss, isotropic, high refractive index metamaterial comprising an array of close-packed cubic elements of cross-linked square metal plates is demonstrated in the microwave regime. The structuring of the cubic elements reduces the diamagnetic response exhibited by arrays of solid metal cubes, whilst maintaining the strongly enhanced permittivity arising from capacitative coupling between adjacent metal elements. The corresponding increase in refractive index can be tailored through appropriate structuring of the faces and/or spacing of the cubes

The Knee Arthroplasty Trial (KAT) : design features, baseline characteristics and two-year functional outcomes after alternative approaches to knee replacement

Background: The aim of continued development of total knee replacement systems has been the further improvement of the quality of life and increasing the duration of prosthetic survival. Our goal was to evaluate the effects of several design features, including metal backing of the tibial component, patellar resurfacing, and a mobile bearing between the tibial and femoral components, on the function and survival of the implant. Methods: A pragmatic, multicenter, randomized, controlled trial involving 116 surgeons in thirty-four centers in the United Kingdom was performed; 2352 participants were randomly allocated to be treated with or without a metal backing of the tibial component (409), with or without patellar resurfacing (1715), and/or with or without a mobile bearing (539). Randomization to more than one comparison was allowed. The primary outcome measures were the Oxford Knee Score (OKS), Short Form-12, EuroQol-5D, and the need for additional surgery. The results up to two years postoperatively are reported. Results: Functional status and quality-of-life scores were low at baseline but improved markedly across all trial groups following knee replacement (mean overall OKS, 17.98 points at baseline and 34.82 points at two years). Most of the change was observed at three months after the surgery. Six percent of the patients had additional knee surgery within two years. There was no evidence of differences in clinical, functional, or quality-of-life measures between the randomized groups at two years. Conclusions: Patients have substantial improvement following total knee replacement. This is the first adequately powered randomized controlled trial, of which we are aware, in which the effects of metal backing, patellar resurfacing, and a mobile bearing were investigated. We found no evidence of an effect of these variants on the rate of early complications or on functional recovery up to two years after total knee replacement. Level of Evidence: Therapeutic Level I. See Instructions to Authors for a complete description of levels of evidence.NIHR Health Technology Assessment Programme (Project Number 95/10/01); Howmedica Osteonics; Zimmer; DePuy, a Johnson and Johnson company; Corin Medical; Smith and Nephew Healthcare. Biomet Merck; and Wright CremascoliPeer reviewe

Clinical effectiveness and cost-effectiveness of open and arthroscopic rotator cuff repair [the UK Rotator Cuff Surgery (UKUFF) randomised trial]

Peer reviewedPublisher PD

Chapter 15: Construction of a Paleozoic–Mesozoic accretionary orogen along the active continental margin of SE Gondwana (South Island, New Zealand): summary and overview

Petrographic features of semi-schists from East Bald Hill (northern Southland). (<b>a</b>) Weakly cleaved volcaniclastic sandstone, with relict elongated clasts of feldspar-phyric extrusive rock in a pelitic matrix; sample N13.134, equivalent of the West Burn Semischist, Caples Terrane; upper northern slopes of East Bald Hill, northern Southland, S45 35790 E 168 16473, viewed under plane polarized light (PPL). (<b>b</b>) Subangular grain of monocrystalline (volcanic) quartz, with strain shadows in sheared volcanogenic matrix; sample N13.137, equivalent of the West Burn Semischist, Caples Terrane; upper northern slopes of East Bald Hill, northern Southland, S45 35523 E 168 16531, viewed under PPL. (<b>c</b>) Volcaniclastic microconglomerate; altered basaltic clast within sheared (relatively incompetent) volcaniclastic fine-grained sandstone/phyllite; sample N13.135, equivalent of the West Burn Semischist, Caples Terrane; upper northern slopes of East Bald Hill, Caples Terrane, S45 35790 E 168 16473, viewed under PPL. (<b>d</b>) Polyphase shearing and folding in partially recrystallized volcaniclastic sandstone/microconglomerate. Note truncation of inclined shear fabric by later-stage sub-horizontal shear fabric; sample N13.135, equivalent of the West Burn Semischist, Caples Terrane; NW upper slope of East Bald Hill, northern Southland; S45 35790 E 168 16473, viewed under PPL. (<b>e</b>) Weakly cleaved volcaniclastic sandstone cut by veins (chlorite-rich) that were later folded; sample N13.135, equivalent of the West Burn Semischist, Caples Terrane; upper northern slopes of East Bald Hill, northern Southland, S45 35790 E 168 16473, viewed under PPL. (<b>f</b>) As above, but showing asymmetrical (top-right) microfolds, viewed under PPL

E-cadherin can limit the transforming properties of activating β-catenin mutations

Wnt pathway deregulation is a common characteristic of many cancers. But only Colorectal Cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of pancreas) have activating mutations in β-catenin (CTNNB1). We have compared the dynamics and the potency of β-catenin mutations in vivo. Within the murine small intestine (SI), an activating mutation of β-catenin took much longer to achieve a Wnt deregulation and acquire a crypt-progenitor-cell (CPC) phenotype than Apc or Gsk3 loss. Within the colon, a single activating mutation of β-catenin was unable to drive Wnt deregulation or induce the CPC phenotype. This ability of β-catenin mutation to differentially transform the SI versus the colon correlated with significantly higher expression of the β-catenin binding partner E-cadherin. This increased expression is associated with a higher number of E-cadherin:β-catenin complexes at the membrane. Reduction of E-cadherin synergised with an activating mutation of β-catenin so there was now a rapid CPC phenotype within the colon and SI. Thus there is a threshold of β-catenin that is required to drive transformation and E-cadherin can act as a buffer to prevent β-catenin accumulation

Confocal laser endomicroscopy is a new imaging modality for recognition of intramucosal bacteria in inflammatory bowel disease in vivo

Interaction of bacteria with the immune system within the intestinal mucosa plays a key role in the pathogenesis of inflammatory bowel disease (IBD). The aim of the current study was to develop a fluorescein-aided confocal laser endomicroscopy (CLE) method to visualise intramucosal enteric bacteria in vivo and to determine the involved mucosal area in the colon and ileum in patients with ulcerative colitis (UC) and Crohn's disease (CD)

Non-holomorphic Corrections from Threebranes in F Theory

We construct solutions of type IIB supergravity dual to N=2 super Yang-Mills theories. By considering a probe moving in a background with constant coupling and an AdS_{5} component in its geometry, we are able to reproduce the exact low energy effective action for the theory with gauge group SU(2) and N_{f}=4 massless flavors. After turning on a mass for the flavors we find corrections to the AdS_{5} geometry. In addition, the coupling shows a power law dependence on the energy scale of the theory. The origin of the power law behaviour of the coupling is traced back to instanton corrections. Instanton corrections to the four derivative terms in the low energy effective action are correctly obtained from a probe analysis. By considering a Wilson loop in this geometry we are also able to compute the instanton effects on the quark-antiquark potential. Finally we consider a solution corresponding to an asymptotically free field theory. Again, the leading form of the four derivative terms in the low energy effective action are in complete agreement with field theory expectations.Comment: 23 pages, uses harvmac, References added, typos corrected and minor improvements to discussion of N dependence, to appear in Phys. Rev.

Endomicroscopic and transcriptomic analysis of impaired barrier function and malabsorption in environmental enteropathy

Introduction: Environmental enteropathy (EE) is associated with growth failure, micronutrient malabsorption and impaired responses to oral vaccines. We set out to define cellular mechanisms of impaired barrier function in EE and explore protective mechanisms. Methods: We studied 49 adults with environmental enteropathy in Lusaka, Zambia using confocal laser endomicroscopy (CLE); histology, immunohistochemistry and mRNA sequencing of small intestinal biopsies; and correlated these with plasma lipopolysaccharide (LPS) and a zinc uptake test. Results: CLE images (median 134 for each study) showed virtually ubiquitous small intestinal damage. Epithelial defects, imaged by histology and claudin 4 immunostaining, were predominantly seen at the tips of villi and corresponded with leakage imaged in vivo by CLE. In multivariate analysis, circulating log-transformed LPS was correlated with cell shedding events (β = 0.83; P = 0.035) and with serum glucagon-like peptide-2 (β = -0.13; P = 0.007). Zinc uptake from a test dose of 25mg was attenuated in 30/47 (64%) individuals and in multivariate analysis was reduced by HIV, but positively correlated with GLP-2 (β = 2.72; P = 0.03). There was a U-shaped relationship between circulating LPS and villus surface area. Transcriptomic analysis identified 23 differentially expressed genes in severe enteropathy, including protective peptides and proteins. Conclusions: Confocal endomicroscopy, claudin 4 immunostaining and histology identify epithelial defects which are probably sites of bacterial translocation, in the presence of which increased epithelial surface area increases the burden of translocation. GLP 2 and other protective peptides may play an important role in mucosal protection in EE

Dietary Supplementation with Soluble Plantain Non-Starch Polysaccharides Inhibits Intestinal Invasion of Salmonella Typhimurium in the Chicken

Soluble fibres (non-starch polysaccharides, NSP) from edible plants but particularly plantain banana (Musa spp.), have been shown in vitro and ex vivo to prevent various enteric pathogens from adhering to, or translocating across, the human intestinal epithelium, a property that we have termed contrabiotic. Here we report that dietary plantain fibre prevents invasion of the chicken intestinal mucosa by Salmonella. In vivo experiments were performed with chicks fed from hatch on a pellet diet containing soluble plantain NSP (0 to 200 mg/d) and orally infected with S.Typhimurium 4/74 at 8 d of age. Birds were sacrificed 3, 6 and 10 d post-infection. Bacteria were enumerated from liver, spleen and caecal contents. In vitro studies were performed using chicken caecal crypts and porcine intestinal epithelial cells infected with Salmonella enterica serovars following pre-treatment separately with soluble plantain NSP and acidic or neutral polysaccharide fractions of plantain NSP, each compared with saline vehicle. Bacterial adherence and invasion were assessed by gentamicin protection assay. In vivo dietary supplementation with plantain NSP 50 mg/d reduced invasion by S.Typhimurium, as reflected by viable bacterial counts from splenic tissue, by 98.9% (95% CI, 98.1–99.7; P<0.0001). In vitro studies confirmed that plantain NSP (5–10 mg/ml) inhibited adhesion of S.Typhimurium 4/74 to a porcine epithelial cell-line (73% mean inhibition (95% CI, 64–81); P<0.001) and to primary chick caecal crypts (82% mean inhibition (95% CI, 75–90); P<0.001). Adherence inhibition was shown to be mediated via an effect on the epithelial cells and Ussing chamber experiments with ex-vivo human ileal mucosa showed that this effect was associated with increased short circuit current but no change in electrical resistance. The inhibitory activity of plantain NSP lay mainly within the acidic/pectic (homogalacturonan-rich) component. Supplementation of chick feed with plantain NSP was well tolerated and shows promise as a simple approach for reducing invasive salmonellosis